Bio- and multifunctional polymer architectures: preparation, analytical methods, and applications
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| Main Authors: | , , , |
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| Format: | Book |
| Language: | English |
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Hoboken, New Jersey
Wiley
[2016]
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| Online Access: | Inhaltsverzeichnis Klappentext |
| Physical Description: | xii, 322 Seiten, 16 ungezählte Seiten Illustrationen |
| ISBN: | 1118158911 9781118158913 |
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| adam_text | CONTENTS
R
Preface xi
Acknowledgments xiii
1 Introduction 1
1.1 What makes Polymers so Interesting?, 1
1.2 Macromolecular Engineering and
Nanostructure Formation, 4
1.3 Specific Needs in Bionanotechnology and Biomedicine, 5
Reference, 6
2 Terminology 7
2.1 Polymer Architectures, 7
2.2 Multifunctionality, 11
2.3 Bioconjugates, 12
2.4 Biocompatibility, 12
2.5 Biodegradation, 14
2.6 Bioactivity, 14
2.7 Multivalency, 15
2.8 Bionanotechnology, 17
References, 18
vi
CONTENTS
3 Preparation Methods and Tools
19
3.1
3.2
3.3
3.4
3.5
3.6
3.7
3.8
3.9
3.10
General Aspects of Polymer Synthesis, 19
3.1.1 Chain Growth Polymerizations, 20
3.1.2 Step Growth Polymerizations, 23
3.1.3 Modification of Polymers, 25
Controlled Polymer Synthesis, 25
3.2.1 Anionic Polymerization, 26
3.2.2 Cationic Polymerization, 30
3.2.3 Controlled Radical Polymerization, 34
3.2.4 Metal-Catalyzed Polymerization, 37
3.2.5 Chain Growth Condensation Polymerization, 41
Effective Polymer Analogous Reactions, 43
Pegylation, 47
Bioconjugation, 51
3.5.1 Polynucleotide Conjugates, 53
3.5.2 Protein Conjugates, 55
3.5.3 Polysaccharide Conjugates, 57
Enzymatic Polymer Synthesis, 59
Solid Phase Synthesis and Biotechnological Approaches, 63
3.7.1 Solid Phase Synthesis, 63
3.7.2 Biotechnology Approaches in the Synthesis
of Biopolymers, 75
Hydrogels and Hydrogel Scaffolds, 81
3.8.1 Hydrogels, 81
3.8.2 Hydrogels as Scaffold Materials, 84
Surface Modification and Film Preparation, 92
3.9.1 Self-Assembled Monolayers, 93
3.9.2 Langmuir-Blodgett Films, 95
3.9.3 Layer-by-Layer Deposition, 96
3.9.4 Immobilization by Chemical Binding to Substrates, 97
3.9.5 Low-Pressure Plasma, 99
3.9.6 Electron Beam Treatment, 101
Microengineering of Polymers and Polymeric Surfaces, 102
References, 107
4 Analytical Methods
113
4.1 Molecular Structure and Molar Mass Determination
of Polymers and Biohybrids, 113
4.1.1 Structural Characterization, 114
CONTENTS
vii
4.1.2 Determination of Molar Mass and Molar Mass
Distribution, 132
4.2 Characterization of Aggregates and Assemblies, 137
4.2.1 Dynamic Light Scattering, 138
4.2.2 Pulsed Field Gradient and Electrophoretic Nuclear
Magnetic Resonance, 139
4.2.3 Field-Flow Fractionation, 142
4.2.4 UV—Vis Spectroscopy and Fluorescence Spectroscopy, 144
4.2.5 Electron Microscopy, 145
4.3 Characterization of Hydrogel Networks, 147
4.3.1 Network Structure of Hydrogels, 148
4.3.2 Swelling Degree, 148
4.3.3 Mechanical Properties, 150
4.3.4 Deriving Microscopic Network Parameters from
Macroscopic Hydrogel Properties, 153
4.4 Surface Characterization, 154
4.4.1 X-Ray Photoelectron Spectroscopy, 154
4.4.2 Contact Angle Measurements by Axisymmetric
Drop Shape Analysis, 157
4.4.3 Electrokinetic Measurements, 158
4.4.4 Spectroscopic Ellipsometry, 159
4.4.5 Quartz Crystal Microbalance with
