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Laboratory animal medicine:

Laboratory Animal Medicine, Third Edition, is a fully revised publication from the American College of Laboratory Medicine's acclaimed blue book series. It presents an up-to-date volume that offers the most thorough coverage of the biology, health, and care of laboratory animals. The book is or...

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Other Authors:	Fox, James G. (Editor), Anderson, Lynn C. (Editor), Otto, Glen M. (Editor), Pritchett-Corning, Kathleen R. (Editor), Whary, Mark, T. (Editor)
Format:	Book
Language:	English
Published:	Amsterdam ; Boston ; Heidelberg ; London Elsevier, Academic Press 2015
Edition:	Third edition
Series:	American College of Laboratory Animal Medicine series
Subjects:	laboratory animals animal experiments America medicine Forschung Medizin Versuchstiere Amerika
Online Access:	Inhaltsverzeichnis Klappentext Inhaltsverzeichnis Klappentext
Summary:	Laboratory Animal Medicine, Third Edition, is a fully revised publication from the American College of Laboratory Medicine's acclaimed blue book series. It presents an up-to-date volume that offers the most thorough coverage of the biology, health, and care of laboratory animals. The book is organized by species, with new inclusions of chinchillas, birds, and program and employee management, and is written and edited by known experts in the fields. Users will find gold-standard guidance on the study of laboratory animal science, as well as valuable information that applies across all of
Physical Description:	xvii, 1708 Seiten Illustrationen
ISBN:	9780124095274 0124095275

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adam_text	Contents List of Reviewers...............................xi List of Contributors...................... xiii Preface to the Third Edition..................xvii L Laboratory Animal Medicine: Historical Perspectives JAMBS G. FOX AND B. TAYLOR BENNETT I. Introduction 1 II. Origins of Animal Experimentation 2 III. Early Veterinarians in Laboratory Animal Science and Medicine 5 IV. The Organizations of Laboratory Animal science 10 V. Education and Training in Laboratory Animal Medicine 17 VI. ACLAM-Sponsored Texts 18 VII. Impact of Laws, Regulations, and Guidelines on Laboratory Animal Medicine 19 VIII. Regulation of Animal Research in the United Kingdom and Canada 19 IX. Commercial and Academic Breeding of Rodents 20 X. Conclusion 20 Acknowledgment 20 References 20 2. Laws, Regulations, and Policies Affecting the Use of Laboratory Animals KATHRYN A.L. BAYNE AND LYNN C. ANDERSON I. Introduction 23 II. Animal Welfare 24 III. Importation and Exportation of Animals and Animal Products 36 IV. Hazardous Substances 40 V. Nucleic Acid and Nanomaterial Research Guidelines 41 References 41 3. Biology and Diseases of Mice MARK T. WHARY, NICOLE BAUMGARTH, JAMES G. FOX AND STEPHEN W. BARTHOLD I. Introduction 43 II. Biology 57 III. Diseases 73 References 137 4. Biology and Diseases of Rats GLEN M. OTTO, CRAIG L. FRANKLIN AND CHARLES B. CLIFFORD I. Introduction 151 II. Biology 153 III. Diseases 166 Acknowledgment 196 References 196 5. Biology and Diseases of Hamsters EMILY L. MIEDEL AND F. CLAIRE HANKENSON I. Introduction 209 II. Syrian Hamster 209 III. Chinese Hamster 229 IV. Armenian Hamster 233 V. European Hamster 233 VI. Djungarian Hamster 235 References 237 6. Biology and Diseases of Guinea Pigs NIRAH H. SHOMER, HILDA HOLCOMBE AND JOHN E. HARKNESS I. Introduction 247 II. Biology 249 III. Diseases 255 References 277 7. Biology and Diseases of Other Rodents THOMAS M. DONNELLY, INGRID BERGIN AND MELANIE IHRIG I. Introduction 286 II. Ground Squirrels: Urocitellus, Ictodomys, and Spermophilus 290 III. Prairie Dogs: Cynomys 293 IV. Pocket Gophers: Geomyidae 297 V. Kangaroo Rats: Dipodomys 299 VI. Pack Rats: Neotoma 301 VII. Grasshopper Mice: Orrychonrys 303 VIII. Deer Mice: Perorrryscus 306 IX. Rice Rats: Oryzomys 308 