Verfügbarkeit: Urea Transporters

Urea Transporters:

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Bibliographische Detailangaben
Format:	Elektronisch E-Book
Sprache:	English
Veröffentlicht:	Dordrecht [u.a.] Springer 2014
Schriftenreihe:	Subcellular Biochemistry 73
Schlagworte:	Biowissenschaften Life sciences Medical genetics Human physiology Toxicology Biochemistry Cell membranes Harnstoff Carrier-Proteine Aufsatzsammlung
Online-Zugang:	TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract
Beschreibung:	1 Online-Ressource
ISBN:	9789401793438
DOI:	10.1007/978-94-017-9343-8

Internformat

MARC


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Datensatz im Suchindex

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adam_text	UREA TRANSPORTERS / : 2014 TABLE OF CONTENTS / INHALTSVERZEICHNIS OVERVIEW AND HISTORICAL PERSPECTIVE UREA MATHEMATICAL MODELING OF UREATRANSPORT IN THEKIDNEY GENES AND PROTEINS OF UREA TRANSPORTERS STRUCTURE OF UREA TRANSPORTERS EXPRESSION OF UREA TRANSPORTERSANDTHEIR REGULATION BIOCHEMICAL PROPERTIES OF UREA TRANSPORTERS TRANSPORT CHARACTERISTICS OF UREA TRANSPORTER-B UREA TRANSPORTER KNOCKOUT MICE AND THEIR RENAL PHENOTYPES.-EXTRARENAL PHENOTYPES OF UT-B KNOCKOUT MOUSE SMALL MOLECULE INHIBITORS OF UREA TRANSPORTERS CLINICAL ASPECT OF UREA TRANSPORTERS ACTIVE UREA TRANSPORT IN LOWER VERTEBRATES AND MAMMALS UREA TRANSPORT MEDIATED BY AQUAPORIN WATER CHANNEL PROTEINS DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT. UREA TRANSPORTERS / : 2014 ABSTRACT / INHALTSTEXT THE MECHANISMS AND PHYSIOLOGICAL FUNCTIONS OF UREA TRANSPORT ACROSS BIOLOGICAL MEMBRANES ARE SUBJECTS OF LONG-STANDING INTEREST. RECENT ADVANCES IN THE MOLECULAR BIOLOGY AND PHYSIOLOGY OF UREA TRANSPORT HAVE YIELDED NEW INSIGHTS INTO HOW AND WHY UREA MOVES ACROSS CELL MEMBRANES. IN THE LAST TWO DECADES, SEVEN FACILITATED UREA TRANSPORTERS (UT-A1-6 AND UT-B) HAVE BEEN CLONED, AND THEIR GENE ORGANIZATION, PROTEIN CRYSTAL STRUCTURE, EXPRESSION LOCALIZATION AND PHYSIOLOGICAL FUNCTIONS IN THE TISSUES HAVE BEEN DESCRIBED. IN RECENT YEARS, THE STUDIES IN UREA TRANSPORTER KNOCKOUT MOUSE MODELS SUGGEST THAT UREA TRANSPORTERS MAY BE USEFUL TARGETS FOR DRUG DISCOVERY OF SELECTIVE INHIBITORS. THE MODULATION OF UREA TRANSPORT ACTIVITY BY PHARMACOLOGICAL AGENTS MAY PROVIDE NOVEL TREATMENTS FOR HYPERTENSION, CONGESTIVE HEART FAILURE AND OTHER FLUID-RETAINING STATES.HOWEVER, ALTHOUGH UREA REPRESENTS ABOUT 40% OF ALL URINARY SOLUTES IN NORMAL HUMAN URINE, THE HANDLING OF THIS SOLUTE IN THE TISSUES HAS BEEN LARGELY NEGLECTED IN THE PAST, AND FEW CLINICAL OR EXPERIMENTAL STUDIES NOW REPORT DATA ABOUT UREA. MOST RECENT PHYSIOLOGICAL TEXTBOOKS INCLUDE CHAPTERS ON WATER AND ELECTROLYTE PHYSIOLOGY BUT NOT A SINGLE CHAPTER ON UREA. OUR AIM IN WRITING THIS BOOK IS TO STIMULATE FURTHER RESEARCH IN NEW DIRECTIONS BY PROVIDING NOVEL AND PROVOCATIVE INSIGHTS INTO FURTHER MECHANISMS AND THE PHYSIOLOGICAL SIGNIFICANCE