Dissipation Monitoring, 160
4.4.6 Surface Plasmon Resonance, 161
4.4.7 Scanning Force Techniques, 162
4.4.8 Environmental Scanning Electron
Microscopy, 164
4.5 Biophysical Characterization and Biocompatibility, 166
4.5.1 Biophysical Characterization, 167
4.5.2 Biocompatibility, 175
References, 183
5 Multifunctional Polymer Architectures 187
5.1 Multifunctional (Block) Copolymers, 187
5.1.1 Multifunctionality through Copolymerization, 187
5.1.2 Multifunctionality by Polymer
Analogous Reactions, 189
5.1.3 Spatially Defined Multifunctionality by Phase Separation
and Self-Assembly of Segmented Copolymers, 190
viii
CONTENTS
5.2 Dendritic Polymers, 196
5.2.1 Synthesis of Dendrimers and Hyperbranched
Polymers, 198
5.2.2 Properties and Applications, 200
5.3 GlyCopolymers, 203
5.3.1 Linear Gly copolymers, 205
5.3.2 Globular Glycomacromolecules, 207
5.4 Peptide-Based Structures, 212
5.4.1 Hierarchical Self-Assembly of Peptide Molecules, 214
5.4.2 General Design Concepts for Peptide-Based Structural
Materials, 215
5.4.3 Noncanonical Amino Acids in Peptide/Protein
Engineering, 217
5.4.4 Peptide-Based Materials Inspired by Naturally
Occurring Structural Proteins, 217
5.4.5 Polypeptide Materials Based on other
Naturally Occurring or De Novo Designed
Self-Assembling Domains such as Coiled Coils, 221
5.4.6 Self-Assembly of Short Peptide Derivates and
Peptide-Based Amphiphilic Molecules, 222
5.5 Biohybrid Hydrogels, 224
5.5.1 Composition, Basic Principles, and
Formation of Biohybrids, 225
5.5.2 Polynucleotide Biohybrids, 228
5.5.3 Polypeptide or Protein Biohybrids, 231
5.5.4 Polysaccharide Biohybrids, 232
References, 235
6 Functional Materials and Applied Systems
6.1 Organic Nanoparticles and Aggregates for Drug
and Gene Delivery, 241
6.1.1 Polymeric Micelles, Polymersomes, and
Nanocapsules, 241
6.1.2 Polymeric Beads and Micro/Nanogels Based on
Dendritic Structures, 254
6.1.3 Polyplexes for Gene Delivery, 263
6.2 Polymer Therapeutics and Targeting Approaches, 264
6.2.1 Current Status of Polymer Therapeutics, 264
6.2.2 Implications and Rationale for
Effective Delivery Systems, 266
Cellular Uptake and Targeting, 267
241
6.2.3
CONTENTS
ix
6.3 Multi- and Polyvalent Polymeric Architectures, 271
6.3.1 Polyvalent Interactions on Biological Interfaces, 272
6.3.2 Prospects for Multivalent Drugs, 277
6.4 Bioresponsive Networks, 280
6.4.1 Active Principle, 280
6.4.2 Homeostatic Regulation of Blood Coagulation, 281
6.4.3 Insulin Release in Response
to Glucose Concentration, 282
6.4.4 Urate-Responsive Release of Urate Oxidase, 283
6.4.5 Cell-Responsive Degradation of Hydrogel Networks, 284
6.5 Biofunctional Surfaces, 284
6.5.1 Concepts and Aims of Biofunctional Material
Surfaces, 284
6.5.2 Biofunctional Surfaces for the Prevention of
Biofouling, 287
6.5.3 Anticoagulant Coatings for
Blood-Contacting Devices, 292
References, 295
Abbreviations
Index
303
309
The book covers concepts and synthetic techniques for the preparation of poiymers for state-
of-the-art use in biomedicine, synthetic biology, and bionanotechnology
Bio- and Multifunctional Polymer Architectures describes the underlying principles and synthetic
strategies for the development of novel polymers, biohybrids, and complex assemblies for
use in growing application areas such as bioactive surfaces and coatings, tissue engineering,
biomedical diagnostics, and polymeric conjugates as well as nanocarriers for therapy.
