Evaluation and pathophysiological characterisation of a bovine model of respiratory Chlamydia psittaci infection:
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| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Berlin
Mensch und Buch Verl.
2013 [erschienen] 2015
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| Subjects: | |
| Online Access: | Volltext Inhaltsverzeichnis |
| Item Description: | Nebentitel: Evaluierung und pathophysiologische Charakterisierung eines bovinen Modells der respiratorischen Chlamydia-psittaci-Infektion |
| Physical Description: | II, 154 S. Ill., graph. Darst. |
| ISBN: | 9783863875879 |
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MARC
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| 100 | 1 | |a Ostermann, Carola Heike |e Verfasser |0 (DE-588)1072113635 |4 aut | |
| 245 | 1 | 0 | |a Evaluation and pathophysiological characterisation of a bovine model of respiratory Chlamydia psittaci infection |c vorgelegt von Carola Heike Ostermann |
| 246 | 1 | 3 | |a Evaluierung und pathophysiologische Charakterisierung eines bovinen Modells der respiratorischen Chlamydia-psittaci-Infektion |
| 264 | 1 | |a Berlin |b Mensch und Buch Verl. |c 2013 [erschienen] 2015 | |
| 300 | |a II, 154 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Nebentitel: Evaluierung und pathophysiologische Charakterisierung eines bovinen Modells der respiratorischen Chlamydia-psittaci-Infektion | ||
| 502 | |a Berlin, Freie Univ., Diss., 2014 | ||
| 650 | 7 | |a Chlamydia psittaci |2 cabt | |
| 650 | 7 | |a animal models |2 cabt | |
| 650 | 7 | |a physiopathology |2 cabt | |
| 650 | 7 | |a calves |2 cabt | |
| 650 | 7 | |a cattle diseases |2 cabt | |
| 650 | 7 | |a zoonoses |2 cabt | |
| 650 | 7 | |a respiratory diseases |2 cabt | |
| 650 | 7 | |a lung function |2 cabt | |
| 650 | 7 | |a lung ventilation |2 cabt | |
| 650 | 7 | |a blood gases |2 cabt | |
| 650 | 7 | |a impedance |2 cabt | |
| 650 | 7 | |a acid base disorders |2 cabt | |
| 650 | 7 | |a transmission |2 cabt | |
| 650 | 7 | |a excretion |2 cabt | |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
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| 912 | |a ebook | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-028038905 | ||
Record in the Search Index
| _version_ | 1804174775526883328 |
|---|---|
| adam_text | I
TABLE OF CONTENTS
1 INTRODUCTION 1
1.1 GENERAL BACKGROUND 1
1.2 CHLAMYDIAE 2
1.2.1 TAXONOMIC CLASSIFICATION 2
1.2.2 CHLAMYDIAL DEVELOPMENTAL CYCLE AND PERSISTENCE 4
1.2.3 CHLAMYDIA PSITTACI 5
1.3 BOVINES AS A SUITABLE MODEL SPECIES 9
1.3.1 STRUCTURAL AND FUNCTIONAL PECULIARITIES OF THE BOVINE RESPIRATORY
TRACT 9
1.3.2 AGE DEPENDENT PECULIARITIES 12
1.3.3 ASSESSMENT OF PULMONARY FUNCTIONS IN CALVES 12
1.4 AIMS OF THE PROJECT 14
1.5 DESIGN OF THE PROJECT 14
2 PUBLICATIONS AND DISCLOSURE OF PERSONAL CONTRIBUTIONS 17
2.1 STUDY 1: A BOVINE MODEL OF RESPIRATORY CHLAMYDIA PSITTACI INFECTION:
CHALLENGE DOSE TITRATION 18
2.2 STUDY 2: DOSE-DEPENDENT EFFECTS OF CHLAMYDIA PSITTACI INFECTION ON
PULMONARY GAS EXCHANGE, INNATE IMMUNITY AND ACUTE-PHASE REACTION IN A
BOVINE RESPIRATORY MODEL 33
2.3 STUDY 3: INFECTION, DISEASE, AND TRANSMISSION DYNAMICS IN CALVES
AFTER
EXPERIMENTAL AND NATURAL CHALLENGE WITH A BOVINE CHLAMYDIA PSITTACI
ISOLATE 44
2.4 STUDY 4: EVALUATION OF PULMONARY DYSFUNCTIONS AND ACID-BASE
IMBALANCES
INDUCED BY CHLAMYDIA PSITTACI IN A BOVINE MODEL OF RESPIRATORY INFECTION
57
CORRECTION: EVALUATION OF PULMONARY DYSFUNCTIONS AND
ACID-BASE IMBALANCES INDUCED BY CHLAMYDIA PSITTACI IN A BOVINE MODEL OF
RESPIRATORY INFECTION 80
3 DISCUSSION 81
3.1 FACTORS DETERMINING, INFLUENCING AND CHARACTERISING THE MODEL 81
3.1.1 METHODOLOGICAL ASPECTS 81
3.1.2 BIOLOGICAL FACTORS 86
3.2 COMPLEX PATHOGENETIC AND PATHOPHYSIOLOGICAL IMPLICATIONS AND THEIR
CONSEQUENCES FOR THE BOVINE HOST 96
3.2.1 INNATE AND ADAPTIVE IMMUNE RESPONSE 96
3.2.2 PATHOGENETIC INTERACTIONS IN THE BOVINE LUNG 100
3.3 EXCRETION AND TRANSMISSION OF C. PSITTACI IN BOVINES 105
HTTP://D-NB.INFO/1074114876
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CONCLUSIONS AND DIRECTIONS FOR FURTHER RESEARCH
SUMMARY
ZUSAMMENFASSUNG
BIBLIOGRAPHY
LIST OF ABBREVIATIONS ,
LIST OF FIGURES
LIST OF TABLES
LIST OF PUBLICATIONS
