Biomolecular Interfaces: Interactions, Functions and Drug Design
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cham [u.a.]
Springer International Publishing
2015
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| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource (XIX, 372 p. 145 illus., 86 illus. in color) |
| ISBN: | 9783319168500 |
| DOI: | 10.1007/978-3-319-16850-0 |
Internformat
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| 650 | 4 | |a Life Sciences | |
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Datensatz im Suchindex
| _version_ | 1804153310122344448 |
|---|---|
| adam_text | BIOMOLECULAR INTERFACES
/ FERNANDEZ STIGLIANO, ARIEL
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
THE AQUEOUS INTERFACE OF A SOLUBLE PROTEIN OR THE BIRTH OF EPISTRUCTURAL
BIOLOGY
ELECTROSTATIC EXPLORATION OF BIOMOLECULAR INTERFACES: THE CHEMICAL
FUNCTION OF INTERFACIAL WATER
SEMIEMPIRICAL SOLUTION TO THE PROTEIN FOLDING PROBLEM THROUGH A
COMBINATION OF STRUCTURAL AND EPISTRUCTURAL APPROACHES
PACKING DEFECTS AND PROTEIN HYDRATION: DYNAMICS OF THE AQUEOUS INTERFACE
PROTEINS IN THE ORDER-DISORDER TWILIGHT: UNSTABLE INTERFACES PROMOTE
PROTEIN AGGREGATION
EVOLUTION OF PROTEIN STRUCTURE DEGRADATION AND LESSONS FOR THE DRUG
DESIGNER
CHEMICAL FUNCTIONALITY OF THE AQUEOUS INTERFACE IN SOLUBLE PROTEINS
THE BIOMOLECULAR INTERFACE AS A SELECTIVITY FILTER FOR DRUG-BASED
TARGETED THERAPY
WRAPPING-BASED RE-ENGINEERING OF AN ANTICANCER DRUG TO MAKE IT SAFER
BIOMOLECULAR INTERFACES PROVIDE UNIVERSAL MARKERS FOR DRUG SPECIFICITY
AND PERSONALIZED MEDICINE
CONTROLLING INDUCED FOLDING THROUGH WRAPPING DRUG DESIGN
WRAPPING DRUG COMBINATIONS FOR THERAPEUTIC EDITING OF SIDE EFFECTS:
SYSTEMS BIOLOGY MEETS WRAPPING TECHNOLOGY
MULTI-TARGET CONTROL OF DRUG IMPACT: A THERAPEUTIC IMPERATIVE IN CANCER
SYSTEMS BIOLOGY
ENGINEERING THERAPEUTIC ALIGNMENTS BETWEEN IMMUNE RESPONSE AND
MOLECULARLY TARGETED CANCER TREATMENT
HIGH-LEVEL QUANTUM CHEMISTRY EMPOWERS THE WRAPPING TECHNOLOGY FOR DRUG
DESIGN
EPILOGUE
APPENDIX 1. CODE FOR DEHYDRON IDENTIFICATION
APPENDIX 2. SOLUTIONS OF PROBLEMS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
BIOMOLECULAR INTERFACES
/ FERNANDEZ STIGLIANO, ARIEL
: 2015
ABSTRACT / INHALTSTEXT
THE BOOK FOCUSES ON THE AQUEOUS INTERFACE OF BIOMOLECULES, A VITAL YET
OVERLOOKED AREA OF BIOPHYSICAL RESEARCH. MOST BIOLOGICAL PHENOMENA
CANNOT BE FULLY UNDERSTOOD AT THE MOLECULAR LEVEL WITHOUT CONSIDERING
INTERFACIAL BEHAVIOR. THE AUTHOR PRESENTS CONCEPTUAL ADVANCES IN
MOLECULAR BIOPHYSICS THAT HERALD THE ADVENT OF A NEW DISCIPLINE,
EPISTRUCTURAL BIOLOGY, CENTERED ON THE INTERACTIONS OF WATER AND
BIOMOLECULAR STRUCTURES ACROSS THE INTERFACE. THE AUTHOR INTRODUCES
POWERFUL THEORETICAL AND COMPUTATIONAL RESOURCES IN ORDER TO ADDRESS
FUNDAMENTAL TOPICS SUCH AS PROTEIN FOLDING, THE PHYSICO-CHEMICAL BASIS
OF ENZYME CATALYSIS AND PROTEIN ASSOCIATIONS. ON THE BASIS OF THIS
INFORMATION, A MULTI-DISCIPLINARY APPROACH IS USED TO ENGINEER
THERAPEUTIC DRUGS AND TO ALLOW SUBSTANTIVE ADVANCES IN TARGETED
MOLECULAR MEDICINE. THIS BOOK WILL BE OF INTEREST TO SCIENTISTS,
STUDENTS AND PRACTITIONERS IN THE FIELDS OF CHEMISTRY, BIOPHYSICS AND
BIOMEDICAL ENGINEERING
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| dewey-tens | 570 - Biology |
| discipline | Biologie |
| doi_str_mv | 10.1007/978-3-319-16850-0 |
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| indexdate | 2024-07-10T01:24:34Z |
| institution | BVB |
| isbn | 9783319168500 |
| language | English |
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| spelling | Fernández Stigliano, Ariel Verfasser aut Biomolecular Interfaces Interactions, Functions and Drug Design Ariel Fernández Stigliano Cham [u.a.] Springer International Publishing 2015 1 Online-Ressource (XIX, 372 p. 145 illus., 86 illus. in color) txt rdacontent c rdamedia cr rdacarrier Life sciences Medicine Pharmaceutical technology RNA-ligand interactions Cell membranes Life Sciences Protein-Ligand Interactions Membrane Biology Molecular Medicine Pharmaceutical Sciences/Technology Biophysics and Biological Physics Biowissenschaften Medizin Erscheint auch als Druckausgabe 978-3-319-16849-4 https://doi.org/10.1007/978-3-319-16850-0 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027978520&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027978520&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Fernández Stigliano, Ariel Biomolecular Interfaces Interactions, Functions and Drug Design Life sciences Medicine Pharmaceutical technology RNA-ligand interactions Cell membranes Life Sciences Protein-Ligand Interactions Membrane Biology Molecular Medicine Pharmaceutical Sciences/Technology Biophysics and Biological Physics Biowissenschaften Medizin |
| title | Biomolecular Interfaces Interactions, Functions and Drug Design |
| title_auth | Biomolecular Interfaces Interactions, Functions and Drug Design |
| title_exact_search | Biomolecular Interfaces Interactions, Functions and Drug Design |
| title_full | Biomolecular Interfaces Interactions, Functions and Drug Design Ariel Fernández Stigliano |
| title_fullStr | Biomolecular Interfaces Interactions, Functions and Drug Design Ariel Fernández Stigliano |
| title_full_unstemmed | Biomolecular Interfaces Interactions, Functions and Drug Design Ariel Fernández Stigliano |
| title_short | Biomolecular Interfaces |
| title_sort | biomolecular interfaces interactions functions and drug design |
| title_sub | Interactions, Functions and Drug Design |
| topic | Life sciences Medicine Pharmaceutical technology RNA-ligand interactions Cell membranes Life Sciences Protein-Ligand Interactions Membrane Biology Molecular Medicine Pharmaceutical Sciences/Technology Biophysics and Biological Physics Biowissenschaften Medizin |
| topic_facet | Life sciences Medicine Pharmaceutical technology RNA-ligand interactions Cell membranes Life Sciences Protein-Ligand Interactions Membrane Biology Molecular Medicine Pharmaceutical Sciences/Technology Biophysics and Biological Physics Biowissenschaften Medizin |
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