In vitro static and dynamic hemocompatibility testing of poly(ether imide) membranes functionalized with oligoglycerols:
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| Format: | Thesis Book |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 126 Bl. Ill., graph. Darst. |
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| 245 | 1 | 0 | |a In vitro static and dynamic hemocompatibility testing of poly(ether imide) membranes functionalized with oligoglycerols |c von Steffen Braune |
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Record in the Search Index
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|---|---|
| adam_text | CONTENT
CONTENT 3
STATEMENT OF ORIGINALITY 5
ACKNOWLEDGEMENTS 6
ABSTRACT 8
ZUSAMMENFASSUNG 10
LIST OF FIGURES 14
LIST OF ABBREVIATIONS 15
CHAPTER 1. INTRODUCTION 17
POLYMER-BASED BIOMATERIALS 20
BULK PROPERTIES AND SURFACE FUNCTIONALIZATION 21
POLYMER-BASED BIOMATERIAL MEMBRANES FOR BIOMEDICAL APPLICATIONS 22
POLY(ETHER IMIDE) AS BIOMEDICAL MEMBRANE SYSTEM 22
STRATEGIES TO IMPROVE THE HEMOCOMPATIBILITY OF BIOMATERIAL SURFACES 23
OLIGO- AND POLYGLYCEROLS FOR SURFACE PASSIVATION/FUNCTIONALIZATION 24
IN VITRO HEMOCOMPATIBILITY TESTING OF BIOMATERIALS 25
IN VITRO STATIC
TEST SYSTEM 26
IN VITRO DYNAMIC TEST SYSTEM 27
CHAPTER 2. MOTIVATION AND AIMS OF THE THESIS 30
CHAPTER 3. STRATEGIES AND CONCEPTS OF THE THESIS 31
CHAPTER 4. ORGANIZATION OF THE THESIS 33
CHAPTERS 33
PUBLICATIONS 34
CHAPTER 5. INTERACTION OF THROMBOCYTES WITH POLY(ETHER IMIDE): THE
INFLUENCE OF PROCESSING 35
CONTRIBUTION TO THE PUBLICATION 36
SHORT SUMMARY OF THE PUBLICATION 38
CHAPTER 6. SURFACE FUNCTIONALIZATION OF POLY(ETHER IMIDE) MEMBRANES WITH
LINEAR, METHYLATED
OLIGOGLYCEROLS FOR REDUCING THROMBOGENICITY 39
CONTRIBUTION TO THE PUBLICATION 40
SHORT SUMMARY OF THE PUBLICATION 42
CHAPTER 7. DYNAMIC IN VITRO HEMOCOMPATIBILITY TESTING OF POLY(ETHER
IMIDE) MEMBRANES
FUNCTIONALIZED WITH LINEAR, METHYLATED OLIGOGLYCEROL AND OLIGO(ETHYLENE
GLYCOL) 44
CONTRIBUTION TO THE PUBLICATION 45
3
HTTP://D-NB.INFO/1066609918
SHORT SUMMARY OF THE PUBLICATION 48
CHAPTER 8. AUTOMATED IMAGE-BASED ANALYSIS OF ADHERENT THROMBOCYTES ON
POLYMER SURFACES 49
CONTRIBUTION TO THE PUBLICATION 50
SHORT SUMMARY OF THE PUBLICATION 52
CHAPTER 9. DISCUSSION 53
POLY(ETHER IMIDE)
- THE INFLUENCE SURFACE PROPERTIES ON THROMBOCYTE ADHESION AND
ACTIVATION 53
SURFACE FUNCTIONALIZATION OF POLY(ETHER IMIDE) MEMBRANES WITH
OLIGOGLYCEROLS 54
PROTEIN ADSORPTION ON SURFACE FUNCTIONALIZED POLY(ETHER IMIDE) MEMBRANES
56
HEMOCOMPATIBILITY OF SURFACE FUNCTIONALIZED POLY(ETHER IMIDE) MEMBRANES
57
AUTOMATIZED DETERMINATION OF SURFACE ADHERENT THROMBOCYTES 60
CHAPTER 10. CONCLUSION AND OUTLOOK 61
REFERENCES 63
APPENDICES ; 70
APPENDIX A. APPLIED PROTOCOLS AND BASIC PRINCIPLES OF METHODS 70
STUDY PARTICIPANTS, BLOOD SAMPLING, PRE-ANALYTICAL BLOOD EVALUATION AND
PREPARATION OF TRP AND
TPP 70
DETERMINATION OF ERYTHROCYTES AND SINGLE CIRCULATING THROMBOCYTES 71
DETERMINATION OF CIRCULATING THROMBOCYTE AGGREGATES 71
