3D bioprinting and nanotechnology in tissue engineering and regenerative medicine:
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| Main Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Amsterdam [und 11 weitere]
Academic Press
2015
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVIII, 373 Seiten Illustrationen |
| ISBN: | 9780128005477 |
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| 245 | 1 | 0 | |a 3D bioprinting and nanotechnology in tissue engineering and regenerative medicine |c Lijie Grace Zhang, John P. Fisher, Kam W. Leong |
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| adam_text | Contents
List of Contributors...................................................................xiii
Preface................................................................................xvii
CHAPTER 1 Nanotechnology: A Toolkit for Cell Behavior.....................................1
1.1 Introduction...............................................................1
1.2 Nanobiomaterials for Tissue Regeneration..................................2
1.2.1 Carbon Nanobiomaterials.............................................2
1.2.2 Self-Assembling Nanobiomaterials....................................6
1.2.3 Polymeric and Ceramic Nanobiomaterials..............................8
1.3 3D Nano/Microfabrication Technology for Tissue Regeneration..............11
1.3.1 3D Nanofibrous and Nanoporous Scaffolds for Tissue
Regeneration........................................................11
1.3.2 3D Printing of Nanomaterial Scaffolds for Tissue Regeneration......13
1.4 Conclusion and Future Directions.........................................16
Acknowledgments...............................................................17
CHAPTER 2 3D Printing and Nanomanufacturing..............................................25
2.1 Introduction.............................................................25
2.2 3D Printing and Nanomanufacturing Techniques.............................26
2.2.1 Selective Laser Sintering..........................................26
2.2.2 Laser-Guided Direct Writing........................................27
2.2.3 Laser-Induced Forward Transfer.....................................28
2.2.4 Matrix-Assisted Pulsed Laser Evaporation Direct Writing............28
2.2.5 Biological Laser Printing..........................................29
2.2.6 Stereolithography Techniques.......................................29
2.2.7 Classification of Additive Biomanufacturing Techniques.............31
2.3 Biomaterials Used with Additive Biomanufacturing Techniques..............31
2.3.1 Powder-Type Materials..............................................32
2.3.2 Gel-Based Biomaterials.............................................35
2.3.3 Photocurable Polyesters............................................39
2.4 Cells and Bioapplications................................................40
2.4.1 Scaffold-Based Approach to Tissue Constructs.......................42
2.4.2 Bioprinting Approach to Tissue Constructs..........................45
2.5 Discussion: Pros and Cons of Each Technique..............................50
2.6 Summary..................................................................52
V
vi Contents
CHAPTER 3 3D Bioprinting Techniques................................................-....57
3.1 Introduction..............................................................57
3.2 Definition and Principles of 3D Bioprinting...............................58
3.3 3D Bioprinting Technologies...............................................60
3.3.1 Ink-Jet-Based Bioprinting...........................................61
3.3.2 Pressure-Assisted bioprinting.......................................63
3.3.3 Laser-Assisted Bioprinting..........................................65
3.3.4 Solenoid Valve-Based Printing.......................................66
3.3.5 Acoustic-Jet Printing...............................................68
3.4 Challenges and Future Development of 3D Bioprinting.......................68
3.5 Conclusion................................................................74
CHAPTER 4 The Power of CAD/CAM Laser Bioprinting at the Single-Cell Level:
Evolution of Printing.....................................................79
4.1 Introduction..............................................................79
4.1.1 Direct-Contact vs. Direct Write for Single-Cell
Printing............................................................79
4.2 Basics of Laser-Assisted Printing: Overview of Systems and
Critical Ancillary Materials..............................................80
4.2.1 Laser-Assisted Cell Transfer System Components......................80
4.2.2 AFA-LIFT............................................................82
4.2.3 MAPLE-DW............................................................83
4.2.4 Ancillary Materials.................................................84
4.3 MAPLE-DW Mechanics........................................................84
4.3.1 Modeling Cellular Droplet Formation.................................85
