Treatment of cancer:
Saved in:
| Other Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Boca Raton ; London ; New York
CRC Press
[2015]
|
| Edition: | Sixth edition |
| Subjects: | |
| Online Access: | Klappentext Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | XLIV, 825 Seiten Illustrationen |
| ISBN: | 1482214946 |
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| adam_text | TREATMENTof
CANCER
Treatment of Cancer, Sixth Edition is a multi-authored work based on a
single theme—the optimal treatment of cancer. A comprehensive guide to
modern cancer treatment, it supports an integrated approach to patient care
including radiotherapy, chemotherapy and surgery.
• Provides a comprehensive guide to modern cancer treatment
focusing on patient management
• Features supporting online content including clinical practice
guidelines, epidemiology and outcome statistics, patient support
resources and more
• Authored by high-profile opinion leaders, making it essential
reading for trainees and physicians
• Includes access to an eBook version with purchase of
the printed book
The sixth edition has been completely updated to create a useful, practical
guide focused on the management of individual tumour types. The charac-
teristic didactic approach to patient care of previous editions is retained,
but now with greater consideration to the options available. This book is a
valuable resource for trainees, oncologists, radiation oncologists, surgical
oncologists and haematologists.
Contents
Foreword xv
Preface xvii
An overview of cancer care xix
Contributors xxxv
List of abbreviations used xxxix
Evidence scoring xlv
Reference annotation xlv
1 Central nervous system 1
Anthony Chalmers, Allan James and Roy Rampling
Pathology )
Imaging 6
Treatment of Central Nervous System Tumours 7
Individual Tumours 17
References 30
2 Ocular and adnexal tumours 33
John L Hungerford and P. Nicholas Plowman
Paediatric Tumours 33
Other Paediatric Tumours 40
Adult Tumours 42
References 52
3 Head and neck cancer 57
Nicholas D. Stafford and Andrzej Wieczorek
Introduction 57
Organization of Services for Patients 57
Incidence 58
Head and Neck Cancer Is a Global Problem 58
Outcome 58
Aetiology 59
Problem of Second Primary Tumours 60
Strategies for Prevention 60
General Principles of Surgery 61
General Principles of Radiotherapy 63
General Principles of Combined Treatment in Head and Neck Carcinoma 68
Palliative Care 70
Staging and Prognosis 70
Assessment of Patients 72
Role of Prophylactic Treatment to the Neck in Patients with Clinical
Negative Neck and Primary Tumours of the Head and Neck
73
vi Contents
Management of Potentially Operable Cervical Lymphadenopathy 74
Treatment of Inoperable Nodal Disease after Previous Radiotherapy 74
Carcinoma of the Lip 74
Tumours of the Oral Cavity 75
Carcinoma of the Oropharynx 77
Hypopharynx 78
Posterior Pharyngeal Wall 79
Larynx 79
Nasopharynx 81
Tumours of the Nose and Paranasal Sinuses 84
Tumours of the Ear 86
Rare and Unusual Tumours of the Head and Neck 87
References 88
4 Thyroid 91
Kate Newbold and Clive Harmer
Introduction 91
Epidemiology 91
Aetiology 91
Pathogenesis 92
Pathology and Natural History 92
Diagnostic Evaluation 95
Tumour, Nodes, Métastasés 96
Management of Differentiated Thyroid Cancer 96
Radioactive Iodine Ablation of Residual Thyroid Tissue 98
Follow-Up 99
Treatment of Metastatic Disease 100
Dosimetry of ,31l Therapy 102
Complications of Radioiodine Treatment 103
External-Beam Radiotherapy and Systemic Therapies 103
Management of Anaplastic Carcinoma 105
Management of Medullary Thyroid Cancer 105
Management of Thyroid Lymphoma 107
Future Prospects 107
References 108
5 Endocrine and neuroendocrine tumours 113
Ashley B. Grossman, Marta Korbonitis, and P. Nicholas Plowman
APUD Concept and Apudomas 113
