Nociceptin opiod:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Vitamins and hormones
97 |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 357 Ill., graph. Darst. |
| ISBN: | 9780128024430 |
Internformat
MARC
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| 245 | 1 | 0 | |a Nociceptin opiod |
| 250 | |a 1. ed. | ||
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| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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Datensatz im Suchindex
| _version_ | 1804153242062422016 |
|---|---|
| adam_text | Titel: Nociceptin opiod
Autor:
Jahr: 2015
CONTENTS
Contributors xi
Preface xv
1. Helix-Constrained Nociceptin Peptides Are Potent Agonists
and Antagonists of ORL-1 and Nociception 1
Rink-Jan Lohman, Rosemary S. Harrison, Gloria G. Ruiz-Gomez,
Huy N. Hoang, Nicholas E. Shepherd, Shiao Chow, Timothy A. Hill,
Praveen K. Madala, and David P. Fairlie
1. Nociception in Brief 2
2. Prospecting the Importance of the N-Terminal Tetrapeptide
of Nociceptin(1-17) 11
3. Other Modifications to Nociceptinfl-17) 13
4. The Importance of Structure in Nociceptin Analogues 15
5. Recent Advances in ORL-1 Active Nociceptin Peptides 17
6. The Development of New Helix-Constrained Nociceptin Analogues 18
7. Biological Properties of Helical Nociceptin Mimetics 28
8. Concluding Remarks 46
References 46
2. Bioinformatics and Evolution of Vertebrate Nociceptin
and Opioid Receptors 57
Craig W. Stevens
1. Introduction 58
2. The Vertebrate Opioid Receptor Sequence Database 65
3. The Human Genome and the Evolution of Opioid Receptors 74
4. The Molecular Evolution of Vertebrate Opioid Family Receptors 79
5. Future Directions 81
6. Conclusions 83
Acknowledgments 84
References 84
3. Ancestral Vertebrate Complexity of the Opioid System 95
Dan Larhammar, Christina Bergqvist, and Gorel Sundstrom
1. Introduction 96
2. Opioid Peptide Family 100
vii J
viii
Contents
3. Opioid Receptor Family 105
4. Discussion: Complexity, Coevolution, and Divergence 113
5. Conclusions 118
Acknowledgement 118
References 118
4. Synthesis and Biological Activity of Small Peptides as NOP and
Opioid Receptors Ligands: View on Current Developments 123
Emilia Naydenova, Petar Todorov, and Rositza Zamfirova
1. introduction 124
2. Endogenous Opioid Peptides and Receptors: Nociceptin and
NOP Receptor Ligands 126
3. Hexapeptides with NOP Receptor Affinity 133
4. Solid-Phase Peptide Synthesis 136
5. Conclusions 141
Acknowledgment 141
References 141
5. Pain Regulation by Nocistatin-Targeting Molecules:
G Protein-Coupled-Receptor and Nocistatin-lnteracting Protein 147
Emiko Okuda-Ashitaka and Seiji Ito
1. Introduction 148
2. Biological Activity by NST Through G Protein-Coupled Receptor 152
3. Pain Regulation Through an NST-lnteracting Protein 155
4. Conclusions 160
Acknowledgment 161
References 161
6. Nociceptin and Meiosis during Spermatogenesis in
Postnatal Testes 167
Ko Eto
1. Introduction 168
2. Regulation of Nociceptin Expression by FSH Signaling in Sertoli Cells 170
3. Function of Nociceptin During Meiosis in Spermatocytes 173
4. Nociceptin is a Novel Paracrine Factor that is Induced in Sertoli Cells and
Mediates to Germ Cells the Effect of FSH on Spermatogenesis 178
5. Nociceptin is a Novel Extrinsic Factor Inducing Rec8 Phosphorylation and
Chromosome Dynamics During Meiosis in Spermatocytes 181
6. Conclusions 183
Contents
ix
Acknowledgments 184
References 184
7. Orphanin FQ-ORL-1 Regulation of Reproduction and
Reproductive Behavior in the Female 187
Kevin Sinchak, Lauren Dalhousay, and Nayna Sanathara
1. Introduction 189
2. Ovarian Hormone Regulation of Reproductive Behavior
and Neuroendocrine Feedback Loops 190
3. OFQ/N-ORL-1 Regulation of Sexual Receptivity 197
