Molecular imaging of inflammation in atherosclerosis: Preclinical study in Apolipoprotein E-Deficient mice and preliminary evaluation in human using positron emission tomography
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| Main Author: | |
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| Format: | Thesis Book |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | Volltext Inhaltsverzeichnis |
| Item Description: | Zsfassung in dt. und engl. Sprache |
| Physical Description: | 105 Bl. Ill., graph. Darst. |
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| 245 | 1 | 0 | |a Molecular imaging of inflammation in atherosclerosis |b Preclinical study in Apolipoprotein E-Deficient mice and preliminary evaluation in human using positron emission tomography |c von Xiang Li |
| 246 | 1 | 3 | |a Molekulare Bildgebung inflammatorischer Prozesse bei Atherosklerose: Präklinische Studie in Apolipoprotein-E Knockout-Mäusen sowie erste Evaluation humaner PET-Studien |
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Record in the Search Index
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|---|---|
| adam_text | MOLECULAR IMAGING OF INFLAMMATION IN ATHEROSCLEROSIS: PRECLINICAL
STUDY IN APOLIPOPROTEIN E-DEFICIENT MICE AND PRELIMINARY EVALUATION
IN HUMAN USING POSITRON EMISSION TOMOGRAPHY
MOLEKULARE BILDGEBUNG INFLAMMATORISCHER PROZESSE BEI
ATHEROSKLEROSE: PRAKLINISCHE STUDIE IN APOLIPOPROTEIN-E KNOCKOUT
MAUSEN SOWIE ERSTE EVALUATION HUMANER PET-STUDIEN.
DOCTORAL THESIS FOR A DOCTORAL DEGREE
AT THE GRADUATE SCHOOL OF LIFE SCIENCES,
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG,
SECTION BIOMEDICINE
SUBMITTED BY
XIANG LI
FROM CHINA
WURZBURG, 2014
HTTP://D-NB.INFO/1065618255
I 7
ORY FEATURES OF ATHEROSCLEROSIS 7
V OF EARLY ENDOTHELIAL INFLAMMATORY PROCESSES 7
MS OF LEUKOCYTE 7
HON IN ATHEROSCLEROSIS PROGRESSION
AND COMPLICATION 8
TION ASSOCIATES PLAQUE DISRUPTION 9
TRESS IN PLAQUE FORMATION 10
PAGING IN CARDIOVASCULAR RESEARCH 12
JSONANCE IMAGING
(MRI] 14
GING 14
IMAGING 15
IGING 15
17
EPET 18
ELECTIN 19
ND AIM OF THE PHO-THESIS 20
ES 21
;A-
DOTATATE
AND
68
GA-FUC0IDAN ON APOLIPROTEIN
E
KNOCKOUT
MICE WITH
21
ND METHODS 21
* AND PREPARATION 21
21
NALYSISFOR THE EXPRESSION OFSSTR-2 AND P-SELECTIN 22
IMMUNOCHEMISTRY 22
LYSIS. 24
RUDY I: MACROPHAGE CHARACTERIZATION OF ATHEROSCLEROSIS:
68
GA-DOTATATE
IN IN MICE
25
RUGA-DOTATATE 25
R
MONOCYTES/MACROPHAGES 25
IFSSTR-2 EXPRESSION ON LEUKOCYTES, ENDOTHELIAL CELLS AND PLATELETS. 25
)HIC ANALYSIS 26
TABLE OF CONTENTS
