Motor proteins and molecular motors:
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| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Boca Raton
CRC Press
[2015]
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturverz. S. 183 - 196 |
| Physical Description: | xxi, 200 Seiten Illustrationen, Diagramme 24 cm |
| ISBN: | 9781482224757 |
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MARC
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| adam_text | Titel: Motor proteins and molecular motors
Autor: Kolomeisky, Anatoly B
Jahr: 2015
Contents
List of Figures xi
List of Tables xv
Preface xvii
Acknowledgments xix
Author xxi
Chapter 1 ¦ Introduction 1
1.1 MOTOR PROTEINS IN BIOLOGICAL SYSTEMS 1
1.2 SINGLE-MOLECULE EXPERIMENTS 6
1.3 DISCUSSION OF THEORETICAL MODELS FOR
MOLECULAR MOTORS 7
1.4 MOTOR PROTEINS AS NANOSCALE MACHINES 9
1.5 OUTLOOK 10
Chapter 2 ¦ Basic Properties of Motor Proteins 13
2.1 HISTORY OF MOTOR PROTEINS 13
2.2 CLASSIFICATION OF BIOLOGICAL MOLECULAR
MOTORS 18
2.3 STRUCTURES OF MOTOR PROTEINS 22
2.4 BIOLOGICAL FUNCTIONS OF MOLECULAR
MOTORS 25
2.5 SUMMARY 27
Chapter 3 ¦ Experimental Studies of Motor Proteins 29
vii
viii ¦ Contents
3.1 INTRODUCTION 29
3.2 BULK CHEMICAL-KINETIC MEASUREMENTS 30
3.3 STRUCTURAL STUDIES 35
3.4 SINGLE-MOLECULE FORCE SPECTROSCOPY 37
3.4.1 Optical-Trap Spectroscopy 39
3.4.2 Magnetic Tweezers Spectroscopy 41
3.4.3 Atomic-Force Microscopy 44
3.5 FLUORESCENT LABELING AND SUPER-
RESOLUTION TECHNIQUES 47
3.6 MAJOR EXPERIMENTAL OBSERVATIONS 51
3.7 SUMMARY 52
Chapter 4 ¦ Fundamental Physical Concepts:
Equilibrium Approaches 53
4.1 INTRODUCTION 53
4.2 BASIC EQUILIBRIUM THERMODYNAMICS 54
4.3 BASIC STATISTICAL MECHANICS 63
4.4 APPLICATION FOR MOTOR PROTEINS 67
4.5 SUMMARY 68
Chapter 5 ¦ Fundamental Physical Concepts:
Non-Equilibrium Approaches 69
5.1 INTRODUCTION 69
5.2 MACROSCOPIC CHEMICAL KINETICS 70
5.2.1 Irreversible Processes 72
5.2.2 Reversible Processes 76
5.2.3 Temperature Dependence 78
5.3 RANDOM WALKS 80
5.4 FIRST-PASSAGE PROCESSES 86
5.5 SUMMARY 90
5.6 MATHEMATICAL APPENDIX 90
5.6.1 Irreversible Second-Order Chemical Reactions 90
5.6.2 Reversible Chemical Reactions 91
5.6.3 Calculations of Average Properties for the
Simplest One-Dimensional Random Walk 92
Contents ¦ ix
5.6.4 Calculations of First-Passage Probabilities and
Dynamic Properties 94
Chapter 6 ¦ Motor Proteins as Enzymes_97
6.1 INTRODUCTION 97
6.2 CATALYSIS 98
6.3 ENZYMATIC PROCESSES 101
6.4 SUMMARY 106
6.5 MATHEMATICAL APPENDIX 107
6.5.1 Michaelis-Menten Mechanism 107
6.5.2 Inhibition Processes 108
6.5.3 Single-Molecule Derivation of the Michaelis-
Menten Equation 109
Chapter 7 ¦ Theory for Motor Proteins: Continuum Ratchets 113
7.1 INTRODUCTION 113
7.2 CONTINUUM RATCHET POTENTIALS 115
7.3 CRITICAL ANALYSIS 121
7.4 SUMMARY 122
Chapter 8 ¦ Theory for Motor Proteins: Discrete-State
Stochastic Models 125
8.1 INTRODUCTION 125
8.2 DISCRETE-STATE STOCHASTIC APPROACH 126
8.2.1 Linear Sequential Models 126
8.2.2 Forces in Motor Proteins 131
8.2.3 Dwell Times and First-Passage Analysis 135
8.2.4 Efficiency of Motor Proteins 138
8.2.5 Discrete-State Stochastic Models for Systems
with Complex Biochemical Pathways 141
8.3 CRITICAL ANALYSIS 142
8.4 SUMMARY 144
8.5 MATHEMATICAL APPENDIX 145
8.5.1 Calculation of Dynamic Properties of Motor
Proteins Using Derrida s Method 145
x ¦ Contents
8.5.2 Calculation of First-Passage Probabilities and
Dynamic Properties for N = 2 Linear Discrete-
State Models 149
Chapter 9 ¦ Collective Properties of Motor Proteins 151
9.1 COOPERATIVITY AND INTERACTIONS IN
MOTOR PROTEINS DYNAMICS 151
9.2 EXPERIMENTAL OBSERVATIONS 152
9.3 THEORETICAL IDEAS 156
9.4 SUMMARY 160
Chapter 10 ¦ Artificial Molecular Motors and Rotors 163
10.1 INTRODUCTION 163
10.2 BIOLOGICAL ARTIFICIAL MOLECULAR
MOTORS 164
10.3 NON-BIOLOGICAL ARTIFICIAL MOLECULAR
MOTORS 170
10.4 ARTIFICIAL MOLECULAR ROTORS 1 73
10.5 SUMMARY 175
Chapter 11 - Future Directions in Studies of Motor Proteins
and Molecular Motors 177
11.1 WHAT WE UNDERSTAND NOW ABOUT MOTOR
PROTEINS AND MOLECULAR MOTORS 1 77
11.2 OPEN QUESTIONS AND PROBLEMS 1 78
11.3 LOOKING INTO THE FUTURE 182
Bibliography 183
Index __197
|
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| author_facet | Kolomeisky, Anatoly B. |
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| author_sort | Kolomeisky, Anatoly B. |
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| dewey-tens | 570 - Biology |
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| institution | BVB |
| isbn | 9781482224757 |
| language | English |
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| spelling | Kolomeisky, Anatoly B. aut Motor proteins and molecular motors Anatoly B. Kolomeisky, Rice University, Houston, Texas Boca Raton CRC Press [2015] xxi, 200 Seiten Illustrationen, Diagramme 24 cm txt rdacontent n rdamedia nc rdacarrier Literaturverz. S. 183 - 196 Kontraktile Proteine (DE-588)4275800-2 gnd rswk-swf Kontraktile Proteine (DE-588)4275800-2 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028244139&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Kolomeisky, Anatoly B. Motor proteins and molecular motors Kontraktile Proteine (DE-588)4275800-2 gnd |
| subject_GND | (DE-588)4275800-2 |
| title | Motor proteins and molecular motors |
| title_auth | Motor proteins and molecular motors |
| title_exact_search | Motor proteins and molecular motors |
| title_full | Motor proteins and molecular motors Anatoly B. Kolomeisky, Rice University, Houston, Texas |
| title_fullStr | Motor proteins and molecular motors Anatoly B. Kolomeisky, Rice University, Houston, Texas |
| title_full_unstemmed | Motor proteins and molecular motors Anatoly B. Kolomeisky, Rice University, Houston, Texas |
| title_short | Motor proteins and molecular motors |
| title_sort | motor proteins and molecular motors |
| topic | Kontraktile Proteine (DE-588)4275800-2 gnd |
| topic_facet | Kontraktile Proteine |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028244139&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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