Novel antimicrobial agents and strategies:
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| Format: | Book |
| Language: | English |
| Published: |
Weinheim
Wiley-VCH
2015
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| Subjects: | |
| Online Access: | Inhaltstext Inhaltsverzeichnis |
| Physical Description: | XXII, 414 S. Ill., graph. Darst. |
| ISBN: | 3527336389 9783527336388 9783527676132 |
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| 245 | 1 | 0 | |a Novel antimicrobial agents and strategies |c ed. by David A. Phoenix ... |
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| _version_ | 1809770631370113024 |
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CONTENTS
LIST OF CONTRIBUTORS XI
PREFACE XVII
1 THE PROBLEM OF MICROBIAL DRUG RESISTANCE 1
IZA RADECKA,
CLAIRE MARTIN,
AND DAVID HILL
1.1 INTRODUCTION 1
1.2 HISTORY OF THE ORIGINS, DEVELOPMENT, AND USE OF CONVENTIONAL
ANTIBIOTICS 1
1.3 PROBLEMS OF ANTIBIOTIC RESISTANCE 4
1.4 MULTIPLE DRUG-RESISTANT (MDR), EXTENSIVELY DRUG-RESISTANT (XDR),
AND PAN-DRUG-RESISTANT (PDR) ORGANISMS 5
1.5 MDR MECHANISMS OF MAJOR PATHOGENS 5
1.6 ANTIMICROBIAL STEWARDSHIP PROGRAMS 11
1.7 DISCUSSION 12
ACKNOWLEDGMENT 13
REFERENCES 13
2 CONVENTIONAL ANTIBIOTICS - REVITALIZED BY NEW AGENTS 17
ANTHONY
COATES AND
YANMIN HU
2.1 INTRODUCTION 17
2.2 CONVENTIONAL ANTIBIOTICS 18
2.3 THE PRINCIPLES OF COMBINATION ANTIBIOTIC "THERAPY 20
2.4 ANTIBIOTIC RESISTANCE BREAKERS: REVITALIZE CONVENTIONAL
ANTIBIOTICS 21
2.4.1 P-LACTAMASE INHIBITORS 21
2.4.2 AMINOGLYCOSIDE-MODIFYING ENZYME INHIBITORS 23
2.4.3 ANTIBIOTIC EFFLUX PUMPS INHIBITORS 23
2.4.4 SYNERGY ASSOCIATED WITH BACTERIAL MEMBRANE PERMEATORS 23
2.5 DISCUSSION 25
ACKNOWLEDGMENTS 26
REFERENCES 26
HTTP://D-NB.INFO/1050181298
VII CONTENTS
3 DEVELOPING NOVEL BACTERIAL TARGETS: CARBONIC ANHYDRASES AS
ANTIBACTERIAL DRUG TARGETS 31
CLEMENTE
CAPASSO AND
CLAUDIU T. SUPURAN
3.1 INTRODUCTION 31
3.2 CARBONIC ANHYDRASES 31
3.3 CA INHIBITORS 32
3.4 CLASSES OF CAS PRESENT IN BACTERIA 33
3.5 PATHOGENIC BACTERIAL CAS 35
3.6 A-CAS IN PATHOGENIC BACTERIA 35
3.7 P-CAS IN PATHOGENIC BACTERIA 37
3.8 Y-CAS FROM PATHOGENIC BACTERIA 39
3.9 CONCLUSIONS 40
REFERENCES 41
4 MAGAININS - A MODEL FOR DEVELOPMENT OF EUKARYOTIC ANTIMICROBIAL
PEPTIDES (AMPS) 47
SARAH R. DENNISON,
FREDERICK HARRIS, AND DAVID A.