OF UREA METABOLISM AND TRANSPORT IN MAMMALS. THE BOOK PROVIDES A STATE-OF-THE-ART REPORT ON THE LATEST FINDINGS ON UREA TRANSPORT AND WHERE THE FIELD IS GOING. ALTHOUGH SOME OLDER WORK IS CITED, THE MAIN FOCUS IS ON ADVANCES MADE OVER THE PAST 20 YEARS WITH REGARD TO THE BIOPHYSICS, GENETICS, PROTEIN STRUCTURE, MOLECULAR BIOLOGY, PHYSIOLOGY, PATHOPHYSIOLOGY AND PHARMACOLOGY OF UREA TRANSPORT IN MAMMALIAN CELL MEMBRANES.THESE ASPECTS ARE ESPECIALLY VALID, AS ADVANCES IN OUR UNDERSTANDING OF UREA TRANSPORTING MECHANISMS AND PHYSIOLOGY PROMISE TO YIELD NEW INSIGHTS INTO BIOLOGY AND MEDICINE DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
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spelling	Urea Transporters Baoxue Yang ; Jeff M. Sands, ed. Dordrecht [u.a.] Springer 2014 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Subcellular Biochemistry 73 Biowissenschaften Life sciences Medical genetics Human physiology Toxicology Biochemistry Cell membranes Harnstoff (DE-588)4159153-7 gnd rswk-swf Carrier-Proteine (DE-588)4213127-3 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Harnstoff (DE-588)4159153-7 s Carrier-Proteine (DE-588)4213127-3 s 2\p DE-604 Yang, Baoxue Sonstige oth Sands, Jeff M. Sonstige oth Erscheint auch als Druckausgabe 978-94-017-9342-1 Subcellular Biochemistry 73 (DE-604)BV041437497 73 https://doi.org/10.1007/978-94-017-9343-8 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027627372&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027627372&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk
spellingShingle	Urea Transporters Subcellular Biochemistry Biowissenschaften Life sciences Medical genetics Human physiology Toxicology Biochemistry Cell membranes Harnstoff (DE-588)4159153-7 gnd Carrier-Proteine (DE-588)4213127-3 gnd
subject_GND	(DE-588)4159153-7 (DE-588)4213127-3 (DE-588)4143413-4
title	Urea Transporters
title_auth	Urea Transporters
title_exact_search	Urea Transporters
title_full	Urea Transporters Baoxue Yang ; Jeff M. Sands, ed.
title_fullStr	Urea Transporters Baoxue Yang ; Jeff M. Sands, ed.
title_full_unstemmed	Urea Transporters Baoxue Yang ; Jeff M. Sands, ed.
title_short	Urea Transporters
title_sort	urea transporters
topic	Biowissenschaften Life sciences Medical genetics Human physiology Toxicology Biochemistry Cell membranes Harnstoff (DE-588)4159153-7 gnd Carrier-Proteine (DE-588)4213127-3 gnd
topic_facet	Biowissenschaften Life sciences Medical genetics Human physiology Toxicology Biochemistry Cell membranes Harnstoff Carrier-Proteine Aufsatzsammlung
url	https://doi.org/10.1007/978-94-017-9343-8 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027627372&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027627372&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA
volume_link	(DE-604)BV041437497
work_keys_str_mv	AT yangbaoxue ureatransporters AT sandsjeffm ureatransporters

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