Entmischungsphänomene in lösemittelbasierenden MALDI-TOF MS Probenpräparationen:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | German |
| Published: |
Berlin
BAM
2015
|
| Series: | BAM-Dissertationsreihe
126 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturverz. S. 114 - 128 |
| Physical Description: | XVI, 128 S. Ill., graph. Darst. |
| ISBN: | 9783981666861 |
Staff View
MARC
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Record in the Search Index
| _version_ | 1804153005063274496 |
|---|---|
| adam_text | INHALTSVERZEICHNIS
1
MOTIVATION....................................................................................................................................1
2 THEORETISCHE GRUNDLAGEN DER MALDI-TOF
MASSENSPEKTROMETRIE....................................3
2.1 HISTORISCHE
ENTWICKLUNG...................................................................................................3
2.2 DER
DESORPTIONS-ZLONISATIONSPROZESS............................................................................7
2.2.1 ROLLE DER
MATRIX.......................................................................................................
7
2.2.2 EINFLUSS DES
SALZES................................................................................................
9
2.2.3 DIE
DESORPTION/IONISATION....................................................................................
10
2.2.3.1 DER
DESORPTIONSPROZESS..................................................................................10
2.2.3 2 DIE
IONISATION.....................................................................................................
12
2.2.3.2.1 ENERGY-POOLING
MODELL...............................................................................
12
2 .2.3.22 LUCKY SURVIVOR
MODELL...............................................................................
15
2.3
MASSENANALYSATOREN......................................................................................................
18
2.3.1 FLUGZEIT (TOF) MASSENANALYSATOR
.....................................................................
18
2.3.2 QUADRUPOL-FLUGZEIT-ANALYSATOREN (Q -T O F
)..................................................... 21
2.3.3 LONENFALLEN (ION
TRAP)...........................................................................................22
2.4
DETEKTOREN.......................................................................................................................
25
2.4.1 MIKROKANALPLATTEN-DETEKTOR (M C P
)....................................................................25
2.4.2 IONEN KONVERTIERUNGSDYNODENDETEKTOR (IC D
)..................................................26
2.4.3 KRYODETEKTOR - SUPRALEITENDER TUNNELUEBERGANGSDETEKTOR (S T J
).................27
2.5
PROBENPRAEPARATION.........................................................................................................
28
2.5.1 LOESEMITTELBASIERENDE
PROBENPRAEPARATIONEN....................................................29
2.5.1.1 MANUELLE
PRAEPARATION.......................................................................................
29
2.5.1.2 AUTOMATISCHES
SPOTTING..................................................................................
29
2.5.2 LOESEMITTELFREIE
PROBENPRAEPARATION....................................................................33
2.5.2.1
ELEKTROSPRAY.......................................................................................................33
2.5 2 .2
PULVERPRAEPARATION.............................................................................................
34
2.5.3 IONISCHE
FLUESSIGKEITEN..........................................................................................35
2.5.4 ANDERE
PRAEPARATIONSTECHNIKEN...........................................................................36
2.6
FRAGMENTIERUNGSTECHNIKEN............................................................................................37
2.7 MALDI-IMAGING M S
........................................................................................................
39
3
EXPERIMENTELLES.......................................................................................................................
41
3.1 VERWENDETE
CHEMIKALIEN..............................................................................................41
3.2 VERWENDETE
GERAETE........................................................................................................
42
3.2.1 M ALDI-TO F-M
S................................................................. 42
3.2.2 FTIR
MIKROSKOP.....................................................................................................
42
3.2.3 N M R
.........................................................................................................................43
3.2.4 KONTAKTWINKELMESSGERAET
.....................................................................................
43
3.2.5
FLUORESZENZSPEKTROMETER....................................................................................
43
3.3
PROBENVORBEREITUNG.........................................................................................................44
3.3.1 DRIED DROPLET PROBENPRAEPARATION
......................................................................
44
3.3.2 SANDWICH PROBENPRAEPARATION
.............................................................................
45
3.3.3 ELEKTROSPRAY
PROBENPRAEPARATION.........................................................................45
3.3.4 PROBENPRAEPARATION MIT IONISCHEN FLUESSIGKEITEN................ 46
3.3.4.1 D H B -IM
...............................................................................................................
46
3.3.4.2 SA-IM
...................................................................................................................47
3.3.4.3
DCTB-IM.............................................................................................................
