Determination of matrix metalloproteinases and interleukin-8 in bronchoalveolar lavage fluid in horses with different lung diseases:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Berlin
Mensch und Buch Verl.
2014
|
| Subjects: | |
| Online Access: | Volltext Inhaltsverzeichnis |
| Item Description: | Nebentitel: Bestimmung von Metalloproteinasen und Interleukin-8 in bronchoalveolären Lavageflüssigkeit bei Pferden mit verschiedenen Pneumopathien |
| Physical Description: | XII, 133 S. Ill., graph. Darst. |
| ISBN: | 9783863875558 |
Staff View
MARC
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| 020 | |a 9783863875558 |9 978-3-86387-555-8 | ||
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| 035 | |a (DE-599)BVBBV042283420 | ||
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| 041 | 0 | |a eng | |
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| 082 | 0 | |a 636.1089624 |2 22/ger | |
| 084 | |a 630 |2 FUB | ||
| 100 | 1 | |a Shety, Tarek Soliman |e Verfasser |0 (DE-588)1065352190 |4 aut | |
| 245 | 1 | 0 | |a Determination of matrix metalloproteinases and interleukin-8 in bronchoalveolar lavage fluid in horses with different lung diseases |c vorgelegt von Tarek Soliman Shety |
| 246 | 1 | 3 | |a Bestimmung von Metalloproteinasen und Interleukin-8 in bronchoalveolären Lavageflüssigkeit bei Pferden mit verschiedenen Pneumopathien |
| 264 | 1 | |a Berlin |b Mensch und Buch Verl. |c 2014 | |
| 300 | |a XII, 133 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Nebentitel: Bestimmung von Metalloproteinasen und Interleukin-8 in bronchoalveolären Lavageflüssigkeit bei Pferden mit verschiedenen Pneumopathien | ||
| 502 | |a Berlin, Freie Univ., Diss., 2014 | ||
| 650 | 7 | |a Horses |2 cabt | |
| 650 | 7 | |a chronic obstructive pulmonary disease |2 cabt | |
| 650 | 7 | |a lungs |2 cabt | |
| 650 | 7 | |a trachea |2 cabt | |
| 650 | 7 | |a scoring |2 cabt | |
| 650 | 7 | |a bronchoalveolar lavage |2 cabt | |
| 650 | 7 | |a secretions |2 cabt | |
| 650 | 7 | |a respirometry |2 cabt | |
| 650 | 7 | |a bronchoscopy |2 cabt | |
| 650 | 7 | |a radiography |2 cabt | |
| 650 | 7 | |a metalloproteinases |2 cabt | |
| 650 | 7 | |a interleukin 8 |2 cabt | |
| 650 | 7 | |a inhalation |2 cabt | |
| 650 | 7 | |a ELISA |2 cabt | |
| 650 | 0 | 7 | |a Interleukin 8 |0 (DE-588)4286437-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Lungenkrankheit |0 (DE-588)4036660-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Metalloproteinasen |0 (DE-588)4284137-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Broncho-alveoläre Lavage |0 (DE-588)4214640-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Pferdekrankheit |0 (DE-588)4045515-4 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Pferdekrankheit |0 (DE-588)4045515-4 |D s |
| 689 | 0 | 1 | |a Lungenkrankheit |0 (DE-588)4036660-1 |D s |
