Molecular Structures and Structural Dynamics of Prion Proteins and Prions: Mechanism Underlying the Resistance to Prion Diseases
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Dordrecht
Springer Netherlands
2015
|
| Schriftenreihe: | Focus on Structural Biology
9 |
| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online Ressource (XIX, 355 p. 179 illus., 176 illus. in color) |
| ISBN: | 9789401773188 |
| DOI: | 10.1007/978-94-017-7318-8 |
Internformat
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| 245 | 1 | 0 | |a Molecular Structures and Structural Dynamics of Prion Proteins and Prions |b Mechanism Underlying the Resistance to Prion Diseases |c Jiapu Zhang |
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| 650 | 4 | |a Chemistry, Physical and theoretical | |
| 650 | 4 | |a Bioinformatics | |
| 650 | 4 | |a Proteins | |
| 650 | 4 | |a Biophysics | |
| 650 | 4 | |a Biological physics | |
| 650 | 4 | |a Life Sciences | |
| 650 | 4 | |a Protein Structure | |
| 650 | 4 | |a Molecular Medicine | |
| 650 | 4 | |a Computational Biology/Bioinformatics | |
| 650 | 4 | |a Theoretical and Computational Chemistry | |
| 650 | 4 | |a Biophysics and Biological Physics | |
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Datensatz im Suchindex
| _version_ | 1804175709333094400 |
|---|---|
| adam_text | MOLECULAR STRUCTURES AND STRUCTURAL DYNAMICS OF PRION PROTEINS AND
PRIONS
/ ZHANG, JIAPU
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
BASIC KNOWLEDGE
THE HOMOLOGY STRUCTURE AND DYNAMICS
THE NMR STRUCTURE AND DYNAMICS OF THE WILD-TYPE AND MUTANTS
COMPARED WITH THE NMR STRUCTURE AND DYNAMICS OF HUMANS AND MICE
COMPARED WITH THE NMR STRUCTURE AND DYNAMICS OF DOGS AND HORSES
COMPARED WITH A HOMOLOGY STRUCTURE AND DYNAMICS OF BUFFALOES
COMPARED WITH NMR STRUCTURE AND DYNAMICS OF ELKS
COMPARED WITH THE X-RAY STRUCTURE AND DYNAMICS OF RABBITS
SURFACE ELECTROSTATIC CHARGE DISTRIBUTIONS
THE HYDROPHOBIC REGION PRP(109–136)
THE HYBRID METHOD OF STEEPEST DESCENT - CONJUGATE GRADIENT WITH
SIMULATED ANNEALING
HYBRID METHOD OF DISCRETE GRADIENT WITH SIMULATED ANNEALING OR GENETIC
ALGORITHM
A NOVEL CANONICAL DUAL GLOBAL OPTIMIZATION COMPUTATIONAL APPROACH
THE HYBRID METHOD OF EVOLUTIONARY COMPUTATIONS WITH SIMULATED ANNEALING
SIMULATED ANNEALING REFINED REPLICA EXCHANGE GLOBAL SEARCH ALGORITHM
LBFGS QUASI-NEWTONIAN METHODS FOR MM PRION AGAAAAGA AMYLOID FIBRILS
PARTICLE SWARM GLOBAL OPTIMIZATION SEARCH ALGORITHM
A SUMMARY OF THE RESEARCH WORKS ON AGAAAAGA.