48
4 ERGEBNISSE UND
DISKUSSION....................................................................................................
51
4.1 EINFLUSS DES LOESEMITTELS AUF DIE SEGREGATION
............................................................
51
4.2 EINFLUSS DER POLYMERE AUF DIE
SEGREGATION................................................................64
4.2.1 KONSTITUTION DER
POLYMERE...................................................................................
65
4.2.1.1
HOMOPOLYMERE..................................................................................................65
4.2.1.2 COPOLYMERE........................... 67
4.2.2
POLYMERBLENDS................................................................................................
72
4.2.3 EINFLUSS DER MOLMASSE DER
POLYMERE................................................................75
4.3 EINFLUSS DER MATRIX AUF DIE
SEGREGATION.......................................................................82
4.3.1 VERTEILUNG DER
MATRIX............................................................................................
82
4.3.2
MATRIXKONZENTRATION.......................................................
84
4.3.3 IONISCHE M
ATRIZES..................................................................................................
94
4.3.3.1
ALLGEMEINES.......................................................................................................
94
4.3.3.2 IONISCHE DHB
MATRIX.........................................................................................95
4.3.3.3 IONISCHE SA
MATRIX............................................................................................
97
4.3.3.4 IONISCHE DCTB
MATRIX......................................................................................
99
5 R ESUEM
EE..................................................................................................................................103
6
VERZEICHNISSE...........................................................................................................................107
6.1
ABKUERZUNGSVERZEICHNIS................................................................................................
107
6.2 PUBLIKATIONSVERZEICHNIS DES AUTORS
.........................................................
.................
111
6.3
LITERATURVERZEICHNIS.......................................................................................................
114
|
| any_adam_object | 1 |
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| author_GND | (DE-588)1067250174 |
| author_facet | Gabriel, Stefan Johannes |
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| bvnumber | BV042369410 |
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| ctrlnum | (OCoLC)906076625 (DE-599)BVBBV042369410 |
| discipline | Chemie / Pharmazie |
| format | Thesis Book |
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| id | DE-604.BV042369410 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T01:19:43Z |
| institution | BVB |
| isbn | 9783981666861 |
| language | German |
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| physical | XVI, 128 S. Ill., graph. Darst. |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | BAM |
| record_format | marc |
| series | BAM-Dissertationsreihe |
| series2 | BAM-Dissertationsreihe |
| spelling | Gabriel, Stefan Johannes Verfasser (DE-588)1067250174 aut Entmischungsphänomene in lösemittelbasierenden MALDI-TOF MS Probenpräparationen Stefan Johannes Gabriel Berlin BAM 2015 XVI, 128 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier BAM-Dissertationsreihe 126 Literaturverz. S. 114 - 128 Zugl.: Berlin, Humboldt-Univ., Diss., 2014 (DE-588)4113937-9 Hochschulschrift gnd-content BAM-Dissertationsreihe 126 (DE-604)BV019539588 126 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027805699&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Gabriel, Stefan Johannes Entmischungsphänomene in lösemittelbasierenden MALDI-TOF MS Probenpräparationen BAM-Dissertationsreihe |
| subject_GND | (DE-588)4113937-9 |
| title | Entmischungsphänomene in lösemittelbasierenden MALDI-TOF MS Probenpräparationen |
| title_auth | Entmischungsphänomene in lösemittelbasierenden MALDI-TOF MS Probenpräparationen |
| title_exact_search | Entmischungsphänomene in lösemittelbasierenden MALDI-TOF MS Probenpräparationen |
| title_full | Entmischungsphänomene in lösemittelbasierenden MALDI-TOF MS Probenpräparationen Stefan Johannes Gabriel |
| title_fullStr | Entmischungsphänomene in lösemittelbasierenden MALDI-TOF MS Probenpräparationen Stefan Johannes Gabriel |
| title_full_unstemmed | Entmischungsphänomene in lösemittelbasierenden MALDI-TOF MS Probenpräparationen Stefan Johannes Gabriel |
| title_short | Entmischungsphänomene in lösemittelbasierenden MALDI-TOF MS Probenpräparationen |
| title_sort | entmischungsphanomene in losemittelbasierenden maldi tof ms probenpraparationen |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027805699&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV019539588 |
| work_keys_str_mv | AT gabrielstefanjohannes entmischungsphanomeneinlosemittelbasierendenmalditofmsprobenpraparationen |