X. Cane Mice: Zygodontomys 309 XL Cotton Rats: Sigmodon 311 XII. White-Tailed Rats: Mystromys 313 V VI CONTENTS XIIL Gerbils and Jirds: Meriones 315 XIV. Voles: Microtus 320 XV Multimammate Rats/Mice: Mastom;ys 324 XVI. Degus: Octodon 326 XVII. Naked Mole Rats: Heterocephalus glaber 328 References 330 8. The Laboratory Woodchuck (Marmota monax) CHRISTINE A. BELLEZZA, SANDRA SEXTON, LESLIE I. CURTIN, PATRICK W. CONCANNON, BETTY H. BALDWIN, LOU ANN GRAHAM, WILLIAM E. HORNBUCKLE, LOIS ROTH AND BUD C. TENNANT L Introduction 352 II. Biology 356 III. Diseases 364 IV. The Woodchuck as an Experimental Animal Model for HBV Research 372 References 380 9. Biology and Diseases of Chinchillas CHARLIE C. HSU, MAIA M. CHAN AND COLETTE L. WHELER I. Introduction 387 II. Biology 389 III. Diseases 392 References 405 10. Biology and Diseases of Rabbits MEGAN H. NOWLAND, DAVID W. BRAMMER, ALEXIS GARCIA AND HOWARD G. RUSH I. Introduction 411 II. Biology 415 III. Diseases 421 References 450 11. Microbiological Quality Control for Laboratory Rodents and Lagomorphs WILLIAM R. SHEK, ABIGAIL L. SMITH AND KATHLEEN R. PRITCHETTCORN1NG I. Introduction 463 II. Microbiological Quality Specifications 465 III. Biosecurity 467 IV. Health Monitoring 476 V. Outbreak Management and Investigation 496 References 499 12. Biology and Diseases of Dogs JEAN A. NEMZEK, PATRICK A. LESTER, A. MARISSA WOLFE, ROBERT C. DYSKO AND DANIEL D. MYERS, JR. I. Introduction 511 II. Biology 513 III. Diseases 521 Acknowledgments 549 References 549 13. Biology and Diseases of Cats TANYA BURKHOLDER, CARMEN LEDESMA FELICIANO, SUE VANDEWOUDE AND HENRY J. BAKER I. Introduction 555 11. Sources of Cats 558 III. Housing 560 IV. Breeding Colony Management 564 V. Nutrition and Feeding 566 VI. Infectious Disease Exclusion and Control 567 Acknowledgments 572 References 572 IT Biology and Diseases of Ferrets JOERG MAYER, ROBERT P. MARINI AND JAMES G. FOX I. Introduction 577 II. Biology 580 III. Diseases 587 Acknowledgment 616 References 616 15. Biology and Diseases of Ruminants (Sheep, Goats, and Cattle) WENDY J. UNDERWOOD, RUTH BLAUWIEKEL, MARGARET L. DELANO, ROSE GILLESBY, SCOTT A. MISCHLER AND ADAM SCHOELL I. Introduction 623 II. Biology 627 III. Diseases 637 References 692 16. Biology and Diseases of Swine KRISTI L. HELKE, PAULA C. EZELL, RAIMON DURAN^STRUUCK AND M. MICHAEL SWINDLE I. Introduction 695 II. Biology 699 III. Diseases 709 Acronyms used in chapter 755 Acknowledgments 756 References 756 17. Nonhuman Primates ELIZABETH R. MAGDEN, KEITH G. MANSFIELD, JOE H. SIMMONS AND CHRISTIAN R. ABEE I. Introduction 772 II. Taxonomy 773 III. Biology 777 IV. Principles of Colony Management 822 V. Medical Management 831 VI. Diseases 845 Acknowledgments 901 References 901 18. Biology and Diseases of Amphibians DORCAS P. O’ROURKE AND MATTHEW D. ROSENBAUM I. Introduction II. Biology III. Diseases References 19. Biology and Diseases of Reptiles DORCAS P. O’ROURKE AND KVIN LERTPIRIYAPONG I. Introduction II. Biology III. Diseases References 20. The Biology and Management of the Zebrafish MICHAEL Y. ESMAIL, KEITH M. ASTROFSKY, CHRISTIAN LAWRENCE AND FABRIZIO C. SERLUCA I. Introduction II. Zebrafish: The Experimental Model in Biomedical Research III. Significances of Healthy Management in the Aquatic Animal Facility IV. Environmental Factors Important to Zebrafish Health V. General Features of Laboratory Zebrafish Facilities VI. Nutrition and Feeding of Zebrafish VII. Pathogen Control Program VIII. Techniques and Anesthesia IX. Significant Diseases of Laboratory Zebrafish Acknowledgment References 21. Biology and Management of Laboratory Fishes MICHAEL K.STOSKOI’F I. Introduction II. Facility Design III. Management and Husbandry IV. Medical Protocols V. Zoonotic Considerations VI. Diseases References 22. Japanese Quail as a Laboratory Animal Model JANET BAER, RUSTY LANSFORD AND KIMBERLY CHENG I. Introduction II. Biology III. Laboratory Management and Husbandry :NTS Vll IV. Breeding