Holdings: Chromosomal Translocations and Genome Rearrangements in Cancer

Chromosomal Translocations and Genome Rearrangements in Cancer:

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Bibliographic Details
Format:	Electronic eBook
Language:	English
Published:	Cham Springer 2015
Subjects:	Medicine Cancer research Human genetics Molecular biology Cell biology Biomedicine Cancer Research Cell Biology Human Genetics Molecular Medicine Medizin
Online Access:	TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract
Physical Description:	1 Online Ressource (IX, 490 p. 72 illus., 69 illus. in color)
ISBN:	9783319199832
DOI:	10.1007/978-3-319-19983-2

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MARC


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adam_text	CHROMOSOMAL TRANSLOCATIONS AND GENOME REARRANGEMENTS IN CANCER / : 2015 TABLE OF CONTENTS / INHALTSVERZEICHNIS PART I INTRODUCTION A SHORT HISTORY OF CHROMOSOME REARRANGEMENTS AND GENE FUSIONS IN CANCER PART II GENERAL MOLECULAR GENETICS METHODS IN DISCOVERY OF CHROMOSOME STRUCTURE MECHANISM OF RECURRENT CHROMOSOMAL TRANSLOCATIONS CHROMOSOME TRANSLOCATIONS, CANCER INITIATION AND CLONAL EVOLUTION.-CHROMOSOMAL FRAGILE SITES AND CANCER COPY NUMBER CHANGES IN CARCINOMAS: APPLICATIONS PART III LEUKAEMIA/LYMPHOMA CHRONIC MYELOID LEUKAEMIA IMMUNOGLOBULIN AND MYC REARRANGEMENTS IN MULTIPLE MYELOMA PATHOGENESIS GENETIC ALTERATIONS IN B CELL LYMPHOMA CHROMOSOMAL TRANSLOCATIONS AND GENE REARRANGEMENTS IN ACUTE LYMPHOBLASTIC LEUKAEMIA CELLULAR AND MOLECULAR BASIS OF MLL LEUKAEMIAS: FROM TRANSFORMATION MECHANISMS TO NOVEL THERAPEUTIC STRATEGIES ACUTE PROMYELOCYTIC LEUKAEMIA: FROM A SPECIFIC TRANSLOCATION TO CURE BY TARGETED THERAPIES CHROMOSOME ABNORMALITIES IN AML AND THEIR CLINICAL IMPORTANCE PART IV SARCOMAS FUSION ONCOGENES OF SARCOMAS TRANSLOCATIONS IN EWING SARCOMA PART V EPITHELIAL TUMOURS RET AND THYROID CARCINOMAS GENE FUSIONS IN PROSTATE CANCER CHROMOSOMAL TRANSLOCATIONS IN LUNG CANCER COLON & OVARIAN TRANSLOCATIONS PART VI OTHER ASPECTS PRE-CLINICAL MODELING OF CHROMOSOMAL TRANSLOCATIONS AND INVERSIONS PROTEIN COMPLEX HIERARCHY & TRANSLOCATION GENE PRODUCTS ABERRANT TRANSCRIPTIONAL PROGRAMMING IN BLOOD CANCERS INDEX DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT. CHROMOSOMAL TRANSLOCATIONS AND GENOME REARRANGEMENTS IN CANCER / : 2015 ABSTRACT / INHALTSTEXT THIS VOLUME COLLATES WORLD EXPERTS’ INSIGHTS INTO THE MOLECULAR BIOLOGY OF CANCER CHROMOSOMES, THEIR ABNORMALITIES AND THE SUBSEQUENT CELLULAR CONSEQUENCES. EXPLORING THEMES INVOLVING ONCOGENES, SUCH AS BY CHROMOSOMAL TRANSLOCATIONS, OTHER GENOME REARRANGEMENTS AND SOMATIC MUTATIONS, THIS BOOK IS A REVIEW OF THE FIELD OF CANCER GENETICS THAT PRESAGES A NEW ERA, AS WHOLE GENOME SEQUENCING BECOMES MORE ACCESSIBLE. THE WORK BEGINS WITH A LOOK AT HISTORICAL THEMES, SUCH AS THE ANALYSIS OF METAPHASE CHROMOSOMES USING MICROSCOPY AND STAINING TECHNIQUES, ADVANCES IN WHICH PROVIDED OUR FIRST BROAD GLIMPSE INTO THE GENETIC ANATOMY OF A MALIGNANT CELL. READERS WILL LEARN ABOUT THE APPLICATION OF DNA MOLECULAR CLONING TECHNIQUES IN THE 1980S, THAT LED TO THE IDENTIFICATION OF THE