4.3.2 Modeling of Droplet Landing Process.................................88
4.4 Cell Viability...........................................................90
4.5 Case Studies and Applications Illustrating the Importance of
Single-Cell Deposition....................................................91
4.5.1 Isolated-Node, Single-Cell Arrays...................................91
4.5.2 Network-Level, Single-Cell Arrays...................................92
4.5.3 Next-Generation Single-Cell Arrays: Integrated, Computation-Driven
Analysis............................................................93
4.5.4 Example Single-Cell Array via MAPLE-DW..............................94
4.5.5 Laser Direct Write for Neurons......................................94
4.6 Conclusion...............................................................97
CHAPTER 5 Engineering 2D and 3D Cellular Microenvironments
Using Laser Direct Write.................................................105
5.1 Introduction.............................................................105
5.1.1 Spatial Influences of the Cellular Microenvironment................105
Contents
VII
5.1.2 Overview of Printing Techniques for Engineering Cellular
Microenvironments....................................................106
5.1.3 LDW Overview........................................................108
5.2 Materials in LDW..........................................................109
5.2.1 Material Properties Influencing Cellular Microenvironments..........109
5.2.2 Matrigel-Based LDW..................................................110
5.2.3 Gelatin-Based LDW...................................................111
5.2.4 Dynamic Release Layers..............................................112
5.2.5 Additional Hydrogels and Hydrogel Processing Used in LDW............112
5.2.6 Customizable Topography of Nonhydrogel Receiving Substrates.........113
5.3 LDW Applications in 2D....................................................113
5.4 LDW Applications in 3D....................................................118
5.4.1 Microenvironments in 3D.............................................118
5.4.2 Layer-By-Layer Approaches...........................................118
5.4.3 LDW Microbeads......................................................119
5.4.4 Fabrication of Shelled Microenvironments............................120
5.5 Conclusions and Future Directions.........................................122
Acknowledgments...............................................................123
CHAPTER 6 Biomaterials for Bioprinting...................................................129
6.1 Introduction..............................................................129
6.2 Parameters for Bioprinting................................................129
6.2.1 Biocompatibility....................................................129
6.2.2 Shear Thinning and Thixotropy.......................................130
6.2.3 Yield Stress........................................................130
6.2.4 Water Content.......................................................130
6.2.5 Swelling Behavior...................................................131
6.2.6 Elasticity..........................................................132
6.2.7 Solute Transportation...............................................132
6.2.8 Degradation.........................................................134
6.3 Hydrogel Cross-Linking Mechanism..........................................134
6.3.1 Physical............................................................134
6.3.2 Chemical............................................................135
6.4 Hydrogels in Bioprinting.................................................136
6.4.1 Natural Hydrogel....................................................137
6.4.2 Synthetic Hydrogels.................................................140
6.5 Integrative Support Materials............................................142
6.6 Conclusion...............................................................144
CHAPTER 7 Blood Vessel Regeneration......................................................149
7.1 Introduction..............................................................149
7.1.1 Additive Manufacturing..............................................150
viii Contents
7.1.2 Important Proteins for Vasculature...................................151
7.1.3 Application to Vascular Implants.....................................151
7.1.4 Electrospinning......................................................153
7.1.5 Stereolithography....................................................155
7.1.6 Fused Deposition Modeling............................................157
7.1.7 Ink-Jet Printing.....................................................158
7.1.8 Extrusion Bioprinting................................................160
7.1.9 Laser-Assisted Bioprinting...........................................161
7.2 Future Directions..........................................................165
Acknowledgments.................................................................165