and Rearing Quail 1097 V. Diseases/Welfare Concerns 1100 References 1104 23. Zebra Finches in Biomedical Research MARY M. PATTERSON AND MICHALE S. FEE I. Introduction 1109 II. History and Taxonomy 1110 III. Research Uses 1110 IV. Biology 1111 V. Laboratory Management and Husbandry 1114 VI. Diseases/Welfare Concerns 1120 References 1130 24. Preanesthesia, Anesthesia, Analgesia, and Euthanasia PAUL FLECKNELL, JENNIFER L.S. LOFGREN, MELISSA C. DYSON, ROBERT P MARINI, M. MICHAEL SWINDLE AND RONALD P WILSON I. Introduction 1136 II. Rodents 1136 III. Rabbits 1149 IV. Ferrets 1156 V. Swine 1162 VI. Small Ruminants 1168 VII. Nonhuman Primates 1180 References 1187 25. Techniques of Experimentation MICHAEL R. TALCOTT, WALTER AKERS AND ROBERT P MARINI I. Introduction 1202 II. Identification Methods 1202 III. Blood Collection and Intravenous Injection 1204 IV. Vascular Cannulation 1211 V. Intraperitoneal Injection 1215 VI. Subcutaneous, Intramuscular, and Intraosseous Injection 1215 VII. Digestive System 1215 VIII. Urinary System Techniques 1221 IX. Respiratory System Techniques 1223 X. Reproductive System 1226 XL Cardiovascular Techniques 1251 XII. Endocrine System Techniques 1233 XIII. Orthopedic Procedures for Laboratory Animals 1235 XIV. Neurosurgical Techniques 1235 XV Tumor Transplantation 1242 XVI. Imaging Techniques 1244 XVII. Radiotelemetry 1245 XVIII. Thymectomy 1245 Acknowledgments 1246 References 1246 CONTI: 931 939 949 960 967 974 984 1005 1016 1017 1022 1023 1026 1031 1032 1034 1038 1057 1057 1063 1064 1072 1073 1076 1078 1086 1087 1089 1094 CONTENTS viii 26. Gnotobiotics TRENTON R. SCHOEB AND RICHARD J. RAHIJA I. Introduction 1263 II. Terminology 1264 III. History 1265 IV. Characteristics of Gnotobiotes 1265 V. Establishing a Gnotobiotic Facility 1266 VI. Operation 1275 VII. Derivation of Germfree Mice 1286 VIII.Resources 1289 References 1290 27. Working Safely with Experimental Animals Exposed to Biohazards JAMES R. SWEARENGEN AND CALVIN B. CARPENTER L Introduction 1297 II. Risk Assessment 1298 III. Managing an Animal Biocontainment Program 1299 IV. Standard Practices 1304 V. Veterinary Care 1306 VI. Other Considerations 1307 VII. Summary 1310 References 1311 28. Selected Zoonoses JAMES G. FOX, GLEN M. OTTO AND LESLEY A. COLBY I. Introduction 1313 II. Viral Diseases 1314 III. Rickettsial Diseases 1334 IV. Chlamydial Infections 1336 V. Bacterial Diseases 1337 VI. Fungal Diseases 1350 VII. Protozoal Diseases 1351 VIII. Helminth Infections 1356 IX. Arthropod Infestations 1356 Acknowledgments 1360 References 1360 29. Xenozoonoses: The Risk of Infection after Xenotransplantation MARIAN G. MICHAELS I. Introduction 1371 II. Lessons from Allotransplantation/Historical Perspective 1372 III. Potential Mechanisms for Cross-Species Infections 1373 IV. Nonviral Agents 1375 V. Development of SPF Herds 1375 VI. Potential Benefits of Xenotransplantation and Other Infectious Disease Issues 1376 VII. Issues after Xenotransplantation 1377 References 1377 30. Occupational Health of Laboratory Animal Workers PETER M. RABINOWITZ, RAFAEL Y. LEFKOWITZ, USA A. CONTI, CARRIE A. REDLICH AND BENJAMIN J. WEIGLER I. Introduction 1382 II. Occupational Illness and Injury in Laboratory Animal Workers 1382 III. Occupational Health Approach 1384 IV. Hazard Identification 1386 V. Hazard Controls 1389 VI. Occupational Medicine Services 1392 Appendix 30.1 1397 Appendix 30.2 1399 References 1401 31. Genetic Monitoring of Laboratory Mice and Rats MARJORIE C. STROBEL, LAURA G. REINHOLDT, RACHEL D. MALCOLM AND KATHLEEN PR IT CHETT-CORNING I. Introduction 1403 II. History of Genetic Monitoring 1404 III. Rodent Strains: Genetic Homogeneity or Genetic Diversity 1407 IV. SNP Analysis: Testing Strain Background 1408 V. Allele-Specific Genotyping: Testing Mutant Strains 1408 VI. Maintaining Strains 1409 VII. Phenotype Quality Control 1412 VIII. The Future of GQC 1412 IX. GQC: Practical Aspects 1413 X. Conclusions 1414 References 