Diagnostic enzymology:
Saved in:
| Other Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Berlin ; Boston, Mass.
De Gruyter
2014
|
| Edition: | 2., fully rev. and extended ed. |
| Series: | De Gruyter graduate
|
| Subjects: | |
| Online Access: | Inhaltstext Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | XV, 197 S. Ill., graph. Darst. 24 cm |
| ISBN: | 9783110207248 3110207249 |
Staff View
MARC
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Record in the Search Index
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CONTENTS
PREFACE V
LIST OF CONTRIBUTING
AUTHORS * VII
1 ANGIOTENSIN CONVERTING ENZYME * 1
JOE M. EL-KHOURY, EDMUNDS REINEKS AND SIHE WANG
1.1 CASE STUDIES 1
1.1.1 PATIENT A * 1
1.1.2 PATIENT B 1
1.1.3 PATIENT C * 2
1.2 BIOCHEMISTRY AND PHYSIOLOGY 3
1.2.1 PHYSIOLOGICAL FUNCTION 3
1.2.2 BIOCHEMISTRY AND MOLECULAR FORMS 3
1.2.3 TISSUE SOURCES 5
1.2.4 REFERENCE RANGES 5
1.3 CHEMICAL PATHOLOGY 7
1.3.1 ACE IN SARCOIDOSIS 7
1.4 ANALYSIS 9
1.4.1 SPECIMEN 9
1.4.2 SPECTROPHOTOMETRIC METHODS 10
1.4.3 HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY 10
1.4.4 FLUOROMETRIC METHODS 11
1.4.5 RADIOASSAYS 11
1.4.6 OTHER METHODS 11
1.4.7 INHIBITORS OF ACE 12
1.5 QUESTIONS AND ANSWERS 12
REFERENCES 13
2 ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE 19
PETER L. PLATTEBORZE
2.1 CASE STUDIES 19
2.1.1 PATIENT A 19
2.1.2 PATIENT B 20
2.1.3 PATIENT C 21
2.1.4 PATIENT D 22
2.1.5 PATIENT E 22
2.2 BIOCHEMISTRY AND PHYSIOLOGY OF THE CHOLINESTERASES
2.2.1 MOLECULAR FORMS 23
2.2.2 INHERITANCE OF BCHE VARIANTS 26
2.3 CHEMICAL PATHOLOGY 29
HTTP://D-NB.INFO/1022140558
X CONTENTS
2.3.1 PESTICIDE AND NERVE AGENT POISONING 29
2.A ANALYTICAL MEASUREMENTS OF ACHE AND BCHE * 36
2.4.1 DESIRED SPECIMENS 36
2.5 QUESTIONS AND ANSWERS 38
REFERENCES * AO
3 ALDOLASE 41
EDMUNDS REINEKS, JOE M. EL-KHOURY AND SIHE WANG
3.1 CASE STUDIES A1
3.1.1 PATIENT A A1
3.1.2 PATIENT B A2
3.1.3 PATIENT C A3
3.2 BIOCHEMISTRY AND PHYSIOLOGY A3
3.2.1 PHYSIOLOGICAL FUNCTION A3
3.2.2 BIOCHEMISTRY AND MOLECULAR STRUCTURE AA
3.2.3 TISSUE SOURCE(S) AND EXPRESSION OF ALD A5
3.2.
