Protein Kinase CK2 Cellular Function in Normal and Disease States:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cham [u.a.]
Springer
2015
|
| Schriftenreihe: | Advances in Biochemistry in Health and Disease
12 |
| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource (XXIII, 378 p. 91 illus., 60 illus. in color) |
| ISBN: | 9783319145440 |
| DOI: | 10.1007/978-3-319-14544-0 |
Internformat
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| 245 | 1 | 0 | |a Protein Kinase CK2 Cellular Function in Normal and Disease States |c Khalil Ahmed, Olaf-Georg Issinger, Ryszard Szyszka, ed. |
| 264 | 1 | |a Cham [u.a.] |b Springer |c 2015 | |
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| 490 | 1 | |a Advances in Biochemistry in Health and Disease |v 12 | |
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| 650 | 4 | |a Oncology | |
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| 650 | 4 | |a Cytology | |
| 650 | 4 | |a Biomedicine | |
| 650 | 4 | |a Cancer Research | |
| 650 | 4 | |a Protein Science | |
| 650 | 4 | |a Apoptosis | |
| 650 | 4 | |a Medizin | |
| 700 | 1 | |a Ahmed, Khalil |e Sonstige |4 oth | |
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Datensatz im Suchindex
| _version_ | 1804153211371651072 |
|---|---|
| adam_text | PROTEIN KINASE CK2 CELLULAR FUNCTION IN NORMAL AND DISEASE STATES
/ AHMED, KHALIL
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
1. CK2 SUPPRESSION OF APOPTOSIS
2. STRUCTURAL DETERMINANTS OF CK2 REGULATION
3. TARGETING PROTEIN KINASE: CK2 SUPPRESSES PRO-SURVIVAL SIGNALING
PATHWAYS AND GROWTH OF GLIOBASTOMA
4. THE ROLES OF CK2 IN DROSOPHILA NEUROGENESIS
5. TARGETING THE CK2 SUBUNIT INTERFACE: CHALLENGE AND USEFULNESS
6. CK2 IN WNT/Β-CATENIN SIGNALING AND EMBRYO DEVELOPMENT
7. DEFECTIVE EXPRESSION OF CK2Β PROMOTES EMT AND STEMNESS PROPERTIES
BOTH REQUIRED FOR BREAST CANCER PROGRESSION
8. CHEMICAL BIOLOGY APPROACHES TO IDENTIFY CK2 SUBSTRATES AND PERFORM
UNBIASED EVALUATION OF CK2 INHIBITORS
9. DEVELOPMENT OF SCREENING SYSTEMS AND IDENTIFICATION OF NOVEL POTENT
INHIBITORS OF HUMAN PROTEIN KINASE CK2
10. PROTEIN KINASE CK2: AT THE CROSSROAD OF REGULATORY CELLULAR PATHWAYS
11. FUNCTIONAL REGULATION OF DYRK FAMILY PROTEIN KINASES BY CELLULAR
BINDING PARTNERS
12. REGULATION OF CK2 IN PANCREATIC Β CELLS
13. RECENT IMPRESSIONS FROM THE CONFIGURATIONAL AND CONFORMATIONAL SPACE
CAPTURED BY PROTEIN KINASE CK2
14. ROLE OF CK2 IN PLANT RESPONSES TO ABIOTIC STRESS
15. “GENUINE” CASEIN KINASE: THE FALSE SISTER OF CK2:
PHOSPHORYLATES-SECRETED PROTEINS
16. CK2: – A NOVEL PLAYER IN L-DOPA INDUCED DYSKINESIA IN A MOUSE
MODEL OF PARKINSON’S DISEASE
17. CK2 FUNCTION IN THE REGULATION OF AKT PATHWAY: NEW FINDINGS AND
PERSPECTIVES
18. CK2 STRUCTURE FROM YEAST TO HUMAN
19. CELLULAR ZINC SIGNALING IS TRIGGERED BY CK2
20. A NANOMEDICINE APPROACH TO TARGETING CK2 FOR CANCER THERAPY
21. BISUBSTRATE APPROACH FOR CONSTRUCTION OF HIGH-AFFINITY INHIBITORS
AND OPTICAL PROBES FOR PROTEIN KINASE CK2
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
PROTEIN KINASE CK2 CELLULAR FUNCTION IN NORMAL AND DISEASE STATES
/ AHMED, KHALIL
: 2015
ABSTRACT / INHALTSTEXT
THE FIELD OF PROTEIN KINASES HAS GREATLY IMPACTED OUR UNDERSTANDING OF
THE BASIC MECHANISMS IN CELL FUNCTION. THE FIELD HAS ALSO BEEN A MAJOR
FOCUS OF DRUG DEVELOPMENT THAT CONSIDERS THE BROAD REACH OF THE PROTEIN
KINASE FUNCTION UNDER DIVERSE CONDITIONS. ONE MEMBER OF THE KINOME,
PROTEIN KINASE CK2, CONTINUES TO EMERGE AS A MAJOR SIGNALING MOLECULE
INVOLVED IN DIVERSE FUNCTIONS IN HEALTH AND DISEASE. THIS KINASE HAS
UNIQUE FEATURES, MOST NOTABLY ITS UBIQUITOUS AND HIGHLY CONSERVED
NATURE. ITS VAST NUMBER OF POTENTIAL SUBSTRATES EXEMPLIFIES ITS
INVOLVEMENT IN VARIOUS FUNCTIONS IN CELLS UNDER BOTH THE NORMAL AND
DISEASED STATES. OF PARTICULAR NOTE IS THE OBSERVATION THAT DUE TO ITS
UBIQUITOUS NATURE, CK2 HAS BEEN FOUND TO BE DYSREGULATED IN ALL CANCERS
THAT HAVE BEEN EXAMINED. AS SUCH, IT IS NOW BEING CONSIDERED A
