Principles of pharmacology: the pathophysiologic basis of drug therapy
Gespeichert in:
| Weitere Verfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Philadelphia ; Baltimore ; New York ; London ; Buenos Aires ; Hong Kong ; Sydney ; Tokyo
Wolters Kluwer
[2017]
|
| Ausgabe: | Fourth edition, international edition |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | xix, 1020 Seiten Illustrationen, Diagramme |
| ISBN: | 9781496320575 1496320573 9781451191004 |
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| 245 | 1 | 0 | |a Principles of pharmacology |b the pathophysiologic basis of drug therapy |c David E. Golan, MD, PhD, editor in chief, Ehrin J. Armstrong, MD, MSc, April W. Armstrong, MD, MPH, associate editors |
| 250 | |a Fourth edition, international edition | ||
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Datensatz im Suchindex
| _version_ | 1804176175331803136 |
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| adam_text | Contents
Preface............................................ix
Preface to the First Edition.......................xi
Acknowledgments..................................xiii
Contributors.......................................xv
SECTION I
Fundamental Principles of Pharmacology 1
1 Drug-Receptor Interactions.....................2
Francis J. Alenghat and David E. Golan
2 Pharmacodynamics..............................17
Quentin J. Baca and David E. Golan
3 Pharmacokinetics..............................27
Quentin J. Baca and David E. Golan
4 Drug Metabolism...............................43
F. Peter Guengerich
5 Drug Transporters.............................56
Baran A. Ersoy and Keith A. Hoffmeister
6 Drug Toxicity.................................70
Michael W. Conner, Catherine Dorian-Conner,
Vishal S. Vaidya, Laura C. Green, and David E. Golan
7 Pharmacogenomics..............................87
Amber Dahlin and Kelan Tantisira
SECTION II
Principles of Neuropharmacology 95
Section IIA
Fundamental Principles of Neuropharmacology 97
8 Principles of Cellular Excitability and
Electrochemical Transmission....................98
Elizabeth Mayne, Lauren K. Buhl, and Gary R. Strichcirtz
9 Principles of Nervous System
Physiology and Pharmacology.....................110
Joshua M. Galanter, Susannah B. Cornes, and
Daniel H. Lowenstein
Section IIB
/u.lcs of Autonomic and Peripheral
•vr-s System Pharmacology 126
l} Cholinergic Pharmacology......................127
Alireza Atri, Michael S. Chang, and Gary R. Strichartz
Vi Adrenergic Pharmacology.......................150
Nidhi Gera, Ehrin J. Armstrong, and David E. Golan
if Local Anesthetic Pharmacology................167
Quentin J. Baca, Joshua M. Schulman, and
Gary R. Strichartz
Section IIC
Principles of Central Nervous System Pharmacology 183
13 Pharmacology of GABAergic and
Glutamatergic Neurotransmission..............184
Stuart A. Forman, Hua-Jun Feng, Janet Chou, Jianren Mao,
and Eng H. Lo
13 Pharmacology of Dopaminergic
Neurotransmission............................206
David G. Standaert and Victor W. Sung
10 Pharmacology of Serotonergic and
Central Adrenergic Neurotransmission.........227
Stephen J. Haggarty and Roy H. Perils
1G Pharmacology of Abnormal Electrical
Neurotransmission in the Central Nervous System.249
Susannah B. Cornes, Edmund A. Griffin, Jr., and
Daniel H. Lowenstein
17 General Anesthetic Pharmacology.............265
Jacob Wouden and Keith W. Miller
18 Pharmacology of Analgesia...................288
Robert S. Griffin and Clifford J. Woolf
19 Pharmacology of Drugs of Abuse..............308
Peter R. Martin and Sachin Patel
SECTION III
Principles of Cardiovascular Pharmacology 335
20 Pharmacology of Cholesterol and
Lipoprotein Metabolism......................336
Tibor I. Krisko, Ehrin J. Armstrong, and David E. Cohen
vii
viii Contents
21 Pharmacology of Volume Regulation...........358
Hakan R. Тока and Seth L. Alper
22 Pharmacology of Vascular Tone.................385
William M. Oldham and Joseph Loscalzo
23 Pharmacology of Hemostasis and Thrombosis....403
Ehrin J. Armstrong and David E. Golan
24 Pharmacology of Cardiac Rhythm...............433
Ehrin J. Armstrong and David E. Clapham
25 Pharmacology of Cardiac Contractility........454
Ehrin J. Armstrong
26 Integrative Cardiovascular Pharmacology:
Hypertension, Ischemic Heart Disease,
and Heart Failure............................469
James M. McCabe and Ehrin J. Armstrong
SECTION IV
Principles of Endocrine Pharmacology 497
27 Pharmacology of the Hypothalamus