A CLEARANCE AND METABOLISM OF ALD A5
3.2.5 REFERENCE RANGES A6
3.3 CHEMICAL PATHOLOGY A7
3.3.1 POLYMYOSITIS/DERMATOMYOSITIS A7
3.3.2 DUCHENNE MUSCULAR DYSTROPHY A8
3.3.3 DRUG-INDUCED MYOPATHY A8
3.3.A PATHOLOGIES IN WHICH CK DOES NOT REFLECT THE EXTENT
OF MUSCLE DAMAGE A9
3.A ANALYSIS 50
3.A.1 SPECIMEN 50
3.A.2 ANALYTE STABILITY 51
3.A.3 INTERFERENCES 51
3.A.A REFERENCE METHODS 51
3.5 QUESTIONS AND ANSWERS 52
REFERENCES 53
4 ALKALINE PHOSPHATASE 57
AMY E. SCHMIDT
4.1 CASE STUDIES 57
4.1.1 PATIENT A * 57
4.1.2 PATIENT B 58
4.1.3 PATIENT C * 59
4.1.4 PATIENT D 60
4.1.5 PATIENT E 60
A.1.6 PATIENT F 61
CONTENTS
XI
4.2
BIOCHEMISTRY AND PHYSIOLOGY 63
4.2.1
STRUCTURE 63
4.2.2
PHYSIOLOGICAL FUNCTION OF ALP IN TISSUE/BLOOD/OTHER FLUIDS 66
4.2.3 TISSUE SOURCES OF ALP 66
4.2.4
CLEARANCE/METABOLISM OF ENZYME 67
4.2.5 REFERENCE RANGES * 67
4.3 CHEMICAL PATHOLOGY 68
4.3.1 LIVER DISEASE 68
4.3.2 BONE DISEASE 69
4.3.3
METASTATIC CANCER 69
4.3.4
MISCELLANEOUS PANCREATIC DISORDERS 69
4.3.5 CYSTIC FIBROSIS 70
4.3.6
CHRONIC RENAL FAILURE 70
4.3.7 DRUG THERAPY 70
4.3.8 MISCELLANEOUS 71
4.4 ANALYSIS 71
4.4.1
TECHNICAL PROBLEMS 71
4.4.2
REFERENCE METHOD 72
4.4.3 ISOENZYME ANALYSIS 72
4.5
QUESTIONS AND ANSWERS 75
ACKNOWLEDGEMENTS 75
REFERENCES 76
5 ASPARTATE AMINOTRANSFERASE AND ALANINE AMINOTRANSFERASE 81
JOE M. EL-KHOURY AND SIHE WANG
5.1
CASE STUDIES 81
5.1.1 PATIENT A 81
5.1.2 PATIENT B 82
5.1.3 PATIENT C 82
5.1.4
PATIENT D 83
5.1.5
PATIENT E 84
5.2
BIOCHEMISTRY AND PHYSIOLOGY 84
5.2.1
MOLECULAR FORMS * 84
5.2.2
BIOCHEMICAL FUNCTION 86
5.2.3 NORMAL PHYSIOLOGY * 86
5.2.4 REFERENCE RANGES 88
5.3 CHEMICAL PATHOLOGY 89
5.3.1 LIVER DISEASE 89
5.3.2
HEMOCHROMATOSIS 92
5.3.3 SKELETAL MUSCLE DISEASE * 93
5.3.4 HEART DISEASE 94
5.3.5
OTHER CAUSES OF AST INCREASE * 95
XII *
CONTENTS
5.4 ANALYSIS 95
5.4.1 SPECIMENS * 95
5.4.2 REACTION USED 95
5.4.3 INTERFERENCES 96
5.4.4 METHODS FOR AST ISOENZYMES 97
5.5 QUESTIONS AND ANSWERS 97
REFERENCES 98
6 CREATINE KINASE, ISOENZYMES, AND ISOFORMS 105
ALAN H.B. WU
6.1 CASE STUDIES 105
6.1.1 PATIENT A 105
6.1.2 PATIENT B 106
6.1.3 PATIENT C 107
6.1.4 PATIENT D 108
6.1.5 PATIENT E 109
6.2 BIOCHEMISTRY AND PHYSIOLOGY 110
6.2.1 MOLECULAR FORMS 110
6.2.2 CK ISOENZYMES, ATYPICAL FORMS, AND ISOFORMS 111
6.2.3 REFERENCE RANGE 114
6.3 CHEMICAL PATHOLOGY 114
6.3.1 HEART DISEASE 114
6.3.2 SKELETAL MUSCLE DISEASE 116
6.3.3 TRAUMA 116
6.4 ANALYTICAL MEASUREMENT OF TOTAL CK AND CK-MB 117
6.5 QUESTIONS AND ANSWERS 118
REFERENCES 119
7 GAMMA-GLUTAMYL TRANSFERASE 121
SARAH M. BROWN
