Multifaceted Roles of Crystallography in Modern Drug Discovery:
Saved in:
| Format: | Electronic eBook |
|---|---|
| Language: | English |
| Published: |
Dordrecht [u.a.]
Springer
2015
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| Series: | NATO Science for Peace and Security Series A: Chemistry and Biology
|
| Subjects: | |
| Online Access: | TUM01 UBT01 Volltext Abstract Inhaltsverzeichnis |
| Physical Description: | 1 Online-Ressource (XI, 240 p. 107 illus., 89 illus. in color) |
| ISBN: | 9789401797191 |
| ISSN: | 1874-6489 |
| DOI: | 10.1007/978-94-017-9719-1 |
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Record in the Search Index
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| adam_text | MULTIFACETED ROLES OF CRYSTALLOGRAPHY IN MODERN DRUG DISCOVERY
/ SCAPIN, GIOVANNA
: 2015
ABSTRACT / INHALTSTEXT
THE PRESENT WORK OFFERS A SNAPSHOT OF THE STATE-OF-THE-ART OF
CRYSTALLOGRAPHIC, ANALYTICAL, AND COMPUTATIONAL METHODS USED IN MODERN
DRUG DESIGN AND DEVELOPMENT. TOPICS DISCUSSED INCLUDE: DRUG DESIGN
AGAINST COMPLEX SYSTEMS (MEMBRANE PROTEINS, CELL SURFACE RECEPTORS,
EPIGENETIC TARGETS, AND RIBOSOMES); MODULATION OF PROTEIN-PROTEIN
INTERACTIONS; THE IMPACT OF SMALL MOLECULE STRUCTURES IN DRUG DISCOVERY
AND THE APPLICATION OF CONCEPTS SUCH AS MOLECULAR GEOMETRY,
CONFORMATION, AND FLEXIBILITY TO DRUG DESIGN; METHODOLOGIES FOR
UNDERSTANDING AND CHARACTERIZING PROTEIN STATES AND PROTEIN-LIGAND
INTERACTIONS DURING THE DRUG DESIGN PROCESS; AND MONOCLONAL ANTIBODY
THERAPIES. THESE METHODS ARE ILLUSTRATED THROUGH THEIR APPLICATION TO
PROBLEMS OF MEDICAL AND BIOLOGICAL SIGNIFICANCE, SUCH AS VIRAL AND
BACTERIAL INFECTIONS, DIABETES, AUTOIMMUNE DISEASE, AND CNS DISEASES. AS
APPROACHES TO DRUG DISCOVERY HAVE CHANGED OVER TIME, SO HAVE THE
METHODOLOGIES USED TO SOLVE THE VARIED, NEW, AND DIFFICULT PROBLEMS
ENCOUNTERED IN DRUG DISCOVERY. IN RECENT YEARS WE HAVE SEEN GREAT
PROGRESS IN THE FIELDS OF GENETICS, BIOLOGY, CHEMISTRY, AND MEDICINE,
BUT THERE ARE STILL MANY UNMET MEDICAL NEEDS, FROM BACTERIAL INFECTIONS
TO CANCER TO CHRONIC MALADIES, THAT REQUIRE NOVEL, DIFFERENT, OR BETTER
THERAPIES. THIS WORK WILL BE OF INTEREST TO RESEARCHERS AND POLICY
MAKERS INTERESTED IN THE LATEST DEVELOPMENTS IN DRUG DESIGN
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
MULTIFACETED ROLES OF CRYSTALLOGRAPHY IN MODERN DRUG DISCOVERY
/ SCAPIN, GIOVANNA
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
PREFACE
LIST OF CONTRIBUTORS
ENGINEERING G PROTEIN-COUPLED RECEPTORS FOR DRUG DESIGN
STRUCTURAL INSIGHTS INTO ACTIVATION AND ALLOSTERIC MODULATION OF G
PROTEIN-COUPLED RECEPTORS
EPIGENETIC DRUG DISCOVERY
CRYSTALLOGRAPHY AND BIOPHARMACEUTICALS
STRUCTURAL CHEMISTRY AND MOLECULAR MODELING IN THE DESIGN OF DPP4
INHIBITORS
CONSIDERATIONS FOR STRUCTURE-BASED DRUG DESIGN TARGETING HIV-1 REVERSE
TRANSCRIPTASE.-PROTEIN-LIGAND INTERACTIONS AS THE BASIS FOR DRUG ACTION
THE PROTEIN DATA BANK: OVERVIEW AND TOOLS FOR DRUG DISCOVERY
SMALL MOLECULE CRYSTAL STRUCTURES IN DRUG DISCOVERY
PROTEIN AGGREGATION AND ITS PREDICTION
IMPORTANCE OF PROTONATION STATES FOR THE BINDING OF LIGANDS TO
PHARMACEUTICAL TARGETS
PROTEIN-PROTEIN INTERACTIONS: STRUCTURES AND DRUGGABILITY
ACHIEVING HIGH QUALITY LIGAND CHEMISTRY IN PROTEIN-LIGAND CRYSTAL
STRUCTURES FOR DRUG DESIGN
MOLECULAR OBESITY, POTENCY AND OTHER ADDICTIONS IN DRUG DISCOVERY
ADVENTURES IN SMALL MOLECULE FRAGMENT SCREENING BY X-RAY CRYSTALLOGRAPHY
FOR DRUG DISCOVERY
STRUCTURE-BASED DRUG DESIGN TO PERTURB FUNCTION OF A TRNA-MODIFYING
