Biophysical and structural aspects of bioenergetics (Royal Society of Chemistry, 2005)
Bioenergetics is a term used to describe the events of primary energy transduction in biology. The field has seen tremendous advances in recent years thanks to developments in the biophysical and computational techniques used to solve the three-dimensional structures of the membrane-bound proteins, which often act as catalysts in these reactions. This has enabled researchers to bring, otherwise static, structures to life and decipher the dynamic function of these intriguing systems. Biophysical and Structural Aspects of Bioenergetics brings together contributions from internationally respected experts, all of whom helped shape and develop the field of bioenergetics. It provides a representative snapshot of the very latest key developments in this multidisciplinary subject, with an emphasis on molecular structure, and how this changes during the bioenergetic function. Offering a comprehensive overview of the current state of the art, and complete with extensive citations in each chapter, this book is the ideal reference for both biochemists and biophysicists studying this fascinating topic
Includes bibliographical references and index
Principles of molecular bioenergetics and the proton pump of cytochrome oxidase -- Proton entry, exit and pathways in cytochrome oxidase : insight from "conserved" water -- Structural chemical studies on the reaction mechanism of cytochrome c oxidase -- Mechanisms of redox-coupled proton pumping by respiratory oxidases -- Quantum chemical models of O₂ bond cleavage and proton pumping in cytochrome oxidase -- The bc₁ complex : what is there left to argue about? -- Insights into the mechanism of mitochondrial complex I from its distant relatives, the [NiFe] hydrogenases -- Current knowledge about the mechanism of energy transduction by Respiratory Complex I -- Structure of Photosystem II from Thermosynechococcus elongatus -- A structural view of proton transport by Bacteriorhodopsin -- The dynamics of proton transfer across Bacteriorhodopsin explored by FT-IR spectroscopy -- Intraprotein proton transfer : concepts and realities from the bacterial photosynthetic reaction center -- Infrared protein spectroscopy as a tool to study protonation reactions within proteins -- Inhibitors of mitochondrial F₁-ATPase -- The passion of the permease -- Hydride transfer and proton translocation by nicotinamide nucleotide transhydrogenase