Organic synthesis via examination of selected natural products - Hart, David J. (World Scientific Pub., 2011)
Includes bibliographical references and index
Complete with problems and solutions, this book is written for advanced graduate and undergraduate students to expose them to a variety of strategies for the synthesis of organic compounds. This is done largely within the context of natural products synthesis, but includes some unnatural products synthesis. Multiple approaches to each group of synthesis targets are presented, and the approaches are compared with one another with an eye on similarities and differences. General problems in organic synthesis (for example, strategies for the preparation of 6-membered rings and 5-membered rings, th
Ch. 1. Introduction -- ch. 2. Steroids -- ch. 3. Prostaglandins -- ch. 4. Pyrrolizidine alkaloids -- ch. 5. Juvabione and the vicinal stereochemistry problem -- ch. 6. Functional group reactivity patterns and difunctional relationships -- ch. 7. Some unnatural products -- Twistane and Triquinacene -- ch. 8. Alkaloids -- Difunctional relationships and the importance of the Mannich reaction -- ch. 9. Alkaloids from "dart-poison" frogs -- ch. 10. Morphine and oxidative phenolic coupling -- ch. 11. Olefin synthesis and Cecropia juvenile hormone -- ch. 12. A recent example of structure determination through total synthesis and convergent syntheses : Lasonolide A -- ch. 13. Ionophores : Calcimycin -- ch. 14. Erythromycin A Aglycone