These multifunctional polymer architectures are often intended to mimic existing biological
components and assemblies in their complexity, and thus incorporate various sensing, healing,
and actuation attributes. Their multifunctionality often occurs at nano- through macro-scales
and on various temporal and compositional levels.
Following an introduction, the book describes the following:
Detailed synthetic methods for the creation of synthetic multifunctional biomaterials
Characterization methods to help assess biocompatibility and biodegradability
Various multifunctional polymer architectures that have heretofore been constructed
Materials, systems, and applications, primarily in biomedical areas
With clear definitions of terms, this book is an ideal reference for graduate students as well
as professionals. A biological rationale and approach runs throughout all the chapters, and
characterization is addressed in order to help assure that safety profiles and application
feasibility of the materials are at the basis of molecular design.
Brigitte Voit is Head of the Institute of Macromolecular Chemistry at the Leibniz Institute of
Polymer Research (IPF) Dresden, Germany, as well as Full Professor of Organic Chemistry of
Polymers at the Technische Universität Dresden (TUD), Germany. In addition, she heads the IPF
Dresden, Germany, as Managing Director and Chief Scientific Officer (Scientific Director).
Rainer Haag is Full Professor of Organic and Macromolecular Chemistry at the Freie Universität,
Berlin, Germany. In addition, he heads the interdisciplinary research center SupraFAB”.
Dietmar Appelhans is a senior scientist in the group of Professor Brigitte Voit, and is Head
of the Department of Bioactive and Responsive Polymers at the Leibniz Institute of Polymer
Research (IPF) Dresden, Germany.
Petra B. Wetzel is a senior researcher at the Institute of Biofunctional Polymer Materials (head:
Professor Carsten Werner), Leibniz Institute of Polymer Research (IPF) Dresden, Max-Bergmann-
Zentrum für Biomaterialien, Germany.
ISBN 978-1-118-1S891-3
|
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| discipline | Chemie / Pharmazie Physik Biologie |
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| spelling | Voit, Brigitte Verfasser aut Bio- and multifunctional polymer architectures preparation, analytical methods, and applications Brigitte Voit, Rainer Haag, Dietmar Appelhans, Petra B. Welzel Hoboken, New Jersey Wiley [2016] xii, 322 Seiten, 16 ungezählte Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Biopolymere (DE-588)4006893-6 gnd rswk-swf Biopolymere (DE-588)4006893-6 s DE-604 Haag, Rainer 1968- Verfasser (DE-588)1098352432 aut Appelhans, Dietmar Verfasser aut Welzel, Petra B. Verfasser aut Erscheint auch als Online-Ausgabe 978-1-119-18889-6 Digitalisierung UB Bayreuth - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027980220&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Bayreuth - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027980220&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Voit, Brigitte Haag, Rainer 1968- Appelhans, Dietmar Welzel, Petra B. Bio- and multifunctional polymer architectures preparation, analytical methods, and applications Biopolymere (DE-588)4006893-6 gnd |
| subject_GND | (DE-588)4006893-6 |
| title | Bio- and multifunctional polymer architectures preparation, analytical methods, and applications |
| title_auth | Bio- and multifunctional polymer architectures preparation, analytical methods, and applications |
| title_exact_search | Bio- and multifunctional polymer architectures preparation, analytical methods, and applications |
| title_full | Bio- and multifunctional polymer architectures preparation, analytical methods, and applications Brigitte Voit, Rainer Haag, Dietmar Appelhans, Petra B. Welzel |
| title_fullStr | Bio- and multifunctional polymer architectures preparation, analytical methods, and applications Brigitte Voit, Rainer Haag, Dietmar Appelhans, Petra B. Welzel |
| title_full_unstemmed | Bio- and multifunctional polymer architectures preparation, analytical methods, and applications Brigitte Voit, Rainer Haag, Dietmar Appelhans, Petra B. Welzel |
| title_short | Bio- and multifunctional polymer architectures |
| title_sort | bio and multifunctional polymer architectures preparation analytical methods and applications |
| title_sub | preparation, analytical methods, and applications |
| topic | Biopolymere (DE-588)4006893-6 gnd |
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