CHAPTER 8 3D Printing and Patterning Vasculature in Engineered
Tissues.....................................................................171
8.1 Introduction................................................................171
8.1.1 Macroporous Constructs as Tissue Templates............................171
8.1.2 Fabricating Fluidic Networks within Biomaterials.....................173
8.1.3 Approaches to Fabricate Endothelialized and Cell-Laden Tissue
Constructs............................................................175
8.1.4 Approaches to Integrate Patterned Vasculature In Vivo................177
8.1.5 Patterning Multiscale Vasculature with Endothelial Function..........180
8.1.6 Angiogenesis, Vasculogenesis, and In Vivo Integration................181
8.1.7 Advanced Technologies which May Assist in Vascular Tissue
Fabrication...........................................................184
CHAPTER 9 Craniofacial and Dental Tissue...........................................191
9.1 Introduction................................................................191
9.2 Clinical Need for Craniofacial and Dental Regenerative Medicine............192
9.2.1 Major Diagnoses and Causes............................................192
9.2.2 Standard-of-Care Procedures..........................................193
9.3 Craniofacial and Dental Regenerative Medicine Research.....................198
9.3.1 Novel Materials.......................................................198
9.3.2 Teeth................................................................198
9.3.3 Bone.................................................................199
9.3.4 Temporomandibular Joint..............................................201
9.4 Bone Tissue Engineering Strategies........................................202
9.4.1 Scaffolds.............................................................203
9.4.2 Growth Factors.......................................................204
9.4.3 Cell-Based Therapies.................................................204
9.4.4 New Craniofacial Tissues.............................................205
9.4.5 Bioreactors..........................................................205
9.5 Conclusions................................................................208
Acknowledgment..................................................................208
Contents
IX
CHAPTER 10 Craniofacial Bone.................................................................215
10.1 Introduction..............................................................215
10.2 Craniofacial Bone Structure...............................................217
10.2.1 Craniofacial Macrogeometry.........................................217
10.2.2 Craniofacial Microstructure........................................219
10.3 Different 3D Printing Techniques and Their Application to Craniofacial
Scaffolds.................................................................219
10.3.1 Case Study 1 : Indirect Mold Method................................221
10.3.2 Case Study 2: Ink-Jet/Binder Method................................221
10.3.3 Case Study 3: Melt Extrusion Method................................223
10.4 Nanotechnology in Craniofacial Graft Design...............................223
10.4.1 Nanocomposites in Craniofacial Bone Regeneration....................223
10.4.2 Nanofibrous Scaffolds in Craniofacial Reconstruction...............224
10.4.3 Nanocarriers in Bioactive Agent Delivery...........................226
10.5 Summary...................................................................227
CHAPTER 11 Additive Manufacturing for Bone Load Bearing Applications.........................231
11.1 Need for Bone Substitutes................................................231
11.2 Compositional, Structural and Mechanical Properties of Bone................232
11.2.1 Compositional Properties of Bone and Requirements
for Bone Substitutes...............................................232
11.2.2 Structural Properties of Bone and Requirements for Bone Substitutes.232
11.2.3 Mechanical Properties of Bone and Requirements for Bone
Substitutes........................................................233
11.3 Difficulties in Achieving an Ideal Bone Substitute........................233
11.4 Metallic Bone Substitutes.................................................234
11.4.1 Metallic Materials, Limitations and Opportunities...................234
11.4.2 AM of Metals for Bone Substitutes..................................237
11.5 Bioceramic Bone Substitutes...............................................240
11.5.1 Bioceramic, Bioactive Glasses and Composite Materials...............242
11.5.2 AM of Bioceramic Materials: Several Techniques,
Limitations, and Opportunities.....................................245
11.6 Nanocomposite Bone Substitutes............................................252
11.6.1 Nanomaterials, Limitations, and Opportunities......................252
11.6.2 AM of Nanocomposites: Several Techniques,
Limitations and Opportunities......................................253
