The molecular basis of viral infection:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam
Acad. Press
2015
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Progress in molecular biology and translational science
129 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIX, 437 S. Ill., graph. Darst. |
| ISBN: | 9780128024614 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804153011499433984 |
|---|---|
| adam_text | Titel: The molecular basis of viral infection
Autor: Klasse, P. J
Jahr: 2015
CONTENTS
Contributors xi
Preface xv
1. Unity in Diversity: Shared Mechanism of Entry Among
Paramyxoviruses 1
Jean-Louis Palgen, Eric M. Jurgens, Anne Moscona, Matteo Porotto,
and Laura M. Palermo
1. Introduction to Paramyxoviruses 2
2. Structure and Function of the Paramyxovirus Glycoproteins 8
3. Proposed Mechanisms of Receptor-Binding Protein and Fusion Protein
Interactions 13
4. Conclusions 22
Acknowledgments 23
References 23
2. Alphavirus Entry into Host Cells 33
Ricardo Vancini, Raquel Hernandez, and Dennis Brown
1. Introduction 34
2. Alphavirus Interaction with Host Cells 36
3. Measuring Viral Entry 41
4. Alphavirus Genome Delivery 45
5. Alphavirus Entry in the Absence of Membrane Fusion 47
6. Challenges and Perspectives 57
Acknowledgments 57
References 57
3. The Mechanism of HCV Entry into Host Cells 63
Florian Douam, Dimitri Lavillette, and Franco is-Loi c Cosset
1. Introduction 64
2. The Viral Particle Organization and Composition: A Fundamental
Key to Decrypt Virus Entry 65
3. Early Steps of Virus Entry 68
4. Receptor Binding and Clustering 72
5. Postbinding Steps and Virus Fusion 83
6. Concluding Remarks 94
vi Contents
Acknowledgments 97
References 97
4. The Evolution of HIV-1 Interactions with Coreceptors
and Mannose C-Type Lectin Receptors 109
Marie Borggren and Marianne Jansson
1. Introduction 110
2. Chemokine Receptors as Critical HIV-1 Coreceptors 110
3. Evolution of Coreceptor Use During Virus Transmission and
Establishment in the New Host 112
4. Intrapatient Evolution of HIV-1 Coreceptor Use 114
5. The Switch Pathway 114
6. The CCR5-Restricted Pathway 117
7. CLRs in HIV-1 Infection 119
8. CLRs and HIV-1 Interactions During Virus Transmission 122
9. CLRs and HIV-1 Interactions During the Chronic Infection Phase 124
10. Clinical Aspects of Virus Evolution at the Interface of Coreceptors
and Mannose CLR 126
Acknowledgments 128
References 128
5. A Game of Numbers: The Stoichiometry of Antibody-Mediated
Neutralization of Flavivirus Infection 141
Theodore C. Pierson and Michael S. Diamond
1. Introduction 142
2. Flavivirus Structure 144
3. A Multiple-Hit Model for the Neutralization of Flaviviruses 146
4. The Stoichiometry of Neutralization and Enhancement of Flaviviruses 150
5. Factors That Modulate the Stoichiometry of Neutralization 154
6. The Stoichiometry of ADE 159
7. Insights into Vaccines and Therapeutics 160
Ackno wledg me nts 160
References 161
6. TRIM21 -Dependent Intracellular Antibody Neutralization
of Virus Infection 167
William A. McEwan and Leo C. James
1. Introduction
2. The Tripartite Motif Family
168
169
Contents vii
3. TRIM21 is a High-Affinity Cytosolic Fc Receptor 170
4. TRIM21 Mediates Antibody-Dependent Intracellular
Neutralization 171
5. TRIM21 is a Sensor for Cytoplasmic Antibody 173
6. TRIM21 Functions are Ubiquitin Dependent 173
7. In Vivo Relevance 174
8. Viral Determinants of TRIM21-Mediated Neutralization 175
9. TRIM21 Exerts Highly Efficient Incremental Neutralization 177
10. The Persistent Fraction 180
11. Comparison of TRIM21 with TRIM5a 180
12. Conclusions 183
Acknowledgments 183
References 183
7. Picornavirus-Host Interactions to Construct Viral Secretory
Membranes
Alexander L. Greninger
1. Back on the Radar
2. Getting to 3A
3. GBF1
4. PI4KB
5. ACBD3
6. Cholesterol
7. 2B-2C Pore Forming With ER-Golgi Membranes
8. Next Steps
9. Conclusion
Acknowledgments
References
8. Retroviral Factors Promoting Infectivity
Emilia Cristiana Cuccurullo, Chiara Valentini, and Massimo Pizzato
1. Introduction 214
2. Retroviral Auxiliary Factors that Promote Infectivity 219