1414 32. Genetically Modified Animals KATHLEEN R. PRITCHETTCORNING AND CARLISLE P. LANDEL I. Introduction 1417 II. Manipulating Animals for Genetic Modification 1418 III. Genetic Modification and Technologies 1422 IV. Colony Management for GM Mice and Rats 1427 V. Finding Mouse and Rat Resources 1437 References 1437 33. Factors That Can Influence Animal Research DAVID G. BAKER AND NEIL S. LIPMAN I. Introduction 1441 II. Intrinsic Considerations 1442 III. Extrinsic Considerations 1444 References 1470 CONTENTS IX 34. Animal Models in Biomedical Research KIRK J. MAURER AND FRED W. QUIMBY I. Introduction 1497 II. What is an Animal Model? 1497 III. Nature of Research 1502 IV. History of Animal Use in Biomedical Research 1505 References 1526 35. Research in Laboratory Animal and Comparative Medicine J. MARK CLINE AND THOMAS B. CLARKSON I. Introduction 1535 II. Principles of Experimentation 1536 III. Role of the Laboratory Animal Specialist in Research 1537 IV. Research Training 1539 V. Summary 1540 Acknowledgment 1540 References 1540 36. Design and Management of Research Facilities NEIL 8. LIPMAN AND STEVEN L. LEARY I. Introduction 1543 II. Facility Planning and Design 1544 III. Environmental Control and Monitoring 1564 IV. Housing and Equipment 1570 V. Materials 1577 VI. Operational Issues 1585 VII. Conclusions 1590 References 1591 37. Program Management STEVEN M. NIEMI I. Introduction and Definitions 1599 II. Mission and Strategy: Where it all Starts 1600 III. Managing People 1601 IV. Managing Money 1605 V. Managing Operations 1608 VI. Concluding Remarks 1612 Appendix 1. Executive Summary of the 14 Toyota Way Principles 1612 References 1614 38. Laboratory Animal Behavior KATHRYN A.L. BAYNE, BONNIE V. BEAVER, JOY A. MENCH AND CHRISTINA WINNICKER I. Introduction 1617 II. Rodents 1619 III. Rabbits 1626 IV. Laboratory Dogs and Cats 1628 V. Nonhuman Primates 1630 VI. Farm Animals 1636 VII. Conclusions 1641 References 1641 39. Animal Welfare MARILYN J. BROWN AND CHRISTINA WINNICKER I. Introduction 1653 II. Animal Welfare as a Key Component in Research, Teaching, and Testing Using Animals 1654 III. Animal Welfare - A Historical and Philosophical Perspective 1655 IV. Guidelines and Principles 1656 V. Strategies to Optimize Animal Welfare 1660 VI. Examples of Challenging Research and Opportunities for Animal Welfare Optimization 1664 VII. Science of Animal Welfare 1666 VIII. Conclusion and Summary 1669 References 1669 Index................................................1673 fteefe § (SsXrt »iijösB £ . é s È mt«ëto( m. iSi SSúam,«* ïMjfâü^K^aGGâîj^ dial! Sí£tíhm MJmsy üfißi•£ %/ AvdtoHíi SíMüátay m imaifscienc c ilfe M-2EEÍ^HSfi3JSÍÉ¿ Q O O Contents List of Reviewers...............................xi List of Contributors...................... xiii Preface to the Third Edition..................xvii L Laboratory Animal Medicine: Historical Perspectives JAMBS G. FOX AND B. TAYLOR BENNETT I. Introduction 1 II. Origins of Animal Experimentation 2 III. Early Veterinarians in Laboratory Animal Science and Medicine 5 IV. The Organizations of Laboratory Animal science 10 V. Education and Training in Laboratory Animal Medicine 17 VI. ACLAM-Sponsored Texts 18 VII. Impact of Laws, Regulations, and Guidelines on Laboratory Animal Medicine 19 VIII. Regulation of Animal Research in the United Kingdom and Canada 19 IX. Commercial and Academic Breeding of Rodents 20 X. Conclusion 20 Acknowledgment 20 References 20 2. Laws, Regulations, and Policies Affecting the Use of Laboratory Animals KATHRYN A.L. BAYNE AND LYNN C. ANDERSON I. Introduction 23 II. Animal Welfare 24 III. Importation and Exportation of Animals and Animal Products 36 IV. Hazardous Substances 40 V. Nucleic Acid and Nanomaterial Research Guidelines 41 References 41 3. Biology and Diseases of Mice MARK T. WHARY, NICOLE BAUMGARTH, JAMES G. FOX AND STEPHEN W. BARTHOLD I. Introduction 43 II. Biology 57 III. Diseases 73 References 137 4. Biology and Diseases of Rats