11.7 Conclusions...............................................................255
CHAPTER 12 Cartilage 3D Printing...................................................265
12.1 General Introduction......................................................265
12.1.1 Articular Cartilage: Function and Organization.....................265
12.1.2 Cartilage Injury, Disease, and Treatment Options...................267
x Contents
12.1.3 3D Bioprinting and Cell Printing Approaches......................268
12.1.4 Applying 3D Printing for Cartilage and Bone......................271
12.1.5 Direct In Situ Printing..........................................272
12.1.6 Major Challenges and Pitfalls....................................273
12.2 Future Directions.......................................................274
Acknowledgments...............................................................274
CHAPTER 13 Bioprinting for Skin..........................................................281
13.1 Skin, Skin Substitutes, Possible Applications
for Printed Skin........................................................281
13.1.1 Skin: Function and Structure.....................................281
13.2 Epidermis...............................................................282
13.2.1 Basement Membrane................................................284
13.2.2 Dermis...........................................................284
13.2.3 Hypodermis.......................................................284
13.2.4 Cutaneous Appendages.............................................285
13.2.5 Skin Substitutes, Applications for Printed Skin..................285
13.2.6 Injuries of the Skin.............................................285
13.3 Research................................................................286
13.3.1 Skin Substitutes Generated by Bioprinting........................286
13.3.2 Hydrogel.........................................................287
13.3.3 Extrusion-Based Bioprinted Skin Cells............................288
13.3.4 Laser-Assisted Bioprinted Skin...................................288
13.3.5 Discussion of the Different Bioprinting Techniques and
Clinical Applicability............................................299
13.3.6 Technical and Biomedical Challenges..............................301
13.3.7 Stem Cells as Possible Cell Sources for Bioprinting of Skin......301
13.4 Conclusion..............................................................302
Acknowledgments...............................................................303
CHAPTER 14 Nanotechnology and 3D Bioprinting for Neural
Tissue Regeneration......................................................307
14.1 Introduction............................................................307
14.2 Nanotechnology for Neural Tissue Regeneration...........................309
14.2.1 Self-Assembling Nanobiomaterials.................................309
14.2.2 Carbon Nanobiomaterials..........................................314
14.2.3 Electrospun Polymeric Nanofibrous Neural Scaffold................317
14.3 3D Bioprinting for Neural Tissue Regeneration...........................321
14.3.1 3D Bioprinting Neural Scaffolds..................................321
14.3.2 3D Bioprinting Cells for Neural Applications.....................321
14.4 Conclusion and Future Directions........................................325
Acknowledgments...............................................................326
Contents xi
CHAPTER 15 Organ Printing..................................................................333
15.1 Introduction..............................................................333
15.1.1 Organ Printing Techniques..........................................334
15.1.2 Challenges in Organ Printing.......................................336
15.1.3 Micro-Organ Printing as Physiological and Disease Platforms........338
15.1.4 Future Perspectives................................................343
CHAPTER 16 Intellectual Property in 3D Printing and Nanotechnology.........................349
16.1 Introduction..............................................................349
16.2 Why is Intellectual Property Important?...................................350
16.3 Types of Intellectual Property............................................350
16.3.1 Patents............................................................351
16.3.2 Copyrights.........................................................351
16.3.3 Trademarks.........................................................352
16.3.4 Trade Secrets......................................................352
16.4 Where does Intellectual Property Law Originate?...........................353
16.5 What Aspects of 3D Bioprinting and Nanotechnology are Protectable?.......353
16.5.1 Hardware...........................................................354
16.5.2 Software...........................................................355
16.5.3 Methods/Processes..................................................356
16.5.4 Materials..........................................................356
