Peptidomimetics in organic and medicinal chemistry:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Chichester, West Sussex, UK
John Wiley & Sons Inc.
2014
|
| Schlagworte: | |
| Online-Zugang: | FRO01 UBG01 Volltext |
| Beschreibung: | "A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"-- "Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature"-- Includes bibliographical references and index |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9781118683149 1118683145 9781118683842 1118683846 9781118683033 111868303X 1119950600 9781119950608 9781306546980 1306546982 |
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| 500 | |a "Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature"-- | ||
| 500 | |a Includes bibliographical references and index | ||
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| 650 | 7 | |a Drugs / Design |2 fast | |
| 650 | 7 | |a Peptide drugs |2 fast | |
| 650 | 7 | |a Proteins / Therapeutic use |2 fast | |
| 650 | 4 | |a Chemie | |
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| 650 | 4 | |a Proteins / Therapeutic use | |
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Datensatz im Suchindex
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|---|---|
| any_adam_object | |
| author | Trabocchi, Andrea |
| author_facet | Trabocchi, Andrea |
| author_role | aut |
| author_sort | Trabocchi, Andrea |
| author_variant | a t at |
| building | Verbundindex |
| bvnumber | BV043396448 |
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| dewey-full | 615.1/9 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.1/9 |
| dewey-search | 615.1/9 |
| dewey-sort | 3615.1 19 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Biologie Medizin |
| format | Electronic eBook |
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| id | DE-604.BV043396448 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:24:51Z |
| institution | BVB |
| isbn | 9781118683149 1118683145 9781118683842 1118683846 9781118683033 111868303X 1119950600 9781119950608 9781306546980 1306546982 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028815032 |
| oclc_num | 867001313 992847767 |
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| publishDate | 2014 |
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| publisher | John Wiley & Sons Inc. |
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| spelling | Trabocchi, Andrea Verfasser aut Peptidomimetics in organic and medicinal chemistry Dr. Andrea Trabocchi and Professor Antonio Guarna Chichester, West Sussex, UK John Wiley & Sons Inc. 2014 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier "A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"-- "Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature"-- Includes bibliographical references and index SCIENCE / Chemistry / Physical & Theoretical bisacsh Drugs / Design fast Peptide drugs fast Proteins / Therapeutic use fast Chemie Peptide drugs Proteins / Therapeutic use Drugs / Design Electronic books Guarna, Antonio Sonstige oth Erscheint auch als Druck-Ausgabe, Hardcover 978-1-119-95060-8 https://onlinelibrary.wiley.com/doi/book/10.1002/9781118683033 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Trabocchi, Andrea Peptidomimetics in organic and medicinal chemistry SCIENCE / Chemistry / Physical & Theoretical bisacsh Drugs / Design fast Peptide drugs fast Proteins / Therapeutic use fast Chemie Peptide drugs Proteins / Therapeutic use Drugs / Design |
| title | Peptidomimetics in organic and medicinal chemistry |
| title_auth | Peptidomimetics in organic and medicinal chemistry |
| title_exact_search | Peptidomimetics in organic and medicinal chemistry |
| title_full | Peptidomimetics in organic and medicinal chemistry Dr. Andrea Trabocchi and Professor Antonio Guarna |
| title_fullStr | Peptidomimetics in organic and medicinal chemistry Dr. Andrea Trabocchi and Professor Antonio Guarna |
| title_full_unstemmed | Peptidomimetics in organic and medicinal chemistry Dr. Andrea Trabocchi and Professor Antonio Guarna |
| title_short | Peptidomimetics in organic and medicinal chemistry |
| title_sort | peptidomimetics in organic and medicinal chemistry |
| topic | SCIENCE / Chemistry / Physical & Theoretical bisacsh Drugs / Design fast Peptide drugs fast Proteins / Therapeutic use fast Chemie Peptide drugs Proteins / Therapeutic use Drugs / Design |
| topic_facet | SCIENCE / Chemistry / Physical & Theoretical Drugs / Design Peptide drugs Proteins / Therapeutic use Chemie |
| url | https://onlinelibrary.wiley.com/doi/book/10.1002/9781118683033 |
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