Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Electronic eBook |
| Language: | English |
| Published: |
Berlin, Heidelberg
Springer
2015
|
| Series: | Springer Theses, Recognizing Outstanding Ph.D. Research
|
| Subjects: | |
| Online Access: | FAW01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Physical Description: | 1 Online-Ressource (XIII, 108 p. 67 illus., 26 illus. in color) |
| ISBN: | 9783662468487 |
| ISSN: | 2190-5053 |
| DOI: | 10.1007/978-3-662-46848-7 |
Staff View
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Record in the Search Index
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| adam_text | SYNTHESIS AND VACCINE EVALUATION OF THE TUMOR ASSOCIATED CARBOHYDRATE
ANTIGEN RM2 FROM PROSTATE CANCER
/ CHUANG, HONG-YANG
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
CHEMICAL SYNTHESIS OF PROPOSED RM2 AND DERIVATIVES
RM2 ANTIGEN: STRUCTURAL CHARACTERIZATION AND DETERMINATION OF KD,SURF
FOR MULTIVALENT CARBOHYDRATE-PROTEIN INTERACTION
RM2 ANTIGEN: SYNTHESIS OF GLYCOCONJUGATES
SYNTHESIS OF THE HEPTASACCHARIDE RM2 PROSTATE TUMOR ANTIGEN: CHEMICAL
SYNTHESIS OF HEPTASACCHARIDE AND TETRASACCHARIDE (INNER CORE OF THE RM2
ANTIGEN)
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
SYNTHESIS AND VACCINE EVALUATION OF THE TUMOR ASSOCIATED CARBOHYDRATE
ANTIGEN RM2 FROM PROSTATE CANCER
/ CHUANG, HONG-YANG
: 2015
ABSTRACT / INHALTSTEXT
THIS THESIS FOCUSES ON THE SYNTHESIS AND VACCINE EVALUATION OF THE
PROSTATE TUMOR- ASSOCIATED CARBOHYDRATE ANTIGEN RM2. THE AUTHOR FIRST
PRESENTS THE USE OF THE [1+2+3] ONE-POT SEQUENTIAL STRATEGY TO
SUCCESSFULLY SYNTHESISE THE RM2 ANTIGEN AND ITS ANALOGUES AS SINGLE
STEREOISOMERS IN EVERY GLYCOSYLATION STEP, PRODUCING GOOD YIELDS AND
STEREOSELECTIVITY. HE THEN INTRODUCES THE CONJUGATION OF THE SYNTHETIC
RM2 ANTIGEN TO THE CARRIER PROTEIN CRM197 IN AN AVERAGE NUMBER OF 1–10
TO CREATE THE PROSTATE CANCER VACCINE CANDIDATE, WHICH IS COMBINED WITH
Α-GALACTOSYLCERAMIDE C1, ITS ANALOGUE C34, OR ALU. THE RESULTS OF THE
VACCINATION STUDIES IN MICE ARE ALSO DESCRIBED AND INDICATE THAT THE
STRONGEST ANTI-RM2 ANTIGEN TITER IS EXHIBITED WHEN ONE MOLECULE OF
DIPHTHERIA TOXIN (DT) IS CONJUGATED WITH AN AVERAGE OF 4.7 MOLECULES OF
RM2 ANTIGEN (DT-RM4.7) AND ADJUVANTED WITH THE GLYCOLIPID C34. MORE
IMPORTANTLY, THE INDUCED MOUSE ANTIBODIES MEDIATE THE EFFECTIVE
COMPLEMENT-DEPENDENT CYTOTOXICITY (CDC) AGAINST THE PROSTATE CANCER CELL
LINE LNCAP. THE STUDY PRESENTED IN THIS THESIS IS THE FIRST EVER TO
SUCCESSFULLY SYNTHESIZE THIS COMPLEX GLYCAN MOLECULE. OWING TO THE
STERIC HINDRANCE OF THE ADJACENT SIALYL MOIETY, THE INTRODUCTION OF TWO
SIALIC ACID UNITS TO THE COMPACT AND RIGID 3,4 DIBRANCHED GALACTOSIDE
UNIT IS VERY CHALLENGING AND THE Β-SELECTIVE AND EFFICIENT
GLYCOSYLATION OF THE GALACTOSAMINE MOIETY AT THE 4-POSITION OF
DIBRANCHED GALACTOSE IS ALSO PROBLEMATIC
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
| any_adam_object | 1 |
| author | Chuang, Hong-Yang |
| author_facet | Chuang, Hong-Yang |
| author_role | aut |
| author_sort | Chuang, Hong-Yang |
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| dewey-sort | 3547.78 |
| dewey-tens | 540 - Chemistry and allied sciences |
| discipline | Chemie / Pharmazie |
| doi_str_mv | 10.1007/978-3-662-46848-7 |
| format | Thesis Electronic eBook |
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| institution | BVB |
| isbn | 9783662468487 |
| issn | 2190-5053 |
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| spelling | Chuang, Hong-Yang Verfasser aut Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer Hong-Yang Chuang Berlin, Heidelberg Springer 2015 1 Online-Ressource (XIII, 108 p. 67 illus., 26 illus. in color) txt rdacontent c rdamedia cr rdacarrier Springer Theses, Recognizing Outstanding Ph.D. Research 2190-5053 Zugl.: Taipei, National Taiwan University, Diss. Chemistry Immunology Vaccines Carbohydrates Biochemistry Carbohydrate Chemistry Vaccine Medicinal Chemistry Chemie (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Druckausgabe 978-3-662-46847-0 https://doi.org/10.1007/978-3-662-46848-7 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027978894&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027978894&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Chuang, Hong-Yang Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer Chemistry Immunology Vaccines Carbohydrates Biochemistry Carbohydrate Chemistry Vaccine Medicinal Chemistry Chemie |
| subject_GND | (DE-588)4113937-9 |
| title | Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer |
| title_auth | Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer |
| title_exact_search | Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer |
| title_full | Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer Hong-Yang Chuang |
| title_fullStr | Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer Hong-Yang Chuang |
| title_full_unstemmed | Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer Hong-Yang Chuang |
| title_short | Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer |
| title_sort | synthesis and vaccine evaluation of the tumor associated carbohydrate antigen rm2 from prostate cancer |
| topic | Chemistry Immunology Vaccines Carbohydrates Biochemistry Carbohydrate Chemistry Vaccine Medicinal Chemistry Chemie |
| topic_facet | Chemistry Immunology Vaccines Carbohydrates Biochemistry Carbohydrate Chemistry Vaccine Medicinal Chemistry Chemie Hochschulschrift |
| url | https://doi.org/10.1007/978-3-662-46848-7 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027978894&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027978894&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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