| 689 | 0 | 2 | |a Broncho-alveoläre Lavage |0 (DE-588)4214640-9 |D s |
| 689 | 0 | 3 | |a Interleukin 8 |0 (DE-588)4286437-9 |D s |
| 689 | 0 | 4 | |a Metalloproteinasen |0 (DE-588)4284137-9 |D s |
| 689 | 0 | |5 DE-604 | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |o urn:nbn:de:kobv:188-fudissthesis000000098204-1 |
| 856 | 4 | 1 | |u http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000098204 |x Resolving-System |z kostenfrei |3 Volltext |
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| 912 | |a ebook | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-027720745 | ||
Record in the Search Index
| _version_ | 1804152849962106880 |
|---|---|
| adam_text | CONTENT
CONTENT
1 INTRODUCTION 1
2 REVIEW OF LITERATURES 3
2.1 RECURRENT AIRWAY OBSTRUCTION 3
2.1.1 GENERAL ASPECTS AND SYNONYMS OF RAO 3
2.1.2 INCIDENCE 4
2.1.3 ETIOLOGY 4
2.1.4 PATHOGENESIS AND THE IMMUNOLOGICAL BASIS OF RAO 5
2.1.5 PATHOPHYSIOLOGY OF RAO IN HORSES 6
2.1.5.1 AIRWAY INFLAMMATION AND MUCUS SECRETION 6
2.1.5.2 AIRWAY OBSTRUCTION 6
2.1.6 DIAGNOSIS OF RAO 7
2.1.6.1 CLINICAL SIGNS 7
2.1.6.1.1 REMISSION PHASE OF RAO 7
2.1.6.1.2 EXACERBATION PHASE OF RAO 7
2.1.6.2 ENDOSCOPY 8
2.1.6.3 PULMONARY FUNCTION TESTING 9
2.1.6.4 CYTOLOGY OF THE RESPIRATORY SECRETIONS IN RAO HORSES 9
2.1.6.5 THORACIC RADIOGRAPHY 11
2.2 OTHER RESPIRATORY DISEASES OF HORSES INCLUDED DURING THE STUDY 11
2.2.1 CHRONIC INTERSTITIAL PNEUMOPATHY 11
2.2.2 ACUTE TO SUBACUTE RESPIRATORY INFECTION 12
2.3 EXTRACELLULAR MATRIX 12
2.3.1 THE ECM COMPOSITION 13
2.3.1.1 COLLAGEN 13
2.3.1.2 ELASTIN 14
2.3.1.3 GLYCOSAMINOGLYCANS AND PROTEOGLYCANS 14
2.4 AIRWAY REMODELING 14
2.5 MATRIX METALLOPROTEINASES 15
2.5.1 PHYSIOLOGICAL AND PATHOLOGICAL IMPORTANCE OF MMPS 15
(I)
HTTP://D-NB.INFO/1064722679
CONTENT
2.5.1.1 PHYSIOLOGICAL IMPORTANCE 15
2.5.1.2 PATHOLOGICAL IMPORTANCE 16
2.5.2 STRUCTURE AND SUBFAMILIES OF MMPS 17
2.5.2.1 COLLAGENASES 17
2.5.2.1.1 MATRIX METALLOPROTEINASE-1 17
2.5.2.1.2 MATRIX METALLOPROTEINASE-8 18
2.5.2.1.3 MATRIX METALLOPROTEINASE-13 18
2.5.2.2 GELATINASES 19
2.5.2.2.1 MATRIX METALLOPROTEINASE-2 19
2.5.2.2.2 MATRIX METALLOPROTEINASE-9 20
2.5.2.3 STROMELYSINS 20
2.5.2.4 MATRILYSIN (MMP-7) 21
2.5.2.5 MACROPHAGE METALLOELASTASE (MMP-12) 21
2.5.2.6 MEMBRANE TYPE MMP (MT-MMP) 21
2.5.2.7 OTHER MMPS 22
2.5.3 REGULATION OF MMPS ACTIVITY 22
2.5.3.1 ACTIVATION 22
2.5.3.2 INHIBITION 23
2.5.4 MMPS AS TARGETS FOR THERAPY 24
2.6 INTERLEUKINS 24
2.6.1 INTERLEUKIN-8 25
2.6.2 OTHER INTERLEUKINS IMPLICATED IN RESPIRATORY DISEASE DEVELOPMENT
25
3 MATERIALS AND METHODS 27
3.1 HORSES 27
3.2 METHODS 30
3.2.1 PHYSICAL EXAMINATION 30
3.2.1.1 CLINICAL SCORING 31
3.2.1.2 EXERCISE TOLERANCE TEST 31
3.2.1.3 PULMONARY FUNCTION TESTING 32
3.2.1.4 ENDOSCOPY 34
3.2.1.5 THORACIC RADIOGRAPHY 34
(II)
CONTENT
3.2.2 SAMPLES AND SAMPLING METHODS 35
3.2.2.1 BLOOD SAMPLES 35
3.2.2.1.1 PERIPHERAL BLOOD 35