Pituitary Tumours 113
Medullary Thyroid Carcinoma 127
Gastro-Entero-Pancreatic Endocrine Tumours 127
Carcinoid Tumours 128
General Oncology Principles for Systemic Management of NET 130
Phaeochromocytoma 130
Multiple Endocrine Neoplasia 132
Parathyroid Adenoma and Carcinoma 134
Adrenocortical Tumours 135
References 137
Bibliography 143
6 Breast cancer 145
Thomas Rackley, Sharath Gangadhara, Elin Evans, Simon Waters and Peter Barrett-Lee
Epidemiology 145
Identification of High-Risk Groups 145
Contents vii
Breast Cancer Chemoprevention 146
Presentation and investigation 146
Staging 146
Screening 146
Molecular Genetics 149
Pathology 150
Surgery for Early Breast Cancer 151
Adjuvant Treatment 153
Locally Advanced Disease 158
Loco-Regional Recurrence 159
Secondary Breast Cancer 159
Complications of Metastatic Breast Cancer 162
Acknowledgments 164
References 164
7 Lung cancer 169
Nadia Yousaf and Sanjay Popat
Epidemiology and Aetiology 169
Classification 170
Prevention and Screening 170
Diagnosis and Staging 171
Management of Non-Small֊Cell
Lung Cancer 172
Management of Small-Cel! Lung Cancer 178
Palliative Care 178
References 179
8 Oesophageal cancer 181
BrionJ, Hoylock and Amir H. Montazeri
Introduction 181
Epidemiology and Aetiological Factors 181
Clinical Manifestations 182
Management of Localized (Operable) Oesophageal Cancer 184
Management of Locally Advanced Oesophageal Cancer 191
Management of Advanced Oesophageal Cancer 192
References 196
Bibliography 199
9 Hepatocellular carcinoma 201
Daniel H. Palmer and Philip J. Johnson
Introduction 201
Incidence 201
Hepatocellular Carcinoma 201
References 209
10 Pancreas 213
Sandra Van Schaeybroeck, Mark Lawler and Patrick G. Johnston
Incidence and Mortality 213
Aetiology 213
Genetics 215
Anatomy 215
Pathology and Staging 215
Symptoms and Signs 216
Natural History 216
Investigation 216
VIH Contents
Treatment 217
Special Considerations in the Management of Pancreatic Cancer 224
References 225
11 Biliary tract cancer 231
Hemant M. Kocher, Ajit 1 Abraham and Satyo Bhattocharyo
Tumours of the Bile Duct (Cholangiocarcmoma) 231
Gall Bladder Cancer 238
Future Trends 241
References 242
12 Gastric cancer 247
Russell D. Petty, Gillian Brand and Shay Nanthakumuron
Incidence 247
Aetiology 247
Diagnosis 248
Pathology 248
Molecular Pathogenesis 248
Staging 249
Treatment 250
Future Directions 256
References 257
13 Bladder cancer 259
Robert Huddart, Alan Horwich and Prodeep Kumar
Introduction 259
Epidemiology 259
Aetiology 259
Genetics of Bladder Cancer 261
Pathology 261
Clinical Presentation and Investigation 262
Management 265
Management of Low-Grade Superficial Non Muscle-Invasive Bladder Cancer 265
High-Grade Non -Muscle-Invasive Bladder Cancer 268
Radiotherapy and Systemic Treatments for Superficial Disease 269
Management of Invasive Bladder Cancer 270
Adjuvant Chemotherapy 271
Surgical Treatment 271
Radiotherapy in the Management of Muscle-Invasive Bladder Cancer 272
Management of Advanced Disease 276
Bibliography 278
References 279
14 Prostate cancer 289
Malcolm Mason
Introduction 289
Epidemiology and Aetiology 289
Prevention and Screening 290
Pathogenesis 290
Pathology and Staging 291
Clinical Features 292
Diagnosis and Staging 294
Principles of Management 294
Contents íx
Management of Organ-Confined Disease 294
Management of Locally Advanced Disease 299
Management of Recurrent Disease after Radical Local therapy 299
Management of Metastatic Disease 300
Concluding Remarks 301
References 302
Colorectal cancer Harpreet Wasan and Richard Adams 307
Introduction 307
Incidence and Cause 307
Diagnosis and the Multidisciplinary Team 309
Pathology of Colorectal Tumours 310
Molecular Pathogenesis of Colorectal Carcinoma 312
Pathology of Invasive Colorectal Cancers 313
Treatment 315
Follow-Up after Initial Treatment 329