GLEN M. OTTO, CRAIG L. FRANKLIN AND CHARLES B. CLIFFORD I. Introduction 151 II. Biology 153 III. Diseases 166 Acknowledgment 196 References 196 5. Biology and Diseases of Hamsters EMILY L. MIEDEL AND F. CLAIRE HANKENSON I. Introduction 209 II. Syrian Hamster 209 III. Chinese Hamster 229 IV. Armenian Hamster 233 V. European Hamster 233 VI. Djungarian Hamster 235 References 237 6. Biology and Diseases of Guinea Pigs NIRAH H. SHOMER, HILDA HOLCOMBE AND JOHN E. HARKNESS I. Introduction 247 II. Biology 249 III. Diseases 255 References 277 7. Biology and Diseases of Other Rodents THOMAS M. DONNELLY, INGRID BERGIN AND MELANIE IHRIG I. Introduction 286 II. Ground Squirrels: Urocitellus, Ictodomys, and Spermophilus 290 III. Prairie Dogs: Cynomys 293 IV. Pocket Gophers: Geomyidae 297 V. Kangaroo Rats: Dipodomys 299 VI. Pack Rats: Neotoma 301 VII. Grasshopper Mice: Orrychonrys 303 VIII. Deer Mice: Perorrryscus 306 IX. Rice Rats: Oryzomys 308 X. Cane Mice: Zygodontomys 309 XL Cotton Rats: Sigmodon 311 XII. White-Tailed Rats: Mystromys 313 V VI CONTENTS XIIL Gerbils and Jirds: Meriones 315 XIV. Voles: Microtus 320 XV Multimammate Rats/Mice: Mastom;ys 324 XVI. Degus: Octodon 326 XVII. Naked Mole Rats: Heterocephalus glaber 328 References 330 8. The Laboratory Woodchuck (Marmota monax) CHRISTINE A. BELLEZZA, SANDRA SEXTON, LESLIE I. CURTIN, PATRICK W. CONCANNON, BETTY H. BALDWIN, LOU ANN GRAHAM, WILLIAM E. HORNBUCKLE, LOIS ROTH AND BUD C. TENNANT L Introduction 352 II. Biology 356 III. Diseases 364 IV. The Woodchuck as an Experimental Animal Model for HBV Research 372 References 380 9. Biology and Diseases of Chinchillas CHARLIE C. HSU, MAIA M. CHAN AND COLETTE L. WHELER I. Introduction 387 II. Biology 389 III. Diseases 392 References 405 10. Biology and Diseases of Rabbits MEGAN H. NOWLAND, DAVID W. BRAMMER, ALEXIS GARCIA AND HOWARD G. RUSH I. Introduction 411 II. Biology 415 III. Diseases 421 References 450 11. Microbiological Quality Control for Laboratory Rodents and Lagomorphs WILLIAM R. SHEK, ABIGAIL L. SMITH AND KATHLEEN R. PRITCHETTCORN1NG I. Introduction 463 II. Microbiological Quality Specifications 465 III. Biosecurity 467 IV. Health Monitoring 476 V. Outbreak Management and Investigation 496 References 499 12. Biology and Diseases of Dogs JEAN A. NEMZEK, PATRICK A. LESTER, A. MARISSA WOLFE, ROBERT C. DYSKO AND DANIEL D. MYERS, JR. I. Introduction 511 II. Biology 513 III. Diseases 521 Acknowledgments 549 References 549 13. Biology and Diseases of Cats TANYA BURKHOLDER, CARMEN LEDESMA FELICIANO, SUE VANDEWOUDE AND HENRY J. BAKER I. Introduction 555 11. Sources of Cats 558 III. Housing 560 IV. Breeding Colony Management 564 V. Nutrition and Feeding 566 VI. Infectious Disease Exclusion and Control 567 Acknowledgments 572 References 572 IT Biology and Diseases of Ferrets JOERG MAYER, ROBERT P. MARINI AND JAMES G. FOX I. Introduction 577 II. Biology 580 III. Diseases 587 Acknowledgment 616 References 616 15. Biology and Diseases of Ruminants (Sheep, Goats, and Cattle) WENDY J. UNDERWOOD, RUTH BLAUWIEKEL, MARGARET L. DELANO, ROSE GILLESBY, SCOTT A. MISCHLER AND ADAM SCHOELL I. Introduction 623 II. Biology 627 III. Diseases 637 References 692 16. Biology and Diseases of Swine KRISTI L. HELKE, PAULA C. EZELL, RAIMON DURAN^STRUUCK AND M. MICHAEL SWINDLE I. Introduction 695 II. Biology 699 III. Diseases 709 Acronyms used in chapter 755 Acknowledgments 756 References 756 17. Nonhuman Primates ELIZABETH R. MAGDEN, KEITH G. MANSFIELD, JOE H. SIMMONS AND CHRISTIAN R. ABEE I. Introduction 772 II. Taxonomy 773 III. Biology 777 IV. Principles of Colony Management 822 V. Medical Management 831 VI. Diseases 845 Acknowledgments 901 References 901 18. Biology and Diseases of Amphibians DORCAS P. O’ROURKE AND MATTHEW D. ROSENBAUM I. Introduction II. Biology III. Diseases References 19. Biology and Diseases of Reptiles DORCAS P. O’ROURKE AND KVIN LERTPIRIYAPONG I. Introduction II. Biology III. Diseases References 20. The