4.1.2 ANIMAL STUDY II: TARGETING P-SELECTIN BY GALLIUM-68 LABELED
FUCOIDAN PET FOR NON
INVASIVE CHARACTERIZATION OF VULNERABLE PLAQUES: CORRELATION WITH IN
VIVO
17.6T MRI
27
PREPARATION OF ^GA-FUCOIDAN 27
CELL UPTAKE OF
68
GA-FUCOIDAN 27
CELL VIABILITY 28
ANIMAL STUDIES
28
BIODISTRIBUTION OF^GA-FUCOIDAN INAPOE-/- MICE 28
MAGNETIC RESONANCE IMAGING 29
PET IMAGING 29
EX VIVO AUTORADIGRAPHIC STUDY 30
4.2 RESULTS 31
4.2.1 ANIMAL STUDY
I: MACROPHAGE CHARACTERIZATION OF ATHEROSCLEROSIS:
68
GA-DOTATATE
EX-VIVO DETECTION IN
MICE 31
FLOW CYTOMETRY OF DIGESTED AORTAS & ENDOTHELIAL CELLS 31
SSTR-2 EXPRESSION ON MACROPHAGES 32
CHARACTERIZATION OF ATHEROSCLEROSIS 32
4.2.2
ANIMAL STUDY II:
TARGETING
P
-SELECTIN BY GALLIUM
-68
LABELED FUCOIDAN
PET
FOR
NON
INVASIVE CHARACTERIZATION OF VULNERABLE PLAQUES: CORRELATION WITH IN
VIVO 17.6T
MRI 36
SYNTHESIS OF ^GA-FUCOIDAN, IN-VITRO STABILITY, AND PHARMACOKINETICS
ANALYSIS 36
LPS ENHANCED
68
GA-FUCOIDAN CELLULAR UPTAKES & CELL VIABILITY ASSESSMENT. 37
EX VIVO DETECTION OFP-SELECTIN EXPRESSION ON ATHEROSCLEROTIC PLAQUES 38
IN VIVO DETECTION OFP-SELECTIN EXPRESSION 42
IN VIVO AND EX VIVO BLOCKING STUDIES 44
4.3 DISCUSSION 47
4.3.1
ANIMAL STUDY I: MACROPHAGE CHARACTERIZATION OF ATHEROSCLEROSIS:
68
GA-DOTATATE
EX-VIVO DETECTION IN MICE
47
4.3.2
ANIMAL STUDY IIITARGETING P-SELECTIN EXPRESSION IN VULNERABLE PLAQUES BY
GALLIUM-
68 LABELED FUCOIDAN PET: CORRELATION WITH IN VIVO 17.6T
MRI
49
4.4 CONCLUSION 52
5. PATIENT STUDY 53
68
GA-DOTATATE PET/CT
FOR THE DETECTION
OF INFLAMMATION
OF LARGE
ARTERIES: CORRELATION WITH
18
F-FDG,
CALCIUM
BURDEN
AND RISK
FACTORS
53
5.1 MATERIALS AND METHODS 53
PATIENTS S3
PET/CT IMAGING 54
TABLE OF CONTENTS
IMAGE ANALYSIS
55
STATISTICAL METHODS 56
5.2 RESULTS 57
PATIENT POPULATION
57
PET/CT IMAGING
59
SUB-GROUP ANALYSIS
65
CORRELATION WITH RISK FACTORS. 68
5.3 DISCUSSION 69
5.4 CONCLUSION 71
6. ADDITIONAL STUDY 72
ENDOTHELIAL CD81 IS A BIOMARKER OF EARLY ATHEROSCLEROTIC PLAQUES FOR
MOLECULAR
IMAGING_TARGETED SUPERPARAMAGNETIC IRON OXIDE
(SPIO)
STUDY
72
6.1 MATERIALS AND METHODS 72
CELL CULTURE AND IN VITRO INDUCTION OFCD81 PROTEINS 72
WESTERN BLOT ANALYSIS FOR THE EXPRESSION OFCD81 PROTEINS. 73
LABELING OF TARGETED SPIO PARTICLES 73
ANIMAL. 73
CELL CULTURE AND STIMULATION OFPMS 74
IN VITRO CELLULAR AFFINITY ASSAY. 74
IN VITRO VASCULAR AFFINITY ASSAY. 74
PRUSSIAN BLUE STAINING
75
IMMUNOHISTOCHEMISTRY
75
6.2 RESULTS 76
CD81 EXPRESSION DETECTION 76
EXAMINATION OFCD81-TARGETED SPIO BINDING AFFINITY TO BEND.3 CELLS.