Summary and Future Developments 330
National Health Service Guidelines 330
Conclusions 331
References 331
Bibliography 335
Anal cancer Bernard J. Cummings and James D. Brierley 337
Anatomy 337
Pathology 337
Epidemiology and Risk Factors 337
Presentation 338
Diagnostic Work-Up and Staging 338
Management 339
Lymph-Node Métastasés 342
Prognostic Factors and Outcome 342
Extra-Pelvic Métastasés 343
Radiation therapy Alone 343
Surgery 343
Non֊Squamous Cell Cancers 343
Peri-Anal Cancer 343
Patients with Human Immunodeficiency Virus Infection 344
References 345
Germ-cell cancer of the testis and related neoplasms AmyKwan and Danish Mazhar 349
Introduction 349
Background 349
Diagnosis and Staging 350
Assessment and Staging of Disease 353
Serum Markers 353
Stage 1 Disease and Risk of Relapse 355
Treatment 356
Metastatic Disease 358
Complications of Treatment 359
References 364
* Contents
18 Renal cell cancer 371
Tom R. Geldart and Sarah Ellis
Introduction and Epidemiology 371
Classification of Renal Tumours 371
Inherited Syndromes and the Molecular Biology of Renal Cell Carcinoma 373
Risk Factors 373
Clinical Features 374
Clinical Evaluation and Staging 375
Localized Disease 375
Disease Relapse 376
Metastatic Disease - Surgical Management 377
Metastatic Disease - Prognostic Factors 378
Metastatic Disease - Non-Surgical Management 378
Treatment Options in Non-Clear Cell Histology 383
Sequencing of Treatments: First-Line, Second-Line and Beyond 383
Conclusion 384
References 384
19 Ovarian and fallopian tube cancer 389
Andrew R. Clamp and Gordon C. Jayson
Epithelial Tumours of the Ovary 389
Low Malignant Potential Tumours of the Ovary 398
Non-Epithelial Tumours of the Ovary 398
References 400
20 Endometrial cancer 405
Christina Totopoulou and Hani Gabro
Pathogenesis 405
Histopathology 405
Pathologic Features Affecting Prognosis 406
Investigation 407
Staging and Tumour Classification 407
Treatment 407
Follow-Up 412
References 413
Bibliography 415
21 Cervical cancer 417
Alexandra Taylor
Incidence and Causes 417
Pathology 418
Prevention and Treatment of Pre-lnvasive Disease 419
Cervical Screening 419
Clinical Features of Invasive Carcinoma of the Cervix 420
Investigations for Invasive Disease 421
Staging and Prognostic Factors 422
Treatment 425
Complications of Treatment 429
New Developments 431
Conclusions 431
Acknowledgments 431
References 432
22 Carcinoma of the vagina and vulva 435
Sadaf Ghaem-Maghami and William Patrick Sautter
Carcinoma of Vagina
435
Contents xi
*
23
24
25
Carcinoma of the Vulva 438
References 444
Gestational trophoblastic neoplasia Fieke E.M. Froeling and Michael J. Seek! 447
Introduction 447
Genetics and Pathology 447
Epidemiology and Aetiological Factors 450
Human Chorionic Gonadotrophin 451
Clinical Features 452
Management and Investigations 454
Summary 465
References 465
Bibliography 468
Non-melanoma skin cancer Stephen L Morris, Sean Whittaker and Margaret Spittle 469
Introduction 469
Aetiology 469
Familial Skin Cancer Syndromes 470
Xeroderma Pigmentosum 472
Pre-Malignant Conditions 473
Actinic Keratosis and Bowen s Disease 473
Basal Cell Carcinoma 474
Squamous Cell Carcinoma 483
Primary Cutaneous Lymphoma 485
Primary Cutaneous T-Cell Lymphoma 486
Primary Cutaneous B-Cell Lymphoma 497
Other Non-Melanoma Skin Cancers 498
Merkel Cell Carcinoma 499
Langerhans Cell Histiocytosis 500
References 502
Malignant: melanoma Kroopo Joshi, James Larkin and Martin Gore 509
Introduction 509
Epidemiology 509
Aetiology 509
Prevention 510
Tumour Biology 510
Diagnosis 511
Pathology 511
Staging and Prognosis 511
Treatment of Primary Melanoma 511
Loco-Regional Recurrent Disease 514
Distant Metastatic Disease 514
Targeted Therapies 516
NRAS Mutated Melanoma 517
Kit Mutated Melanoma 517
Targeted Agents ¡n Uveal Melanoma 517
Systemic Therapies 518
