Mechanical blood trauma in circulatory-assist devices:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
New York, [New York] (222 East 46th Street, New York, NY 10017)
Momentum Press
2015
|
| Schriftenreihe: | Biomedical & nanomedical technologies
|
| Schlagworte: | |
| Beschreibung: | Mode of access: World Wide Web. - System requirements: Adobe Acrobat reader Includes bibliographical references (pages 39-50) and index Mechanical cardiovascular assist devices must be properly designed to avoid damage to the blood they contact. The factors that affect the hemocompatibility of a cardiovascular assist device include three major non-physiological components - the material, fluid flow paths, and flow related stresses - as well as the device interaction with the native vasculature. Furthermore, the interaction of the device with the blood is not static. Foreign surfaces activate blood components including platelets, leukocytes and the coagulation cascade. Thrombus formation on the surface of the device can alter the fluid dynamics in a manner that causes erythrocyte damage ranging from significant hemolysis to sub-lethal trauma that can take many days to weeks to develop into a significant clinical problem. This sub-lethal blood trauma is not easily detectable without special equipment, which is typically unavailable in routine clinical practice. Surveillance for blood damage is often suboptimal in the clinical setting, but once clinically relevant hemolysis occurs, crucial decisions - device removal, replacement, or additional medical therapies including surgery or plasmapheresis - that take into account the risk/benefit of intervention must be quickly evaluated. The various pre-clinical designs and testing, surgical considerations, available surveillance techniques, and clinical consequences will be discussed using recent and historical case reports to highlight key points |
| Beschreibung: | 1 Online-Ressource (50 pages) |
| ISBN: | 9781606507841 9781606507834 |
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| 245 | 1 | 0 | |a Mechanical blood trauma in circulatory-assist devices |c Timothy M. Maul, Marina V. Kameneva, Peter D. Wearden |
| 264 | 1 | |a New York, [New York] (222 East 46th Street, New York, NY 10017) |b Momentum Press |c 2015 | |
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| 490 | 0 | |a Biomedical & nanomedical technologies | |
| 500 | |a Mode of access: World Wide Web. - System requirements: Adobe Acrobat reader | ||
| 500 | |a Includes bibliographical references (pages 39-50) and index | ||
| 500 | |a Mechanical cardiovascular assist devices must be properly designed to avoid damage to the blood they contact. The factors that affect the hemocompatibility of a cardiovascular assist device include three major non-physiological components - the material, fluid flow paths, and flow related stresses - as well as the device interaction with the native vasculature. Furthermore, the interaction of the device with the blood is not static. Foreign surfaces activate blood components including platelets, leukocytes and the coagulation cascade. Thrombus formation on the surface of the device can alter the fluid dynamics in a manner that causes erythrocyte damage ranging from significant hemolysis to sub-lethal trauma that can take many days to weeks to develop into a significant clinical problem. This sub-lethal blood trauma is not easily detectable without special equipment, which is typically unavailable in routine clinical practice. Surveillance for blood damage is often suboptimal in the clinical setting, but once clinically relevant hemolysis occurs, crucial decisions - device removal, replacement, or additional medical therapies including surgery or plasmapheresis - that take into account the risk/benefit of intervention must be quickly evaluated. The various pre-clinical designs and testing, surgical considerations, available surveillance techniques, and clinical consequences will be discussed using recent and historical case reports to highlight key points | ||
| 505 | 0 | |a 1. Introduction -- | |
| 505 | 0 | |a 2. Hemolysis -- | |
| 505 | 0 | |a 3. Testing blood trauma in circulatory assist devices -- 3.1 Historical overview -- 3.2 Mechanical stresses which produce high levels of hemolysis -- | |
| 505 | 0 | |a 4. Sublethal blood trauma -- 4.1 Effect of mechanical stress on RBC deformability -- 4.2 Effect of mechanical stress on RBC aggregation -- 4.3 Mechanical fragility of red blood cells -- | |
| 505 | 0 | |a 5. Damage to leukocytes -- 5.1 Thrombosis and bleeding -- 5.1.1 In vitro studies of the mechanical stress effects on platelets -- | |