3.2.2.1.2 ARTERIAL BLOOD 35
3.2.2.2 RESPIRATORY FLUID SAMPLES 36
3.2.2.2.1 TBS COLLECTION AND PROCESSING 36
3.2.2.2.2 BAL COLLECTION AND PROCESSING 36
3.2.3 LABORATORY ASSAYS 37
3.2.3.1 GELATIN ZYMOGRAPHY 37
3.2.3.1.1 SAMPLES DILUTION 37
3.2.3.1.2 POLYACIYLAMIDE GEL ELECTROPHORESIS (PAGE) 37
3.2.3.1.3 LOADING THE GEL 37
3.2.3.1.4 RUNNING THE GEL 37
3.2.3.1.5 STAINING THE GELS 38
3.2.3.1.6 ANALYZING THE GELS 38
3.2.3.2 ENZYME LINKED IMMUNOSORBENT ASSAY (ELISA) 39
3.2.3.3 FLUORESCENT METHOD FORMMP-8 CONCENTRATION 40
3.2.3.3.1 PRO-MMP-8 ACTIVATION IN THE SAMPLES 40
3.2.3.3.2 MMP-8 SUBSTRATE WORKING SOLUTION 40
3.2.3.3.3 NEGATIVE AND POSITIVE CONTROLS 41
3.2.3.3.4 STANDARD PREPARATION 41
3.2.3.3.5 STARTING THE ENZYMATIC REACTION 41
3.2.3.3.6 CALCULATIONS 42
3.2.4 STATISTICAL ANALYSIS 42
4 RESULTS 45
4.1 HISTORY, CLINICAL SIGNS AND BASIS OF CLASSIFICATIONS 45
4.2 GENERAL INFORMATION ON THE PATIENTS 46
4.2.1 GENDER 46
4.2.2 AGE AND BODY WEIGHT OF HORSES 47
4.3 GENERAL CLINICAL EXAMINATION 47
4.4 CLINICAL EXAMINATION OF THE LUNG 47
(ILL)
CONTENT
4.5 CLINICAL EXAMINATION SCORE SYSTEM 50
4.6 ENDOSCOPIC ASSESSMENT OF THE LOWER AIRWAYS 52
4.7 THORACIC RADIOGRAPHY 53
4.8 LUNG FUNCTION TESTING 54
4.9 CYTOLOGY OF RESPIRATORY SECRETIONS 57
4.9.1 TRACHEOBRONCHIAL SECRETIONS CYTOLOGY 57
4.9.2 BRONCHOALVEOLAR LAVAGE FLUID CYTOLOGY 57
4.10 RESULTS OF INFLAMMATORY MARKERS 60
4.10.1 ELISA ASSAYS 60
4.10.1.1 IL-8 ELISA ASSAY 60
4.10.1.2 MMP-2 ELISA ASSAY 60
4.10.1.3 MMP-9 ELISA ASSAY 61
4.10.2 FLUORESCENT METHOD FOR MMP-8 61
4.10.3 GELATIN ZYMOGRAPHY 64
4.11 CORRELATIONS BETWEEN DIFFERENT EXAMINED PARAMETERS 66
4.11.1 CORRELATION OF REPIRATOIY RATE AND CLINICAL SCORES 66
4.11.2 CORRELATION BETWEEN BAL, TBS CYTOLOGY AND CLINICAL SCORE 67
4.11.3 CORRELATION OF BALF AND TBS CYTOLOGY, MMPS AND IL-8 67
4.11.4 CORRELATION OF CLINICAL SCORES, MMPS AND IL-8 67
4.11.5 CORRELATION OF LUNG FUNCTION AND CLINICAL SCORE 68
4.11.6 CORRELATIONS BETWEEN MMP METHODS 68
4.11.7 CORRELATIONS BETWEEN ENDOSCOPY SCORING METHODS 68
5 DISCUSSION 71
5.1 DISCUSSION OF THE METHODS 71
5.1.1 COLLECTION METHODS FOR TBS AND BALF 71
5.1.2 DISCUSSION OF GELATIN ZYMOGRAPHY 72
5.1.3 DISCUSSION OF FLUORIMETRY METHOD 73
5.2 DISCUSSION OF THE RESULTS 73
6 CONCLUSIONS 81
7 SUMMARY 83
8 ZUSAMMENFASSUNG 85
(IV)
CONTENT
9 REFERENCES 87
10 APPENDIX 113
10.1 CHEMICALS USED IN THE PRESENT STUDY 122
10.2 EQUIPMENTS USED IN THE PRESENT STUDY 123
10.3 CLINICAL EXAMINATION REPORTS AND FORMS 124
10.4 DATABASE SOFTWARE INTERFACE 129
11 ACKNOWLEDGEMENTS 132
12 SELBSTSNDIGKEITSERKLSRUNG 133
(V)
|
| any_adam_object | 1 |
| author | Shety, Tarek Soliman |
| author_GND | (DE-588)1065352190 |
| author_facet | Shety, Tarek Soliman |
| author_role | aut |
| author_sort | Shety, Tarek Soliman |
| author_variant | t s s ts tss |
| building | Verbundindex |
| bvnumber | BV042283420 |
| collection | ebook |
