Lipids in Protein Misfolding:
Saved in:
| Format: | Electronic eBook |
|---|---|
| Language: | English |
| Published: |
Cham [u.a.]
Springer International Publishing
2015
|
| Series: | Advances in Experimental Medicine and Biology
855 |
| Subjects: | |
| Online Access: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Physical Description: | 1 Online-Ressource (XIII, 260 p. 83 illus., 57 illus. in color) |
| ISBN: | 9783319173443 |
| DOI: | 10.1007/978-3-319-17344-3 |
Staff View
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Record in the Search Index
| _version_ | 1804174942143512576 |
|---|---|
| adam_text | LIPIDS IN PROTEIN MISFOLDING
/
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
ROLE OF LIPIDS IN FOLDING, MISFOLDING AND FUNCTION OF INTEGRAL MEMBRANE
PROTEINS
PROTEINMISFOLDING IN LIPID-MIMETIC ENVIRONMENTS.-LIPIDS IN
AMYLOID-Β PROCESSING, AGGREGATION, AND TOXICITY
ROLE OF CHOLESTEROL AND PHOSPHOLIPIDS IN AMYLIN MISFOLDING, AGGREGATION
AND ETIOLOGY OF ISLET AMYLOIDOSIS
STABILITY, OLIGOMERIZATION, AND AMYLOIDOGENICITY OF APO SERUM AMYLOID A
INTERACTIONS OF LIPID MEMBRANES WITH FIBRILLAR PROTEIN AGGREGATES
THE ROLE OF LIPID IN MISFOLDING AND AMYLOID FIBRIL FORMATION BY
APOLIPOPROTEIN C-II
AMYLOID-FORMING PROPERTIES OF HUMAN APOLIPOPROTEINS: SEQUENCE ANALYSES
AND STRUCTURAL INSIGHTS
COMPUTATIONAL APPROACHES TO IDENTIFICATION OF AGGREGATION SITES AND THE
MECHANISM OF AMYLOID GROWTH
ROLE OF SYNDECANS IN LIPID METABOLISM AND HUMAN DISEASES
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
LIPIDS IN PROTEIN MISFOLDING
/
: 2015
ABSTRACT / INHALTSTEXT
THIS BOOK ADDRESSES MOLECULAR MECHANISMS OF PROTEIN MISFOLDING AND THE
ROLE OF LIPIDS AND RELATED MOLECULES IN THESE COMPLEX PROCESSES. THE
FOCUS IS ON THE BIOPHYSICAL AND STRUCTURAL STUDIES OF PROTEINS THAT ARE
INVOLVED IN MAJOR HUMAN DISORDERS SUCH AS ALZHEIMER’S DISEASE,
SYSTEMIC AMYLOIDOSES, DIABETES II, INFLAMMATION AND ATHEROSCLEROSIS.
MISFOLDING OFTEN RESULTS FROM PROTEIN MUTATIONS OR MODIFICATIONS.
MISFOLDING OF MEMBRANE PROTEINS CAN CAUSE TOPOLOGICAL CHANGES THAT
TARGET THE PROTEINS FOR DEGRADATION. MISFOLDING OF SOLUBLE GLOBULAR
PROTEINS AND PEPTIDES CONVERTS THEM INTO Β-SHEET-RICH AGGREGATES AND
AMYLOID FIBRILS. THIS PROCESS CAN DISRUPT THE STRUCTURAL INTEGRITY OF
THE LIPID MEMBRANES AND THEREBY CONTRIBUTE TO AMYLOID TOXICITY. IN TURN,
LIPIDS AND LIPID-ASSOCIATED MOLECULES SUCH AS APOLIPOPROTEINS AND
HEPARAN SULFATE PROTEOGLYCANS, WHICH ARE UBIQUITOUS CONSTITUENTS OF
AMYLOID PLAQUES, CAN INFLUENCE PROTEIN MISFOLDING VIA DIVERSE MECHANISMS
THAT ARE ADDRESSED IN THIS BOOK. THE BOOK FEATURES CHAPTERS DESCRIBING
THE ROLE OF LIPIDS IN THE MISFOLDING OF A WIDE RANGE OF PROTEINS,
INCLUDING SMALL PEPTIDES, GLOBULAR PROTEINS, LIPID SURFACE-BINDING
PROTEINS, AND INTEGRAL MEMBRANE PROTEINS. THE ROLE OF INDIVIDUAL LIPID
MOLECULES, LIPID SURFACES, AND THE MEMBRANE FIELD IS ADDRESSED,
INCLUDING SPECIFIC AND NON-SPECIFIC INTERACTIONS WITH PROTEIN OLIGOMERS
AND MATURE FIBRILS. DISTINCT EFFECTS OF VARIOUS LIPIDS ON THE NUCLEATION
AND GROWTH OF AMYLOID FIBRILS ARE DISCUSSED. MODERN COMPUTATIONAL
APPROACHES TO THE ANALYSIS OF AMYLOID FORMATION ARE ADDRESSED. THE
BOOK SHOULD BE USEFUL TO EXPERTS IN THE FIELD BUT IS ALSO ACCESSIBLE TO
NOVICES
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| dewey-full | 572.633 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
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| discipline | Biologie |
| doi_str_mv | 10.1007/978-3-319-17344-3 |
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| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:08:24Z |
| institution | BVB |
| isbn | 9783319173443 |
| language | English |
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| owner_facet | DE-91 DE-BY-TUM DE-703 |
| physical | 1 Online-Ressource (XIII, 260 p. 83 illus., 57 illus. in color) |
| psigel | ZDB-2-SBL ZDB-2-SBL_2015 |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Springer International Publishing |
| record_format | marc |
| series | Advances in Experimental Medicine and Biology |
| series2 | Advances in Experimental Medicine and Biology |
| spelling | Lipids in Protein Misfolding Olga Gursky, ed. Cham [u.a.] Springer International Publishing 2015 1 Online-Ressource (XIII, 260 p. 83 illus., 57 illus. in color) txt rdacontent c rdamedia cr rdacarrier Advances in Experimental Medicine and Biology 855 Life sciences Medicine Bioorganic chemistry Biochemistry Life Sciences Protein Structure Biomedicine general Bioorganic Chemistry Biowissenschaften Medizin Gursky, Olga Sonstige oth Erscheint auch als Druckausgabe 978-3-319-17343-6 Advances in Experimental Medicine and Biology 855 (DE-604)BV023059251 855 https://doi.org/10.1007/978-3-319-17344-3 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028161483&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028161483&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Lipids in Protein Misfolding Advances in Experimental Medicine and Biology Life sciences Medicine Bioorganic chemistry Biochemistry Life Sciences Protein Structure Biomedicine general Bioorganic Chemistry Biowissenschaften Medizin |
| title | Lipids in Protein Misfolding |
| title_auth | Lipids in Protein Misfolding |
| title_exact_search | Lipids in Protein Misfolding |
| title_full | Lipids in Protein Misfolding Olga Gursky, ed. |
| title_fullStr | Lipids in Protein Misfolding Olga Gursky, ed. |
| title_full_unstemmed | Lipids in Protein Misfolding Olga Gursky, ed. |
| title_short | Lipids in Protein Misfolding |
| title_sort | lipids in protein misfolding |
| topic | Life sciences Medicine Bioorganic chemistry Biochemistry Life Sciences Protein Structure Biomedicine general Bioorganic Chemistry Biowissenschaften Medizin |
| topic_facet | Life sciences Medicine Bioorganic chemistry Biochemistry Life Sciences Protein Structure Biomedicine general Bioorganic Chemistry Biowissenschaften Medizin |
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