| 505 | 0 | |a 6. In vitro testing devices for blood biocompatibility -- 6.1 Methods of plasma free Hb measurement -- 6.1.1 OxyHb absorbency at 540 nm -- 6.1.2 Cripps method -- 6.2 Normalized Index of Hemolysis -- | |
| 505 | 0 | |a 7. Clinical issues and experience -- 7.1 Sequelae from hemolysis -- 7.2 Hemoglobin-haptoglobin complex -- 7.3 Effect of free Hb on platelets -- 7.4 Historical review of devices and resultant hemolysis issues -- 7.5 Surgical approaches to limit hemolysis -- | |
| 505 | 0 | |a 8. Medical therapy elevated plasma free hemoglobin -- | |
| 505 | 0 | |a 9. Concluding remarks -- | |
| 505 | 0 | |a 10. References -- | |
| 505 | 0 | |a 11. Author biographies | |
| 650 | 4 | |a Congestive heart failure |x Treatment | |
| 650 | 4 | |a Blood |x Circulation, Artificial | |
| 650 | 4 | |a Cardiovascular instruments, Implanted | |
| 650 | 0 | 7 | |a Blut |0 (DE-588)4007259-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Blutpumpe |0 (DE-588)4146083-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Trauma |0 (DE-588)4060748-3 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Blutpumpe |0 (DE-588)4146083-2 |D s |
| 689 | 0 | 1 | |a Blut |0 (DE-588)4007259-9 |D s |
| 689 | 0 | 2 | |a Trauma |0 (DE-588)4060748-3 |D s |
| 689 | 0 | |8 1\p |5 DE-604 | |
| 700 | 1 | |a Kameneva, Marina V. |e Sonstige |4 oth | |
| 700 | 1 | |a Wearden, Peter D. |e Sonstige |4 oth | |
| 912 | |a ZDB-38-EBR | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-028055134 | ||
| 883 | 1 | |8 1\p |a cgwrk |d 20201028 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | |
Datensatz im Suchindex
| _version_ | 1804174798202339328 |
|---|---|
| any_adam_object | |
| author | Maul, Timothy Michael |
| author_facet | Maul, Timothy Michael |
| author_role | aut |
| author_sort | Maul, Timothy Michael |
| author_variant | t m m tm tmm |
| building | Verbundindex |
| bvnumber | BV042622444 |
| collection | ZDB-38-EBR |
| contents | 1. Introduction -- 2. Hemolysis -- 3. Testing blood trauma in circulatory assist devices -- 3.1 Historical overview -- 3.2 Mechanical stresses which produce high levels of hemolysis -- 4. Sublethal blood trauma -- 4.1 Effect of mechanical stress on RBC deformability -- 4.2 Effect of mechanical stress on RBC aggregation -- 4.3 Mechanical fragility of red blood cells -- 5. Damage to leukocytes -- 5.1 Thrombosis and bleeding -- 5.1.1 In vitro studies of the mechanical stress effects on platelets -- 6. In vitro testing devices for blood biocompatibility -- 6.1 Methods of plasma free Hb measurement -- 6.1.1 OxyHb absorbency at 540 nm -- 6.1.2 Cripps method -- 6.2 Normalized Index of Hemolysis -- 7. Clinical issues and experience -- 7.1 Sequelae from hemolysis -- 7.2 Hemoglobin-haptoglobin complex -- 7.3 Effect of free Hb on platelets -- 7.4 Historical review of devices and resultant hemolysis issues -- 7.5 Surgical approaches to limit hemolysis -- 8. Medical therapy elevated plasma free hemoglobin -- 9. Concluding remarks -- 10. References -- 11. Author biographies |
| ctrlnum | (OCoLC)904424827 (DE-599)BVBBV042622444 |
| dewey-full | 616.129 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.129 |
| dewey-search | 616.129 |
| dewey-sort | 3616.129 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:06:07Z |
| institution | BVB |
| isbn | 9781606507841 9781606507834 |
| language | English |
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| spelling | Maul, Timothy Michael. Verfasser aut Mechanical blood trauma in circulatory-assist devices Timothy M. Maul, Marina V. Kameneva, Peter D. Wearden New York, [New York] (222 East 46th Street, New York, NY 10017) Momentum Press 2015 1 Online-Ressource (50 pages) txt rdacontent c rdamedia cr rdacarrier Biomedical & nanomedical technologies Mode of access: World Wide Web. - System requirements: Adobe Acrobat reader Includes bibliographical references (pages 39-50) and index Mechanical cardiovascular assist devices must be properly designed to avoid damage to the blood they contact. The factors that affect the hemocompatibility of a cardiovascular assist device include three major non-physiological components - the material, fluid flow paths, and flow related stresses - as well as the device interaction with the native vasculature. Furthermore, the interaction of the device with the blood is not static. Foreign surfaces activate blood components including platelets, leukocytes and the coagulation cascade. Thrombus formation on the surface of the device can alter the fluid dynamics in a manner that causes erythrocyte damage ranging from significant hemolysis to sub-lethal trauma that can take many days to weeks to develop into a significant clinical problem. This sub-lethal blood trauma is not easily detectable without special equipment, which is typically unavailable in routine clinical practice. Surveillance for