Personalized medicine:
Saved in:
| Other Authors: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Amsterdam
Elsevier Academic Press
2016
|
| Edition: | First edition |
| Series: | Advances in protein chemistry and structural biology
volume 102 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIII, 384 Seiten |
| ISBN: | 9780128047958 |
Staff View
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Record in the Search Index
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| adam_text | Titel: Personalized medicine
Autor: Donev, Rossen
Jahr: 2016
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CONTENTS
Contributors
Preface
1. High-Performance Affinity Chromatography: Applications in
Drug-Protein Binding Studies and Personalized Medicine
Zhao Li, Sandya R. Beeram, Cong Bi, D. Suresh, Xiwei Zheng, and
David S. Hage
1. Introduction
2. Frontal Analysis Studies of Drug-Protein Interactions
3. Zonal Elution Studies of Drug-Protein Interactions
4. Other Methods for Examining Drug-Protein Interactions
5. Conclusion
Acknowledgments
References
2. Role of Proteomics in the Development of Personalized Medicine
Kewal K. Jain
1. Introduction
2. Protein Biomarkers
3. Protein Biochips
4. Role of Proteomics-Based Molecular Diagnostics in Personalized Medicine
5. Pharmacoproteomics
6. Concluding Remarks About Application of Proteomics for
Personalized Medicine
References
3. Metaboiomics and Personalized Medicine
Nadia Koen, Use Du Preez, and Du Toit Loots
1. Introduction
2. The Value of Omics Technologies in the Development of
Personalized Medicine
3. What is Metaboiomics?
4. The Application of Metaboiomics Toward Personalized Medicine
5. Concluding Remarks
Acknowledgments
References
vi
Contents
4. Clinical Perspectives on Targeting Therapies for
Personalized Medicine 79
Donald RJ. Singer and Zoulikha M. Zai r
1. Introduction 80
2. What Are Personalized Medicines? 81
3. Rare Diseases 81
4. Evidence for Precision Medicines from Real World Data 82
5. Using Real World Data 82
6. Ethical Concerns 83
7. Adaptive Trial Design 84
8. Companion Diagnostics 85
9. Biological Treatments 86
10. Case Studies: Targets for Precision Medicines and Companion Diagnostics 88
11. Network Pharmacology 101
12. Future Developments 103
Acknowledgments 104
References 104
5. Personalized Medicine in Respiratory Disease: Role of Proteomics 115
V.S. Priyadharshini and Luis M. Teran
1. Introduction 116
2. Personalized Medicine 117
3. Proteomics 118
4. Respiratory Proteomics 120
5. Asthma 121
6. Chronic Obstructive Pulmonary Disease 124
7. Idiopathic Pulmonary Fibrosis 126
8. Aspirin-Exacerbated Respiratory Disease 128
9. Cystic Fibrosis 129
10. Lung Cancer 134
11. Conclusions 138
Acknowledgments 138
References 138
6. Computational Approaches to Accelerating Novel Medicine and
Better Patient Care from Bedside to Benchtop 147
Theodore Sakellaropoulos, Junguk Hur, loannis N. Melas, Ellen Y. Guo,
Leonidas Alexopoulos, Mohammad Bohlooly, and Jane P.F. Bai
1. Introduction 148
2. Currently Approved Products Targeting Protein Kinases in Oncology 150
Contents
vii
3. Tumor Heterogeneity 154
4. Computational Methods for Identifying Driver Mutations 157
5. Literature Mining in Oncology Research 163
6. Precise Genome Editing 166
7. Conclusion 169
Supplementary Material 170
References 170
7. Molecular Dynamics: New Frontier in Personalized Medicine 181
P. Sneha and C. George Priya Doss
1. Introduction 182
2. Single Nucleotide Polymorphisms in Drug Response 186
3. Drug Discovery 187
4. Advent of Personalized Medicine 188
5. Evolution of Molecular dynamics in the Field of Macromolecule
and Binding Interaction Analysis 189
6. Molecular Dynamics—A Boon in Personalized Medicine 191
7. MD Trajectories Analysis 198
8. Application of MD in SNP Analysis Toward Drug Discovery 205
9. Plausible Ways to Overcome the Disadvantages of Molecular Dynamics 207
10. Conclusion 211
Acknowledgments 212
References 212
8. Personalized Pharmacoperones for Lysosomal Storage Disorder:
Approach for Next-Generation Treatment 225
S.A. Syed Haneef and C. George Priya Doss
1. Introduction 226
2. LSDs Classification 228
3. Treatment of LSDs 242
4. Pharmacological Chaperones Versus Chemical Chaperones 250
5. Combination Therapy for LSDs 250
6. How Can PCT Personalized? 251
7. Computational Studies in PCT 253
8. Advantages and Disadvantages of Various Therapies in LSDs 254
9. Future of PCTs 255
10. Conclusion 256
Acknowledgments 256
References 256
viii
Contents
9. Investigating the Inhibitory Effect of Wortmannin in the Hotspot
Mutation at Codon 1047 of PIK3CA Kinase Domain: A Molecular
Docking and Molecular Dynamics Approach 267
D. Thirumal Kumar and C. George Priya Doss
1. Introduction 268
2. Materials and Methods 271
3. Results 273
4. Discussion 282
5. Conclusion 291
Acknowledgments 291
References 291
10. Role of von Willebrand Factor—A1 Domain Variants P1266L,
H1268D, C1272R, and C1272F in VWD: A Molecular Modeling
and Simulation Analysis Approach 299
C. George Priya Doss and Shabana Kouser Ali
1. Introduction 300
2. Material and Methods 305
3. Results 308
4. Discussion 322
5. Conclusion 324
Acknowledgment 325
References 325
Author Index 331
Subject Index 373
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| spelling | Personalized medicine edited by Rossen Donev First edition Amsterdam Elsevier Academic Press 2016 XIII, 384 Seiten txt rdacontent n rdamedia nc rdacarrier Advances in protein chemistry and structural biology volume 102 Mensch (DE-588)4038639-9 gnd rswk-swf Individualisierte Medizin (DE-588)7660544-9 gnd rswk-swf Pharmakotherapie (DE-588)4076066-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Mensch (DE-588)4038639-9 s Individualisierte Medizin (DE-588)7660544-9 s Pharmakotherapie (DE-588)4076066-2 s DE-604 Donev, Rossen (DE-588)14373945X edt Advances in protein chemistry and structural biology volume 102 (DE-604)BV035242330 102 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028822919&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| subject_GND | (DE-588)4038639-9 (DE-588)7660544-9 (DE-588)4076066-2 (DE-588)4143413-4 |
| title | Personalized medicine |
| title_auth | Personalized medicine |
| title_exact_search | Personalized medicine |
| title_full | Personalized medicine edited by Rossen Donev |
| title_fullStr | Personalized medicine edited by Rossen Donev |
| title_full_unstemmed | Personalized medicine edited by Rossen Donev |
| title_short | Personalized medicine |
| title_sort | personalized medicine |
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