Introduction to statistical analysis of laboratory data:
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| Main Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Hoboken, New Jersey
Wiley
2016
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | xiii, 238 Seiten Illustrationen, Diagramme |
| ISBN: | 9781118736869 |
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MARC
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| 245 | 1 | 0 | |a Introduction to statistical analysis of laboratory data |c Alfred A. Bartolucci, University of Alabama at Birmingham, Birmingham, Alabama, USA; Karan P. Singh, University of Alabama at Birmingham, Birmingham, Alabama, USA; Sejong Bae, University of Alabama at Birmingham, Birmingham, Alabama, USA |
| 264 | 1 | |a Hoboken, New Jersey |b Wiley |c 2016 | |
| 300 | |a xiii, 238 Seiten |b Illustrationen, Diagramme | ||
| 336 | |b txt |2 rdacontent | ||
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| 650 | 7 | |a MEDICAL / Diseases |2 bisacsh | |
| 650 | 7 | |a MEDICAL / Evidence-Based Medicine |2 bisacsh | |
| 650 | 7 | |a MEDICAL / Internal Medicine |2 bisacsh | |
| 650 | 7 | |a Diagnosis, Laboratory / Statistical methods |2 fast | |
| 650 | 7 | |a Statistics |2 fast | |
| 650 | 4 | |a Evidenz-basierte Medizin | |
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| 650 | 4 | |a Diagnosis, Laboratory / Statistical methods | |
| 650 | 4 | |a Statistics | |
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| 700 | 1 | |a Bae, Sejong |e Verfasser |0 (DE-588)1091594430 |4 aut | |
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Record in the Search Index
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| adam_text | CONTENTS
Preface
Acknowledgments
1 DESCRIPTIVE STATISTICS
1.1 Measures of Central Tendency, 1
1.2 Measures of Variation, 4
1.3 Laboratory Example, 7
1.4 Putting it All Together, 8
1.5 Summary, 10
References, 10
2 DISTRIBUTIONS AND HYPOTHESIS TESTING IN FORMAL
STATISTICAL LABORATORY PROCEDURES
2.1 Introduction, 11
2.2 Confidence Intervals (CT), 19
2.2.1 Confidence Interval (Cl) for the Population Mean - The
¿-Distribution, 20
2.2.2 Confidence Interval for the Variance and Standard
Deviation, 21
2.3 Inferential Statistics - Hypothesis Testing, 23
2.3.1 ¿-Test for Means, 25
2.3.2 Test for Variation: Coefficient of Variation (CV), 28
2.3.3 Two-Sample Test of the Population Means, 29
viii
CONTENTS
2.3.4 One-Way Analysis of Variance (ANOVA), 34
2.3.5 Nonparametric Tests for Skewed Data, 40
References, 41
3 METHOD VALIDATION 43
3.1 Introduction, 43
3.2 Accuracy, 45
3.2.1 Method 1, 45
3.2.2 Method 2, 56
3.3 Brief Introduction to Bioassay, 59
3.3.1 Direct Assay, 59
3.3.2 Indirect Assay, 61
3.4 Sensitivity, Specificity (Selectivity), 69
3.5 Method Validation and Method Agreement - Bland-Altman, 73
References, 76
4 METHODOLOGIES IN OUTLIER ANALYSIS 79
4.1 Introduction, 79
4.2 Some Outlier Determination Techniques, 80
4.2.1 Grubb Statistic, 82
4.2.2 Other Forms of the Grubb Statistic, 84
4.2.3 Studentized Range Statistic, 85
4.2.4 Sequential Test of Many Outliers, 86
4.2.5 Mahalanobis Distance Measure, 88
4.2.6 Dixon g-Test for a Single Outlier, 91
4.2.7 The Box Plot, 94
4.2.8 Median Absolute Deviation, 95
4.3 Combined Method Comparison Outlier Analysis, 96
4.3.1 Further Outlier Considerations, 96
4.3.2 Combined Method Comparison Outlier Analysis - Refined
