Cellular response to the genotoxic insult: the question of threshold for genotoxic carcinogens
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cambridge, U.K.
Royal Society of Chemistry
2012
|
| Schriftenreihe: | Issues in toxicology
13 |
| Schlagworte: | |
| Online-Zugang: | FAW01 FAW02 Volltext |
| Beschreibung: | Includes index "Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of mutagens. Distinguishing the point at which exposure to a carcinogen increases mutation rates beyond the background level is challenging. In fact, there is now general agreement that, for genotoxic carcinogens, no specific threshold can be identified. However, NOAELs (No Observed Adverse Effect Levels) may be used in the process of establishing a dose-response relationship. These denote the level of exposure at which there is no significant increase in adverse effects in the exposed population when compared to an appropriate control. Such a scientifically defendable threshold allows us to propose health based exposure limits for genotoxic carcinogens. This book describes the various cellular defence mechanisms individually and explains how they are regulated. The processes covered include metabolic inactivation, epigenetic regulation, scavenging mechanisms, DNA-repair and apoptosis. It also considers dose-dependent threshold mechanisms of carcinogenesis and the rate limiting parameters. Aimed at graduate level and above, the book discusses the consequences of genotoxic evaluation and urges readers to question the idea that even low exposures present a cancer risk."-- |
| Beschreibung: | 1 Online-Ressource (xiv, 319 p.) |
| ISBN: | 1849732922 9781849732925 |
Internformat
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| 245 | 1 | 0 | |a Cellular response to the genotoxic insult |b the question of threshold for genotoxic carcinogens |c editors, Helmut Greim and Richard Albertini |
| 264 | 1 | |a Cambridge, U.K. |b Royal Society of Chemistry |c 2012 | |
| 300 | |a 1 Online-Ressource (xiv, 319 p.) | ||
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| 490 | 0 | |a Issues in toxicology |v 13 | |
| 500 | |a Includes index | ||
| 500 | |a "Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of mutagens. Distinguishing the point at which exposure to a carcinogen increases mutation rates beyond the background level is challenging. In fact, there is now general agreement that, for genotoxic carcinogens, no specific threshold can be identified. However, NOAELs (No Observed Adverse Effect Levels) may be used in the process of establishing a dose-response relationship. These denote the level of exposure at which there is no significant increase in adverse effects in the exposed population when compared to an appropriate control. Such a scientifically defendable threshold allows us to propose health based exposure limits for genotoxic carcinogens. This book describes the various cellular defence mechanisms individually and explains how they are regulated. The processes covered include metabolic inactivation, epigenetic regulation, scavenging mechanisms, DNA-repair and apoptosis. It also considers dose-dependent threshold mechanisms of carcinogenesis and the rate limiting parameters. Aimed at graduate level and above, the book discusses the consequences of genotoxic evaluation and urges readers to question the idea that even low exposures present a cancer risk."-- | ||
| 650 | 4 | |a Carcinogens / toxicity | |
| 650 | 4 | |a DNA Damage | |
| 650 | 4 | |a Cell Death | |
| 650 | 4 | |a Cell Transformation, Neoplastic | |
| 650 | 4 | |a DNA Repair | |
| 650 | 7 | |a HEALTH & FITNESS / Diseases / Genetic |2 bisacsh | |
| 650 | 7 | |a MEDICAL / Genetics |2 bisacsh | |
| 650 | 7 | |a Carcinogenesis |2 fast | |
| 650 | 7 | |a Cellular control mechanisms |2 fast | |
| 650 | 7 | |a Genetic toxicology |2 fast | |
| 650 | 4 | |a Medizin | |
| 650 | 4 | |a Genetic toxicology | |
| 650 | 4 | |a Carcinogenesis | |
| 650 | 4 | |a Cellular control mechanisms | |
| 700 | 1 | |a Greim, Helmut |e Sonstige |4 oth | |
| 700 | 1 | |a Albertini, Richard J. |e Sonstige |4 oth | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druckausgabe |z 978-1-84973-177-5 |
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Datensatz im Suchindex
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| dewey-full | 616.042 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.042 |
| dewey-search | 616.042 |
| dewey-sort | 3616.042 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Electronic eBook |
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| id | DE-604.BV043132746 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:18:26Z |
| institution | BVB |
| isbn | 1849732922 9781849732925 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028556937 |
