Oxford textbook of clinical and biochemical disorders of the skeleton:
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| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Oxford, United Kingdom ; New York, NY, United States of America
Oxford University Press
2016
|
| Edition: | Second edition |
| Series: | Oxford textbooks in rheumatology
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Die erste Auflage erschien 2005 unter dem Titel: Smith, Roger: Clinical and biochemical disorders of the skeleton |
| Physical Description: | xvii, 429 Seiten Illustrationen |
| ISBN: | 9780199607990 0199607990 |
Staff View
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| 245 | 1 | 0 | |a Oxford textbook of clinical and biochemical disorders of the skeleton |c Roger Smith (Honorary Consultant Physician, Nuffield Orthopaedic Centre, Oxford, UK), Paul Wordsworth (Professor of Clinical Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculosceletal Sciences, University of Oxford, UK) |
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| 500 | |a Die erste Auflage erschien 2005 unter dem Titel: Smith, Roger: Clinical and biochemical disorders of the skeleton | ||
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Record in the Search Index
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Contents
1. Introduction i
2. The physiology and pathology of bone 5
Introduction to the physiology and
pathology of bone 5
Skeletal development 6
Structure of bone 6
Bone cells 7
Bone mass 19
Bone matrix 23
Cartilage matrix 28
Bone mineralization 29
Mineral metabolism 30
Calcium homeostasis 30
Phosphorus homeostasis 35
Magnesium metabolism 35
Measurements of bone cell turnover 36
Genetics, the human genome,
and DNA technology 39
Transgenic animals in bone biology 49
Bone and cartilage in disease 50
Discussion of physiology and pathology of bone 50
Summary of physiology and pathology of bone 51
3. Diagnosis and investigation 59
Introduction to diagnosis and investigation 59
Growth and stature 59
Clinical features 60
Investigation 65
Biochemistry 66
Radiological investigations 76
Bone biopsy 81
Other investigations 84
Discussion of diagnosis and investigation 84
Summary of diagnosis and investigation 84
4. Osteoporosis 87
Introduction to osteoporosis 87
Definition of osteoporosis 87
Osteoporosis and fracture 88
Epidemiology and cost of fracture 90
Pathophysiology of osteoporosis 96
Bone mass and density in osteoporosis 98
Bone strength in osteoporosis 100
Causes of osteoporosis 101
Postmenopausal osteoporosis 101
Other causes of osteoporosis no
Discussion of osteoporosis 120
Summary of osteoporosis 120
5. Osteomalacia and rickets 129
Introduction to osteomalacia and rickets 129
Causes of osteomalacia and rickets 130
Pathophysiology of osteomalacia and rickets 130
Clinical features of osteomalacia and rickets 132
Specific types of osteomalacia 138
Discussion of osteomalacia and rickets 153
Summary of osteomalacia and rickets 154
6. Parathyroids and the skeleton m
introduction to parathyroids and the skeleton 161
Hypercalcaemia 161
Parathyroid overactivity 161
Parathyroid deficiency and resistance to PTH 168
Discussion of parathyroids and the skeleton 172
Summary of parathyroids and the skeleton №
svi CONTENTS
7. Paget disease r:
introduction to Paget disease 177
Pathophysiology of Paget disease i77
Epidemiology of Paget disease 178
Causes of Paget disease ISO
Clinical features of Paget disease isi
Biochemistry of Paget disease і85
Radiology in Paget disease 186
Pathology of Paget disease 187
Differential diagnosis of Paget disease 187
Treatment of Paget disease 188
juvenile Paget disease (idiopathic
hyperphosphatasia) 192
Paget disease and frontotemporal dementia 192
Familial expansile osteolysis (FEO) ¡92
Expansile skeletal hyperphosphatasia (ESH) 193
Discussion of Paget disease ¡93
Summary of Paget disease 194
8. Neoplastic disease and other non-parathyroid
causes of hypercalcaemia m
Introduction to neoplastic disease and other
non-parathyroid causes of hypercalcaemia 199
Pathophysiology of cancer of the skeleton 199
Other non-parathyroid causes of hypercalcaemia 204
Pathophysiology of hypercalcaemia 205
Clinical features of hypercalcaemia 206
