The hERG cardiac potassium channel structure, function, and long QT syndrome (J. Wiley, 2005)
Proceedings of the Symposium on The hERG Cardiac Potassium Channel: Structure, Function and Long QT Syndrome, held at Novartis Foundation, London, May 4-6, 2004. - Editors: Derek J. Chadwick, Jamie Goode
Includes bibliographical references and indexes
This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding.¡It features regulatory authority perspectives on preferred preclinical test systems and includes topics on¡hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks