Trafficking of GPCRs:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Amsterdam
Acad. Press
2015
|
| Edition: | 1. ed. |
| Series: | Progress in molecular biology and translational science
132 |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIII, 314 S. Ill., graph. Darst. |
| ISBN: | 9780128029398 |
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| 245 | 1 | 0 | |a Trafficking of GPCRs |c ed. by Guangyu Wu |
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Record in the Search Index
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| adam_text | Titel: Trafficking of GPCRs
Autor: Wu, Guangyu
Jahr: 2015
CONTENTS
Contributors ix
Preface xiii
1. Arrestins: Critical Players in Trafficking of Many GPCRs 1
Vsevolod V. Gurevich and Eugenia V. Gurevich
1. Arrestins and GPCR Trafficking 2
2. Non-visual Arrestins Mediate GPCR Internalization via Coated Pits 2
3. Visual Arrestins and Trafficking Proteins 4
4. Ubiquitination and Deubiquitination in GPCR Cycling and Signaling 6
5. Faster Cycling Prevents Receptor Downregulation 7
6. Arrestins in Receptor Recycling and Vesicle Trafficking: Questions
Without Answers 8
7. Conclusions and Future Directions 9
References 10
2. Regulation of GPCR Trafficking by Ubiquitin 15
Justine E. Kennedy and Adriano Marchese
1. Introduction 16
2. Ubiquitination Machinery 17
3. Mechanisms of GPCR Ubiquitination 19
4. GPCR Regulation by E3 Ubiquitin Ligases 20
5. Role of Ubiquitin in GPCR Internalization 23
6. Role of Ubiquitin in GPCR Endosome to Lysosome Sorting 25
7. Role of Deubiquitination in GPCR Lysosomal Sorting 29
8. Effect of Biased Agonism on GPCR Trafficking: Role of Ubiquitin 31
9. Conclusion 32
Acknowledgments 32
References 33
3. Rhodopsin Trafficking and Mistrafficking: Signals,
Molecular Components, and Mechanisms 39
Ina Nemet, Philip Ropelewski, and Yoshikazu Imanishi
1. Introduction 40
2. Trafficking Signals of Rhodopsin 41
3. Molecular Components and Mechanisms for Specific OS
Targeting of Rhodopsin 44
vi
Contents
4. Mislocalization of Rhodopsin Mutants 56
5. Future Perspectives 61
Acknowledgment 62
References 62
4. Intracellular Trafficking of Neuropeptide Y Receptors 73
Karin Morl and Annette G. Beck-Sickinger
1. Introduction: The Neuropeptide Y Receptor Family 73
2. Evolution of the NPY Receptor Family 75
3. Intracellular Trafficking of Y Receptors 76
4. Modulation of Internalization by Ligand Modification 89
5. Conclusions 90
References 91
5. Insights into Serotonin Receptor Trafficking: Cell
Membrane Targeting and Internalization 97
Michèle Darmon, Sana AI Awabdh, Michel-Boris Emerit,
and Justine Masson
1. Introduction 98
2. Trafficking of the 5-HT,R 99
3. Trafficking of the 5-HT2R 108
4. Trafficking of the 5-HT4R 115
5. Trafficking of the 5-HT6R 116
6. Trafficking of the 5-HTyR 118
7. Conclusion 120
References 120
6. Calcium-Sensing Receptor: Trafficking, Endocytosis,
Recycling, and Importance of Interacting Proteins 127
Kausik Ray
1. Introduction 128
2. CaSR Structure and Function 130
3. Anterograde Trafficking of CaSR Through Secretory Pathway 134
4. Unique Regulation of CaSR Agonist-Driven Insertional Signaling
at the Cell Surface 139
5. Cell-Surface Compartmentalization and Cytoskeletal Alteration
of CaSR Signaling 141
6. Endocytosis and Recycling of CaSR 142
7. Proteosomal and Lysosomal Degradation Pathways 144
8. Conclusion 145
References 146
Contents
vii
7. Trafficking of ß-Adrenergic Receptors: Implications
in Intracellular Receptor Signaling
Qin Fu and Yang K. Xiang
1. Introduction
2. Cell Surface ßAR Distribution and Signaling
3. Molecular Machinery for ßAR Endocytosis
4. Posttranslational Modifications of ßAR in Trafficking and Signaling
5. Regulation of Endosome ßAR Signaling
6. Conclusion and Remarks
Acknowledgments
References
151
152
153
159
162
169
177
179
179
8. Postendocytic Sorting of Adrenergic and Opioid Receptors:
New Mechanisms and Functions 189
Shanna L. Bowman and Manojkumar A. Puthenveedu
1. Introduction: The Endosome as a Sorting Station for Internalized GPCRs 190
2. Mechanisms of Sequence-Dependent GPCR Sorting 191
3. Regulation of Sequence-Dependent Recycling by Modifying Steps in
Hierarchical Sorting 197
4. Relevance of Sequence-Dependent GPCR Recycling in the Endosome 199
5. Summary and Perspectives 201
References 202
9. a2 Adrenergic Receptor Trafficking as a Therapeutic
Target in Antidepressant Drug Action 207
Christopher Cottingham, Craig J. Ferryman, and Qin Wang
1. Introduction 207
2. Physiological Basis for Studying o2aAR Trafficking in Depression 209
3. Arrestin-Biased Regulation of the a2AAR by the TCA Drug Class 211
4. Therapeutic Implications 216
References 219
10. Regulation of a2B-Adrenerigc Receptor Export Trafficking
by Specific Motifs 227
Guangyu Wu, Jason E. Davis, and Maoxiang Zhang
1. Export Trafficking of GPCRs 228
2. Regulation of a2g-AR Export from the ER 229
3. Regulation of a2g-AR Post-Golgi Transport 236
4. Concluding Remarks 239
Acknowledgment 239
References 239
viii Contents
11. Temperature-Sensitive Intracellular Traffic of
a2c-Adrenergic Receptor 245
Catalin M. Filipeanu
1. a2-Adrenergic Receptors Classification 246
2. x2c-AR Tissue Localization 247
3. «2C-AR and Raynaud Phenomenon 249
4. Mechanisms Involved in the Transport of a2C-AR to the Cell Surface 250
5. Conclusions 260
Acknowledgments 261
References 261
12. N-Terminal Signal Peptides of G Protein-Coupled Receptors:
Significance for Receptor Biosynthesis, Trafficking,
and Signal Transduction 267
Claudia Rutz, Wolfgang Klein, and Ralf Schülein
1. Introduction 268
2. Structure and Basic Properties of Signal Peptides 269
3. Signal Peptide Functions During the Early Secretory Pathway 270
4. Signal Peptide Functions of GPCRs During the ER Insertion Process 271
5. Post-ER Functions of G PCR Signal Peptides 275
6. Signal Peptides of GPCRs as Potential Drug Targets 280
7. Concluding Remarks 282
Acknowledgments 282
References 282
13. Regulation of GPCR Anterograde Trafficking by
Molecular Chaperones and Motifs 289
Brent Young, Jaime Wertman, and Denis J. Dupré
1. Introduction 290
2. General Chaperone System Involved in GPCR Trafficking 291
3. Receptor-Specific Proteins Involved in Anterograde Trafficking 294
4. Conserved Motifs Involved in GPCR Trafficking 296
5. Conclusions 300
Acknowledgments 300
References 300
Index
307
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| id | DE-604.BV042764622 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:09:06Z |
| institution | BVB |
| isbn | 9780128029398 |
| language | English |
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| physical | XIII, 314 S. Ill., graph. Darst. |
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| series | Progress in molecular biology and translational science |
| series2 | Progress in molecular biology and translational science |
| spelling | Trafficking of GPCRs ed. by Guangyu Wu 1. ed. Amsterdam Acad. Press 2015 XIII, 314 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Progress in molecular biology and translational science 132 Wu, Guangyu Sonstige (DE-588)1072793512 oth Progress in molecular biology and translational science 132 (DE-604)BV035256576 132 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028195073&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Trafficking of GPCRs Progress in molecular biology and translational science |
| title | Trafficking of GPCRs |
| title_auth | Trafficking of GPCRs |
| title_exact_search | Trafficking of GPCRs |
| title_full | Trafficking of GPCRs ed. by Guangyu Wu |
| title_fullStr | Trafficking of GPCRs ed. by Guangyu Wu |
| title_full_unstemmed | Trafficking of GPCRs ed. by Guangyu Wu |
| title_short | Trafficking of GPCRs |
| title_sort | trafficking of gpcrs |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028195073&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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