Method Comparisons Using Bland - Altman, 98
4.4 Some Consequences of Outlier Removal, 103
4.5 Considering Outlier Variance, 104
4.5.1 The Cochran C test, 104
4.5.2 Cochran G Test, 107
References, 110
5 STATISTICAL PROCESS CONTROL 113
5.1 Introduction, 113
5.2 Control Charts, 115
5.2.1 Means (X-bar) Control Charts, 117
5.2.2 Range Control Charts, 122
5.2.3 The S-Chart, 124
CONTENTS
5.2.4 The Median Chart, 126
5.2.5 Mean (X-bar) and 5-Charts Based on the Median
Absolute Deviation (MAD), 128
5.3 Capability Analysis, 131
5.4 Capability Analysis - An Alternative Consideration, 137
References, 139
6 LIMITS OF CALIBRATION
6.1 Calibration: Limit Strategies for Laboratory Assay Data, 141
6.1.1 Definition — Calibration, 141
6.2 Limit Strategies, 142
6.2.1 Example - Estimation of LoB and LoD for Drug
Assay, 142
6.2.2 LoQ Results, 144
6.2.3 A Comparison of Empirical and Statistical Approaches
to the LoD and LoQ, 145
6.2.4 Example - LoD/LoQ, GC - MS Approach, 145
6.2.5 LoD/LoQ, GC - MS Approach, 146
6.2.6 Explanation of the Difficulty of the Statistical Methodology
for the LoD and LoQ, 147
6.2.7 Another LoQ Method, 151
6.3 Method Detection Limits (EPA), 151
6.3.1 Method Detection Limits, 151
6.3.2 Example — Atrazine by Gas Chromatography (GC), 152
6.3.3 LoD and LoQ Summary, 153
6.4 Data Near the Detection Limits, 154
6.4.1 Biased Estimators, 154
6.4.2 Computing Some Statistics with the LoD in the Data, 154
6.5 More on Statistical Management of Nondetects, 156
6.5.1 Model-Based Examples of Measuring Nondetects, 157
6.5.2 An Alternative Regression Approach with Improvements
(Refer to the Box Cox Transformation in Chapter 5), 160
6.5.3 Extension of the ROS Method for Multiple NDs in Various
Positions, 163
6.5.4 Cohen’s Adjustment, 165
6.6 The Kaplan - Meier Method (Nonparametric Approach) for
Analysis of Laboratory Data with Nondetects, 170
References, 174
7 CALIBRATION BIAS
7.1 Error, 177
7.1.1 Types of Error, 179
7.2 U ncertainty, 180
7.3 Sources of Uncertainty, 180
X
CONTENTS
7.4 Estimation Methods of Uncertainty, 181
7.4.1 Statistical Estimation Methods of Type A Uncertainty, 181
7.4.2 Estimation Methods of Type B Uncertainty, 183
7.4.3 Estimation Methods of Combined and Expanded Uncertainties
(Normal Data), 187
7.4.4 Estimation Methods of Combined and Expanded Uncertainties
(Nonnormal Data), 190
7.4.5 Another Method of Estimating Uncertainties for Nonnormal
Data (Nonparametric), 192
7.5 Calibration Bias, 194
7.5.1 Gas Chromatographic/Mass Spectrometric (GC — MS)
Calibration Bias, 197
7.5.2 Discussion, 205
7.6 Multiple Instruments, 205
7.7 Crude Versus Precise Methodologies, 208
References, 210
8 ROBUSTNESS AND RUGGEDNESS 213
8.1 Introduction, 213
8.2 Robustness, 214
8.3 Ruggedness, 216
8.4 An Alternative Procedure for Ruggedness Determination, 224
8.5 Ruggedness and System Suitability Tests, 227
8.5.1 Determining the SST Limits from Replicated
Experimentation, 228
8.5.2 Determining the SST Limits from Statistical Prediction, 231
References, 233
Index
235
|
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| isbn | 9781118736869 |