POTENTIALLY IMPORTANT TARGET FOR CANCER THERAPY. PROTEIN KINASE CK2
PLAYS EQUALLY IMPORTANT FUNCTIONS IN DEVELOPMENT AND INTRACELLULAR
ACTIVITIES, AND HAS A GLOBAL IMPACT ON CELL GROWTH AND PROLIFERATION. AN
ADDITIONAL KEY FUNCTION OF CK2 IS THE IMPACT OF ITS ACTIVITY ON CELL
DEATH PROCESSES. GIVEN THE VAST NATURE OF ITS FUNCTIONS, CK2 HAS BEEN
PROPOSED TO SERVE AS A “MASTER REGULATOR” OF CELL FUNCTION.
THECHAPTERS INCLUDED IN THIS WORKCOVER A WIDE RANGE OF TOPICS
DEALING WITH SOME OF THE FUNCTIONS MENTIONED ABOVE, PROVIDINGAN
IMPORTANT STARTING POINT FOR RESEARCH INVESTIGATORS AND GRADUATE
STUDENTS INTERESTED IN THIS FIELD
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
| any_adam_object | 1 |
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| dewey-full | 614.5999 |
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| dewey-ones | 614 - Forensic medicine; incidence of disease |
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| discipline | Biologie Medizin |
| doi_str_mv | 10.1007/978-3-319-14544-0 |
| format | Electronic eBook |
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| id | DE-604.BV042481791 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T01:23:00Z |
| institution | BVB |
| isbn | 9783319145440 |
| language | English |
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| physical | 1 Online-Ressource (XXIII, 378 p. 91 illus., 60 illus. in color) |
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| series | Advances in Biochemistry in Health and Disease |
| series2 | Advances in Biochemistry in Health and Disease |
| spelling | Protein Kinase CK2 Cellular Function in Normal and Disease States Khalil Ahmed, Olaf-Georg Issinger, Ryszard Szyszka, ed. Cham [u.a.] Springer 2015 1 Online-Ressource (XXIII, 378 p. 91 illus., 60 illus. in color) txt rdacontent c rdamedia cr rdacarrier Advances in Biochemistry in Health and Disease 12 Medicine Oncology Biochemistry Cytology Biomedicine Cancer Research Protein Science Apoptosis Medizin Ahmed, Khalil Sonstige oth Issinger, Olaf-Georg Sonstige oth Szyszka, Ryszard Sonstige oth Erscheint auch als Druckausgabe 978-3-319-14543-3 Advances in Biochemistry in Health and Disease 12 (DE-604)BV022371875 12 https://doi.org/10.1007/978-3-319-14544-0 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027916750&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027916750&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Protein Kinase CK2 Cellular Function in Normal and Disease States Advances in Biochemistry in Health and Disease Medicine Oncology Biochemistry Cytology Biomedicine Cancer Research Protein Science Apoptosis Medizin |
| title | Protein Kinase CK2 Cellular Function in Normal and Disease States |
| title_auth | Protein Kinase CK2 Cellular Function in Normal and Disease States |
| title_exact_search | Protein Kinase CK2 Cellular Function in Normal and Disease States |
| title_full | Protein Kinase CK2 Cellular Function in Normal and Disease States Khalil Ahmed, Olaf-Georg Issinger, Ryszard Szyszka, ed. |
| title_fullStr | Protein Kinase CK2 Cellular Function in Normal and Disease States Khalil Ahmed, Olaf-Georg Issinger, Ryszard Szyszka, ed. |
| title_full_unstemmed | Protein Kinase CK2 Cellular Function in Normal and Disease States Khalil Ahmed, Olaf-Georg Issinger, Ryszard Szyszka, ed. |
| title_short | Protein Kinase CK2 Cellular Function in Normal and Disease States |
| title_sort | protein kinase ck2 cellular function in normal and disease states |
| topic | Medicine Oncology Biochemistry Cytology Biomedicine Cancer Research Protein Science Apoptosis Medizin |
| topic_facet | Medicine Oncology Biochemistry Cytology Biomedicine Cancer Research Protein Science Apoptosis Medizin |
| url | https://doi.org/10.1007/978-3-319-14544-0 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027916750&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027916750&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV022371875 |
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