Biology and Management of the Zebrafish MICHAEL Y. ESMAIL, KEITH M. ASTROFSKY, CHRISTIAN LAWRENCE AND FABRIZIO C. SERLUCA I. Introduction II. Zebrafish: The Experimental Model in Biomedical Research III. Significances of Healthy Management in the Aquatic Animal Facility IV. Environmental Factors Important to Zebrafish Health V. General Features of Laboratory Zebrafish Facilities VI. Nutrition and Feeding of Zebrafish VII. Pathogen Control Program VIII. Techniques and Anesthesia IX. Significant Diseases of Laboratory Zebrafish Acknowledgment References 21. Biology and Management of Laboratory Fishes MICHAEL K.STOSKOI’F I. Introduction II. Facility Design III. Management and Husbandry IV. Medical Protocols V. Zoonotic Considerations VI. Diseases References 22. Japanese Quail as a Laboratory Animal Model JANET BAER, RUSTY LANSFORD AND KIMBERLY CHENG I. Introduction II. Biology III. Laboratory Management and Husbandry :NTS Vll IV. Breeding and Rearing Quail 1097 V. Diseases/Welfare Concerns 1100 References 1104 23. Zebra Finches in Biomedical Research MARY M. PATTERSON AND MICHALE S. FEE I. Introduction 1109 II. History and Taxonomy 1110 III. Research Uses 1110 IV. Biology 1111 V. Laboratory Management and Husbandry 1114 VI. Diseases/Welfare Concerns 1120 References 1130 24. Preanesthesia, Anesthesia, Analgesia, and Euthanasia PAUL FLECKNELL, JENNIFER L.S. LOFGREN, MELISSA C. DYSON, ROBERT P MARINI, M. MICHAEL SWINDLE AND RONALD P WILSON I. Introduction 1136 II. Rodents 1136 III. Rabbits 1149 IV. Ferrets 1156 V. Swine 1162 VI. Small Ruminants 1168 VII. Nonhuman Primates 1180 References 1187 25. Techniques of Experimentation MICHAEL R. TALCOTT, WALTER AKERS AND ROBERT P MARINI I. Introduction 1202 II. Identification Methods 1202 III. Blood Collection and Intravenous Injection 1204 IV. Vascular Cannulation 1211 V. Intraperitoneal Injection 1215 VI. Subcutaneous, Intramuscular, and Intraosseous Injection 1215 VII. Digestive System 1215 VIII. Urinary System Techniques 1221 IX. Respiratory System Techniques 1223 X. Reproductive System 1226 XL Cardiovascular Techniques 1251 XII. Endocrine System Techniques 1233 XIII. Orthopedic Procedures for Laboratory Animals 1235 XIV. Neurosurgical Techniques 1235 XV Tumor Transplantation 1242 XVI. Imaging Techniques 1244 XVII. Radiotelemetry 1245 XVIII. Thymectomy 1245 Acknowledgments 1246 References 1246 CONTI: 931 939 949 960 967 974 984 1005 1016 1017 1022 1023 1026 1031 1032 1034 1038 1057 1057 1063 1064 1072 1073 1076 1078 1086 1087 1089 1094 CONTENTS viii 26. Gnotobiotics TRENTON R. SCHOEB AND RICHARD J. RAHIJA I. Introduction 1263 II. Terminology 1264 III. History 1265 IV. Characteristics of Gnotobiotes 1265 V. Establishing a Gnotobiotic Facility 1266 VI. Operation 1275 VII. Derivation of Germfree Mice 1286 VIII.Resources 1289 References 1290 27. Working Safely with Experimental Animals Exposed to Biohazards JAMES R. SWEARENGEN AND CALVIN B. CARPENTER L Introduction 1297 II. Risk Assessment 1298 III. Managing an Animal Biocontainment Program 1299 IV. Standard Practices 1304 V. Veterinary Care 1306 VI. Other Considerations 1307 VII. Summary 1310 References 1311 28. Selected Zoonoses JAMES G. FOX, GLEN M. OTTO AND LESLEY A. COLBY I. Introduction 1313 II. Viral Diseases 1314 III. Rickettsial Diseases 1334 IV. Chlamydial Infections 1336 V. Bacterial Diseases 1337 VI. Fungal Diseases 1350 VII. Protozoal Diseases 1351 VIII. Helminth Infections 1356 IX. Arthropod Infestations 1356 Acknowledgments 1360 References 1360 29. Xenozoonoses: The Risk of Infection after Xenotransplantation MARIAN G. MICHAELS I. Introduction 1371 II. Lessons from Allotransplantation/Historical Perspective 1372 III. Potential Mechanisms for Cross-Species Infections 1373 IV. Nonviral Agents 1375 V. Development of SPF Herds 1375 VI. Potential Benefits of Xenotransplantation and Other Infectious Disease Issues 1376 VII. Issues after Xenotransplantation 1377 References 1377 30. Occupational