3. Retrovirus Factors that Promote Virion Infectivity with a
Yet Unknown Mechanism: The Nef and glycoGag Enigma 228
4. Final Remarks 237
References 238
189
190
190
192
193
195
198
199
200
204
205
205
213
viii
Contents
9. The Cytoplasmic Tail of Retroviral Envelope Glycoproteins 253
Philip R. Tedbury and Eric O. Freed
1. Introduction 254
2. Retroviral Assembly 258
3. Synthesis and Function of Env 259
4. Function of the Retroviral Env CT 261
5. Conclusions 271
Acknowledgments 272
References 272
10. Molecular Determinants of the Ratio of Inert to Infectious
Virus Particles 285
PJ. Klasse
1. Introduction: A Wide Range of Particle-to-lnfectious-Unit Ratio 286
2. Infectious or Infecting? 287
3. Defective from the Start 295
4. Decay in Suspension 307
5. Abortive Infection 309
6. Conclusions 315
Acknowledg ment 317
References 317
11. The Role of Chance in Primate Lentiviral Infectivity:
From Protomer to Host Organism 327
Roland R. Regoes and Carsten Magnus
1. Introduction 327
2. Host Entry 329
3. Cell Entry 335
4. Synthesis and Outlook 343
Acknowledgments 345
References 346
12. Virus-Encoded 7 Transmembrane Receptors 353
Ann-Sofie Molleskov-Jensen, Martha Trindade Oliveira,
Helen Elizabeth Farrell, and Nick Davis-Poynter
1. Evolutionary Context of v7TMRs 354
2. Functional Divergence from Cellular Chemokine Receptors 362
Contents ix
3. Biological Roles of Viral CKRs 371
4. Concluding Remarks 382
References 382
13. EBV, the Human Host, and the 7TM Receptors: Defense
or Offense? 395
Kristine Niss Arfelt, Suzan Fares, and Mette M. Rosenkilde
1. EBV Infection 396
2. Immune Response and Immune Evasion 402
3. EBV-BILF1—A Virus-Encoded 7TM Receptor with Immune
Evasive Functions 404
4. EBI2: An Endogenous 7TM Receptor Manipulated by EBV 407
5. Manipulation of the Host Immune System 7TM Receptors
and Ligands by EBV—The Chemokine System 411
6. EBV-Associated Diseases 414
7. Drug-Target Potential 418
8. Conclusions 419
Acknowledgment 419
References 419
Index
429
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| indexdate | 2024-07-10T01:19:49Z |
| institution | BVB |
| isbn | 9780128024614 |
| language | English |
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| physical | XIX, 437 S. Ill., graph. Darst. |
| publishDate | 2015 |
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| series | Progress in molecular biology and translational science |
| series2 | Progress in molecular biology and translational science |
| spelling | The molecular basis of viral infection ed. by P. J. Klasse 1. ed. Amsterdam Acad. Press 2015 XIX, 437 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Progress in molecular biology and translational science 129 Virusinfektion (DE-588)4188401-2 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Virusinfektion (DE-588)4188401-2 s Molekularbiologie (DE-588)4039983-7 s DE-604 Klasse, P. J. Sonstige oth Progress in molecular biology and translational science 129 (DE-604)BV035256576 129 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027809674&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The molecular basis of viral infection Progress in molecular biology and translational science Virusinfektion (DE-588)4188401-2 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4188401-2 (DE-588)4039983-7 (DE-588)4143413-4 |
| title | The molecular basis of viral infection |
| title_auth | The molecular basis of viral infection |
| title_exact_search | The molecular basis of viral infection |
| title_full | The molecular basis of viral infection ed. by P. J. Klasse |
| title_fullStr | The molecular basis of viral infection ed. by P. J. Klasse |
| title_full_unstemmed | The molecular basis of viral infection ed. by P. J. Klasse |
| title_short | The molecular basis of viral infection |
| title_sort | the molecular basis of viral infection |
| topic | Virusinfektion (DE-588)4188401-2 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Virusinfektion Molekularbiologie Aufsatzsammlung |
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