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| spelling | Bartolucci, Alfred A. Verfasser (DE-588)1089080212 aut Introduction to statistical analysis of laboratory data Alfred A. Bartolucci, University of Alabama at Birmingham, Birmingham, Alabama, USA; Karan P. Singh, University of Alabama at Birmingham, Birmingham, Alabama, USA; Sejong Bae, University of Alabama at Birmingham, Birmingham, Alabama, USA Hoboken, New Jersey Wiley 2016 xiii, 238 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier HEALTH & FITNESS / Diseases / General bisacsh MEDICAL / Clinical Medicine bisacsh MEDICAL / Diseases bisacsh MEDICAL / Evidence-Based Medicine bisacsh MEDICAL / Internal Medicine bisacsh Diagnosis, Laboratory / Statistical methods fast Statistics fast Evidenz-basierte Medizin Innere Medizin Medizin Statistik Diagnosis, Laboratory / Statistical methods Statistics Singh, Karan P. Verfasser (DE-588)1089080344 aut Bae, Sejong Verfasser (DE-588)1091594430 aut Digitalisierung UB Bayreuth - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028892352&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bartolucci, Alfred A. Singh, Karan P. Bae, Sejong Introduction to statistical analysis of laboratory data HEALTH & FITNESS / Diseases / General bisacsh MEDICAL / Clinical Medicine bisacsh MEDICAL / Diseases bisacsh MEDICAL / Evidence-Based Medicine bisacsh MEDICAL / Internal Medicine bisacsh Diagnosis, Laboratory / Statistical methods fast Statistics fast Evidenz-basierte Medizin Innere Medizin Medizin Statistik Diagnosis, Laboratory / Statistical methods Statistics |
| title | Introduction to statistical analysis of laboratory data |
| title_auth | Introduction to statistical analysis of laboratory data |
| title_exact_search | Introduction to statistical analysis of laboratory data |
| title_full | Introduction to statistical analysis of laboratory data Alfred A. Bartolucci, University of Alabama at Birmingham, Birmingham, Alabama, USA; Karan P. Singh, University of Alabama at Birmingham, Birmingham, Alabama, USA; Sejong Bae, University of Alabama at Birmingham, Birmingham, Alabama, USA |
| title_fullStr | Introduction to statistical analysis of laboratory data Alfred A. Bartolucci, University of Alabama at Birmingham, Birmingham, Alabama, USA; Karan P. Singh, University of Alabama at Birmingham, Birmingham, Alabama, USA; Sejong Bae, University of Alabama at Birmingham, Birmingham, Alabama, USA |
| title_full_unstemmed | Introduction to statistical analysis of laboratory data Alfred A. Bartolucci, University of Alabama at Birmingham, Birmingham, Alabama, USA; Karan P. Singh, University of Alabama at Birmingham, Birmingham, Alabama, USA; Sejong Bae, University of Alabama at Birmingham, Birmingham, Alabama, USA |
| title_short | Introduction to statistical analysis of laboratory data |
| title_sort | introduction to statistical analysis of laboratory data |
| topic | HEALTH & FITNESS / Diseases / General bisacsh MEDICAL / Clinical Medicine bisacsh MEDICAL / Diseases bisacsh MEDICAL / Evidence-Based Medicine bisacsh MEDICAL / Internal Medicine bisacsh Diagnosis, Laboratory / Statistical methods fast Statistics fast Evidenz-basierte Medizin Innere Medizin Medizin Statistik Diagnosis, Laboratory / Statistical methods Statistics |
| topic_facet | HEALTH & FITNESS / Diseases / General MEDICAL / Clinical Medicine MEDICAL / Diseases MEDICAL / Evidence-Based Medicine MEDICAL / Internal Medicine Diagnosis, Laboratory / Statistical methods Statistics Evidenz-basierte Medizin Innere Medizin Medizin Statistik |
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