Delection of Caspase-8 in liver parenchymal cells protects against cholestatic liver injury:
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| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
2015
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 174 S. Ill., graph. Darst. 21 cm |
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Record in the Search Index
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| adam_text | TABLE OF CONTENTS
1. INTRODUCTION 1
1.1 ANATOMY, PHYSIOLOGY AND FUNCTION
OF THE LIVER 1
1.2 APOPTOSIS 6
1.2.1 MORPHOLOGICAL FEATURES OF
APOPTOSIS 6
1.2.2 APOPTOSIS SIGNALING
PATHWAYS 9
1.3 CLASSIFICATION OF CASPASES 13
1.4 ACTIVATION OF CASPASE-8 14
1.5 TNF-SIGNALING PATHWAYS MEDIATE
INFLAMMATORY OR APOPTOTIC SIGNALS 16
1.6 LIVER FIBROSIS 19
1.6.1 CLINICAL SIGNS AND AETIOLOGY OF
LIVER FIBROSIS 19
1.6.2 PATHOPHYSIOLOGY OF LIVER
FIBROSIS 20
1.6.3 HSCS AND LIVER FIBROSIS 23
1.7 CHOLESTATIC LIVER INJURY AND BILE DUCT
LIGATION 29
HTTP://D-NB.INFO/1070671428
TABLE OF CONTENTS
1.8 AIMS OF THIS STUDY 31
2. MATERIALS AND METHODS 34
2.1 MATERIALS 34
2.1.1 CHEMICALS 34
2.1.2 STANDARD BUFFER AND MEDIA... .40
2.1.3 STANDARD KITS AND ENZYMES....41
2.1.4 ANTIBODIES USED FOR
IMMUNOSTAINING AND/OR WESTERN
BLOT 42
2.1.5 PRIMER SEQUENCES USED FOR
QRT-PCR 45
2.1.6 PRIMER SEQUENCES USED FOR
GENOTYPING PCR 47
2.1.7 INSTRUMENTS AND OTHER
EQUIPMENT 48
2.2 METHODS 53
2.2.1 BILE DUCT LIGATION 53
2.2.2 HOUSING AND BREEDING OF
MICE 54
2.2.3 MICE STRAINS 55
TABLE OF CONTENTS
2.2.4 GENOTYPING OF GENETICALLY
MODIFIED MICE 56
2.2.5 BLOOD AND TISSUE SAMPLING
PROCEDURES 59
3. RESULTS 87
3.1 DELETION OF CASPASE-8 IN LIVER
PARENCHYMAL CELLS DECREASES BILIARY
INFARCTS AND TRANSAMINASES AFTER
CHOLESTATIC LIVER INJURY
87
3.2 DELETION OF CASPASE-8 IN LIVER
PARENCHYMAL CELLS REDUCES CELL DEATH AFTER
CHOLESTATIC LIVER INJURY
93
3.3 DELETION OF CASPASE-8 IN LIVER
PARENCHYMAL CELLS DECREASES THE
COMPENSATORY PROLIFERATION AFTER
CHOLESTATIC LIVER INJURY
95
3.4 CASPASE-8 IN LIVER PARENCHYMAL CELLS
PROMOTES LIVER FIBROGENESIS AFTER
CHOLESTATIC LIVER INJURY 99
3.5 CASPASE-8 IN LIVER PARENCHYMAL
CELLS PROMOTES LIVER INFLAMMATION AFTER
CHOLESTATIC LIVER INJURY 106
3.6 CASPASE-8 IN LIVER PARENCHYMAL
CELLS PROMOTES P-JNK, RIP-3 AND RIP-1
EXPRESSION AFTER CHOLESTATIC LIVER INJURY 110
TABLE OF CONTENTS
3.7 DELETION OF CASPASE-8 IN LIVER
PARENCHYMAL CELLS HAS NO IMPACT ON BILE
INFARCTS AND TRANSAMINASE LEVELS DURING
ACUTE CHOLESTATIC LIVER INJURY 113
4. DISCUSSION 118
5. SUMMARY 131
6. ZUSAMMENFASSUNG 134
ZUSAMMENFASSEND 136
7. REFERENCES: 138
8. APPENDIX 159
ABBREVIATIONS 159
FLICE-LIKE INHIBITORY PROTEIN 161
PUBLICATIONS 166
EIDESSTATTLICHE ERKLARUNG GEMAB § 5 ABS.
(1) UND § 11 ABS. (3) 12. DER
PROMOTIONSORDNUNG 167
ACKNOWLEDGEMENTS 169
ERKLARUNG § 5 ABS. 1 ZUR
DATENAUFBEWAHRUNG 172
CURRICULUM VITAE 173
|
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| author_facet | Peng, Jin 1984- |
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| illustrated | Illustrated |
| indexdate | 2024-07-10T07:13:21Z |
| institution | BVB |
| language | English |
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| physical | 174 S. Ill., graph. Darst. 21 cm |
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| spelling | Peng, Jin 1984- Verfasser (DE-588)106748017X aut Delection of Caspase-8 in liver parenchymal cells protects against cholestatic liver injury vorgelegt von Jin Peng 2015 174 S. Ill., graph. Darst. 21 cm txt rdacontent n rdamedia nc rdacarrier Aachen, Techn. Hochsch., Diss., 2015 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028368776&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Peng, Jin 1984- Delection of Caspase-8 in liver parenchymal cells protects against cholestatic liver injury |
| subject_GND | (DE-588)4113937-9 |
| title | Delection of Caspase-8 in liver parenchymal cells protects against cholestatic liver injury |
| title_auth | Delection of Caspase-8 in liver parenchymal cells protects against cholestatic liver injury |
| title_exact_search | Delection of Caspase-8 in liver parenchymal cells protects against cholestatic liver injury |
| title_full | Delection of Caspase-8 in liver parenchymal cells protects against cholestatic liver injury vorgelegt von Jin Peng |
| title_fullStr | Delection of Caspase-8 in liver parenchymal cells protects against cholestatic liver injury vorgelegt von Jin Peng |
| title_full_unstemmed | Delection of Caspase-8 in liver parenchymal cells protects against cholestatic liver injury vorgelegt von Jin Peng |
| title_short | Delection of Caspase-8 in liver parenchymal cells protects against cholestatic liver injury |
| title_sort | delection of caspase 8 in liver parenchymal cells protects against cholestatic liver injury |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028368776&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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