Novel (Trans)dermal Drug Delivery Strategies: Micro- and Nano-scale Assessments
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Electronic eBook |
| Language: | English |
| Published: |
Cham
Springer
2016
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| Series: | Springer Theses
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| Subjects: | |
| Online Access: | TUM01 UBT01 Volltext Abstract Inhaltsverzeichnis |
| Physical Description: | 1 Online Ressource (XVIII, 114 p. 49 illus., 25 illus. in color) |
| ISBN: | 9783319289014 |
| DOI: | 10.1007/978-3-319-28901-4 |
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Record in the Search Index
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| adam_text | NOVEL (TRANS)DERMAL DRUG DELIVERY STRATEGIES
/ GARVIE-COOK, HAZEL
: 2016
ABSTRACT / INHALTSTEXT
THIS WORK REPRESENTS AN INVENTIVE ATTEMPT TO APPLY RECENT ADVANCES IN
NANOTECHNOLOGY TO IDENTIFY AND CHARACTERISE NOVEL POLYMER SYSTEMS FOR
DRUG DELIVERY THROUGH THE SKIN. ATOMIC FORCE MICROSCOPY (AFM)
MEASUREMENTS OF THE NANOSCALE MECHANICAL PROPERTIES OF TOPICAL,
DRUG-CONTAINING POLYMERIC FILMS ENABLED THE AUTHOR TO IDENTIFY OPTIMAL
COMPOSITIONS, IN TERMS OF FLEXIBILITY AND SUBSTANTIVITY, FOR APPLICATION
TO THE SKIN. TO ELUCIDATE THE ENHANCED DRUG RELEASE FROM POLYACRYLATE
FILMS INCORPORATING MEDIUM CHAIN TRIGLYCERIDES, THE AUTHOR COMBINED AFM
STUDIES WITH THE COMPLEMENTARY TECHNIQUE OF RAMAN MICRO-SPECTROSCOPY.
THIS EXPERIMENTAL STRATEGY REVEALED THAT THE SIGNIFICANT INCREASE IN THE
DRUG RELEASED FROM THESE FILMS IS THE RESULT OF A NANOSCALE TWO-PHASE
STRUCTURE. FINALLY, IN EXPERIMENTS EXAMINING THE MICROPORATION OF SKIN
USING FEMTOSECOND LASER ABLATION, THE AUTHOR DEMONSTRATED THAT THE
THRESHOLD AT WHICH THE SKIN S BARRIER FUNCTION IS UNDERMINED CAN BE
DRAMATICALLY REDUCED BY THE PRE-APPLICATION OF INK. THE APPROACH ALLOWS
THERMAL DAMAGE AT THE PORE EDGE TO BE MINIMISED, SUGGESTING A VERY REAL
POTENTIAL FOR SUBSTANTIALLY INCREASING DRUG DELIVERY IN A MINIMALLY
INVASIVE FASHION
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
NOVEL (TRANS)DERMAL DRUG DELIVERY STRATEGIES
/ GARVIE-COOK, HAZEL
: 2016
TABLE OF CONTENTS / INHALTSVERZEICHNIS
INTRODUCTION
BACKGROUND
METHODOLOGY
TEC PLASTICIZATION OF TOPICAL POLYMERIC FILMS
LIPID INCORPORATION INTO TOPICAL POLYMERIC FILMS
LASER MICROPORATION OF SKIN
CONCLUSION
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| author | Garvie-Cook, Hazel |
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| dewey-full | 610.153 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610.153 |
| dewey-search | 610.153 |
| dewey-sort | 3610.153 |
| dewey-tens | 610 - Medicine and health |
| discipline | Physik Medizin |
| doi_str_mv | 10.1007/978-3-319-28901-4 |
| format | Thesis Electronic eBook |
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| isbn | 9783319289014 |
| language | English |
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| spelling | Garvie-Cook, Hazel Verfasser aut Novel (Trans)dermal Drug Delivery Strategies Micro- and Nano-scale Assessments Hazel Garvie-Cook Cham Springer 2016 1 Online Ressource (XVIII, 114 p. 49 illus., 25 illus. in color) txt rdacontent c rdamedia cr rdacarrier Springer Theses Zugl.: University of Bath, Diss. Physics Biomedical engineering Polymers Medical physics Radiation Nanotechnology Medical and Radiation Physics Biomedical Engineering/Biotechnology Polymer Sciences Biomedical Engineering (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Druckausgabe 978-3-319-28900-7 https://doi.org/10.1007/978-3-319-28901-4 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028826477&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Abstract Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028826477&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Garvie-Cook, Hazel Novel (Trans)dermal Drug Delivery Strategies Micro- and Nano-scale Assessments Physics Biomedical engineering Polymers Medical physics Radiation Nanotechnology Medical and Radiation Physics Biomedical Engineering/Biotechnology Polymer Sciences Biomedical Engineering |
| subject_GND | (DE-588)4113937-9 |
| title | Novel (Trans)dermal Drug Delivery Strategies Micro- and Nano-scale Assessments |
| title_auth | Novel (Trans)dermal Drug Delivery Strategies Micro- and Nano-scale Assessments |
| title_exact_search | Novel (Trans)dermal Drug Delivery Strategies Micro- and Nano-scale Assessments |
| title_full | Novel (Trans)dermal Drug Delivery Strategies Micro- and Nano-scale Assessments Hazel Garvie-Cook |
| title_fullStr | Novel (Trans)dermal Drug Delivery Strategies Micro- and Nano-scale Assessments Hazel Garvie-Cook |
| title_full_unstemmed | Novel (Trans)dermal Drug Delivery Strategies Micro- and Nano-scale Assessments Hazel Garvie-Cook |
| title_short | Novel (Trans)dermal Drug Delivery Strategies |
| title_sort | novel trans dermal drug delivery strategies micro and nano scale assessments |
| title_sub | Micro- and Nano-scale Assessments |
| topic | Physics Biomedical engineering Polymers Medical physics Radiation Nanotechnology Medical and Radiation Physics Biomedical Engineering/Biotechnology Polymer Sciences Biomedical Engineering |
| topic_facet | Physics Biomedical engineering Polymers Medical physics Radiation Nanotechnology Medical and Radiation Physics Biomedical Engineering/Biotechnology Polymer Sciences Biomedical Engineering Hochschulschrift |
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