7.1 CASE STUDIES 121
7.1.1 PATIENT A 121
7.1.2 PATIENT B 121
7.1.3 PATIENT C 122
7.1.4 PATIENT D 123
7.1.5 PATIENT E *124
7.2 BIOCHEMISTRY AND PHYSIOLOGY 124
7.2.1 MOLECULAR FORMS AND POST-TRANSLATIONAL
MODIFICATION *124
7.2.2 BIOCHEMICAL FUNCTION 125
7.2.3 TISSUE ACTIVITIES AND CONCENTRATIONS 125
7.2.4 METABOLIC CLEARANCE 126
7.2.5 REFERENCE INTERVALS 126
CONTENTS
XIII
7.3 CHEMICAL PATHOLOGY 126
7.3.1 CAUSES OF INCREASED OR DECREASED CONCENTRATIONS
OR ACTIVITIES 126
7.3.2 DIAGNOSTIC UTILITY OF GGT 127
7.4 ANALYSIS 131
7.4.1 SPECIMEN AND STABILITY *131
7.4.2 PREFERRED METHOD FOR GGT ACTIVITY 131
7.5 QUESTIONS AND ANSWERS 132
REFERENCES 132
8 LACTATE DEHYDROGENASE 135
OLAJUMOKE OLADIPO AND DENNIS J. DIETZEN
9.1 CASE STUDIES 135
8.1.1 PATIENT A 135
8.1.2 PATIENT B 136
8.1.3 PATIENT C 137
8.1.4 PATIENT D 138
8.1.5 PATIENT E 139
8.2 BIOCHEMISTRY AND PHYSIOLOGY 140
8.2.1 PHYSIOLOGICAL FUNCTION 140
8.2.2 TISSUE SOURCES 140
8.2.3 REFERENCE RANGES 141
8.3 CHEMICAL PATHOLOGY 141
8.3.1 CARDIOLOGY 142
8.3.2 HEPATOLOGY 142
8.3.3 HEMATOLOGY 142
8.3.4 ONCOLOGY 143
8.3.5 NEUROLOGY 143
8.3.6 MACRO-LD 144
8.3.7 GENETIC DEFICIENCIES 144
8.4 ANALYSIS 144
8.4.1 LD ISOENZYME DETERMINATION 145
8.4.2 IFCC REFERENCE METHOD 145
8.4.3 SPECIMEN 146
8.5 QUESTIONS AND ANSWERS 146
REFERENCES 147
9 PANCREATIC LIPASE 153
WAN-MING ZHANG, EDMUNDS REINEKS, JOE M. EL-KHOURY AND SIHE WANG
9.1 CASE STUDIES *153
9.1.1 PATIENT A 153
9.1.2 PATIENT B *154
XIV
CONTENTS
9.1.3 PATIENT C 155
9.1.4 PATIENT D *156
9.2 BIOCHEMISTRY AND PHYSIOLOGY 157
9.2.1 MOLECULAR FORMS 157
9.2.2 MOLECULAR STRUCTURE AND TISSUE EXPRESSION 158
9.2.3 MECHANISM OF CATALYSIS *159
9.2.4 FUNCTIONAL REGULATION 159
9.2.5 LIPASE IN SERUM 161
9.2.6 OTHER LIPASES 162
9.2.7 REFERENCE RANGE AND STANDARDIZATION 164
9.3 CHEMICAL PATHOLOGY 164
9.3.1 ACUTE PANCREATITIS 164
9.3.2 PANCREATIC CANCER 165
9.3.3 CYSTIC FIBROSIS 166
9.3.4 DIABETIC KETOACIDOSIS 166
9.3.5 CHRONIC RENAL FAILURE 167
9.3.6 IATROGENIC EFFECTS 167
9.3.7 DRUG EFFECTS 167
9.4 ANALYSIS 168
9.4.1 SPECIMEN 168
9.4.2 METHODS AND INSTRUMENTATION 168
9.5 QUESTIONS AND ANSWERS 171
REFERENCES 172
10 NATRIURETIC PEPTIDES 181
ROBERT H. CHRISTENSON AND HASSAN M.E. AZZAZY
10.1 CASE STUDIES 181
10.1.1 PATIENT A 181
10.1.2 PATIENT B 182
10.1.3 PATIENT C 182
10.1.4 PATIENT D 183
10.1.5 PATIENT E 184
10.1.6 PATIENT F 185
10.2 BIOCHEMISTRY AND PHYSIOLOGY OF CARDIAC NATRIURETIC PEPTIDES 185
10.3 CHEMICAL PATHOLOGY OF NATRIURETIC PEPTIDES 186
10.3.1 BNP IN DIAGNOSIS OF SYMPTOMATIC HF PATIENTS *187