| ctrlnum | (OCoLC)907542863 (DE-599)BVBBV042283420 |
| dewey-full | 636.1089624 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 636 - Animal husbandry |
| dewey-raw | 636.1089624 |
| dewey-search | 636.1089624 |
| dewey-sort | 3636.1089624 |
| dewey-tens | 630 - Agriculture and related technologies |
| discipline | Agrar-/Forst-/Ernährungs-/Haushaltswissenschaft / Gartenbau |
| format | Thesis Book |
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| indexdate | 2024-07-10T01:17:15Z |
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| publisher | Mensch und Buch Verl. |
| record_format | marc |
| spelling | Shety, Tarek Soliman Verfasser (DE-588)1065352190 aut Determination of matrix metalloproteinases and interleukin-8 in bronchoalveolar lavage fluid in horses with different lung diseases vorgelegt von Tarek Soliman Shety Bestimmung von Metalloproteinasen und Interleukin-8 in bronchoalveolären Lavageflüssigkeit bei Pferden mit verschiedenen Pneumopathien Berlin Mensch und Buch Verl. 2014 XII, 133 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Nebentitel: Bestimmung von Metalloproteinasen und Interleukin-8 in bronchoalveolären Lavageflüssigkeit bei Pferden mit verschiedenen Pneumopathien Berlin, Freie Univ., Diss., 2014 Horses cabt chronic obstructive pulmonary disease cabt lungs cabt trachea cabt scoring cabt bronchoalveolar lavage cabt secretions cabt respirometry cabt bronchoscopy cabt radiography cabt metalloproteinases cabt interleukin 8 cabt inhalation cabt ELISA cabt Interleukin 8 (DE-588)4286437-9 gnd rswk-swf Lungenkrankheit (DE-588)4036660-1 gnd rswk-swf Metalloproteinasen (DE-588)4284137-9 gnd rswk-swf Broncho-alveoläre Lavage (DE-588)4214640-9 gnd rswk-swf Pferdekrankheit (DE-588)4045515-4 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Pferdekrankheit (DE-588)4045515-4 s Lungenkrankheit (DE-588)4036660-1 s Broncho-alveoläre Lavage (DE-588)4214640-9 s Interleukin 8 (DE-588)4286437-9 s Metalloproteinasen (DE-588)4284137-9 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:kobv:188-fudissthesis000000098204-1 http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000098204 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027720745&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Shety, Tarek Soliman Determination of matrix metalloproteinases and interleukin-8 in bronchoalveolar lavage fluid in horses with different lung diseases Horses cabt chronic obstructive pulmonary disease cabt lungs cabt trachea cabt scoring cabt bronchoalveolar lavage cabt secretions cabt respirometry cabt bronchoscopy cabt radiography cabt metalloproteinases cabt interleukin 8 cabt inhalation cabt ELISA cabt Interleukin 8 (DE-588)4286437-9 gnd Lungenkrankheit (DE-588)4036660-1 gnd Metalloproteinasen (DE-588)4284137-9 gnd Broncho-alveoläre Lavage (DE-588)4214640-9 gnd Pferdekrankheit (DE-588)4045515-4 gnd |