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
MOLECULAR STRUCTURES AND STRUCTURAL DYNAMICS OF PRION PROTEINS AND
PRIONS
/ ZHANG, JIAPU
: 2015
ABSTRACT / INHALTSTEXT
THIS MONOGRAPH IS THE FIRST EASY-TO-READ-AND-UNDERSTAND BOOK ON PRION
PROTEINS MOLECULAR DYNAMICS (MD) SIMULATIONS AND ON PRIONS MOLECULAR
MODELLING (MM) CONSTRUCTIONS. IT ENABLES RESEARCHERS TO SEE WHAT IS
CRUCIAL TO THE CONFORMATIONAL CHANGE FROM NORMAL CELLULAR PRION PROTEIN
(PRPC) TO DISEASED INFECTIOUS PRIONS (PRPSC), USING MD AND MM
TECHNIQUES. AS WE ALL KNOW, PRION DISEASES, CAUSED BY THE BODY S OWN
PROTEINS, ARE INVARIABLY FATAL AND HIGHLY INFECTIOUS NEURODEGENERATIVE
DISEASES EFFECTING HUMANS AND ALMOST ALL ANIMALS FOR A MAJOR PUBLIC
HEALTH CONCERN. PRION CONTAINS NO NUCLEIC ACIDS AND IT IS A MISSHAPEN OR
CONFORMATION-CHANGED PROTEIN THAT ACTS LIKE AN INFECTIOUS AGENT; THUS
PRION DISEASES ARE CALLED “PROTEIN STRUCTURAL CONFORMATIONAL”
DISEASES. PRPC IS PREDOMINANT IN Α-HELICES BUT PRPSC ARE RICH IN
Β-SHEETS IN THE FORM AS AMYLOID FIBRILS; SO VERY AMENABLE TO BE STUDIED
BY MD TECHNIQUES. THROUGH MD, STUDIES ON THE PROTEIN STRUCTURES AND THE
STRUCTURAL CONVERSION ARE VERY IMPORTANT FOR REVEALING SECRETS OF PRION
DISEASES AND FOR STRUCTURE-BASED DRUG DESIGN OR DISCOVERY. RABBITS,
DOGS, HORSES AND BUFFALOES ARE REPORTED TO BE THE FEW LOW SUSCEPTIBILITY
SPECIES TO PRION DISEASES; THIS BOOK S MD STUDIES ON THESE SPECIES ARE
CLEARLY HELPFUL TO UNDERSTAND THE MECHANISM UNDERLYING THE RESISTANCE TO
PRION DISEASES. PRP(1-120) USUALLY HAS NO CLEAR MOLECULAR STRUCTURES;
THIS BOOK ALSO STUDIES THIS UNSTRUCTURED REGION THROUGH MD AND
ESPECIALLY MM TECHNIQUES FROM THE GLOBAL OPTIMIZATION POINT OF VIEW.
THIS BOOK IS IDEAL FOR PRACTITIONERS IN COMPUTING OF BIOPHYSICS,
BIOCHEMISTRY, BIOMEDICINE, BIOINFORMATICS, CHEMINFORMATICS, MATERIALS
SCIENCE AND ENGINEERING, APPLIED MATHEMATICS AND THEORETICAL PHYSICS,
INFORMATION TECHNOLOGY, OPERATIONS RESEARCH, BIOSTATISTICS, ETC. AS AN
ACCESSIBLE INTRODUCTION TO THESE FIELDS, THIS BOOK IS ALSO IDEAL AS A
TEACHING MATERIAL FOR STUDENTS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
| any_adam_object | 1 |
| author | Zhang, Jiapu 1971- |
| author_GND | (DE-588)1136047387 |
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| author_role | aut |
| author_sort | Zhang, Jiapu 1971- |
| author_variant | j z jz |
| building | Verbundindex |
| bvnumber | BV043209808 |
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| classification_tum | BIO 000 |
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| ctrlnum | (OCoLC)923659768 (DE-599)BVBBV043209808 |
| dewey-full | 572.633 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572.633 |
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| dewey-tens | 570 - Biology |
| discipline | Biologie |
| doi_str_mv | 10.1007/978-94-017-7318-8 |
| format | Electronic eBook |
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| id | DE-604.BV043209808 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:20:36Z |
| institution | BVB |
| isbn | 9789401773188 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028632969 |
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| owner_facet | DE-91 DE-BY-TUM DE-703 |
| physical | 1 Online Ressource (XIX, 355 p. 179 illus., 176 illus. in color) |
| psigel | ZDB-2-SBL ZDB-2-SBL_2015 |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Springer Netherlands |
| record_format | marc |
| series | Focus on Structural Biology |
| series2 | Focus on Structural Biology |
