Models of life: dynamics and regulation in biological systems
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Cambridge
Cambridge Univ. Press
2014
|
| Edition: | 1. publ. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | X, 342 S. Ill., graph. Darst. |
| ISBN: | 9781107061903 1107061903 |
Staff View
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV042382048 | ||
| 003 | DE-604 | ||
| 005 | 20150316 | ||
| 007 | t | ||
| 008 | 150226s2014 ad|| |||| 00||| eng d | ||
| 020 | |a 9781107061903 |c hbk. |9 978-1-107-06190-3 | ||
| 020 | |a 1107061903 |c hbk. |9 1-107-06190-3 | ||
| 024 | 3 | |a 9781107061903 | |
| 035 | |a (OCoLC)935404817 | ||
| 035 | |a (DE-599)BSZ414029135 | ||
| 040 | |a DE-604 |b ger | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-11 |a DE-703 |a DE-29T |a DE-1028 |a DE-20 | ||
| 082 | 0 | |a 570.151 | |
| 084 | |a WD 9200 |0 (DE-625)148253: |2 rvk | ||
| 100 | 1 | |a Sneppen, Kim |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Models of life |b dynamics and regulation in biological systems |c Kim Sneppen |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Cambridge |b Cambridge Univ. Press |c 2014 | |
| 300 | |a X, 342 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Biowissenschaften | |
| 650 | 4 | |a Mathematisches Modell | |
| 650 | 4 | |a Life sciences / Mathematical models | |
| 650 | 4 | |a Biology / Mathematical models | |
| 650 | 0 | 7 | |a Mathematisches Modell |0 (DE-588)4114528-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Biologisches System |0 (DE-588)4122930-7 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Biologisches System |0 (DE-588)4122930-7 |D s |
| 689 | 0 | 1 | |a Mathematisches Modell |0 (DE-588)4114528-8 |D s |
| 689 | 0 | |5 DE-604 | |
| 856 | 4 | 2 | |m HEBIS Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027818108&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-027818108 | ||
Record in the Search Index
| _version_ | 1804153025492680704 |
|---|---|
| adam_text | Models of Life
Dynamics and Regulation
in Biological Systems
KIM SNEPPEN
Niels Bohr Institute and Center for Models of Life,
Copenhagen University, Denmark
CAMBRIDGE
UNIVERSITY PRESS
Contents
Preface Page ix
1 Life from a physics perspective 1
1 1 Life copies from itself and from other life 1
1 2 Biology is the result of a very long historical process 2
1 3 Self-assembly and the genetic code 3
1 4 Biological molecules have long backbones 6
1 5 Computation 6
1 6 Information gathering and communication 7
1 7 Feedback 7
1 8 Push-pull 8
1 9a Life is modular 9
1 9b Life is not modular 9
1 10 Stochastic processes play an important role in life 9
1 11 Life harvests energy and converts it to cyclic motion 10
1 12 Biological physics is keT physics 13
2 E coli as a model system 17
2 1 DNA, RNA and proteins 17
2 2 The E coli cell 22
2 3 Transcription and translation numbers 24
24E coli content varies with its growth rate 32
2 5 Summary 35
3 Dynamics of regulatory links 36
3 1 Regulating a piece of DNA 36
3 2 Transcription regulation 41
3 3 Post-transcriptional regulation 44
3 4 Summary 48
4 Statistical mechanics of phage A 49
4 1 Lifecycle of A phage 49
4 2 Bacterial growth and counting 56
v
vi Contents
4 3 Chemical binding and counting 59 ]
4 4 Chemistry and co-operativity as statistical mechanics 62 I
4 5 Distant DNA in gene regulation 68 j
4 6 Summary 78 j
5 Diffusion and randomness in transcription 79
5 1 Random walks and diffusion 79 j
5 2 Timescales for target location in a cell 83
5 3 Traffic on DNA 89
5 4 Bursty transcription initiation 94 !
