Verfügbarkeit: ABC Transporters - 40 Years on

ABC Transporters - 40 Years on:

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Bibliographische Detailangaben
Weitere Verfasser:	George, Anthony M. (HerausgeberIn)
Format:	Elektronisch E-Book
Sprache:	English
Veröffentlicht:	Cham Springer International Publishing 2016 2016
Ausgabe:	1st edition
Schlagworte:	Life sciences Drug resistance Biochemistry Cell membranes Biophysics Biological physics Life Sciences Membrane Biology Biophysics and Biological Physics Biochemistry, general Drug Resistance Biowissenschaften ABC-Transporter Aufsatzsammlung
Online-Zugang:	DE-523 DE-91 DE-355 Volltext Inhaltsverzeichnis Abstract
Beschreibung:	1 Online-Ressource (XIV, 376 Seiten)
ISBN:	9783319234762
DOI:	10.1007/978-3-319-23476-2

Internformat

MARC


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Datensatz im Suchindex

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adam_text	ABC TRANSPORTERS - 40 YEARS ON / : 2016 TABLE OF CONTENTS / INHALTSVERZEICHNIS ABC IMPORTERS INBORN ERRORS AND POTENTIAL CORRECTION OF THE CELLULAR EXPRESSION AND LOCALIZATION OF MEDICALLY IMPORTANT ABC TRANSPORTERS HUMAN ABC TRANSPORTER ABCC11: MOLECULAR MECHANISTIC, PHARMACOLOGICAL, AND ANTHROPOLOGICAL ASPECTS BIOLOGY OF MITOCHONDRIAL ABCS AND THEIR CONTRIBUTION TO PATHOLOGY ABC TRANSPORTERS AND MULTIDRUG RESISTANCE IN FUNGI AND YEAST STRUCTURAL AND MECHANISTIC INSIGHTS INTO MODULATION OF P-GLYCOPROTEIN (ABCB1)FUNCTION BY TYROSINE KINASE INHIBITORS TECHNIQUES FOR THE PURIFICATION OF ABC TRANSPORTERS HDAC INHIBITORS AND MDR ABC TRANSPORTERS THE ROLE OF POLYMORPHISMS IN P-GLYCOPROTEIN (ABCB1) ON FUNCTION INTERACTION OF ABC TRANSPORTERS WITH DRUGS ABC INSIGHTS FROM CFTR. DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT. ABC TRANSPORTERS - 40 YEARS ON / : 2016 ABSTRACT / INHALTSTEXT THIS BOOK PROVIDES NEW STRUCTURAL, BIOCHEMICAL, AND CLINICAL INFORMATION ON ABC TRANSPORTERS. THE AUTHORS EXPLORE AND DESCRIBE THE STATE OF THE ART OF RESEARCH, KNOWLEDGE, AND PROSPECTS FOR THE FUTURE FOR THIS IMPORTANT FAMILY OF PROTEINS. THE FIRST ABC TRANSPORTER WAS DISCOVERED IN 1973 AND WAS NAMED P-GLYCOPROTEIN. IT ELICITS RESISTANCE TO CYTOTOXIC DRUGS, CHIEFLY IN HUMAN TUMOURS, WITHIN WHICH CHEMOTHERAPY FAILURE IS OBSERVED IN ABOUT 50% OF CASES. TOGETHER WITH ITS COMPLEX PHARMACOLOGY, AND EVEN A SUSPECTED ROLE IN ALZHEIMER’S DISEASE, THIS ABC TRANSPORTER STILL ELUDES A CLINICAL SOLUTION TO ITS MULTIDRUG RESISTANCE PROPERTY. ABC TRANSPORTERS ARE INTEGRAL MEMBRANE ACTIVE PROTEINS AND THEY BELONG TO ONE OF THE LARGEST PROTEIN FAMILIES ACROSS ALL SPECIES. THEIR MYRIAD ROLES ENCOMPASS THE IMPORT OR EXPORT OF A DIVERSE RANGE OF ALLOCRITES, INCLUDING ION, NUTRIENTS, PEPTIDES, POLYSACCHARIDES, LIPIDS, AND XENOBIOTICS. THEY ARE OF MAJOR MEDICAL IMPORTANCE WITH MANY MEMBERS ELABORATING MULTIDRUG RESISTANCE IN BACTERIA, FUNGI, YEAST, PARASITES, AND HUMANS. OTHER ABC TRANSPORTERS ARE INVOLVED IN A NUMBER OF INHERITED DISEASES, INCLUDING CYSTIC FIBROSIS, MACULAR DEGENERATION, GOUT, AND SEVERAL OTHER METABOLIC DISORDERS DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
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discipline	Biologie
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format	Electronic eBook
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spelling	ABC Transporters - 40 Years on edited by Anthony M. George 1st edition Cham Springer International Publishing 2016 2016 1 Online-Ressource (XIV, 376 Seiten) txt rdacontent c rdamedia cr rdacarrier Life sciences Drug resistance Biochemistry Cell membranes Biophysics Biological physics Life Sciences Membrane Biology Biophysics and Biological Physics Biochemistry, general Drug Resistance Biowissenschaften ABC-Transporter (DE-588)4472594-2 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content ABC-Transporter (DE-588)4472594-2 s 2\p DE-604 George, Anthony M. (DE-588)1095667300 edt Erscheint auch als Druckausgabe 978-3-319-23475-5 https://doi.org/10.1007/978-3-319-23476-2 Verlag URL des Erstveröffentlichers Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028962358&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028962358&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk
spellingShingle	ABC Transporters - 40 Years on Life sciences Drug resistance Biochemistry Cell membranes Biophysics Biological physics Life Sciences Membrane Biology Biophysics and Biological Physics Biochemistry, general Drug Resistance Biowissenschaften ABC-Transporter (DE-588)4472594-2 gnd
subject_GND	(DE-588)4472594-2 (DE-588)4143413-4
title	ABC Transporters - 40 Years on
title_auth	ABC Transporters - 40 Years on
title_exact_search	ABC Transporters - 40 Years on
title_full	ABC Transporters - 40 Years on edited by Anthony M. George
title_fullStr	ABC Transporters - 40 Years on edited by Anthony M. George
title_full_unstemmed	ABC Transporters - 40 Years on edited by Anthony M. George
title_short	ABC Transporters - 40 Years on
title_sort	abc transporters 40 years on
topic	Life sciences Drug resistance Biochemistry Cell membranes Biophysics Biological physics Life Sciences Membrane Biology Biophysics and Biological Physics Biochemistry, general Drug Resistance Biowissenschaften ABC-Transporter (DE-588)4472594-2 gnd
topic_facet	Life sciences Drug resistance Biochemistry Cell membranes Biophysics Biological physics Life Sciences Membrane Biology Biophysics and Biological Physics Biochemistry, general Drug Resistance Biowissenschaften ABC-Transporter Aufsatzsammlung
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