GENES INVOLVED IN THE PHILADELPHIA AND BURKITT S LYMPHOMA CHROMOSOMAL TRANSLOCATIONS, SOLIDIFYING THE ROLE OF ONCOGENES AND TUMOUR SUPPRESSOR GENES IN CANCER AETIOLOGY VIA CHROMOSOMAL ALTERATIONS, AND WHICH LAUNCHED A FIELD IN CANCER GENETICS. SUBSEQUENT CHAPTERS BRING THE READER UP TO DATE BY REVIEWING RECENT DEVELOPMENTS IN THE FIELD, WITH DEDICATED SECTIONS ON LEUKAEMIA/LYMPHOMA, SARCOMAS AND EPITHELIAL TUMOURS. CONTRIBUTIONS FEATURE NUMEROUS COLOUR TABLES AND ILLUSTRATIONS AND THIS VOLUME WILL PROVIDE A BASIS FOR UNDERSTANDING CANCER CHROMOSOMES FOR MANY YEARS TO COME DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
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spelling	Chromosomal Translocations and Genome Rearrangements in Cancer Janet D. Rowley, Michelle M. Le Beau, Terence H. Rabbitts, ed. Cham Springer 2015 1 Online Ressource (IX, 490 p. 72 illus., 69 illus. in color) txt rdacontent c rdamedia cr rdacarrier Medicine Cancer research Human genetics Molecular biology Cell biology Biomedicine Cancer Research Cell Biology Human Genetics Molecular Medicine Medizin Rowley, Janet D. 1925-2013 Sonstige (DE-588)1081463120 oth Le Beau, Michelle M. Sonstige (DE-588)1081463392 oth Rabbitts, Terence H. Sonstige oth Erscheint auch als Druckausgabe 978-3-319-19982-5 https://doi.org/10.1007/978-3-319-19983-2 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028730142&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028730142&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract
spellingShingle	Chromosomal Translocations and Genome Rearrangements in Cancer Medicine Cancer research Human genetics Molecular biology Cell biology Biomedicine Cancer Research Cell Biology Human Genetics Molecular Medicine Medizin
title	Chromosomal Translocations and Genome Rearrangements in Cancer
title_auth	Chromosomal Translocations and Genome Rearrangements in Cancer
title_exact_search	Chromosomal Translocations and Genome Rearrangements in Cancer
title_full	Chromosomal Translocations and Genome Rearrangements in Cancer Janet D. Rowley, Michelle M. Le Beau, Terence H. Rabbitts, ed.
title_fullStr	Chromosomal Translocations and Genome Rearrangements in Cancer Janet D. Rowley, Michelle M. Le Beau, Terence H. Rabbitts, ed.
title_full_unstemmed	Chromosomal Translocations and Genome Rearrangements in Cancer Janet D. Rowley, Michelle M. Le Beau, Terence H. Rabbitts, ed.
title_short	Chromosomal Translocations and Genome Rearrangements in Cancer
title_sort	chromosomal translocations and genome rearrangements in cancer
topic	Medicine Cancer research Human genetics Molecular biology Cell biology Biomedicine Cancer Research Cell Biology Human Genetics Molecular Medicine Medizin
topic_facet	Medicine Cancer research Human genetics Molecular biology Cell biology Biomedicine Cancer Research Cell Biology Human Genetics Molecular Medicine Medizin
url	https://doi.org/10.1007/978-3-319-19983-2 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028730142&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028730142&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA
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