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| physical | 1 Online-Ressource (xiv, 319 p.) |
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| publishDate | 2012 |
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| publishDateSort | 2012 |
| publisher | Royal Society of Chemistry |
| record_format | marc |
| series2 | Issues in toxicology |
| spelling | Cellular response to the genotoxic insult the question of threshold for genotoxic carcinogens editors, Helmut Greim and Richard Albertini Cambridge, U.K. Royal Society of Chemistry 2012 1 Online-Ressource (xiv, 319 p.) txt rdacontent c rdamedia cr rdacarrier Issues in toxicology 13 Includes index "Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of mutagens. Distinguishing the point at which exposure to a carcinogen increases mutation rates beyond the background level is challenging. In fact, there is now general agreement that, for genotoxic carcinogens, no specific threshold can be identified. However, NOAELs (No Observed Adverse Effect Levels) may be used in the process of establishing a dose-response relationship. These denote the level of exposure at which there is no significant increase in adverse effects in the exposed population when compared to an appropriate control. Such a scientifically defendable threshold allows us to propose health based exposure limits for genotoxic carcinogens. This book describes the various cellular defence mechanisms individually and explains how they are regulated. The processes covered include metabolic inactivation, epigenetic regulation, scavenging mechanisms, DNA-repair and apoptosis. It also considers dose-dependent threshold mechanisms of carcinogenesis and the rate limiting parameters. Aimed at graduate level and above, the book discusses the consequences of genotoxic evaluation and urges readers to question the idea that even low exposures present a cancer risk."-- Carcinogens / toxicity DNA Damage Cell Death Cell Transformation, Neoplastic DNA Repair HEALTH & FITNESS / Diseases / Genetic bisacsh MEDICAL / Genetics bisacsh Carcinogenesis fast Cellular control mechanisms fast Genetic toxicology fast Medizin Genetic toxicology Carcinogenesis Cellular control mechanisms Greim, Helmut Sonstige oth Albertini, Richard J. Sonstige oth Erscheint auch als Druckausgabe 978-1-84973-177-5 http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=519343 Aggregator Volltext |
| spellingShingle | Cellular response to the genotoxic insult the question of threshold for genotoxic carcinogens Carcinogens / toxicity DNA Damage Cell Death Cell Transformation, Neoplastic DNA Repair HEALTH & FITNESS / Diseases / Genetic bisacsh MEDICAL / Genetics bisacsh Carcinogenesis fast Cellular control mechanisms fast Genetic toxicology fast Medizin Genetic toxicology Carcinogenesis Cellular control mechanisms |
| title | Cellular response to the genotoxic insult the question of threshold for genotoxic carcinogens |
| title_auth | Cellular response to the genotoxic insult the question of threshold for genotoxic carcinogens |
| title_exact_search | Cellular response to the genotoxic insult the question of threshold for genotoxic carcinogens |
| title_full | Cellular response to the genotoxic insult the question of threshold for genotoxic carcinogens editors, Helmut Greim and Richard Albertini |
| title_fullStr | Cellular response to the genotoxic insult the question of threshold for genotoxic carcinogens editors, Helmut Greim and Richard Albertini |
| title_full_unstemmed | Cellular response to the genotoxic insult the question of threshold for genotoxic carcinogens editors, Helmut Greim and Richard Albertini |
| title_short | Cellular response to the genotoxic insult |
| title_sort | cellular response to the genotoxic insult the question of threshold for genotoxic carcinogens |
| title_sub | the question of threshold for genotoxic carcinogens |
| topic | Carcinogens / toxicity DNA Damage Cell Death Cell Transformation, Neoplastic DNA Repair HEALTH & FITNESS / Diseases / Genetic bisacsh MEDICAL / Genetics bisacsh Carcinogenesis fast Cellular control mechanisms fast Genetic toxicology fast Medizin Genetic toxicology Carcinogenesis Cellular control mechanisms |
| topic_facet | Carcinogens / toxicity DNA Damage Cell Death Cell Transformation, Neoplastic DNA Repair HEALTH & FITNESS / Diseases / Genetic MEDICAL / Genetics Carcinogenesis Cellular control mechanisms Genetic toxicology Medizin |
| url | http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=519343 |
| work_keys_str_mv | AT greimhelmut cellularresponsetothegenotoxicinsultthequestionofthresholdforgenotoxiccarcinogens AT albertinirichardj cellularresponsetothegenotoxicinsultthequestionofthresholdforgenotoxiccarcinogens |