Mass Spectrometry in the Biological Sciences: A Tutorial:
Saved in:
| Main Author: | |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Dordrecht
Springer Netherlands
1992
|
| Series: | NATO ASI Series, Series C: Mathematical and Physical Sciences
353 |
| Subjects: | |
| Online Access: | Volltext |
| Item Description: | The developments in mass spectrometry over the past fifteen years have been impressive in their implications in bioanalytical chemistry. The achievements begin with the inventions of Cf-252 Plasma Desorption Mass Spectrometry by Macfarlane and Fourier Transform Mass Spectrometry by Comisarow and Marshall in the mid 1970s. The former showed the feasibility of producing large gas-phase ions from large biomolecules whereas the latter enhanced the capabilities for ion trapping especially in analytical mass spectrometry. A major achievement was the development by Barber of Fast Atom Bombardment (FAB) mass spectrometry, an advance that heralded a new era in biological mass spectrometry. Contemporary and routine instruments such as magnetic sectors and quadrupoles were rapidly adapted to F AB, and nearly the entire universe of small molecules became amenable to study by mass spectrometry. The introduction of FAB also paved the way for improvement of instrument capability. For example, the upper mass limit of magnet sector mass spectrometers was increased by nearly an order of magnitude by the instrument manufacturers. Furthermore, the technique of tandem mass spectrometry (MS/MS) was given new meaning because important structural information for biomolecules could now be produced for ions introduced by FAB into the tandem instrument. The evolution of MS/MS continues today with the development of ion traps, time-of-flight, and sector instruments equipped with array detection |
| Physical Description: | 1 Online-Ressource (XXI, 461 p) |
| ISBN: | 9789401126182 9789401051576 |
| ISSN: | 1389-2185 |
| DOI: | 10.1007/978-94-011-2618-2 |
Staff View
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| spelling | Gross, Michael L. Verfasser aut Mass Spectrometry in the Biological Sciences: A Tutorial edited by Michael L. Gross Proceedings of the NATO Advanced Study Institute on Mass Spectrometry in the Molecular Sciences, Cetraro, Italy, June 17-29, 1990 Dordrecht Springer Netherlands 1992 1 Online-Ressource (XXI, 461 p) txt rdacontent c rdamedia cr rdacarrier NATO ASI Series, Series C: Mathematical and Physical Sciences 353 1389-2185 The developments in mass spectrometry over the past fifteen years have been impressive in their implications in bioanalytical chemistry. The achievements begin with the inventions of Cf-252 Plasma Desorption Mass Spectrometry by Macfarlane and Fourier Transform Mass Spectrometry by Comisarow and Marshall in the mid 1970s. The former showed the feasibility of producing large gas-phase ions from large biomolecules whereas the latter enhanced the capabilities for ion trapping especially in analytical mass spectrometry. A major achievement was the development by Barber of Fast Atom Bombardment (FAB) mass spectrometry, an advance that heralded a new era in biological mass spectrometry. Contemporary and routine instruments such as magnetic sectors and quadrupoles were rapidly adapted to F AB, and nearly the entire universe of small molecules became amenable to study by mass spectrometry. The introduction of FAB also paved the way for improvement of instrument capability. For example, the upper mass limit of magnet sector mass spectrometers was increased by nearly an order of magnitude by the instrument manufacturers. Furthermore, the technique of tandem mass spectrometry (MS/MS) was given new meaning because important structural information for biomolecules could now be produced for ions introduced by FAB into the tandem instrument. The evolution of MS/MS continues today with the development of ion traps, time-of-flight, and sector instruments equipped with array detection Chemistry Chemistry, Physical organic Physical Chemistry Chemie Biomolekül (DE-588)4135124-1 gnd rswk-swf Massenspektrometrie (DE-588)4037882-2 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf 1\p (DE-588)1071861417 Konferenzschrift 1990 Cetraro gnd-content Biochemie (DE-588)4006777-4 s Massenspektrometrie (DE-588)4037882-2 s 2\p DE-604 Biomolekül (DE-588)4135124-1 s 3\p DE-604 https://doi.org/10.1007/978-94-011-2618-2 Verlag Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Gross, Michael L. Mass Spectrometry in the Biological Sciences: A Tutorial Chemistry Chemistry, Physical organic Physical Chemistry Chemie Biomolekül (DE-588)4135124-1 gnd Massenspektrometrie (DE-588)4037882-2 gnd Biochemie (DE-588)4006777-4 gnd |
| subject_GND | (DE-588)4135124-1 (DE-588)4037882-2 (DE-588)4006777-4 (DE-588)1071861417 |
| title | Mass Spectrometry in the Biological Sciences: A Tutorial |
| title_alt | Proceedings of the NATO Advanced Study Institute on Mass Spectrometry in the Molecular Sciences, Cetraro, Italy, June 17-29, 1990 |
| title_auth | Mass Spectrometry in the Biological Sciences: A Tutorial |
| title_exact_search | Mass Spectrometry in the Biological Sciences: A Tutorial |
| title_full | Mass Spectrometry in the Biological Sciences: A Tutorial edited by Michael L. Gross |
| title_fullStr | Mass Spectrometry in the Biological Sciences: A Tutorial edited by Michael L. Gross |
| title_full_unstemmed | Mass Spectrometry in the Biological Sciences: A Tutorial edited by Michael L. Gross |
| title_short | Mass Spectrometry in the Biological Sciences: A Tutorial |
| title_sort | mass spectrometry in the biological sciences a tutorial |
| topic | Chemistry Chemistry, Physical organic Physical Chemistry Chemie Biomolekül (DE-588)4135124-1 gnd Massenspektrometrie (DE-588)4037882-2 gnd Biochemie (DE-588)4006777-4 gnd |
| topic_facet | Chemistry Chemistry, Physical organic Physical Chemistry Chemie Biomolekül Massenspektrometrie Biochemie Konferenzschrift 1990 Cetraro |
| url | https://doi.org/10.1007/978-94-011-2618-2 |
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