blood damage is often suboptimal in the clinical setting, but once clinically relevant hemolysis occurs, crucial decisions - device removal, replacement, or additional medical therapies including surgery or plasmapheresis - that take into account the risk/benefit of intervention must be quickly evaluated. The various pre-clinical designs and testing, surgical considerations, available surveillance techniques, and clinical consequences will be discussed using recent and historical case reports to highlight key points 1. Introduction -- 2. Hemolysis -- 3. Testing blood trauma in circulatory assist devices -- 3.1 Historical overview -- 3.2 Mechanical stresses which produce high levels of hemolysis -- 4. Sublethal blood trauma -- 4.1 Effect of mechanical stress on RBC deformability -- 4.2 Effect of mechanical stress on RBC aggregation -- 4.3 Mechanical fragility of red blood cells -- 5. Damage to leukocytes -- 5.1 Thrombosis and bleeding -- 5.1.1 In vitro studies of the mechanical stress effects on platelets -- 6. In vitro testing devices for blood biocompatibility -- 6.1 Methods of plasma free Hb measurement -- 6.1.1 OxyHb absorbency at 540 nm -- 6.1.2 Cripps method -- 6.2 Normalized Index of Hemolysis -- 7. Clinical issues and experience -- 7.1 Sequelae from hemolysis -- 7.2 Hemoglobin-haptoglobin complex -- 7.3 Effect of free Hb on platelets -- 7.4 Historical review of devices and resultant hemolysis issues -- 7.5 Surgical approaches to limit hemolysis -- 8. Medical therapy elevated plasma free hemoglobin -- 9. Concluding remarks -- 10. References -- 11. Author biographies Congestive heart failure Treatment Blood Circulation, Artificial Cardiovascular instruments, Implanted Blut (DE-588)4007259-9 gnd rswk-swf Blutpumpe (DE-588)4146083-2 gnd rswk-swf Trauma (DE-588)4060748-3 gnd rswk-swf Blutpumpe (DE-588)4146083-2 s Blut (DE-588)4007259-9 s Trauma (DE-588)4060748-3 s 1\p DE-604 Kameneva, Marina V. Sonstige oth Wearden, Peter D. Sonstige oth 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Maul, Timothy Michael Mechanical blood trauma in circulatory-assist devices 1. Introduction -- 2. Hemolysis -- 3. Testing blood trauma in circulatory assist devices -- 3.1 Historical overview -- 3.2 Mechanical stresses which produce high levels of hemolysis -- 4. Sublethal blood trauma -- 4.1 Effect of mechanical stress on RBC deformability -- 4.2 Effect of mechanical stress on RBC aggregation -- 4.3 Mechanical fragility of red blood cells -- 5. Damage to leukocytes -- 5.1 Thrombosis and bleeding -- 5.1.1 In vitro studies of the mechanical stress effects on platelets -- 6. In vitro testing devices for blood biocompatibility -- 6.1 Methods of plasma free Hb measurement -- 6.1.1 OxyHb absorbency at 540 nm -- 6.1.2 Cripps method -- 6.2 Normalized Index of Hemolysis -- 7. Clinical issues and experience -- 7.1 Sequelae from hemolysis -- 7.2 Hemoglobin-haptoglobin complex -- 7.3 Effect of free Hb on platelets -- 7.4 Historical review of devices and resultant hemolysis issues -- 7.5 Surgical approaches to limit hemolysis -- 8. Medical therapy elevated plasma free hemoglobin -- 9. Concluding remarks -- 10. References -- 11. Author biographies Congestive heart failure Treatment Blood Circulation, Artificial Cardiovascular instruments, Implanted Blut (DE-588)4007259-9 gnd Blutpumpe (DE-588)4146083-2 gnd Trauma (DE-588)4060748-3 gnd |
| subject_GND | (DE-588)4007259-9 (DE-588)4146083-2 (DE-588)4060748-3 |
| title | Mechanical blood trauma in circulatory-assist devices |
| title_auth | Mechanical blood trauma in circulatory-assist devices |
| title_exact_search | Mechanical blood trauma in circulatory-assist devices |
| title_full | Mechanical blood trauma in circulatory-assist devices Timothy M. Maul, Marina V. Kameneva, Peter D. Wearden |
| title_fullStr | Mechanical blood trauma in circulatory-assist devices Timothy M. Maul, Marina V. Kameneva, Peter D. Wearden |
| title_full_unstemmed | Mechanical blood trauma in circulatory-assist devices Timothy M. Maul, Marina V. Kameneva, Peter D. Wearden |
| title_short | Mechanical blood trauma in circulatory-assist devices |
| title_sort | mechanical blood trauma in circulatory assist devices |
| topic | Congestive heart failure Treatment Blood Circulation, Artificial Cardiovascular instruments, Implanted Blut (DE-588)4007259-9 gnd Blutpumpe (DE-588)4146083-2 gnd Trauma (DE-588)4060748-3 gnd |
| topic_facet | Congestive heart failure Treatment Blood Circulation, Artificial Cardiovascular instruments, Implanted Blut Blutpumpe Trauma |
| work_keys_str_mv | AT maultimothymichael mechanicalbloodtraumaincirculatoryassistdevices AT kamenevamarinav mechanicalbloodtraumaincirculatoryassistdevices AT weardenpeterd mechanicalbloodtraumaincirculatoryassistdevices |