Differential diagnosis of hypercalcaemia 206
Treatment of hypercalcaemia 206
Discussion of neoplastic disease and other non-
parathyroid causes of hypercalcaemia 207
Summary of neoplastic disease and other non-
parathyroid causes of hypercalcaemia 208
9. Osteogenesis imperfecta and other
disorders of low bone density 211
Introduction to osteogenesis imperfecta and
other disorders of low bone density 211
Definition and classification of
osteogenesis imperfecta 211
Pathophysiology of osteogenesis imperfecta 213
Clinical types of osteogenesis imperfecta 215
Investigation of osteogenesis imperfecta 221
Diagnosis of osteogenesis imperfecta and
other disorders of low bone density 222
Prognosis of osteogenesis imperfecta 223
Management of osteogenesis imperfecta 224
Biochemistry: genotype and phenotype
of osteogenesis imperfecta 227
Genetic advice for osteogenesis imperfecta 229
Prenatal diagnosis of osteogenesis imperfecta 230
Non-accidental injury 231
Other heritable causes of reduced
bone mineral density 231
Discussion of osteogenesis imperfecta and
other disorders of low bone density 232
Summary of osteogenesis imperfecta and
other disorders of low bone density 234
10. Skeletal dysplasias and related conditions 241
Introduction to skeletal dysplasias
and related conditions 241
Definition and classification of the
chondrodysplasias 244
Pathophysiology of the chondrodysplasias 247
FGFR3-related disorders 247
Spondyloepiphyseal dysplasias 250
Type 2 collagenopathies 251
Multiple epiphyseal dysplasias 253
Metaphyseal chondrodysplasias 258
Rare metaphyseal dysplasias 261
Other dysplasias 265
Dysostoses 267
The craniosynostoses 269
Other related disorders of the skeleton 270
Discussion of skeletal dysplasias and
related conditions 271
Summary of skeletal dysplasias and
related conditions 272
11. Osteopetrosis and osteosclerosis 277
Introduction to osteopetrosis and osteosclerosis 277
Classification of osteopetrosis and osteosclerosis 278
The osteopetroses 278
The osteoscleroses 285
Discussion of osteopetrosis and osteosclerosis 293
Summary of osteopetrosis and osteosclerosis 294
12. Marfan syndrome and related disorders 297
Introduction to Marfan syndrome
and related disorders 29՜
Marfan syndrome (MFS) 297
Disorders related to Marfan syndrome 311
Discussion of Marfan syndrome
and related disorders 312
CONTENTS
xvu
Summary of Marfan syndrome and
related disorders 313
13. Ehlers-Danlos syndrome and
related disorders 317
Introduction to Ehlers-Danlos syndrome
and related disorders 317
Classification of Ehlers-Danlos syndrome 317
Pathophysiology of Ehlers-Danlos syndrome 318
Clinical features of Ehlers-Danlos syndrome
and related disorders 320
Specific types of Ehlers-Danlos syndrome 322
Other forms of Ehlers-Danlos syndrome 325
Differential diagnosis of Ehlers-Danlos
syndrome 326
Management of Ehlers-Danlos syndrome
and related disorders 326
Discussion of Ehlers-Danlos syndrome
and related disorders 327
Summary of Ehlers-Danlos syndrome
and related disorders 327
14. Enzyme defects and the skeleton 331
Introduction to enzyme defects
and the skeleton 331
Homocystinuria 331
Hypophosphatasia 334
Alkaptonuria 338
The mucopolysaccharidoses 340
Disorders of copper enzymes 343
Discussion of enzyme defects and the skeleton 345
Summary of enzyme defects and the skeleton 345
15. Fibrous dysplasia 349
Introduction to fibrous dysplasia 349
Cause of fibrous dysplasia 349
Skeletal pathology 351
Clinical features of fibrous dysplasia 352
Differential diagnosis of fibrous dysplasia 354
Treatment of fibrous dysplasia 354
Cherubism 357
Familial craniofacial fibrous dysplasia 357
Discussion of fibrous dysplasia 357
Summary of fibrous dysplasia 359
16. Fibrogenesis imperfecta ossium and
other disorders of mineralization 363
Introduction to fibrogenesis imperfecta ossium
and other disorders of mineralization 363
Fibrogenesis imperfecta ossium 363
Other disorders of mineralization 367
Discussion of fibrogenesis imperfecta ossium
and other disorders of mineralization 369
Summary of fibrogenesis imperfecta ossium
and other disorders of mineralization 369
17. Ectopic mineralization 37i
Introduction to ectopic mineralization 371
Ectopic calcification 371