16.6 Intellectual Property Protection Limitations for Engineered Tissue........357
16.7 Ethical Considerations of Engineered Tissue Intellectual Property.........358
16.8 Intellectual Property Infringement........................................359
16.8.1 Trademark Infringement.............................................360
16.8.2 Trade Secret Misappropriation......................................360
16.8.3 Copyright Infringement.............................................360
16.8.4 Patent Infringement................................................361
16.9 Conclusion................................................................362
Index......................................................................................365
|
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| author | Zhang, Lijie Grace Fisher, John P. Leong, Kam W. |
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| dewey-ones | 612 - Human physiology |
| dewey-raw | 612/.028 |
| dewey-search | 612/.028 |
| dewey-sort | 3612 228 |
| dewey-tens | 610 - Medicine and health |
| discipline | Werkstoffwissenschaften / Fertigungstechnik Medizin |
| format | Book |
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| id | DE-604.BV042594961 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:05:30Z |
| institution | BVB |
| isbn | 9780128005477 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028028132 |
| oclc_num | 900464415 |
| open_access_boolean | |
| owner | DE-703 |
| owner_facet | DE-703 |
| physical | XVIII, 373 Seiten Illustrationen |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Academic Press |
| record_format | marc |
| spelling | Zhang, Lijie Grace Verfasser aut 3D bioprinting and nanotechnology in tissue engineering and regenerative medicine Lijie Grace Zhang, John P. Fisher, Kam W. Leong Amsterdam [und 11 weitere] Academic Press 2015 2015 XVIII, 373 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Tissue engineering Guided tissue regeneration Nanomedicine Nanotechnology Medizintechnik (DE-588)4074676-8 gnd rswk-swf Biomaterial (DE-588)4267769-5 gnd rswk-swf 3D-Druck (DE-588)1032223197 gnd rswk-swf Herstellung (DE-588)4159653-5 gnd rswk-swf Werkstoff (DE-588)4065579-9 gnd rswk-swf Rapid Prototyping Fertigung (DE-588)4389159-7 gnd rswk-swf Biomedizinische Technik (DE-588)4006882-1 gnd rswk-swf Biomedizinische Technik (DE-588)4006882-1 s Biomaterial (DE-588)4267769-5 s Herstellung (DE-588)4159653-5 s DE-604 Rapid Prototyping Fertigung (DE-588)4389159-7 s Werkstoff (DE-588)4065579-9 s Medizintechnik (DE-588)4074676-8 s 3D-Druck (DE-588)1032223197 s Fisher, John P. Verfasser (DE-588)1062938216 aut Leong, Kam W. Verfasser aut Digitalisierung UB Bayreuth - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028028132&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Zhang, Lijie Grace Fisher, John P. Leong, Kam W. 3D bioprinting and nanotechnology in tissue engineering and regenerative medicine Tissue engineering Guided tissue regeneration Nanomedicine Nanotechnology Medizintechnik (DE-588)4074676-8 gnd Biomaterial (DE-588)4267769-5 gnd 3D-Druck (DE-588)1032223197 gnd Herstellung (DE-588)4159653-5 gnd Werkstoff (DE-588)4065579-9 gnd Rapid Prototyping Fertigung (DE-588)4389159-7 gnd Biomedizinische Technik (DE-588)4006882-1 gnd |
| subject_GND | (DE-588)4074676-8 (DE-588)4267769-5 (DE-588)1032223197 (DE-588)4159653-5 (DE-588)4065579-9 (DE-588)4389159-7 (DE-588)4006882-1 |
| title | 3D bioprinting and nanotechnology in tissue engineering and regenerative medicine |
| title_auth | 3D bioprinting and nanotechnology in tissue engineering and regenerative medicine |
| title_exact_search | 3D bioprinting and nanotechnology in tissue engineering and regenerative medicine |
| title_full | 3D bioprinting and nanotechnology in tissue engineering and regenerative medicine Lijie Grace Zhang, John P. Fisher, Kam W. Leong |
| title_fullStr | 3D bioprinting and nanotechnology in tissue engineering and regenerative medicine Lijie Grace Zhang, John P. Fisher, Kam W. Leong |
| title_full_unstemmed | 3D bioprinting and nanotechnology in tissue engineering and regenerative medicine Lijie Grace Zhang, John P. Fisher, Kam W. Leong |
| title_short | 3D bioprinting and nanotechnology in tissue engineering and regenerative medicine |
| title_sort | 3d bioprinting and nanotechnology in tissue engineering and regenerative medicine |
| topic | Tissue engineering Guided tissue regeneration Nanomedicine Nanotechnology Medizintechnik (DE-588)4074676-8 gnd Biomaterial (DE-588)4267769-5 gnd 3D-Druck (DE-588)1032223197 gnd Herstellung (DE-588)4159653-5 gnd Werkstoff (DE-588)4065579-9 gnd Rapid Prototyping Fertigung (DE-588)4389159-7 gnd Biomedizinische Technik (DE-588)4006882-1 gnd |
| topic_facet | Tissue engineering Guided tissue regeneration Nanomedicine Nanotechnology Medizintechnik Biomaterial 3D-Druck Herstellung Werkstoff Rapid Prototyping Fertigung Biomedizinische Technik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028028132&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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