Conclusions 518
References 519
521
521
521
522
527
531
534
534
535
535
537
537
538
544
547
551
551
566
568
569
569
570
570
574
575
576
582
597
597
597
612
630
630
637
637
637
640
643
644
645
646
646
646
649
649
655
659
660
xi Contents
26 Primary bone tumours
Jeremy S Whelan, Rob C Pollock, Anna M Cassom and Rachael E Windsor
Introduction
Incidence and Aetiology
General Principles of Management
Osteosarcoma
Ewing Sarcoma
Chondrosarcoma
Other Primary Bone Tumours
Key References
References
27 Soft tissue sarcomas
Thomas F. Delaney, David C. Harmon, Sam S. Yoon, David G Kirsch, Andrew E Rosenberg,
Henry J. Mankin, Daniel I. Rosenthal and Francis J. Horniček
Introduction
Aetiology
Clinical Evaluation
Pathology
Staging
Management of the Extremity, Trunk, or Head and Neck Primary Tumour
Adjuvant Chemotherapy
Functional Outcome
Treatment of Local Recurrence
Radiotherapy Alone
Treatment of Unresectable or Locally Advanced Soft Tissue Sarcoma
Management of the Retroperitoneal Primary Lesion
Treatment of Metastatic Soft Tissue Sarcoma
Management of Gastrointestinal Stromal Tumours
Desmoid Tumours
References
28 Leukaemias
Tariq I. Mughal
Introduction
Acute Leukaemias
Chronic Leukaemias
Acknowledgments
References
29 Hodgkin lymphoma
Beate Klimm, Dennis A. Eichenouer and Andreas Engert
Introduction
Diagnosis, Staging and Choice of Treatment
First-Line Treatment
Treatment of Relapsed Hodgkin Lymphoma
Special Considerations
New Drugs
Acknowledgments
Key References
References
30 Non-Hodgkin lymphoma
Piers Blombery, Adrian Bloorand David C. Linch
Epidemiology and Risk Factors, Classification, Staging and Molecular Pathogenesis of Non-Hodgkin Lymphoma
Aggressive Non-Hodgkin Lymphoma
Primary Mediastinal (Thymic) Large B-Cell Lymphoma
Central Nervous System Lymphoma and Prophylactic Central Nervous System Chemotherapy
Contents xiii
Burkitt Lymphoma 661
Mantle Cell Lymphoma 662
Human Immunodeficiency Virus ֊ Associated Lymphoma 663
Peripheral T-Cell Lymphoma 663
Indolent Non-Hodgkin Lymphoma 666
Marginal Zone Lymphoma 669
Future Developments 669
Key Reference 670
References 670
Multiple myeloma Jennifer M. Bird and Guy Pratt 679
Introduction 679
Incidence and Aetiology 679
Pathogenesis and Biology 680
Clinical Features and Complications 684
Investigation, Diagnosis and Staging 685
Prognostic Factors and Staging 686
Course of the Disease 687
When to Start Treatment and Criteria for Response 688
General Aspects of Care 688
Myeloma therapy 689
Radiotherapy 691
High-Dose therapy and Stem-Cell Transplantation 691
Maintenance and Consolidation therapy 693
Bisphosphonates 693
Refractory and Relapsed Disease 694
New Approaches to Treatment 694
Other Related Conditions 695
References 696
Paediatric oncology Stephen Lowis, Rachel Cox, John Moppett and Antony Ng 703
General Introduction 703
Epidemiology of Childhood Cancer 704
Childhood Leukaemia 704
Hodgkin Lymphoma 709
Nodular Lymphocyte Predominant Hodgkin Lymphoma 710
Non-Hodgkin Lymphoma 711
Burkitt s Lymphoma and Diffuse Large B-Cell Lymphoma 712
Precursor T- and B-Cell Lymphoblastic Lymphoma 712
Anaplastic Large-Cell Lymphoma 713
Liver Cancers 713
Neuroblastoma 714
Ewing s Family Tumours 716
Treatment 717
Osteosarcoma 719
Renal Tumours 722
Staging Investigations 723
Malignant Germ Cell Tumours 726
Non-Central Nervous System Tumours 727
Rhabdomyosarcoma 728
Central Nervous System Tumours 730
Primitive Neuroectodermal Tumours 731
Astrocytic Tumours 734
Central Nervous System Germ Cell Tumours 739
xiv Contents
Atypical Teratoid Rhabdoid Tumours 740
Central Nervous System Tumours in Infants and Very Young Children 742
Organ Toxicity 744
Psychological Aspects of Childhood Cancer 746
Management of Acute Neurological Complications 747
References 748
33 AIDS-related malignancy 761
Mark Bower and Christopher Coyle
