n-Butanol: CAS: 71-6-3
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Brussels
ECETOC
2003
|
| Schriftenreihe: | JACC report / ECETOC
41 |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 116 S. graph. Darst. |
Internformat
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Datensatz im Suchindex
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| adam_text | f^^mm^m^^^ n-Butanol (CAS No. 71 -36-3)
n-Butanol (CAS No. 71-36-3)
CONTENTS
EXECUTIVE SUMMARY 1
THE ECETOC SCHEME FOR THE JOINT ASSESSMENT OF COMMODITY CHEMICALS 2
1. SUMMARY AND CONCLUSIONS 3
2. IDENTTITY, PHYSICAL AND CHEMICAL PROPERTIES, ANALYTICAL METHODS 5
2.1 Identify 5
2.2 EU classification and labelling 5
2.3 Physical and chemical properties 6
2.4 Conversion factors 8
2.5 Analytical methods 9
2.5.1 In workplace air 9
2.5.2 In environmental media 9
2.5.3 In biological media 9
3. PRODUCTION, STORAGE, TRANSPORT AND USE 11
3.1 Production 11
3.2 Storage 11
3.3 Transport 11
3.4 Use 12
4. ENVIRONMENTAL DISTRIBUTION AND TRANSFORMATION 13
4.1 Emissions 13
4.1.1 Natural sources 13
4.1.2 Emissions during production and use 13
4.2 Environmental distribution 14
4.3 Environmental fate and biotransformation 15
4.3.1 Atmospheric fate 15
4.3.2 Aquatic fate 15
4.3.3 Terrestrial fate 15
4.3.4 Biodegradation 15
4.3.5 Bioaccumulation 16
4.3.6 Summary and evaluation 16
5. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE 17
5.1 Environmental levels 17
5.1.1 Air 17
5.1.2 Water 17
5.2 Human exposure levels and hygiene standards 18
5.2.1 Non-occupational exposure 18
5.2.2 Occupational exposure 18
5.2.3 Hygiene standards 20
No. 41 ^^H
^^¦¦l^^^^^H n-Butanol (CAS No. 71 -36-3)
5.2.4 RfC, RfD and IDLH values 20
5.2.5 Summary 21
6. EFFECTS ON ORGANISMS IN THE ENVIRONMENT 22
6.1 Micro-organisms 22
6.2 Aquatic organisms 23
6.3 Terrestrial organisms 24
6.4 Summary and evaluation 24
7. KINETICS AND METABOLISM 25
7.1 Absorption and excretion 25
7.1.1 Humans 25
7.1.2 Animals 26
7.2 Distribution and metabolism 32
7.2.1 In vivo data 32
7.2.2 /n w fro data 33
7.3 Evaluation 35
8. EFFECTS ON EXPERIMENTAL ANIMALS AND IN VITRO TEST SYSTEMS 37
8.1 Acute toxicity 37
8.1.1 Oral 37
8.1.2 Dermal 38
8.1.3 nhalation 38
8.2.4 Other routes 39
8.1.5 Summary 39
8.2 Skin, respiratory tract and eye irritation, sensitisation 39
8.2.1 Skin irritation 39
8.2.2 Eye irritation 40
8.2.3 Respiratory tract irritation 42
8.2.4 Sensitisation 42
8.2.5 Evaluation 42
8.3 Repeated dose toxicity 43
8.3.1 Oral 43
8.3.2 Dermal 44
8.3.3 Inhalation 44
8.3.4 Summary and evaluation 45
8.4 Genotoxicity 46
8.4.1 hi vitro studies 46
8.4.2 In vivo studies 47
8.4.3 Evaluation 48
8.5 Chronic toxicity and carcinogenicity 48
8.6 Reproductive toxicity 48
8.6.2 Developmental toxicity 48
8.6.2 Fertility and effects on reproductive organs 51
8.6.3 Summary and evaluation 51
8.7 Neurotoxicity 52
¦ 41 MHB ECETOC JACC N
^^¦MHMi^^H n-Butanol (CAS No. 71 -36-3)
9. OTHER CONSIDERATIONS AND SUPPORTIVE DATA ON n-BUTYL ACETATE 53
9.1 Metabolism 53
9.1.1 Formation ofnBA 53
9.2 Repeated dose toxicity 54
9.3 Reproductive toxicity 56
9.3.1 Developmental toxicity 56
9.3.2 Fertility and effects on reproductive organs 57
9.4 Neurotoxicity 58
10. EFFECTS ON HUMANS 61
10.1 Acute and subchronic toxicity 61
10.2.2 Acute toxicity 61
20.1.2 Short- and long-term exposure 61
20.1.3 Evaluation 63
10.2 Eye and respiratory irritation 63
20.2.1 Epidemiological studies 63
10.2.2 Studies with volunteers I controlled clinical studies 64
10.2.3 Evaluation 65
11. HAZARD ASSESSMENT 66
12. FIRST AID AND SAFE HANDLING ADVICE 70
12.1 First aid and medical treatment 70
12.2.2 Skin and eye injuries 70
12.1.2 Inhalation 70
22.2.3 Ingestion 70
12.2 Safe handling 70
12.2.1 Safety at work 70
12.2.2 Storage safety 70
22.2.3 Fire safety and extinguishers 71
22.2.4 Protection against fire and explosion 71
12.3 Management of spillage and waste 71
13. BIBLIOGRAPHY 72
13.1 Databases consulted 72
13.2 References quoted 72
13.3 References not quoted 90
APPENDIX A: ABBREVIATIONS 108
APPENDIX B: CRITERIA FOR RELIABILITY CATEGORIES 109
MEMBERS OF THE TASK FORCE 110
MEMBERS OF THE SCIENTIFIC COMMITTEE 111
lo. 41 HIM
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| illustrated | Illustrated |
| indexdate | 2024-07-10T01:14:49Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027624312 |
| oclc_num | 897078510 |
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| owner | DE-M49 DE-BY-TUM |
| owner_facet | DE-M49 DE-BY-TUM |
| physical | 116 S. graph. Darst. |
| publishDate | 2003 |
| publishDateSearch | 2003 |
| publishDateSort | 2003 |
| publisher | ECETOC |
| record_format | marc |
| series2 | JACC report / ECETOC |
| spelling | n-Butanol CAS: 71-6-3 Brussels ECETOC 2003 116 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier JACC report / ECETOC 41 ECETOC JACC report 41 (DE-604)BV021664692 41 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027624312&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | n-Butanol CAS: 71-6-3 |
| title | n-Butanol CAS: 71-6-3 |
| title_auth | n-Butanol CAS: 71-6-3 |
| title_exact_search | n-Butanol CAS: 71-6-3 |
| title_full | n-Butanol CAS: 71-6-3 |
| title_fullStr | n-Butanol CAS: 71-6-3 |
| title_full_unstemmed | n-Butanol CAS: 71-6-3 |
| title_short | n-Butanol |
| title_sort | n butanol cas 71 6 3 |
| title_sub | CAS: 71-6-3 |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027624312&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV021664692 |