PHOENIX
4.1 INTRODUCTION 47
4.2 MAGAININS AND THEIR ANTIMICROBIAL ACTION 49
4.3 MAGAININS AS ANTIBIOTICS 51
4.4 OTHER ANTIMICROBIAL USES OF MAGAININS 55
4.5 FUTURE PROSPECTS FOR MAGAININS 57
REFERENCES 58
5 ANTIMICROBIAL PEPTIDES FROM PROKARYOTES 71
MARYAM HASSAN,
MORTEN KJOS, INGOLFF. NES,
DZUNG
FT
DIEP,
AND FARZANEH LOTFIPOUR
5.1 INTRODUCTION 71
5.2 BACTERIOCINS 73
5.2.1 MICROCINS - PEPTIDE BACTERIOCINS FROM GRAM-NEGATIVE BACTERIA 73
5.2.2 LANTHIBIOTICS - POST-TRANSLATIONALLY MODIFIED PEPTIDES FROM
GRAM-POSITIVE BACTERIA 76
5.2.3 NON-MODIFIED PEPTIDES FROM GRAM-POSITIVE BACTERIA 77
5.3 APPLICATIONS OF PROKARYOTIC AMPS 79
5.3.1 FOOD BIOPRESERVATION 79
5.3.2 BACTERIOCINOGENIC PROBIOTICS 80
5.3.3 CLINICAL APPLICATION 81
5.3.4 APPLICATIONS IN DENTAL CARE 82
5.4 DEVELOPMENT AND DISCOVERY OF NOVEL AMP 82
REFERENCES 84
6 PEPTIDOMIMETICS AS ANTIMICROBIAL AGENTS 91
PENG TENG, HAIFAN
WU,
AND JIANFENG CAI
6.1 INTRODUCTION 91
6.2 ANTIMICROBIAL PEPTIDOMIMETICS 93
6.2.1 PEPTOIDS 93
6.2.2 P~ PEPTIDES 94
6.2.3 ARYLAMIDES 96
6.2.4 P-PEPTOID- PEPTIDE HYBRID OLIGOMERS 97
6.2.5 OLIGOUREA AND Y
4
-PEPTIDE-BASED OLIGOMERS 98
6.2.6 AAPEPTIDES 98
6.2.6.1 A-AAPEPTIDES 99
6.2.6.2 Y-AAPEPTIDES 101
6.3 DISCUSSION 102
ACKNOWLEDGMENTS 103
REFERENCES 103
7 SYNTHETIC BIOLOGY AND THERAPIES FOR INFECTIOUS DISEASES 109
HIROKI ANDO,
ROBERT CITORIK,
SARA
CLETO,
SEBASTIEN LEMIRE, MARK MIMEE,
AND TIMOTHY LU
7.1 CURRENT CHALLENGES IN THE TREATMENT OF INFECTIOUS DISEASES 109
7.2 INTRODUCTION TO SYNTHETIC BIOLOGY 112
7.3 VACCINOLOGY 113
7.3.1 GENETIC ENGINEERING AND VACCINE DEVELOPMENT 114
7.3.2 RATIONAL ANTIGEN DESIGN THROUGH REVERSE VACCINOLOGY 119
7.4 BACTERIOPHAGES: A RE-EMERGING SOLUTION? 122
7.4.1 A BRIEF HISTORY OF BACTERIOPHAGES 122
7.4.2 ADDRESSING THE PROBLEM OF THE RESTRICTED HOST RANGE OF PHAGES 124
7.4.3 PHAGE GENOME ENGINEERING FOR ENHANCED THERAPEUTICS 129
7.4.4 PHAGES AS DELIVERY AGENTS FOR ANTIBACTERIAL CARGOS 132
7.5 ISOLATED PHAGE PARTS AS ANTIMICROBIALS 133
7.5.1 ENGINEERED PHAGE LYSINS 133
7.5.2 PYOCINS: DEADLY PHAGE TAILS 135
7.5.3 UNTAPPED RESERVOIRS OF ANTIBACTERIAL ACTIVITY 136
7.6 PREDATORY BACTERIA AND PROBIOTIC BACTERIAL THERAPY 136
7.7 NATURAL PRODUCTS DISCOVERY AND ENGINEERING 139
7.7.1 IN SILICO AND IN VITRO GENOME MINING FOR NATURAL PRODUCTS 140
7.7.2 STRAIN ENGINEERING FOR NATURAL PRODUCTS 144
7.72.1 PRODUCTION OF THE ANTIMALARIAL ARTEMISININ 145
7.7.2.2 DAPTOMYCIN (CUBICIN) 147
7.7.2.3 ECHINOMYCIN 147
7.7.2.4 CLAVULANIC ACID 148
7.7.2.5 PRODUCTION OF THE ANTIPARASITIC AVERMECTIN AND ITS ANALOGS
