sec-Butanol: CAS: 78-92-2
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| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Brussels
ECETOC
2003
|
| Series: | JACC report / ECETOC
43 |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 76 S. graph. Darst. |
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Record in the Search Index
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| adam_text | ¦M^H^H^^Hi sec-Butanol (CAS No. 78-92-2)
sec-Butanol (CAS No. 78-92-2)
CONTENTS
EXECUTIVE SUMMARY 1
THE ECETOC SCHEME FOR THE JOINT ASSESSMENT OF COMMODITY CHEMICALS 2
1. SUMMARY AND CONCLUSIONS 3
2. IDENTITY, PHYSICAL AND CHEMICAL PROPERTIES, ANALYTICAL METHODS 5
2.1 Identity 5
2.2 EU classification and labelling 6
2.3 Physical and chemical properties 6
2.4 Conversion factors 8
2.5 Analytical methods 8
2.5.1 Workplace air 8
2.5.2 Environmental media 9
2.5.3 In Biological media 9
3. PRODUCTION, STORAGE, TRANSPORT AND USE 10
3.1 Production 10
3.2 Storage 10
3.3 Transport 10
3.4 Use 10
4. ENVIRONMENTAL DISTRIBUTION AND TRANSFORMATION 11
4.1 Emissions 11
4.1.1 Natural sources 11
4.1.2 Emissions during production and use 11
4.1.3 Other sources 12
4.2 Environmental distribution 12
4.3 Environmental fate and biotransformation 14
4.3.1 Atmospheric fate 14
4.3.2 Aquatic fate 15
4.3.3 Terrestrial fate 15
4.3.4 Biodegradation 15
4.3.5 Bioaccumulation 17
4.3.6 Summary and evaluation 17
5. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE 18
5.1 Environmental levels 18
5.1.1 In air 18
5.2.2 In water 20
5.1.3 In soil 20
5.2 Human exposure levels and hygiene standards 20
5.2.3 Non-occupational exposure 20
5.2.2 Occupational exposure 22
5.2.3 Hygiene standards 22
5.2.4 Other standards 23
5.2.5 Summary 23
No. 43IHH
¦¦^¦^¦¦^^¦1 sec-Butanol (CAS No. 78-92-2)
6. EFFEaS ON ORGANISMS IN THE ENVIRONMENT 24
6.1 Micro-organisms 24
6.2 Aquatic organisms 24
6.3 Terrestrial organisms 26
6.4 Summary and evaluation 26
7. KINETICS AND METABOLISM 27
7.1 Absorption, metabolism and excretion in vivo 27
7.1.1 Animals 27
7.2.2 Humans 29
7.2 In vitro Metabolism 30
7.3 Evaluation 30
8. EFFECTS ON EXPERIMENTAL ANIMALS AND IN VITRO TEST SYSTEMS 31
8.1 Acute toxicity 31
8.1.1 Oral 31
8.1.2 Dermal 31
8.1.3 Inhalation 32
8.2 Skin, respiratory and eye irritation, sensitisation 33
8.2.1 Skin irritation 33
8.2.2 Eye irritation 33
8.2.3 Respiratory tract irritation 34
8.2.4 Sensitisation 34
8.2.5 Evaluation 34
8.3 Repeated dose toxicity 34
8.3.1 Oral 34
8.3.2 Dermal 35
8.3.3 Inhalation 35
8.3.4 Evaluation 35
8.4 Genotoxicity 35
8.4.1 In vitro 35
8.4.2 In vivo 36
8.5 Chronic toxicity and carcinogenicity 36
8.6 Reproduction, embryotoxicity, and teratogenicity 37
8.6.1 Reproductive toxicity 37
8.6.2 Developmental toxicity 37
8.6.3 Evaluation 38
8.7 Neurotoxicity 38
8.8 Other effects 39
9. OTHER CONSIDERATIONS AND SUPPORTIVE DATA ON METHYL ETHYL KETONE 40
9.1 Subchronic toxicity 40
9.2 Genotoxicity 41
9.2.1 In vitro 41
9.2.2 In vivo 41
9.2.3 Conclusion 41
9.3 Reproductive and developmental toxicity 42
9.3.1 Reproductive toxicity 42
9.3.2 Developmental toxicity 42
9.3.3 Evaluation 43
^^^ ECETOCJAG
MH^^^^^^^H sec-Butanol (CAS No. 78-92-2)
9.4 Neurotoxicity 44
9.4.1 Potentiation ofhexacarbon neurotoxicity 44
9.5 Potentiation of haloalkane toxicity 45
10. EFFECTS ON HUMANS 46
10.1 Acute and subchronic toxicity 46
10.2 Irritation and sensitisation 46
11. FIRST AID AND SAFE HANDLING ADVICE 47
11.1 First aid and medical treatment 47
11.1.1 Skin and eye injuries 47
11.1.2 Inhalation 47
11.1.3 Ingestion 47
11.2 Safe handling 47
11.2.1 Safety at work 47
11.2.2 Storage safety 47
11.2.3 Fire safety and extinguishers 48
11.2.4 Protection against fire and explosion 48
11.3 Management of spillage and waste 48
APPENDIX A: ABBREVIATIONS 49
APPENDIX B: CRITERIA FOR RELIABILITY CATEGORIES 50
13. BIBLIOGRAPHY 51
13.1 Databases consulted 51
13.2 References quoted 51
13.3 References not quoted 66
MEMBERS OF THE TASK FORCE 70
MEMBERS OF THE SCIENTIFIC COMMITTEE 71
: No. 43 ^mtm
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| illustrated | Illustrated |
| indexdate | 2024-07-10T01:14:49Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027624328 |
| oclc_num | 897086134 |
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| owner | DE-M49 DE-BY-TUM |
| owner_facet | DE-M49 DE-BY-TUM |
| physical | 76 S. graph. Darst. |
| publishDate | 2003 |
| publishDateSearch | 2003 |
| publishDateSort | 2003 |
| publisher | ECETOC |
| record_format | marc |
| series2 | JACC report / ECETOC |
| spelling | sec-Butanol CAS: 78-92-2 Brussels ECETOC 2003 76 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier JACC report / ECETOC 43 ECETOC JACC report 43 (DE-604)BV021664692 43 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027624328&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | sec-Butanol CAS: 78-92-2 |
| title | sec-Butanol CAS: 78-92-2 |
| title_auth | sec-Butanol CAS: 78-92-2 |
| title_exact_search | sec-Butanol CAS: 78-92-2 |
| title_full | sec-Butanol CAS: 78-92-2 |
| title_fullStr | sec-Butanol CAS: 78-92-2 |
| title_full_unstemmed | sec-Butanol CAS: 78-92-2 |
| title_short | sec-Butanol |
| title_sort | sec butanol cas 78 92 2 |
| title_sub | CAS: 78-92-2 |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027624328&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV021664692 |