Biophysics of DNA:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cambridge
Cambridge Univ. Press
2015
|
| Ausgabe: | 1. publ. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | VI, 254 S. Ill., graph. Darst. |
| ISBN: | 9781107034938 |
Internformat
MARC
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| 245 | 1 | 0 | |a Biophysics of DNA |c Alexander Vologodskii |
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| 300 | |a VI, 254 S. |b Ill., graph. Darst. | ||
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Datensatz im Suchindex
| _version_ | 1804152847863906304 |
|---|---|
| adam_text | Contents
Preface
page vii
DNA
structures
1
1.1 Chemical
structure and conformational flexibility of single-stranded
DNA 1
1.2
Double helices
4
1.3
Triple helices
8
1.4
G-quadruplexes
11
1.5
Stacking in single-stranded
DNA 13
1.6
Structure of mismatches and bulge loops
14
1.7
Experimental and theoretical studies of
DNA
structure
15
Conformational transitions
23
2.1
Theoretical analysis of conformational transitions in
DNA 23
2.2 DNA
melting
27
2.3
B
-А
transition
49
2.4
B-Z transition
51
2.5
Thermal fluctuations of
DNA
secondary structure
55
2.6
Correlations between the states of base pairs
58
2.7
Binding small Hgands with
DNA 61
Equilibrium large-scale conformatJonal properties of
DNA 72
3.1 DNA
and basic concepts of polymer statistical physics
72
3.2
Conformational parameters of
DNA 83
3.3 DNA
condensation
101
3.4
Computational and experimental methods specific for
DNA
studies
103
3.5 DNA
nanotechnology
123
DNA
dynamics
137
4.1
Large-scale conformational dynamics
137
4.2
Kinetics of
DNA
melting and renaturation
147
4.3
Kinetics of
B
-А
and B-Z conformational transitions
151
4.4
Dynamics of
DNA
junctions
152
vi
Contents
4.5
Gel electrophoresis
of
DNA 155
4.6
Moving
DNA
molecules through nanop ore
s
158
DMA-protein interaction
165
5.1
Nonspecific
DNA—
protein binding
165
5.2
Selectivity of nucleosome core binding with
DNA 168
5.3
Search for specific
DNA
sites by proteins
170
5.4
Recognition of specific
DNA
sites by proteins
172
5.5
Formation of protein-bndged
DNA
loops
175
5.6
DNAhelicases
178
Circular
DNA 184
6.1
Linking number of complementary strands and
DNA
supercoilmg
184
6.2
Twist and wnthe
187
6.3
Experimental studies of
DNA
supercoilmg
1.92
6.4
Conformations of supercoiled
DNA 202
6.5
Formation of alternative structures in supercoiled
DNA 206
6.6
How
supercoiling
can affect
DNA
biological functions
217
6.7
Knots and links in
DNA
molecules
220
6.
S
DNA
supercoilmg inside living cells
226
6.9 DNA topoisomerases 232
Index
251
Color plates are between pages
152
and
153.
Surveying the last
60
years of research, this book describes the physical
properties of
DNA
in the context of its biological functioning. It is designed
to enable both students and researchers of molecular biology, biochemistry
and physics to better understand the biophysics of
DNA,
addressing key
questions and facilitating further research.
The chapters integrate theoretical and experimental approaches,
emphasizing throughout the importance of a quantitative knowledge of
physical properties in building and analyzing models of
DNA
functioning.
For example, the book shows how the relationship between
DNA
mechanical properties and the sequence specificity of DNA-protein
binding can be analyzed quantitatively by using our current knowledge
of the physical and
structura]
properties of
DNA.
Theoretical models and
experimental methods in the field are critically considered to enable the
reader to engage effectively with the current scientific literature on the
physical properties of
DNA.
Alexander Vologodskii began his research career as a theorist, pioneering
theoretical studies of knots and links in circular
DNA
and designing
statistical mechanical models and computational methods to predict the
appearance of alternative structures in supercoiled
DNA.
He later ran a
research laboratory at New York University, where he made important
contributions to topics related to
DNA
topology and supercoiling,
DNA
topoisomerases and the physics of
DNA
bending.
|
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| indexdate | 2024-07-10T01:17:13Z |
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| isbn | 9781107034938 |
| language | English |
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| title | Biophysics of DNA |
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| title_full | Biophysics of DNA Alexander Vologodskii |
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