Health of Laboratory Animal Workers PETER M. RABINOWITZ, RAFAEL Y. LEFKOWITZ, USA A. CONTI, CARRIE A. REDLICH AND BENJAMIN J. WEIGLER I. Introduction 1382 II. Occupational Illness and Injury in Laboratory Animal Workers 1382 III. Occupational Health Approach 1384 IV. Hazard Identification 1386 V. Hazard Controls 1389 VI. Occupational Medicine Services 1392 Appendix 30.1 1397 Appendix 30.2 1399 References 1401 31. Genetic Monitoring of Laboratory Mice and Rats MARJORIE C. STROBEL, LAURA G. REINHOLDT, RACHEL D. MALCOLM AND KATHLEEN PR IT CHETT-CORNING I. Introduction 1403 II. History of Genetic Monitoring 1404 III. Rodent Strains: Genetic Homogeneity or Genetic Diversity 1407 IV. SNP Analysis: Testing Strain Background 1408 V. Allele-Specific Genotyping: Testing Mutant Strains 1408 VI. Maintaining Strains 1409 VII. Phenotype Quality Control 1412 VIII. The Future of GQC 1412 IX. GQC: Practical Aspects 1413 X. Conclusions 1414 References 1414 32. Genetically Modified Animals KATHLEEN R. PRITCHETTCORNING AND CARLISLE P. LANDEL I. Introduction 1417 II. Manipulating Animals for Genetic Modification 1418 III. Genetic Modification and Technologies 1422 IV. Colony Management for GM Mice and Rats 1427 V. Finding Mouse and Rat Resources 1437 References 1437 33. Factors That Can Influence Animal Research DAVID G. BAKER AND NEIL S. LIPMAN I. Introduction 1441 II. Intrinsic Considerations 1442 III. Extrinsic Considerations 1444 References 1470 CONTENTS IX 34. Animal Models in Biomedical Research KIRK J. MAURER AND FRED W. QUIMBY I. Introduction 1497 II. What is an Animal Model? 1497 III. Nature of Research 1502 IV. History of Animal Use in Biomedical Research 1505 References 1526 35. Research in Laboratory Animal and Comparative Medicine J. MARK CLINE AND THOMAS B. CLARKSON I. Introduction 1535 II. Principles of Experimentation 1536 III. Role of the Laboratory Animal Specialist in Research 1537 IV. Research Training 1539 V. Summary 1540 Acknowledgment 1540 References 1540 36. Design and Management of Research Facilities NEIL 8. LIPMAN AND STEVEN L. LEARY I. Introduction 1543 II. Facility Planning and Design 1544 III. Environmental Control and Monitoring 1564 IV. Housing and Equipment 1570 V. Materials 1577 VI. Operational Issues 1585 VII. Conclusions 1590 References 1591 37. Program Management STEVEN M. NIEMI I. Introduction and Definitions 1599 II. Mission and Strategy: Where it all Starts 1600 III. Managing People 1601 IV. Managing Money 1605 V. Managing Operations 1608 VI. Concluding Remarks 1612 Appendix 1. Executive Summary of the 14 Toyota Way Principles 1612 References 1614 38. Laboratory Animal Behavior KATHRYN A.L. BAYNE, BONNIE V. BEAVER, JOY A. MENCH AND CHRISTINA WINNICKER I. Introduction 1617 II. Rodents 1619 III. Rabbits 1626 IV. Laboratory Dogs and Cats 1628 V. Nonhuman Primates 1630 VI. Farm Animals 1636 VII. Conclusions 1641 References 1641 39. Animal Welfare MARILYN J. BROWN AND CHRISTINA WINNICKER I. Introduction 1653 II. Animal Welfare as a Key Component in Research, Teaching, and Testing Using Animals 1654 III. Animal Welfare - A Historical and Philosophical Perspective 1655 IV. Guidelines and Principles 1656 V. Strategies to Optimize Animal Welfare 1660 VI. Examples of Challenging Research and Opportunities for Animal Welfare Optimization 1664 VII. Science of Animal Welfare 1666 VIII. Conclusion and Summary 1669 References 1669 Index................................................1673 fteefe § (SsXrt »iijösB £ . é s È mt«ëto( m. iSi SSúam,«* ïMjfâü^K^aGGâîj^ dial! Sí£tíhm MJmsy üfißi•£ %/ AvdtoHíi SíMüátay m imaifscienc c ilfe M-2EEÍ^HSfi3JSÍÉ¿ Q O O
any_adam_object	1
author2	Fox, James G. Anderson, Lynn C. Otto, Glen M. Pritchett-Corning, Kathleen R. Whary, Mark, T.
author2_role	edt edt edt edt edt
author2_variant	j g f jg jgf l c a lc lca g m o gm gmo k r p c krp krpc m t w mt mtw
author_facet	Fox, James G. Anderson, Lynn C. Otto, Glen M. Pritchett-Corning, Kathleen R. Whary, Mark, T.