| spelling | Zhang, Jiapu 1971- Verfasser (DE-588)1136047387 aut Molecular Structures and Structural Dynamics of Prion Proteins and Prions Mechanism Underlying the Resistance to Prion Diseases Jiapu Zhang Dordrecht Springer Netherlands 2015 1 Online Ressource (XIX, 355 p. 179 illus., 176 illus. in color) txt rdacontent c rdamedia cr rdacarrier Focus on Structural Biology 9 Life sciences Molecular biology Chemistry, Physical and theoretical Bioinformatics Proteins Biophysics Biological physics Life Sciences Protein Structure Molecular Medicine Computational Biology/Bioinformatics Theoretical and Computational Chemistry Biophysics and Biological Physics Biowissenschaften Erscheint auch als Druckausgabe 978-94-017-7317-1 Focus on Structural Biology 9 (DE-604)BV043279814 9 https://doi.org/10.1007/978-94-017-7318-8 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028632969&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028632969&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Zhang, Jiapu 1971- Molecular Structures and Structural Dynamics of Prion Proteins and Prions Mechanism Underlying the Resistance to Prion Diseases Focus on Structural Biology Life sciences Molecular biology Chemistry, Physical and theoretical Bioinformatics Proteins Biophysics Biological physics Life Sciences Protein Structure Molecular Medicine Computational Biology/Bioinformatics Theoretical and Computational Chemistry Biophysics and Biological Physics Biowissenschaften |
| title | Molecular Structures and Structural Dynamics of Prion Proteins and Prions Mechanism Underlying the Resistance to Prion Diseases |
| title_auth | Molecular Structures and Structural Dynamics of Prion Proteins and Prions Mechanism Underlying the Resistance to Prion Diseases |
| title_exact_search | Molecular Structures and Structural Dynamics of Prion Proteins and Prions Mechanism Underlying the Resistance to Prion Diseases |
| title_full | Molecular Structures and Structural Dynamics of Prion Proteins and Prions Mechanism Underlying the Resistance to Prion Diseases Jiapu Zhang |
| title_fullStr | Molecular Structures and Structural Dynamics of Prion Proteins and Prions Mechanism Underlying the Resistance to Prion Diseases Jiapu Zhang |
| title_full_unstemmed | Molecular Structures and Structural Dynamics of Prion Proteins and Prions Mechanism Underlying the Resistance to Prion Diseases Jiapu Zhang |
| title_short | Molecular Structures and Structural Dynamics of Prion Proteins and Prions |
| title_sort | molecular structures and structural dynamics of prion proteins and prions mechanism underlying the resistance to prion diseases |
| title_sub | Mechanism Underlying the Resistance to Prion Diseases |
| topic | Life sciences Molecular biology Chemistry, Physical and theoretical Bioinformatics Proteins Biophysics Biological physics Life Sciences Protein Structure Molecular Medicine Computational Biology/Bioinformatics Theoretical and Computational Chemistry Biophysics and Biological Physics Biowissenschaften |
| topic_facet | Life sciences Molecular biology Chemistry, Physical and theoretical Bioinformatics Proteins Biophysics Biological physics Life Sciences Protein Structure Molecular Medicine Computational Biology/Bioinformatics Theoretical and Computational Chemistry Biophysics and Biological Physics Biowissenschaften |
| url | https://doi.org/10.1007/978-94-017-7318-8 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028632969&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028632969&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV043279814 |
| work_keys_str_mv | AT zhangjiapu molecularstructuresandstructuraldynamicsofprionproteinsandprionsmechanismunderlyingtheresistancetopriondiseases |