DORAMECTIN AND IVERMECTIN 149
7.7.2.6 PRODUCTION OF DOXORUBICIN/DAUNORUBICIN 149
7.7.2.7 DEVELOPMENT OF HOSTS FOR THE EXPRESSION OF NONRIBOSOMAL PEPTIDES
AND POLYKETIDES ISO
7.7.3 GENERATION OF NOVEL MOLECULES BY RATIONAL REPROGRAMMING 152
7.7.4 ENGINEERING NRPS AND PKS DOMAINS 154
7.7.5 ACTIVATION OF CRYPTIC GENES/CLUSTERS 155
CONTENTS VII
VIIII
CONTENTS
7.7.6 MUTASYNTHESIS AS A SOURCE OF NOVEL ANALOGS 157
7.8 SUMMARY 157
ACKNOWLEDGMENTS 157
REFERENCES 158
8 NANO-ANTIMICROBIALS BASED ON METALS 181
MARIA CHIARA
SPORTELLI, ROSARIA
ANNA PICCA,
AND NICOLA C/OFFI
8.1 INTRODUCTION 181
8.2 SILVER NANO-ANTIMICROBIALS 182
8.2.1 SYNTHESIS OF SILVER NANOSTRUCTURES 182
8.2.1.1 PHYSICAL APPROACHES 183
8.2.1.2 LASER ABLATION IN LIQUIDS 183
8.2.1.3 CHEMICAL APPROACHES 183
8.2.1.4 BIOLOGICAL AND BIOTECHNOLOGICAL APPROACHES 184
8.2.1.5 ELECTROCHEMICAL APPROACHES 184
8.2.2 CHARACTERIZATION OF SILVER NANOSTRUCTURES 185
8.2.3 APPLICATIONS OF SILVER NANOSTRUCTURES 187
8.2.3.1 SILVER-BASED NANO-ANTIMICROBIALS 187
8.3 COPPER NANO-ANTIMICROBIALS 190
8.3.1 PREPARATION AND APPLICATIONS OF ANTIMICROBIAL CU
NANOSTRUCTURES 190
8.3.1.1 PHYSICAL METHODS 190
8.3.1.2 WET-CHEMICAL METHODS 192
8.3.1.3 ELECTROCHEMICAL SYNTHESES 195
8.3.1.4 LASER ABLATION IN LIQUIDS 196
8.3.1.5 BIOLOGICAL SYNTHESES 197
8.4 ZINC OXIDE NANO-ANTIMICROBIALS 197
8.4.1 SYNTHESIS OF ZINC OXIDE NANOSTRUCTURES 197
8.4.1.1 PHYSICAL APPROACHES 198
8.4.1.2 CHEMICAL APPROACHES 198
8.4.1.3 ELECTROCHEMICAL APPROACHES 200
8.5 CONCLUSIONS 201
REFERENCES 201
9 NATURAL PRODUCTS AS ANTIMICROBIAL AGENTS - AN UPDATE 219
MUHAMMAD SALEEM
9.1 INTRODUCTION 219
9.2 ANTIMICROBIAL NATURAL PRODUCTS FROM PLANTS 220
9.2.1 ANTIMICROBIAL ALKALOIDS FROM PLANTS 220
9.2.2 ANTIMICROBIAL ALKALOIDS FROM MICROBIAL SOURCES 223
9.2.3 ANTIMICROBIAL ALKALOIDS FROM MARINE SOURCES 225
9.3 ANTIMICROBIAL NATURAL PRODUCTS BEARING AN ACETYLENE FUNCTION 226
9.4 ANTIMICROBIAL CARBOHYDRATES 228
9.5 ANTIMICROBIAL NATURAL CHROMENES 228
9.6 ANTIMICROBIAL NATURAL COUMARINS 229
CONTENTS | IX
9.6.1 ANTIMICROBIAL COUMARINS FROM PLANTS 229
9.6.1.1 ANTIMICROBIAL COUMARINS FROM BACTERIA 232
9.7 ANTIMICROBIAL FLAVONOIDS 232
9.7.1 ANTIMICROBIAL FLAVONOIDS FROM PLANTS 233
9.8 ANTIMICROBIAL IRIDOIDS 237
9.8.1 ANTIMICROBIAL IRIDOIDS FROM PLANTS 237
9.9 ANTIMICROBIAL LIGNANS 238
9.9.1 ANTIMICROBIAL LIGNANS FROM PLANTS 238
9.10 ANTIMICROBIAL PHENOLICS OTHER THAN FLAVONOIDS AND LIGNANS 240
9.10.1 ANTIMICROBIAL PHENOLICS FROM PLANTS 240
9.10.2 ANTIMICROBIAL PHENOLICS FROM MICROBIAL SOURCES 244
