Novel insights into adaptive immunity based on analysis of patients with combined immunodeficiency:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Enth. Sonderabdr. |
| Beschreibung: | 126 S. Ill., graph. Darst. 30 cm |
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| adam_text | NOVEL INSIGHTS INTO ADAPTIVE IMMUNITY BASED ON ANALYSIS OF
PATIENTS WITH COMBINED IMMUNODEFICIENCY
INAUGURAL-DISSERTATION
ZUR ERLANGUNG DER DOKTORWURDE
DER FAKULTAT FUR BIOLOGIE UND DER MEDIZINISCHEN FAKULTAT
DER ALBERT-LUDWIGS-L/NIVERSITAT FREIBURG IM BREISGAU
VORGELEGT VON
SEBASTIAN FUCHS
GEBOREN IN
KOLN
FREIBURG IM BREISGAU
JUNI 2014
ANGEFERTIGT AM
CENTRUM FUR CHRONISCHE IMMUNDEFIZIENZ (CC1)
ABTEILUNG PADIATRISCHE IMMUNOLOGIE
HTTP://D-NB.INFO/1062548248
TABLE
OF CONTENT
1. INTRODUCTION
1.1 THE HUMAN IMMUNE SYSTEM: BALANCING HOST DEFENSE AND
3
SELF TOLERANCE
1.2 PRIMARY IMMUNODEFICIENCIES ARE A HETEROGENEOUS GROUP
3
OF DISEASES
1.3 COMBINED IMMUNODEFICIENCY 4
1.4 THE IMMUNOPATHOLOGY - PARADOX 5
1.5 HUMAN CID: A DIAGNOSTIC CHALLENGE 6
1.6 HUMAN RESEARCH: MONOGENETIC DISEASES CAN HELP TO
7
UNDERSTAND THE IMMUNE SYSTEM
2. OBJECTIVE OF THE DISSERTATION 9
3. PATIENTS AND METHODS 10
4. NOVEL INSIGHTS INTO ADAPTIVE IMMUNITY BY ANALYSIS OF
CID
PATIENTS
4.1 OVERVIEW 11
14.2 ANTIVIRAL AND REGULATORY T CELL IMMUNITY IN A PATIENT
WITH STIM1 DEFICIENCY
4.3 CLINICAL AND IMMUNOLOGICAL IMPLICATIONS OF THE
IL2RGR222C MUTATION LEADING TO AN ATYPICAL X-SCID VARIANT
4.4 DEFICIENCY OF INNATE AND ACQUIRED IMMUNITY CAUSED BY
AN IKBKB MUTATION
4.5 OMENN SYNDROME CAUSED BY A FUNCTIONAL REVERSION OF
CARD11 DEFICIENCY
5. DISCUSSION AND OUTLOOK 74
6. REFERENCES 80
LIST OF PUBLICATIONS 84
DANKSAGUNG 85
SUPPLEMENTS
ANTIVIRAL AND REGULATORY T CELL IMMUNITY IN A PATIENT WITH
STIM1 DEFICIENCY
CLINICAL AND IMMUNOLOGICAL IMPLICATIONS OF THE IL2RGR222C
MUTATION LEADING TO AN ATYPICAL X-SCID VARIANT
DEFICIENCY OF INNATE AND ACQUIRED IMMUNITY CAUSED BY AN
IKBKB MUTATION
OMENN SYNDROME CAUSED BY A FUNCTIONAL REVERSION OF
CARD11 DEFICIENCY
12
27
43
57
86
88
96
122
|
| any_adam_object | 1 |
| author | Fuchs, Sebastian |
| author_GND | (DE-588)1059922398 |
| author_facet | Fuchs, Sebastian |
| author_role | aut |
| author_sort | Fuchs, Sebastian |
| author_variant | s f sf |
| building | Verbundindex |
| bvnumber | BV042705067 |
| ctrlnum | (OCoLC)900641208 (DE-599)DNB1062548248 |
| dewey-full | 610 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610 |
| dewey-search | 610 |
| dewey-sort | 3610 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Thesis Book |
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| spelling | Fuchs, Sebastian Verfasser (DE-588)1059922398 aut Novel insights into adaptive immunity based on analysis of patients with combined immunodeficiency vorgelegt von Sebastian Fuchs 2014 126 S. Ill., graph. Darst. 30 cm txt rdacontent n rdamedia nc rdacarrier Enth. Sonderabdr. Freiburg (Breisgau), Univ., Diss., 2014 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028136517&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Fuchs, Sebastian Novel insights into adaptive immunity based on analysis of patients with combined immunodeficiency |
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| title | Novel insights into adaptive immunity based on analysis of patients with combined immunodeficiency |
| title_auth | Novel insights into adaptive immunity based on analysis of patients with combined immunodeficiency |
| title_exact_search | Novel insights into adaptive immunity based on analysis of patients with combined immunodeficiency |
| title_full | Novel insights into adaptive immunity based on analysis of patients with combined immunodeficiency vorgelegt von Sebastian Fuchs |
| title_fullStr | Novel insights into adaptive immunity based on analysis of patients with combined immunodeficiency vorgelegt von Sebastian Fuchs |
| title_full_unstemmed | Novel insights into adaptive immunity based on analysis of patients with combined immunodeficiency vorgelegt von Sebastian Fuchs |
| title_short | Novel insights into adaptive immunity based on analysis of patients with combined immunodeficiency |
| title_sort | novel insights into adaptive immunity based on analysis of patients with combined immunodeficiency |
| topic_facet | Hochschulschrift |
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