Biomolecular feedback systems:
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Princeton [u.a.]
Princeton Univ. Press
2015
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturverz. S. 259 - 265 |
| Physical Description: | VI, 275 S. Ill., graph. Darst. |
| ISBN: | 9780691161532 |
Staff View
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Record in the Search Index
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|---|---|
| adam_text | Biomolecular Feedback Systems
Domitilla Del Vecchio
Richard M Murray
Princeton University Press
Princeton and Oxford
Contents
Preface vii
1 Introductory Concepts 1
1 1 Systems biology: Modeling, analysis and role of feedback 1
1 2 The cell as a system 8
1 3 Control and dynamical systems tools 11
1 4 Input/output modeling 18
1 5 From systems to synthetic biology 22
1 6 Further reading 28
2 Dynamic Modeling of Core Processes 29
2 1 Modeling chemical reactions 29
2 2 Transcription and translation 44
2 3 Transcriptional regulation 55
2 4 Post-transcriptional regulation 70
2 5 Cellular subsystems 81
Exercises 86
3 Analysis of Dynamic Behavior 89
3 1 Analysis near equilibria 89
3 2 Robustness 103
3 3 Oscillatory behavior 113
3 4 Bifurcations 124
3 5 Model reduction techniques 127
Exercises 133
4 Stochastic Modeling and Analysis 139
4 1 Stochastic modeling of biochemical systems 139
4 2 Simulation of stochastic systems 154
4 3 Input/output linear stochastic systems 157
Exercises 164
vi CONTENTS
5 Biological Circuit Components 169
5 1 Introduction to biological circuit design 169
5 2 Negative autoregulation 171
5 3 The toggle switch 177
5 4 The repressilator 180
5 5 Activator-repressor clock 184
5 6 An incoherent feedforward loop (IFFL) 189
5 7 Bacterial chemotaxis 191
Exercises 203
6 Interconnecting Components 205
6 1 Input/output modeling and the modularity assumption 205
6 2 Introduction to retroactivity 206
6 3 Retroactivity in gene circuits 209
6 4 Retroactivity in signaling systems 214
6 5 Insulation devices: Retroactivity attenuation 219
66A case study on the use of insulation devices 236
Exercises 239
7 Design Tradeoffs 243
7 1 Competition for shared cellular resources 243
7 2 Stochastic effects: Design tradeoffs in systems with large gains 253
Exercises 257
Bibliography 259
Index 267
c
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| any_adam_object | 1 |
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| author_role | aut aut |
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| bvnumber | BV042396073 |
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| dewey-ones | 612 - Human physiology |
| dewey-raw | 612.8233 |
| dewey-search | 612.8233 |
| dewey-sort | 3612.8233 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| format | Book |
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| isbn | 9780691161532 |
| language | English |
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| spelling | Del Vecchio, Domitilla 1975- Verfasser (DE-588)1061013227 aut Biomolecular feedback systems Domitilla Del Vecchio ; Richard M. Murray Princeton [u.a.] Princeton Univ. Press 2015 VI, 275 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturverz. S. 259 - 265 Reaktionssystem (DE-588)4177124-2 gnd rswk-swf Stochastisches Modell (DE-588)4057633-4 gnd rswk-swf Modell (DE-588)4039798-1 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf Regulation (DE-588)4049075-0 gnd rswk-swf Systembiologie (DE-588)4809615-5 gnd rswk-swf Biomolekül (DE-588)4135124-1 gnd rswk-swf Biomolekül (DE-588)4135124-1 s Systembiologie (DE-588)4809615-5 s Regulation (DE-588)4049075-0 s Modell (DE-588)4039798-1 s DE-604 Biochemie (DE-588)4006777-4 s Reaktionssystem (DE-588)4177124-2 s Stochastisches Modell (DE-588)4057633-4 s Murray, Richard M. 1963- Verfasser (DE-588)1145971725 aut HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027831853&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Del Vecchio, Domitilla 1975- Murray, Richard M. 1963- Biomolecular feedback systems Reaktionssystem (DE-588)4177124-2 gnd Stochastisches Modell (DE-588)4057633-4 gnd Modell (DE-588)4039798-1 gnd Biochemie (DE-588)4006777-4 gnd Regulation (DE-588)4049075-0 gnd Systembiologie (DE-588)4809615-5 gnd Biomolekül (DE-588)4135124-1 gnd |
| subject_GND | (DE-588)4177124-2 (DE-588)4057633-4 (DE-588)4039798-1 (DE-588)4006777-4 (DE-588)4049075-0 (DE-588)4809615-5 (DE-588)4135124-1 |
| title | Biomolecular feedback systems |
| title_auth | Biomolecular feedback systems |
| title_exact_search | Biomolecular feedback systems |
| title_full | Biomolecular feedback systems Domitilla Del Vecchio ; Richard M. Murray |
| title_fullStr | Biomolecular feedback systems Domitilla Del Vecchio ; Richard M. Murray |
| title_full_unstemmed | Biomolecular feedback systems Domitilla Del Vecchio ; Richard M. Murray |
| title_short | Biomolecular feedback systems |
| title_sort | biomolecular feedback systems |
| topic | Reaktionssystem (DE-588)4177124-2 gnd Stochastisches Modell (DE-588)4057633-4 gnd Modell (DE-588)4039798-1 gnd Biochemie (DE-588)4006777-4 gnd Regulation (DE-588)4049075-0 gnd Systembiologie (DE-588)4809615-5 gnd Biomolekül (DE-588)4135124-1 gnd |
| topic_facet | Reaktionssystem Stochastisches Modell Modell Biochemie Regulation Systembiologie Biomolekül |
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