4. Ovarian Steroid Regulation of OFQ/N and ORL-1 Expression and Signaling 202
5. OFQ/N-ORL-1 Regulation of GnRH and LH Release During Positive
and Negative Feedback 206
6. Conclusions 209
Acknowledgments 209
References 210
8. Effects of Nociceptin and Nocistatin on Uterine Contraction 223
Robert Gaspar, Beata H. Deak, Anna Klukovits, Eszter Ducza,
and Kornelia Tekes
1. Roles of PNOC, N/OFQ, and NST in Different Peripheral Tissues 224
2. Presence of PNOC, N/OFQ, and NST in Uterine Tissue 227
3. The Effects and Mechanisms of Action of N/OFQ and NST on
Uterine Contractility 231
4. Conclusions 235
References 237
9. Nociceptin/Orphanin FQ-NOP Receptor System in
Inflammatory and Immune-Mediated Diseases 241
Elaine C. Gavioli, Iris Ucella de Medeiros, Marta C. Monteiro, Girolamo Calo,
and Pedro R.T. Romao
1. A Brief Overview of the Immune Response 242
2. N/OFQ and Its Receptor 244
3. N/OFQ and NOP Receptor Expression in Leukocytes 245
4. Effects of NOP Receptor Activation on the Immune Response 245
5. NOP Receptor Activation and Inflammatory and Autoimmune Diseases 250
6. Molecular Mechanisms Underlying N/OFQ Actions on Immune Functions 255
7. Relationship Between N/OFQ, Stress, and HPA Axis 256
8. Conclusions 259
X
Contents
Acknowledgments 259
References 259
10. Endogenous Nociceptin System Involvement in
Stress Responses and Anxiety Behavior 267
Allison Jane Fulford
1. Introduction 268
2. The Neuroanatomical Basis of Fear Conditioning 275
3. Evidence for a Role of Nociceptin in Fear Learning and Memory 276
4. Nociceptin and Neurochemical Substrates of Fear Conditioning:
Focus on Biogenic Amines 277
5. Maternal Adaptations of the Nociceptin System 279
6. Conclusions 283
References 283
11. The Neuronal Circuit Between Nociceptin/Orphanin FQ and
Hypocretins/Orexins Coordinately Modulates Stress-Induced
Analgesia and Anxiety-Related Behavior 295
Xinmin (Simon) Xie
1. Introduction 296
2. The N/OFQ System 297
3. The Hypocretins/Orexins System 300
4. Interaction Between the N/OFQ and Hcrt Systems 303
5. Conclusions 313
Acknowledgments 316
References 316
12. Nociceptin/Orphanin-FQ Modulation of Learning and Memory 323
Ouagazzal Abdel-Mouttalib
1. Introduction 323
2. N/OFQ Modulation of Mnemonic Functions 325
3. Mechanisms of N/OFQ-Mediated Modulation of Cognitive Functions 338
4. Conclusion and Remarks 340
Acknowledgments 341
References 341
Index 547
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| id | DE-604.BV042502293 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T01:23:29Z |
| institution | BVB |
| isbn | 9780128024430 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027936994 |
| oclc_num | 944121423 |
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| owner_facet | DE-29 |
| physical | XVI, 357 Ill., graph. Darst. |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
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| series | Vitamins and hormones |
| series2 | Vitamins and hormones |
| spelling | Nociceptin opiod 1. ed. Amsterdam [u.a.] Elsevier XVI, 357 Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Vitamins and hormones 97 Vitamins and hormones 97 (DE-604)BV002530597 97 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027936994&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nociceptin opiod Vitamins and hormones |
| title | Nociceptin opiod |
| title_auth | Nociceptin opiod |
| title_exact_search | Nociceptin opiod |
| title_full | Nociceptin opiod |
| title_fullStr | Nociceptin opiod |
| title_full_unstemmed | Nociceptin opiod |
| title_short | Nociceptin opiod |
| title_sort | nociceptin opiod |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027936994&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002530597 |