77
IN VITRO ASSESSMENT OF CD81 TARGETED SPIO TO MURINE AORTA 78
6.3 DISCUSSION 80
6.4 CONCLUSION 82
7. CONCLUSION 83
8. REFERENCE 84
9 APPENDIX 99
9.1 ABBREVIATION 99
9.2 ACKNOWLEDGEMENT 100
TABLE OF CONTENTS
9.3 AFFIDAVIT 101
9.4 PUBLICATIONS LIST 102
9.5 CURRICULUM VITAE 103
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| spelling | Li, Xiang 1984- Verfasser (DE-588)1062976584 aut Molecular imaging of inflammation in atherosclerosis Preclinical study in Apolipoprotein E-Deficient mice and preliminary evaluation in human using positron emission tomography von Xiang Li Molekulare Bildgebung inflammatorischer Prozesse bei Atherosklerose: Präklinische Studie in Apolipoprotein-E Knockout-Mäusen sowie erste Evaluation humaner PET-Studien 2014 105 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Zsfassung in dt. und engl. Sprache Würzburg, Univ., Diss., 2014 Positronen-Emissions-Tomografie (DE-588)4129799-4 gnd rswk-swf Entzündung (DE-588)4014975-4 gnd rswk-swf Arteriosklerose (DE-588)4068866-5 gnd rswk-swf Makrophage (DE-588)4193041-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Arteriosklerose (DE-588)4068866-5 s Entzündung (DE-588)4014975-4 s Makrophage (DE-588)4193041-1 s Positronen-Emissions-Tomografie (DE-588)4129799-4 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:20-opus-104622 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-104622 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027657045&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Li, Xiang 1984- Molecular imaging of inflammation in atherosclerosis Preclinical study in Apolipoprotein E-Deficient mice and preliminary evaluation in human using positron emission tomography Positronen-Emissions-Tomografie (DE-588)4129799-4 gnd Entzündung (DE-588)4014975-4 gnd Arteriosklerose (DE-588)4068866-5 gnd Makrophage (DE-588)4193041-1 gnd |
| subject_GND | (DE-588)4129799-4 (DE-588)4014975-4 (DE-588)4068866-5 (DE-588)4193041-1 (DE-588)4113937-9 |
| title | Molecular imaging of inflammation in atherosclerosis Preclinical study in Apolipoprotein E-Deficient mice and preliminary evaluation in human using positron emission tomography |
| title_alt | Molekulare Bildgebung inflammatorischer Prozesse bei Atherosklerose: Präklinische Studie in Apolipoprotein-E Knockout-Mäusen sowie erste Evaluation humaner PET-Studien |
| title_auth | Molecular imaging of inflammation in atherosclerosis Preclinical study in Apolipoprotein E-Deficient mice and preliminary evaluation in human using positron emission tomography |
| title_exact_search | Molecular imaging of inflammation in atherosclerosis Preclinical study in Apolipoprotein E-Deficient mice and preliminary evaluation in human using positron emission tomography |
| title_full | Molecular imaging of inflammation in atherosclerosis Preclinical study in Apolipoprotein E-Deficient mice and preliminary evaluation in human using positron emission tomography von Xiang Li |
| title_fullStr | Molecular imaging of inflammation in atherosclerosis Preclinical study in Apolipoprotein E-Deficient mice and preliminary evaluation in human using positron emission tomography von Xiang Li |
| title_full_unstemmed | Molecular imaging of inflammation in atherosclerosis Preclinical study in Apolipoprotein E-Deficient mice and preliminary evaluation in human using positron emission tomography von Xiang Li |
| title_short | Molecular imaging of inflammation in atherosclerosis |
| title_sort | molecular imaging of inflammation in atherosclerosis preclinical study in apolipoprotein e deficient mice and preliminary evaluation in human using positron emission tomography |
| title_sub | Preclinical study in Apolipoprotein E-Deficient mice and preliminary evaluation in human using positron emission tomography |
| topic | Positronen-Emissions-Tomografie (DE-588)4129799-4 gnd Entzündung (DE-588)4014975-4 gnd Arteriosklerose (DE-588)4068866-5 gnd Makrophage (DE-588)4193041-1 gnd |
| topic_facet | Positronen-Emissions-Tomografie Entzündung Arteriosklerose Makrophage Hochschulschrift |
| url | https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-104622 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027657045&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT lixiang molecularimagingofinflammationinatherosclerosispreclinicalstudyinapolipoproteinedeficientmiceandpreliminaryevaluationinhumanusingpositronemissiontomography AT lixiang molekularebildgebunginflammatorischerprozessebeiatherosklerosepraklinischestudieinapolipoproteineknockoutmausensowieersteevaluationhumanerpetstudien |