10.3.2 PROGNOSIS AND RISK STRATIFICATION OF HF PATIENTS 187
10.3.3 BNP AND
NT-PROBNP AS PROGNOSTIC
RISK MARKERS IN ACUTE
CORONARY SYNDROME PATIENTS 188
10.3.4 RECOMMENDATIONS FOR USE OF BIOCHEMICAL MARKERS IN HEART
FAILURE 188
CONTENTS * XV
10.4 ANALYTICAL MEASUREMENTS OF BNP AND NT-PROBNP 188
10.4.1 DESIRED SPECIMENS 188
10.4.2 CONSIDERATIONS FOR MEASUREMENTS OF BNP AND NT-PROBNP 189
10.4.3 METHODS FOR MEASUREMENTS 190
10.5 QUESTIONS AND ANSWERS 191
REFERENCES *192
INDEX 195 |
| any_adam_object | 1 |
| author2 | Kazmierczak, Steven C. Azzazy, Hassan M. E. |
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| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
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| dewey-search | 616.0756 |
| dewey-sort | 3616.0756 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 2., fully rev. and extended ed. |
| format | Book |
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| indexdate | 2024-09-10T01:54:38Z |
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| isbn | 9783110207248 3110207249 |
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| spelling | Diagnostic enzymology ed. by Steven C. Kazmierczak ; Hassan M. E. Azzazy 2., fully rev. and extended ed. Berlin ; Boston, Mass. De Gruyter 2014 XV, 197 S. Ill., graph. Darst. 24 cm txt rdacontent n rdamedia nc rdacarrier De Gruyter graduate Literaturangaben Enzymdiagnostik (DE-588)4133537-5 gnd rswk-swf (DE-588)4522595-3 Fallstudiensammlung gnd-content Enzymdiagnostik (DE-588)4133537-5 s DE-604 Kazmierczak, Steven C. (DE-588)105147096X edt Azzazy, Hassan M. E. (DE-588)1050250923 edt X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=4032434&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028355823&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Diagnostic enzymology Enzymdiagnostik (DE-588)4133537-5 gnd |
| subject_GND | (DE-588)4133537-5 (DE-588)4522595-3 |
| title | Diagnostic enzymology |
| title_auth | Diagnostic enzymology |
| title_exact_search | Diagnostic enzymology |
| title_full | Diagnostic enzymology ed. by Steven C. Kazmierczak ; Hassan M. E. Azzazy |
| title_fullStr | Diagnostic enzymology ed. by Steven C. Kazmierczak ; Hassan M. E. Azzazy |
| title_full_unstemmed | Diagnostic enzymology ed. by Steven C. Kazmierczak ; Hassan M. E. Azzazy |
| title_short | Diagnostic enzymology |
| title_sort | diagnostic enzymology |
| topic | Enzymdiagnostik (DE-588)4133537-5 gnd |
| topic_facet | Enzymdiagnostik Fallstudiensammlung |
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