DETERMINATION OF THROMBOCYTE FUNCTION (PFA-100) 72
FIXATION AND STAINING OF ADHERENT THROMBOCYTES 72
IMMUNFLUORESCENCE STAINING 72
VISUALIZATION OF ADHERENT THROMBOCYTES
- CONFOCAL LASER SCANNING MICROSCOPY 73
FLOW CYTOMETRY 73
ENZYME-LINKED IMMUNOSORBENT ASSAY 74
APPENDIX B 75
APPENDIX C 76
APPENDIX D 77
APPENDIX E 78
CURRICULUM VITAE 79
4
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| spelling | Braune, Steffen 1979- Verfasser (DE-588)1064282741 aut In vitro static and dynamic hemocompatibility testing of poly(ether imide) membranes functionalized with oligoglycerols von Steffen Braune 2014 126 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Potsdam, Univ., Diss., 2014 Biomaterial (DE-588)4267769-5 gnd rswk-swf Blut (DE-588)4007259-9 gnd rswk-swf Histokompatibilität (DE-588)4025090-8 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Biomaterial (DE-588)4267769-5 s Histokompatibilität (DE-588)4025090-8 s Blut (DE-588)4007259-9 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027725915&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Braune, Steffen 1979- In vitro static and dynamic hemocompatibility testing of poly(ether imide) membranes functionalized with oligoglycerols Biomaterial (DE-588)4267769-5 gnd Blut (DE-588)4007259-9 gnd Histokompatibilität (DE-588)4025090-8 gnd |
| subject_GND | (DE-588)4267769-5 (DE-588)4007259-9 (DE-588)4025090-8 (DE-588)4113937-9 |
| title | In vitro static and dynamic hemocompatibility testing of poly(ether imide) membranes functionalized with oligoglycerols |
| title_auth | In vitro static and dynamic hemocompatibility testing of poly(ether imide) membranes functionalized with oligoglycerols |
| title_exact_search | In vitro static and dynamic hemocompatibility testing of poly(ether imide) membranes functionalized with oligoglycerols |
| title_full | In vitro static and dynamic hemocompatibility testing of poly(ether imide) membranes functionalized with oligoglycerols von Steffen Braune |
| title_fullStr | In vitro static and dynamic hemocompatibility testing of poly(ether imide) membranes functionalized with oligoglycerols von Steffen Braune |
| title_full_unstemmed | In vitro static and dynamic hemocompatibility testing of poly(ether imide) membranes functionalized with oligoglycerols von Steffen Braune |
| title_short | In vitro static and dynamic hemocompatibility testing of poly(ether imide) membranes functionalized with oligoglycerols |
| title_sort | in vitro static and dynamic hemocompatibility testing of poly ether imide membranes functionalized with oligoglycerols |
| topic | Biomaterial (DE-588)4267769-5 gnd Blut (DE-588)4007259-9 gnd Histokompatibilität (DE-588)4025090-8 gnd |
| topic_facet | Biomaterial Blut Histokompatibilität Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027725915&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT braunesteffen invitrostaticanddynamichemocompatibilitytestingofpolyetherimidemembranesfunctionalizedwitholigoglycerols |