PUBLICATIONS IN PEER-REVIEWED JOURNALS
PUBLISHED ABSTRACTS
DANKSAGUNG
SELBSTSTANDIGKEITSERKLSRUNG
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| id | DE-604.BV042605938 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:05:45Z |
| institution | BVB |
| isbn | 9783863875879 |
| language | English |
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| physical | II, 154 S. Ill., graph. Darst. |
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| publishDate | 2013 |
| publishDateSearch | 2015 |
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| spelling | Ostermann, Carola Heike Verfasser (DE-588)1072113635 aut Evaluation and pathophysiological characterisation of a bovine model of respiratory Chlamydia psittaci infection vorgelegt von Carola Heike Ostermann Evaluierung und pathophysiologische Charakterisierung eines bovinen Modells der respiratorischen Chlamydia-psittaci-Infektion Berlin Mensch und Buch Verl. 2013 [erschienen] 2015 II, 154 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Nebentitel: Evaluierung und pathophysiologische Charakterisierung eines bovinen Modells der respiratorischen Chlamydia-psittaci-Infektion Berlin, Freie Univ., Diss., 2014 Chlamydia psittaci cabt animal models cabt physiopathology cabt calves cabt cattle diseases cabt zoonoses cabt respiratory diseases cabt lung function cabt lung ventilation cabt blood gases cabt impedance cabt acid base disorders cabt transmission cabt excretion cabt (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:kobv:188-fudissthesis000000099325-5 http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000099325 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028038905&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ostermann, Carola Heike Evaluation and pathophysiological characterisation of a bovine model of respiratory Chlamydia psittaci infection Chlamydia psittaci cabt animal models cabt physiopathology cabt calves cabt cattle diseases cabt zoonoses cabt respiratory diseases cabt lung function cabt lung ventilation cabt blood gases cabt impedance cabt acid base disorders cabt transmission cabt excretion cabt |
| subject_GND | (DE-588)4113937-9 |
| title | Evaluation and pathophysiological characterisation of a bovine model of respiratory Chlamydia psittaci infection |
| title_alt | Evaluierung und pathophysiologische Charakterisierung eines bovinen Modells der respiratorischen Chlamydia-psittaci-Infektion |
| title_auth | Evaluation and pathophysiological characterisation of a bovine model of respiratory Chlamydia psittaci infection |
| title_exact_search | Evaluation and pathophysiological characterisation of a bovine model of respiratory Chlamydia psittaci infection |
| title_full | Evaluation and pathophysiological characterisation of a bovine model of respiratory Chlamydia psittaci infection vorgelegt von Carola Heike Ostermann |
| title_fullStr | Evaluation and pathophysiological characterisation of a bovine model of respiratory Chlamydia psittaci infection vorgelegt von Carola Heike Ostermann |
| title_full_unstemmed | Evaluation and pathophysiological characterisation of a bovine model of respiratory Chlamydia psittaci infection vorgelegt von Carola Heike Ostermann |
| title_short | Evaluation and pathophysiological characterisation of a bovine model of respiratory Chlamydia psittaci infection |
| title_sort | evaluation and pathophysiological characterisation of a bovine model of respiratory chlamydia psittaci infection |
| topic | Chlamydia psittaci cabt animal models cabt physiopathology cabt calves cabt cattle diseases cabt zoonoses cabt respiratory diseases cabt lung function cabt lung ventilation cabt blood gases cabt impedance cabt acid base disorders cabt transmission cabt excretion cabt |
| topic_facet | Chlamydia psittaci animal models physiopathology calves cattle diseases zoonoses respiratory diseases lung function lung ventilation blood gases impedance acid base disorders transmission excretion Hochschulschrift |
| url | http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000099325 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028038905&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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