and Pituitary Gland....................... 498
Anand Vaidya and Ursula B. Kaiser
28 Pharmacology of the Thyroid Gland..........514
Anthony Hollenberg and William W. Chin
29 Pharmacology of the Adrenal Cortex..........524
Rajesh Garg and Gail K. Adler
30 Pharmacology of Reproduction................541
Ehrin J. Armstrong and Robert L. Bărbieri
31 Pharmacology of the Endocrine Pancreas
and Glucose Homeostasis.....................561
Giulio R. Romeo and Steven E, Shoelson
32 Pharmacology of Bone Mineral Homeostasis....580
David M. Slovik and Ehrin J. Armstrong
SECTION V
Principles of Chemotherapy 602
33 Principles of Antimicrobial and
Antineoplastic Pharmacology.....................603
Donald JVf. Coen, Vidyasagar Koduri, and David E. Golan
34 Pharmacology of Bacterial Infections: DNA
Replication, Transcription, and Translation.....622
Alexander J. Me Adam and Donald M. Coen
35 Pharmacology of Bacterial and Mycobacterial
Infections: Cell Wall Synthesis................ 641
David W. Kubiak, Ramy A. Arnaout, and Sarah R Hammond
36 Pharmacology of Fungal Infections..............661
Chelsea Ma and April W. Armstrong
37 Pharmacology of Parasitic Infections............674
Louise C. Ivers and Edward T Ryan
38 Pharmacology of Viral Infections.............. 694
Jonathan Z. Li and Donald M. Coen
39 Pharmacology of Cancer: Genome Synthesis,
Stability, and Maintenance......................723
David A. Barbie and David A. Frank
40 Pharmacology of Cancer: Signal Transduction..750
David A. Barbie and David A. Frank
41 Principles of Combination Chemotherapy.......770
Quentin J. Baca, Donald M. Coen, and David E. Golan
SECTION VI
Principles of inflammation and immune Pharmacology 782
42 Principles of Inflammation and
the Immune System...............................783
Eryn L. Royer and April W. Armstrong
43 Pharmacology of Eicosanoids....................794
David M. Dudziński and Charles N. Serhan
44 Histamine Pharmacology..........................819
Elizabeth A. Brezinski and April W. Armstrong
45 Pharmacology of Hematopoiesis
and Immunomodulation............................830
Andrew J. Wagner, Ramy A. Arnaout, and George D. Demetri
48 Pharmacology of Immunosuppression...............844
Elizabeth A. Brezinski, Lloyd B. Klickstein, and
April W. Armstrong
47 Integrative Inflammation Pharmacology:
Peptic Ulcer Disease............................864
Dalia S. Nagel and Helen M. Shields
48 Integrative Inflammation Pharmacology: Asthma.877
Joshua M. Galanter and Stephen Lazarus
49 Integrative Inflammation Pharmacology: Gout.895
Ehrin J. Armstrong and Lloyd B. Klickstein
SECTION VII
Environmental Toxicology 904
50 Environmental Toxicology..........................905
Laura G Green, Sarah R. Armstrong, and
Joshua M. Galanter
SECTION VIII
Fundamentals of Drug Development and Regulation 918
51 Drug Discovery and Preclinical Development..919
John L. Vahle, David L. Hutto, and Maarten Postema
52 Clinical Drug Evaluation and
Regulatory Approval.........................933
Mark A. Goldberg and Alexander E. Kuta
53 Systematic Detection of Adverse Drug Events.946
Jerry Avorn
SECTION IX
Frontiers in Pharmacology 954
54 Protein Therapeutics........................955
Quentin J. Baca, Benjamin Leader, and David E. Golan
55 Drug Delivery Modalities....................979
Joshua D. Moss and Robert Langer
Credit List.....................................987
Index...........................................991
Principles of
Pharmacology
The Pathophysiologic Basis of Drug Therapy
Editor in Chief
David E. Golan, MD, PhD
Associate Editors
Ehrin J. Armstrong, MD, MSc
April W. Armstrong, MD, MPH
Highly regarded by both students and instructors, Principles of Pharmacology: The Pathophysiologic Basis
of Drug Therapy, 4th Edition, offers an integrated mechanism-based and systems-based approach to
contemporary pharmacology and drug development An easy-to-follow format helps first- and second-year
students grasp challenging concepts quickly and efficiently. Each section presents the pharmacology of a
physiologic or biochemical system, followed by the pharmacology of a particular aspect of that system; a
clinical vignette; a discussion of the biochemistry, physiology, and pathophysiology of the system; and,
finally, the drugs and drug classes that activate or inhibit the system by interacting with specific molecular
and cellular targets. Clear, concise illustrations highlight key points, and drug summary tables offer quick
access to essential information.
