Physiology and pathology of chloride transporters and channels in the nervous system: from molecules to diseases
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam
Elsevier/Academic
2009
|
| Ausgabe: | 1st ed |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Beschreibung: | The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl- ), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. * The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years * Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. * The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. * Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. * Involves all of the leading researchers in the field. * INcludes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field Includes bibliographical references and index |
| Beschreibung: | 1 Online-Ressource (xii, 617 pages) |
| ISBN: | 9780080922034 0080922031 9780123743732 0123743737 |
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| 500 | |a The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl- ), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. | ||
| 500 | |a In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. * The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years * Chloride is the most abundant free anion in animal cells. | ||
| 500 | |a THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. * The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. * Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. * Involves all of the leading researchers in the field. | ||
| 500 | |a * INcludes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field | ||
| 500 | |a Includes bibliographical references and index | ||
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Datensatz im Suchindex
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| dewey-full | 571.641 |
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| dewey-ones | 571 - Physiology & related subjects |
| dewey-raw | 571.641 |
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| discipline | Biologie |
| edition | 1st ed |
| format | Electronic eBook |
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| illustrated | Not Illustrated |
| indexdate | 2024-07-10T01:18:03Z |
| institution | BVB |
| isbn | 9780080922034 0080922031 9780123743732 0123743737 |
| language | English |
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| physical | 1 Online-Ressource (xii, 617 pages) |
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| spelling | Physiology and pathology of chloride transporters and channels in the nervous system from molecules to diseases edited by F. Javier Alvarez-Leefmans and Eric Delpire 1st ed Amsterdam Elsevier/Academic 2009 1 Online-Ressource (xii, 617 pages) txt rdacontent c rdamedia cr rdacarrier The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl- ), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. * The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years * Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. * The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. * Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. * Involves all of the leading researchers in the field. * INcludes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field Includes bibliographical references and index SCIENCE / Life Sciences / Cell Biology bisacsh Chloride channels Chlorides Physiological transport Chloridkanal (DE-588)4291189-8 gnd rswk-swf Nervensystem (DE-588)4041643-4 gnd rswk-swf Electronic books Nervensystem (DE-588)4041643-4 s Chloridkanal (DE-588)4291189-8 s 1\p DE-604 Alvarez-Leefmans, F. J. Sonstige oth Delpire, Eric Sonstige oth http://www.sciencedirect.com/science/book/9780123743732 Verlag Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Physiology and pathology of chloride transporters and channels in the nervous system from molecules to diseases SCIENCE / Life Sciences / Cell Biology bisacsh Chloride channels Chlorides Physiological transport Chloridkanal (DE-588)4291189-8 gnd Nervensystem (DE-588)4041643-4 gnd |
| subject_GND | (DE-588)4291189-8 (DE-588)4041643-4 |
| title | Physiology and pathology of chloride transporters and channels in the nervous system from molecules to diseases |
| title_auth | Physiology and pathology of chloride transporters and channels in the nervous system from molecules to diseases |
| title_exact_search | Physiology and pathology of chloride transporters and channels in the nervous system from molecules to diseases |
| title_full | Physiology and pathology of chloride transporters and channels in the nervous system from molecules to diseases edited by F. Javier Alvarez-Leefmans and Eric Delpire |
| title_fullStr | Physiology and pathology of chloride transporters and channels in the nervous system from molecules to diseases edited by F. Javier Alvarez-Leefmans and Eric Delpire |
| title_full_unstemmed | Physiology and pathology of chloride transporters and channels in the nervous system from molecules to diseases edited by F. Javier Alvarez-Leefmans and Eric Delpire |
| title_short | Physiology and pathology of chloride transporters and channels in the nervous system |
| title_sort | physiology and pathology of chloride transporters and channels in the nervous system from molecules to diseases |
| title_sub | from molecules to diseases |
| topic | SCIENCE / Life Sciences / Cell Biology bisacsh Chloride channels Chlorides Physiological transport Chloridkanal (DE-588)4291189-8 gnd Nervensystem (DE-588)4041643-4 gnd |
| topic_facet | SCIENCE / Life Sciences / Cell Biology Chloride channels Chlorides Physiological transport Chloridkanal Nervensystem |
| url | http://www.sciencedirect.com/science/book/9780123743732 |
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