9.10.3 ANTIMICROBIAL PHENOLICS FROM MARINE SOURCE 246
9.11 ANTIMICROBIAL POLYPEPTIDES 247
9.12 ANTIMICROBIAL POLYKETIDES 249
9.12.1 ANTIMICROBIAL POLYKETIDES AS MACROLIDES 250
9.12.2 ANTIMICROBIAL POLYKETIDES AS QUINONES AND XANTHONES 252
9.12.2.1 ANTIMICROBIAL QUINONES AND XANTHONES FROM PLANTS 252
9.12.2.2 ANTIMICROBIAL QUINONES FROM BACTERIA 256
9.12.2.3 ANTIMICROBIAL QUINONES AND XANTHONES FROM FUNGI 257
9.12.3 ANTIMICROBIAL FATTY ACIDS AND OTHER POLYKETIDES 261
9.13 ANTIMICROBIAL STEROIDS 263
9.13.1 ANTIMICROBIAL STEROIDS FROM PLANTS 264
9.13.2 STEROIDS FROM FUNGI 266
9.14 ANTIMICROBIAL TERPENOIDS 267
9.14.1 ANTIMICROBIAL TERPENOIDS FROM PLANTS 267
9.14.2 ANTIMICROBIAL TERPENOIDS FROM MICROBIAL SOURCES 273
9.14.3 ANTIMICROBIAL TERPENOIDS FROM MARINE SOURCES 274
9.15 MISCELLANEOUS ANTIMICROBIAL COMPOUNDS 275
9.15.1 MISCELLANEOUS ANTIMICROBIAL NATURAL PRODUCTS FROM PLANTS 275
9.15.2 MISCELLANEOUS ANTIMICROBIALS FROM BACTERIA 278
9.15.3 MISCELLANEOUS ANTIMICROBIALS FROM FUNGI 280
9.16 PLATENSIMYCIN FAMILY AS ANTIBACTERIAL NATURAL PRODUCTS 282
REFERENCES 284
10 PHOTODYNAMIC ANTIMICROBIAL CHEMOTHERAPY 295
DAVID A. PHOENIX,
SARAH R. DENNISON,
AND FREDERICK HARRIS
10.1 INTRODUCTION 295
10.2 THE ADMINISTRATION AND PHOTOACTIVATION OF PS 296
10.3 APPLICATIONS OF PACT BASED ON MB 301
10.4 THE APPLICATIONS OF PACT BASED ON ALA 303
10.4.1 FOOD DECONTAMINATION USING PACT BASED ON ALA 303
10.4.2 DERMATOLOGY USING PACT BASED ON ALA 305
10.5 FUTURE PROSPECTS 308
REFERENCES 310
X | CONTENTS
11 THE ANTIMICROBIAL EFFECTS OF ULTRASOUND 331
FREDERICK HARRIS, SARAH R. DENNISON,
AND DAVID A. PHOENIX
11.1 INTRODUCTION 331
11.2 THE ANTIMICROBIAL ACTIVITY OF ULTRASOUND ALONE 332
11.3 THE ANTIMICROBIAL ACTIVITY OF ASSISTED ULTRASOUND 335
11.3.1 SYNERGISTIC EFFECTS 336
11.3.2 SONOSENSITIZERS 338
11.4 FUTURE PROSPECTS 341
REFERENCES 343
12 ANTIMICROBIAL THERAPY BASED ON ANTISENSE AGENTS 357
GLENDA M. BEAMAN,
SARAH R. DENNISON,
AND DAVID A. PHOENIX
12.1 INTRODUCTION 357
12.2 ANTISENSE OLIGONUCLEOTIDES 358
12.3 FIRST-GENERATION ASOS 360
12.4 SECOND-GENERATION ASOS 361
12.5 THIRD-GENERATION ASOS 362
12.6 ANTISENSE ANTIBACTERIALS 364
12.7 BROAD-SPECTRUM ANTISENSE ANTIBACTERIALS 365
12.8 METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) 371
12.9 RNA INTERFERENCE (RNAI) 371
12.10 PROGRESS USING SIRNA 374
12.10.1 MYCOBACTERIUM TUBERCULOSIS 374
12.10.2 MRSA 375
12.11 DISCUSSION 376
REFERENCES 377
13 NEW DELIVERY SYSTEMS - LIPOSOMES FOR PULMONARY DELIVERY OF
ANTIBACTERIAL DRUGS 387
ABDEIBARY M.A.