The Fourth Edition features.
• Comprehensive updates to all chapters, including recently approved drugs
• Nearly 40 popular and practical Drug Summary Tables with state-of-the-art information on clinical
applications, serious and common adverse effects, contraindications, and therapeutic considerations
• A new chapter on drug transporters, and extensively revised information on drug-receptor interactions,
pharmacodynamics, drug toxicity, and pharmacogenomics
• Key changes to Section 1: Fundamental Principles of Pharmacology, which now provides a comprehensive
framework for material in all subsequent chapters.
• Hundreds of meticulously updated and colorized illustrations, including many that are new or
substantially modified to highlight new understanding of physiologic, pathophysiologic, and
pharmacologic mechanisms
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| spelling | Principles of pharmacology the pathophysiologic basis of drug therapy David E. Golan, MD, PhD, editor in chief, Ehrin J. Armstrong, MD, MSc, April W. Armstrong, MD, MPH, associate editors Fourth edition, international edition Philadelphia ; Baltimore ; New York ; London ; Buenos Aires ; Hong Kong ; Sydney ; Tokyo Wolters Kluwer [2017] © 2017 xix, 1020 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Pharmacological Phenomena Drug Therapy Pharmakologie (DE-588)4045687-0 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Pharmakologie (DE-588)4045687-0 s DE-604 Golan, David E. edt Armstrong, Ehrin J. edt Armstrong, April W. edt Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028942084&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028942084&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Principles of pharmacology the pathophysiologic basis of drug therapy Pharmacological Phenomena Drug Therapy Pharmakologie (DE-588)4045687-0 gnd |
| subject_GND | (DE-588)4045687-0 (DE-588)4123623-3 |
| title | Principles of pharmacology the pathophysiologic basis of drug therapy |
| title_auth | Principles of pharmacology the pathophysiologic basis of drug therapy |
| title_exact_search | Principles of pharmacology the pathophysiologic basis of drug therapy |
| title_full | Principles of pharmacology the pathophysiologic basis of drug therapy David E. Golan, MD, PhD, editor in chief, Ehrin J. Armstrong, MD, MSc, April W. Armstrong, MD, MPH, associate editors |
| title_fullStr | Principles of pharmacology the pathophysiologic basis of drug therapy David E. Golan, MD, PhD, editor in chief, Ehrin J. Armstrong, MD, MSc, April W. Armstrong, MD, MPH, associate editors |
| title_full_unstemmed | Principles of pharmacology the pathophysiologic basis of drug therapy David E. Golan, MD, PhD, editor in chief, Ehrin J. Armstrong, MD, MSc, April W. Armstrong, MD, MPH, associate editors |
| title_short | Principles of pharmacology |
| title_sort | principles of pharmacology the pathophysiologic basis of drug therapy |
| title_sub | the pathophysiologic basis of drug therapy |
| topic | Pharmacological Phenomena Drug Therapy Pharmakologie (DE-588)4045687-0 gnd |
| topic_facet | Pharmacological Phenomena Drug Therapy Pharmakologie Lehrbuch |
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