Enzyme systems that metabolise drugs and other xenobiotics:
Saved in:
| Format: | Electronic eBook |
|---|---|
| Language: | English |
| Published: |
Chichester
J. Wiley
©2002
|
| Series: | Current toxicology series
|
| Subjects: | |
| Online Access: | FRO01 UBG01 Volltext |
| Item Description: | Includes bibliographical references and index This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include:*enzyme function in the metabolism and bioactivation of xenobiotics*substrate specificity*tissue distribution*species distribution (to include laboratory animals and humans)*hormonal regulation*sex differences*modulation by prior exposure to other chemicals*age-dependent expression*pharmacogenetics and modulation by disease. Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists |
| Physical Description: | 1 Online-Ressource (viii, 578 pages) |
| ISBN: | 0470851988 9780470851982 0470846305 9780470846308 0471894664 9780471894667 128065435X 9781280654350 |
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| isbn | 0470851988 9780470851982 0470846305 9780470846308 0471894664 9780471894667 128065435X 9781280654350 |
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| spelling | Enzyme systems that metabolise drugs and other xenobiotics edited by Costas Ioannides Chichester J. Wiley ©2002 1 Online-Ressource (viii, 578 pages) txt rdacontent c rdamedia cr rdacarrier Current toxicology series Includes bibliographical references and index This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include:*enzyme function in the metabolism and bioactivation of xenobiotics*substrate specificity*tissue distribution*species distribution (to include laboratory animals and humans)*hormonal regulation*sex differences*modulation by prior exposure to other chemicals*age-dependent expression*pharmacogenetics and modulation by disease. Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists Pharmaceutical medicinal chemistry Pharmaceutical Preparations / metabolism Enzymes / physiology Metabolic Detoxication, Drug / physiology Xenobiotics / metabolism Farmacología Drogas para el metabolismo Enzimas MEDICAL / Pharmacology bisacsh Fármacos (metabolismo) larpcal Xenobiótico (metabolismo) larpcal Medizin Drugs / Metabolism Xenobiotics / Metabolism Enzymes / Mechanism of action Xenobiotikum (DE-588)4193155-5 gnd rswk-swf Enzymsystem (DE-588)4123145-4 gnd rswk-swf Arzneimittel (DE-588)4003115-9 gnd rswk-swf Stoffwechsel (DE-588)4057699-1 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Xenobiotikum (DE-588)4193155-5 s Stoffwechsel (DE-588)4057699-1 s Enzymsystem (DE-588)4123145-4 s 2\p DE-604 Arzneimittel (DE-588)4003115-9 s 3\p DE-604 Ioannides, Costas Sonstige oth https://onlinelibrary.wiley.com/doi/book/10.1002/0470846305 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Enzyme systems that metabolise drugs and other xenobiotics Pharmaceutical medicinal chemistry Pharmaceutical Preparations / metabolism Enzymes / physiology Metabolic Detoxication, Drug / physiology Xenobiotics / metabolism Farmacología Drogas para el metabolismo Enzimas MEDICAL / Pharmacology bisacsh Fármacos (metabolismo) larpcal Xenobiótico (metabolismo) larpcal Medizin Drugs / Metabolism Xenobiotics / Metabolism Enzymes / Mechanism of action Xenobiotikum (DE-588)4193155-5 gnd Enzymsystem (DE-588)4123145-4 gnd Arzneimittel (DE-588)4003115-9 gnd Stoffwechsel (DE-588)4057699-1 gnd |
| subject_GND | (DE-588)4193155-5 (DE-588)4123145-4 (DE-588)4003115-9 (DE-588)4057699-1 (DE-588)4143413-4 |
| title | Enzyme systems that metabolise drugs and other xenobiotics |
| title_auth | Enzyme systems that metabolise drugs and other xenobiotics |
| title_exact_search | Enzyme systems that metabolise drugs and other xenobiotics |
| title_full | Enzyme systems that metabolise drugs and other xenobiotics edited by Costas Ioannides |
| title_fullStr | Enzyme systems that metabolise drugs and other xenobiotics edited by Costas Ioannides |
| title_full_unstemmed | Enzyme systems that metabolise drugs and other xenobiotics edited by Costas Ioannides |
| title_short | Enzyme systems that metabolise drugs and other xenobiotics |
| title_sort | enzyme systems that metabolise drugs and other xenobiotics |
| topic | Pharmaceutical medicinal chemistry Pharmaceutical Preparations / metabolism Enzymes / physiology Metabolic Detoxication, Drug / physiology Xenobiotics / metabolism Farmacología Drogas para el metabolismo Enzimas MEDICAL / Pharmacology bisacsh Fármacos (metabolismo) larpcal Xenobiótico (metabolismo) larpcal Medizin Drugs / Metabolism Xenobiotics / Metabolism Enzymes / Mechanism of action Xenobiotikum (DE-588)4193155-5 gnd Enzymsystem (DE-588)4123145-4 gnd Arzneimittel (DE-588)4003115-9 gnd Stoffwechsel (DE-588)4057699-1 gnd |
| topic_facet | Pharmaceutical medicinal chemistry Pharmaceutical Preparations / metabolism Enzymes / physiology Metabolic Detoxication, Drug / physiology Xenobiotics / metabolism Farmacología Drogas para el metabolismo Enzimas MEDICAL / Pharmacology Fármacos (metabolismo) Xenobiótico (metabolismo) Medizin Drugs / Metabolism Xenobiotics / Metabolism Enzymes / Mechanism of action Xenobiotikum Enzymsystem Arzneimittel Stoffwechsel Aufsatzsammlung |
| url | https://onlinelibrary.wiley.com/doi/book/10.1002/0470846305 |
| work_keys_str_mv | AT ioannidescostas enzymesystemsthatmetabolisedrugsandotherxenobiotics |