ELHISSI, SARAH
R. DENNISON,
WAQAR AHMED,
KEVIN M.G. TAYLOR
AND DAVID A. PHOENIX
13.1 INTRODUCTION 387
13.2 PULMONARY DRUG DELIVERY 389
13.3 LIPOSOMES AS DRUG CARRIERS IN PULMONARY DELIVERY 389
13.3.1 LIPOSOMES FOR PULMONARY DELIVERY OF ANTIBACTERIAL DRUGS 390
13.3.1.1 DELIVERY OF ANTIBACTERIAL LIPOSOMES USING PMDIS 391
13.3.1.2 DELIVERY OF ANTIBACTERIAL LIPOSOMES USING DPIS 392
13.3.1.3 DELIVERY OF ANTIBACTERIAL LIPOSOMES USING NEBULIZERS 394
13.4 PRESENT AND FUTURE TRENDS OF LIPOSOME RESEARCH IN PULMONARY DRUG
DELIVERY 398
13.5 CONCLUSIONS 401
REFERENCES 401
INDEX 407 |
| any_adam_object | 1 |
| author2 | Phoenix, David A. |
| author2_role | edt |
| author2_variant | d a p da dap |
| author_facet | Phoenix, David A. |
| building | Verbundindex |
| bvnumber | BV042170737 |
| classification_rvk | VC 6250 VS 5350 VS 8700 VS 9400 |
| ctrlnum | (OCoLC)878979349 (DE-599)DNB1050181298 |
| dewey-full | 615.3 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.3 |
| dewey-search | 615.3 |
| dewey-sort | 3615.3 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV042170737 |
| illustrated | Illustrated |
| indexdate | 2024-09-10T01:29:28Z |
| institution | BVB |
| isbn | 3527336389 9783527336388 9783527676132 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027610163 |
| oclc_num | 878979349 |
| open_access_boolean | |
| owner | DE-11 DE-188 DE-19 DE-BY-UBM |
| owner_facet | DE-11 DE-188 DE-19 DE-BY-UBM |
| physical | XXII, 414 S. Ill., graph. Darst. |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Novel antimicrobial agents and strategies ed. by David A. Phoenix ... Weinheim Wiley-VCH 2015 XXII, 414 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Antimikrobieller Wirkstoff (DE-588)4142688-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Antimikrobieller Wirkstoff (DE-588)4142688-5 s DE-604 Phoenix, David A. edt Erscheint auch als Online-Ausgabe, EPUB 978-3-527-67615-6 Erscheint auch als Online-Ausgabe, MOBI 978-3-527-67616-3 Erscheint auch als Online-Ausgabe, PDF 978-3-527-67614-9 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=4642588&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027610163&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Novel antimicrobial agents and strategies Antimikrobieller Wirkstoff (DE-588)4142688-5 gnd |
| subject_GND | (DE-588)4142688-5 (DE-588)4143413-4 |
| title | Novel antimicrobial agents and strategies |
| title_auth | Novel antimicrobial agents and strategies |
| title_exact_search | Novel antimicrobial agents and strategies |
| title_full | Novel antimicrobial agents and strategies ed. by David A. Phoenix ... |
| title_fullStr | Novel antimicrobial agents and strategies ed. by David A. Phoenix ... |
| title_full_unstemmed | Novel antimicrobial agents and strategies ed. by David A. Phoenix ... |
| title_short | Novel antimicrobial agents and strategies |
| title_sort | novel antimicrobial agents and strategies |
| topic | Antimikrobieller Wirkstoff (DE-588)4142688-5 gnd |
| topic_facet | Antimikrobieller Wirkstoff Aufsatzsammlung |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=4642588&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027610163&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT phoenixdavida novelantimicrobialagentsandstrategies |