Introduction 761
Aids-Defining Malignancies 761
Non-Aids-Defining Malignancies 768
Other Non-Aids-Defining Malignancies 769
Castleman s Disease 769
References 770
34 Clinical cancer genetics 775
Lisa J. Walker and Ros A. Eeles
Introduction 775
Cancer Pre-Disposition Genes 775
Research Approaches for the Identification of Cancer Pre-Disposition Genes 780
Cancer Risks Associated with Cancer Pre-Disposition Genes 781
Management of a Known or Suspected Cancer Pre-Disposition Gene Mutation Carrier 784
Summary 793
Key References 793
References 793
35 Lifestyle factors In cancer survivorship 797
Robert Thomas
Adiposity and Weight Gain 797
Diet and Dietary Supplements 799
Foods Supplements 799
Carcinogen Avoidance 801
Smoking 802
Alcohol 802
Physical Activity after Cancer 803
Evidence That Physical Activity Improves Survival and Reduces Relapse Rates 805
Summary 808
References 808
Index
815
|
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| id | DE-604.BV042951193 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:13:33Z |
| institution | BVB |
| isbn | 1482214946 |
| language | English |
| lccn | 014034190 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028377319 |
| oclc_num | 932376182 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XLIV, 825 Seiten Illustrationen |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | CRC Press |
| record_format | marc |
| spelling | Treatment of cancer edited by Pat Price (Visiting Professor of Oncology, Imperial College, London, UK), Karol Sikora (Chief Medical Officer, Cancer Partners UK, London and Dean, University of Buckingham Medical School, Buckingham, UK) Sixth edition Boca Raton ; London ; New York CRC Press [2015] XLIV, 825 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Cancer Treatment Therapie (DE-588)4059798-2 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 s Therapie (DE-588)4059798-2 s DE-604 Price, Pat edt Sikora, Karol edt Erscheint auch als Online-Ausgabe 978-1-4822-1494-9 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028377319&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Klappentext Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028377319&sequence=000002&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Treatment of cancer Cancer Treatment Therapie (DE-588)4059798-2 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| subject_GND | (DE-588)4059798-2 (DE-588)4073781-0 |
| title | Treatment of cancer |
| title_auth | Treatment of cancer |
| title_exact_search | Treatment of cancer |
| title_full | Treatment of cancer edited by Pat Price (Visiting Professor of Oncology, Imperial College, London, UK), Karol Sikora (Chief Medical Officer, Cancer Partners UK, London and Dean, University of Buckingham Medical School, Buckingham, UK) |
| title_fullStr | Treatment of cancer edited by Pat Price (Visiting Professor of Oncology, Imperial College, London, UK), Karol Sikora (Chief Medical Officer, Cancer Partners UK, London and Dean, University of Buckingham Medical School, Buckingham, UK) |
| title_full_unstemmed | Treatment of cancer edited by Pat Price (Visiting Professor of Oncology, Imperial College, London, UK), Karol Sikora (Chief Medical Officer, Cancer Partners UK, London and Dean, University of Buckingham Medical School, Buckingham, UK) |
| title_short | Treatment of cancer |
| title_sort | treatment of cancer |
| topic | Cancer Treatment Therapie (DE-588)4059798-2 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| topic_facet | Cancer Treatment Therapie Krebs Medizin |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028377319&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028377319&sequence=000002&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT pricepat treatmentofcancer AT sikorakarol treatmentofcancer |