Ectopic (heterotopic) ossification 377
Discussion of ectopic mineralization 389
Summary of ectopic mineralization 391
18. Recent advances 395
Appendix 1: Recommendations for bone
marker nomenclature and abbreviations 403
Appendix 2: Height charts 405
Height chart for girls 406
Height chart for boys 407
Appendix 3: Relation of body surface to aortic
root diameter at the sinus of Valsalva 409
Appendix 4: Useful websites and
patient self-help groups 411
General websites for further information
and links to organizations 411
Disease organizations and support groups 411
Glossary 413
Index 419 |
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| spelling | Smith, Roger Verfasser (DE-588)136841848 aut Oxford textbook of clinical and biochemical disorders of the skeleton Roger Smith (Honorary Consultant Physician, Nuffield Orthopaedic Centre, Oxford, UK), Paul Wordsworth (Professor of Clinical Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculosceletal Sciences, University of Oxford, UK) Second edition Oxford, United Kingdom ; New York, NY, United States of America Oxford University Press 2016 xvii, 429 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Oxford textbooks in rheumatology Die erste Auflage erschien 2005 unter dem Titel: Smith, Roger: Clinical and biochemical disorders of the skeleton Human skeleton Abnormalities Bones Metabolism Disorders Bone Diseases, Metabolic Bone Diseases, Developmental Krankheit (DE-588)4032844-2 gnd rswk-swf Stoffwechselkrankheit (DE-588)4057700-4 gnd rswk-swf Skelett (DE-588)4133111-4 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Skelett (DE-588)4133111-4 s Stoffwechselkrankheit (DE-588)4057700-4 s DE-604 Krankheit (DE-588)4032844-2 s Wordsworth, Paul Verfasser aut Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028799560&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Smith, Roger Wordsworth, Paul Oxford textbook of clinical and biochemical disorders of the skeleton Human skeleton Abnormalities Bones Metabolism Disorders Bone Diseases, Metabolic Bone Diseases, Developmental Krankheit (DE-588)4032844-2 gnd Stoffwechselkrankheit (DE-588)4057700-4 gnd Skelett (DE-588)4133111-4 gnd |
| subject_GND | (DE-588)4032844-2 (DE-588)4057700-4 (DE-588)4133111-4 (DE-588)4123623-3 |
| title | Oxford textbook of clinical and biochemical disorders of the skeleton |
| title_auth | Oxford textbook of clinical and biochemical disorders of the skeleton |
| title_exact_search | Oxford textbook of clinical and biochemical disorders of the skeleton |
| title_full | Oxford textbook of clinical and biochemical disorders of the skeleton Roger Smith (Honorary Consultant Physician, Nuffield Orthopaedic Centre, Oxford, UK), Paul Wordsworth (Professor of Clinical Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculosceletal Sciences, University of Oxford, UK) |
| title_fullStr | Oxford textbook of clinical and biochemical disorders of the skeleton Roger Smith (Honorary Consultant Physician, Nuffield Orthopaedic Centre, Oxford, UK), Paul Wordsworth (Professor of Clinical Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculosceletal Sciences, University of Oxford, UK) |
| title_full_unstemmed | Oxford textbook of clinical and biochemical disorders of the skeleton Roger Smith (Honorary Consultant Physician, Nuffield Orthopaedic Centre, Oxford, UK), Paul Wordsworth (Professor of Clinical Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculosceletal Sciences, University of Oxford, UK) |
| title_short | Oxford textbook of clinical and biochemical disorders of the skeleton |
| title_sort | oxford textbook of clinical and biochemical disorders of the skeleton |
| topic | Human skeleton Abnormalities Bones Metabolism Disorders Bone Diseases, Metabolic Bone Diseases, Developmental Krankheit (DE-588)4032844-2 gnd Stoffwechselkrankheit (DE-588)4057700-4 gnd Skelett (DE-588)4133111-4 gnd |
| topic_facet | Human skeleton Abnormalities Bones Metabolism Disorders Bone Diseases, Metabolic Bone Diseases, Developmental Krankheit Stoffwechselkrankheit Skelett Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028799560&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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