building	Verbundindex
bvnumber	BV042952907
callnumber-first	S - Agriculture
callnumber-label	SF996
callnumber-raw	SF996.5 .L33 2015
callnumber-search	SF996.5 .L33 2015
callnumber-sort	SF 3996.5 L33 42015
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classification_rvk	WC 6300 YV 1512
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dewey-full	636.089
dewey-hundreds	600 - Technology (Applied sciences)
dewey-ones	636 - Animal husbandry
dewey-raw	636.089
dewey-search	636.089
dewey-sort	3636.089
dewey-tens	630 - Agriculture and related technologies
discipline	Biologie Agrar-/Forst-/Ernährungs-/Haushaltswissenschaft / Gartenbau Medizin
edition	Third edition
format	Book
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id	DE-604.BV042952907
illustrated	Illustrated
indexdate	2024-07-10T07:13:36Z
institution	BVB
isbn	9780124095274 0124095275
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-028378976
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owner	DE-19 DE-BY-UBM DE-188 DE-355 DE-BY-UBR
owner_facet	DE-19 DE-BY-UBM DE-188 DE-355 DE-BY-UBR
physical	xvii, 1708 Seiten Illustrationen
publishDate	2015
publishDateSearch	2015
publishDateSort	2015
publisher	Elsevier, Academic Press
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series2	American College of Laboratory Animal Medicine series
spelling	Laboratory animal medicine edited by James G. Fox (editor-in-chief), Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA, Lynn C. Anderson, Global Animal and Comparative Medicine, Covance Laboratories Inc., Madison, WI, USA, Glen M. Otto, Animal Resources Center, University of Texas at Austin, Austin, TX, USA [und 2 weitere] Third edition Amsterdam ; Boston ; Heidelberg ; London Elsevier, Academic Press 2015 xvii, 1708 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier American College of Laboratory Animal Medicine series Laboratory Animal Medicine, Third Edition, is a fully revised publication from the American College of Laboratory Medicine's acclaimed blue book series. It presents an up-to-date volume that offers the most thorough coverage of the biology, health, and care of laboratory animals. The book is organized by species, with new inclusions of chinchillas, birds, and program and employee management, and is written and edited by known experts in the fields. Users will find gold-standard guidance on the study of laboratory animal science, as well as valuable information that applies across all of laboratory animals cabt animal experiments cabt America cabt medicine cabt Forschung (DE-588)4017894-8 gnd rswk-swf Medizin (DE-588)4038243-6 gnd rswk-swf Versuchstiere (DE-588)4078861-1 gnd rswk-swf Amerika Versuchstiere (DE-588)4078861-1 s Medizin (DE-588)4038243-6 s Forschung (DE-588)4017894-8 s DE-604 Fox, James G. edt wpr Anderson, Lynn C. edt wpr Otto, Glen M. edt wpr Pritchett-Corning, Kathleen R. edt wpr Whary, Mark, T. edt wpr Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028378976&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028378976&sequence=000002&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028378976&sequence=000005&line_number=0003&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028378976&sequence=000006&line_number=0004&func_code=DB_RECORDS&service_type=MEDIA Klappentext
spellingShingle	Laboratory animal medicine laboratory animals cabt animal experiments cabt America cabt medicine cabt Forschung (DE-588)4017894-8 gnd Medizin (DE-588)4038243-6 gnd Versuchstiere (DE-588)4078861-1 gnd
subject_GND	(DE-588)4017894-8 (DE-588)4038243-6 (DE-588)4078861-1
title	Laboratory animal medicine
title_auth	Laboratory animal medicine
title_exact_search	Laboratory animal medicine
title_full	Laboratory animal medicine edited by James G. Fox (editor-in-chief), Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA, Lynn C. Anderson, Global Animal and Comparative Medicine, Covance Laboratories Inc., Madison, WI, USA, Glen M. Otto, Animal Resources Center, University of Texas at Austin, Austin, TX, USA [und 2 weitere]
title_fullStr	Laboratory animal medicine edited by James G. Fox (editor-in-chief), Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA, Lynn C. Anderson, Global Animal and Comparative Medicine, Covance Laboratories Inc., Madison, WI, USA, Glen M. Otto, Animal Resources Center, University of Texas at Austin, Austin, TX, USA [und 2 weitere]
title_full_unstemmed	Laboratory animal medicine edited by James G. Fox (editor-in-chief), Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA, Lynn C. Anderson, Global Animal and Comparative Medicine, Covance Laboratories Inc., Madison, WI, USA, Glen M. Otto, Animal Resources Center, University of Texas at Austin, Austin, TX, USA [und 2 weitere]
title_short	Laboratory animal medicine
title_sort	laboratory animal medicine
topic	laboratory animals cabt animal experiments cabt America cabt medicine cabt Forschung (DE-588)4017894-8 gnd Medizin (DE-588)4038243-6 gnd Versuchstiere (DE-588)4078861-1 gnd
topic_facet	laboratory animals animal experiments America medicine Forschung Medizin Versuchstiere Amerika
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028378976&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028378976&sequence=000002&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028378976&sequence=000005&line_number=0003&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028378976&sequence=000006&line_number=0004&func_code=DB_RECORDS&service_type=MEDIA
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