ENZYME BY ACTIVE SITE AND PROTEIN-PROTEIN INTERFACE INHIBITION
MOLECULAR INTERACTION ANALYSIS FOR DISCOVERY OF DRUGS TARGETING ENZYMES
AND FOR RESOLVING BIOLOGICAL FUNCTION
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| dewey-full | 572.6 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
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| discipline | Biologie |
| doi_str_mv | 10.1007/978-94-017-9719-1 |
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| isbn | 9789401797191 |
| issn | 1874-6489 |
| language | English |
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| series2 | NATO Science for Peace and Security Series A: Chemistry and Biology |
| spelling | Multifaceted Roles of Crystallography in Modern Drug Discovery Giovanna Scapin, Disha Patel, Eddy Arnold, ed. Dordrecht [u.a.] Springer 2015 1 Online-Ressource (XI, 240 p. 107 illus., 89 illus. in color) txt rdacontent c rdamedia cr rdacarrier NATO Science for Peace and Security Series A: Chemistry and Biology 1874-6489 Life sciences Medicine Chemistry Biochemistry RNA-ligand interactions Crystallography Life Sciences Protein-Ligand Interactions Medicinal Chemistry Molecular Medicine Theoretical and Computational Chemistry Biowissenschaften Chemie Medizin Scapin, Giovanna Sonstige oth Patel, Disha Sonstige oth Arnold, Eddy Sonstige (DE-588)1019609664 oth Erscheint auch als Druckausgabe 978-94-017-9718-4 https://doi.org/10.1007/978-94-017-9719-1 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027823452&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Abstract Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027823452&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Multifaceted Roles of Crystallography in Modern Drug Discovery Life sciences Medicine Chemistry Biochemistry RNA-ligand interactions Crystallography Life Sciences Protein-Ligand Interactions Medicinal Chemistry Molecular Medicine Theoretical and Computational Chemistry Biowissenschaften Chemie Medizin |
| title | Multifaceted Roles of Crystallography in Modern Drug Discovery |
| title_auth | Multifaceted Roles of Crystallography in Modern Drug Discovery |
| title_exact_search | Multifaceted Roles of Crystallography in Modern Drug Discovery |
| title_full | Multifaceted Roles of Crystallography in Modern Drug Discovery Giovanna Scapin, Disha Patel, Eddy Arnold, ed. |
| title_fullStr | Multifaceted Roles of Crystallography in Modern Drug Discovery Giovanna Scapin, Disha Patel, Eddy Arnold, ed. |
| title_full_unstemmed | Multifaceted Roles of Crystallography in Modern Drug Discovery Giovanna Scapin, Disha Patel, Eddy Arnold, ed. |
| title_short | Multifaceted Roles of Crystallography in Modern Drug Discovery |
| title_sort | multifaceted roles of crystallography in modern drug discovery |
| topic | Life sciences Medicine Chemistry Biochemistry RNA-ligand interactions Crystallography Life Sciences Protein-Ligand Interactions Medicinal Chemistry Molecular Medicine Theoretical and Computational Chemistry Biowissenschaften Chemie Medizin |
| topic_facet | Life sciences Medicine Chemistry Biochemistry RNA-ligand interactions Crystallography Life Sciences Protein-Ligand Interactions Medicinal Chemistry Molecular Medicine Theoretical and Computational Chemistry Biowissenschaften Chemie Medizin |
| url | https://doi.org/10.1007/978-94-017-9719-1 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027823452&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027823452&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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