| subject_GND | (DE-588)4286437-9 (DE-588)4036660-1 (DE-588)4284137-9 (DE-588)4214640-9 (DE-588)4045515-4 (DE-588)4113937-9 |
| title | Determination of matrix metalloproteinases and interleukin-8 in bronchoalveolar lavage fluid in horses with different lung diseases |
| title_alt | Bestimmung von Metalloproteinasen und Interleukin-8 in bronchoalveolären Lavageflüssigkeit bei Pferden mit verschiedenen Pneumopathien |
| title_auth | Determination of matrix metalloproteinases and interleukin-8 in bronchoalveolar lavage fluid in horses with different lung diseases |
| title_exact_search | Determination of matrix metalloproteinases and interleukin-8 in bronchoalveolar lavage fluid in horses with different lung diseases |
| title_full | Determination of matrix metalloproteinases and interleukin-8 in bronchoalveolar lavage fluid in horses with different lung diseases vorgelegt von Tarek Soliman Shety |
| title_fullStr | Determination of matrix metalloproteinases and interleukin-8 in bronchoalveolar lavage fluid in horses with different lung diseases vorgelegt von Tarek Soliman Shety |
| title_full_unstemmed | Determination of matrix metalloproteinases and interleukin-8 in bronchoalveolar lavage fluid in horses with different lung diseases vorgelegt von Tarek Soliman Shety |
| title_short | Determination of matrix metalloproteinases and interleukin-8 in bronchoalveolar lavage fluid in horses with different lung diseases |
| title_sort | determination of matrix metalloproteinases and interleukin 8 in bronchoalveolar lavage fluid in horses with different lung diseases |
| topic | Horses cabt chronic obstructive pulmonary disease cabt lungs cabt trachea cabt scoring cabt bronchoalveolar lavage cabt secretions cabt respirometry cabt bronchoscopy cabt radiography cabt metalloproteinases cabt interleukin 8 cabt inhalation cabt ELISA cabt Interleukin 8 (DE-588)4286437-9 gnd Lungenkrankheit (DE-588)4036660-1 gnd Metalloproteinasen (DE-588)4284137-9 gnd Broncho-alveoläre Lavage (DE-588)4214640-9 gnd Pferdekrankheit (DE-588)4045515-4 gnd |
| topic_facet | Horses chronic obstructive pulmonary disease lungs trachea scoring bronchoalveolar lavage secretions respirometry bronchoscopy radiography metalloproteinases interleukin 8 inhalation ELISA Interleukin 8 Lungenkrankheit Metalloproteinasen Broncho-alveoläre Lavage Pferdekrankheit Hochschulschrift |
| url | http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000098204 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027720745&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT shetytareksoliman determinationofmatrixmetalloproteinasesandinterleukin8inbronchoalveolarlavagefluidinhorseswithdifferentlungdiseases AT shetytareksoliman bestimmungvonmetalloproteinasenundinterleukin8inbronchoalveolarenlavageflussigkeitbeipferdenmitverschiedenenpneumopathien |