5 5 Economy of operons: noise minimization 100 j
5 6 Summary 102
i
6 Stochastic genes and persistent decisions 104 j
j
6 1 Stochastic simulations 104 j
6 2 Maintenance of lysogeny in the X system 109 j
6 3 The phage X circuit beyond CI and Cro 117 J
6 4 Summary 122
7 c/s-Acting gene regulation and epigenetics 123
7 1 Nucleosomes and their enzymes 123
7 2 Nucleosome-mediated epigenetics 127
73A regulated two-state model 135
7 4 Coupled epigenetics in olfactoric differentiation 142 :
7 5 Other models for cis-mediated gene regulation 146 ;
7 6 Summary 149
8 Feedback circuits 150
8 1 Small regulatory subnetworks 150
8 2 Negative feedback 151
8 3 Positive feedback 159
8 4 Combining feedback in small-molecule regulation 161
8 5 Combined feedback loops and spatial organization 167
8 6 Summary 176 ;
9 Networks 177
9 1 Convergent computation 177
9 2 Connectedness 178
|93 Large-scale molecular networks 190
P ,9 4 Analysis of network topologies 193
/95 Models for scale-free molecular networks 198
*96 Summary 204
Contents vii
10 Signaling and metabolic networks 205
10 1 Signaling across networks 205
10 2 Enzyme kinetics and phosphorylation 212
10 3 Adaptation 216
10 4 Metabolic fluxes 219
10 5 Summary 225
11 Agent-based models of signaling and selection 226
11 1 Excitable agents as cells in a tissue 226
11 2 Information spreading on social scales 227
11 3 Tragedy of the commons 235
11 4 Summary 241
12 Competition and diversity 242
12 1 Phage worlds 242
12 2 Phage-bacteria ecology 252
12 3 Phage games: lysogeny or lysis 265
12 4 Speciation and biodiversity of sessile species 272
12 5 Summary 277
13 Evolution and extinction 279
13 1 History 279
13 2 Fitness landscapes 282
13 3 Punctuated equilibrium and co-evolution 286
13 4 Summary 295
Appendix 296
Langevin versus Fokker-Planck equation 296
Kramers equation 297
First passage for random walks 299
References
Index
|
| any_adam_object | 1 |
| author | Sneppen, Kim |
| author_facet | Sneppen, Kim |
| author_role | aut |
| author_sort | Sneppen, Kim |
| author_variant | k s ks |
| building | Verbundindex |
| bvnumber | BV042382048 |
| classification_rvk | WD 9200 |
| ctrlnum | (OCoLC)935404817 (DE-599)BSZ414029135 |
| dewey-full | 570.151 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 570 - Biology |
| dewey-raw | 570.151 |
| dewey-search | 570.151 |
| dewey-sort | 3570.151 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| edition | 1. publ. |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01647nam a2200433 c 4500</leader><controlfield tag="001">BV042382048</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20150316 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">150226s2014 ad|| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9781107061903</subfield><subfield code="c">hbk.</subfield><subfield code="9">978-1-107-06190-3</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">1107061903</subfield><subfield code="c">hbk.</subfield><subfield code="9">1-107-06190-3</subfield></datafield><datafield tag="024" ind1="3" ind2=" "><subfield code="a">9781107061903</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)935404817</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BSZ414029135</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-11</subfield><subfield code="a">DE-703</subfield><subfield code="a">DE-29T</subfield><subfield code="a">DE-1028</subfield><subfield code="a">DE-20</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">570.151</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WD 9200</subfield><subfield code="0">(DE-625)148253:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Sneppen, Kim</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Models of life</subfield><subfield code="b">dynamics and regulation in biological systems</subfield><subfield code="c">Kim Sneppen</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">1. publ.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Cambridge</subfield><subfield code="b">Cambridge Univ. Press</subfield><subfield code="c">2014</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">X, 342 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biowissenschaften</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mathematisches Modell</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Life sciences / Mathematical models</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biology / Mathematical models</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Mathematisches Modell</subfield><subfield code="0">(DE-588)4114528-8</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Biologisches System</subfield><subfield code="0">(DE-588)4122930-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Biologisches System</subfield><subfield code="0">(DE-588)4122930-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Mathematisches Modell</subfield><subfield code="0">(DE-588)4114528-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HEBIS Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027818108&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-027818108</subfield></datafield></record></collection> |
| id | DE-604.BV042382048 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T01:20:03Z |
| institution | BVB |
| isbn | 9781107061903 1107061903 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027818108 |
| oclc_num | 935404817 |
| open_access_boolean | |
| owner | DE-11 DE-703 DE-29T DE-1028 DE-20 |
| owner_facet | DE-11 DE-703 DE-29T DE-1028 DE-20 |
| physical | X, 342 S. Ill., graph. Darst. |
| publishDate | 2014 |
| publishDateSearch | 2014 |
| publishDateSort | 2014 |
| publisher | Cambridge Univ. Press |
| record_format | marc |
| spelling | Sneppen, Kim Verfasser aut Models of life dynamics and regulation in biological systems Kim Sneppen 1. publ. Cambridge Cambridge Univ. Press 2014 X, 342 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biowissenschaften Mathematisches Modell Life sciences / Mathematical models Biology / Mathematical models Mathematisches Modell (DE-588)4114528-8 gnd rswk-swf Biologisches System (DE-588)4122930-7 gnd rswk-swf Biologisches System (DE-588)4122930-7 s Mathematisches Modell (DE-588)4114528-8 s DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027818108&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Sneppen, Kim Models of life dynamics and regulation in biological systems Biowissenschaften Mathematisches Modell Life sciences / Mathematical models Biology / Mathematical models Mathematisches Modell (DE-588)4114528-8 gnd Biologisches System (DE-588)4122930-7 gnd |
| subject_GND | (DE-588)4114528-8 (DE-588)4122930-7 |
| title | Models of life dynamics and regulation in biological systems |
| title_auth | Models of life dynamics and regulation in biological systems |
| title_exact_search | Models of life dynamics and regulation in biological systems |
| title_full | Models of life dynamics and regulation in biological systems Kim Sneppen |
| title_fullStr | Models of life dynamics and regulation in biological systems Kim Sneppen |
| title_full_unstemmed | Models of life dynamics and regulation in biological systems Kim Sneppen |
| title_short | Models of life |
| title_sort | models of life dynamics and regulation in biological systems |
| title_sub | dynamics and regulation in biological systems |
| topic | Biowissenschaften Mathematisches Modell Life sciences / Mathematical models Biology / Mathematical models Mathematisches Modell (DE-588)4114528-8 gnd Biologisches System (DE-588)4122930-7 gnd |
| topic_facet | Biowissenschaften Mathematisches Modell Life sciences / Mathematical models Biology / Mathematical models Biologisches System |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027818108&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT sneppenkim modelsoflifedynamicsandregulationinbiologicalsystems |