Molecular immunotoxicology:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH-Verl.
2015
|
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XVIII, 333 S. Ill., graph. Darst. |
| ISBN: | 9783527335190 3527335196 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV042167068 | ||
| 003 | DE-604 | ||
| 005 | 20160425 | ||
| 007 | t | ||
| 008 | 141104s2015 gw ad|| |||| 00||| eng d | ||
| 015 | |a 14,N18 |2 dnb | ||
| 015 | |a 14,A44 |2 dnb | ||
| 016 | 7 | |a 1050181166 |2 DE-101 | |
| 020 | |a 9783527335190 |c Pp. : EUR 139.00 (DE, freier Pr.), EUR 142.90 (AT, freier Pr.), sfr 187.00 (freier Pr.) |9 978-3-527-33519-0 | ||
| 020 | |a 3527335196 |9 3-527-33519-6 | ||
| 024 | 3 | |a 9783527335190 | |
| 035 | |a (OCoLC)878979292 | ||
| 035 | |a (DE-599)DNB1050181166 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 044 | |a gw |c XA-DE-BW | ||
| 049 | |a DE-20 |a DE-188 |a DE-19 | ||
| 082 | 0 | |a 616.97071 |2 22/ger | |
| 084 | |a VT 5300 |0 (DE-625)147745:253 |2 rvk | ||
| 084 | |a XI 6600 |0 (DE-625)153022:12905 |2 rvk | ||
| 084 | |a 610 |2 sdnb | ||
| 245 | 1 | 0 | |a Molecular immunotoxicology |c ed. by Emanuela Corsini ... |
| 264 | 1 | |a Weinheim |b Wiley-VCH-Verl. |c 2015 | |
| 300 | |a XVIII, 333 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Literaturangaben | ||
| 650 | 0 | 7 | |a Immuntoxikologie |0 (DE-588)1059845393 |2 gnd |9 rswk-swf |
| 653 | |a Immuntoxikologie | ||
| 653 | |a Toxikologie | ||
| 653 | |a Umwelttoxikologie | ||
| 653 | |a TN000 | ||
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Immuntoxikologie |0 (DE-588)1059845393 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Corsini, Emanuela |0 (DE-588)1059725436 |4 edt | |
| 856 | 4 | 2 | |m X:MVB |q text/html |u http://deposit.dnb.de/cgi-bin/dokserv?id=4642575&prov=M&dok_var=1&dok_ext=htm |3 Inhaltstext |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027606585&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-027606585 | |
Datensatz im Suchindex
| _version_ | 1809770624868941824 |
|---|---|
| adam_text |
CONTENTS
PREFACE XIII
LIST OF CONTRIBUTORS XV
1 THE EVOLUTION OF IMMUNOTOXICOLOGY 1
MICHAEL I. LUSTER
1.1 INTRODUCTION 1
1.2 IMMUNE-MEDIATED ENVIRONMENTAL LUNG DISEASES 1
1.3 IMMUNOTOXIC DRUG REACTIONS 3
1.4 AUTOIMMUNITY 3
1.5 IMMUNOSUPPRESSION 4
1.6 ALLERGIC CONTACT DERMATITIS (ACD) 6
1.7 SUMMARY 7
REFERENCES 7
2 OVERVIEW ON THE MECHANISMS UNDERLYING CHEMICAL-INDUCED
IMMUNOTOXICITY 11
EMANUELA CORSINI
2.1 INTRODUCTION 11
2.2 MECHANISMS OF IMMUNOTOXICITY 13
2.2.1 INTERFERENCE WITH CELLULAR SIGNALING 14
2.2.1.1 RECEPTOR-MEDIATED IMMUNOTOXICITY 14
2.2.1.2 NON-RECEPTOR-MEDIATED IMMUNOTOXICITY 20
2.2.2 ADDUCTS FORMATION AND ROLE OF ROS 21
2.3 CONCLUSIONS 22
REFERENCES 22
3 USE OF TOXICOGENOMICS IN IMMUNOTOXICOLOGY 27
RACHEL FRAWLEY, DORI
GERMOLEC,
AND HENK VAN LOVEREN
3.1 INTRODUCTION 27
3.2 TOXICOGENOMICS 28
3.2.1 PROFILING GENE EXPRESSION 30
3.2.2 PATHWAY ARRAYS 35
3.2.3 COMPARATIVE EVALUATION OF IMMUNOTOXICANTS 36
HTTP://D-NB.INFO/1050181166
VI |
CONTENTS
3.2.4
3.2.5
3.2.6
3.2.7
3.2.8
3.2.9
3.3
3.3.1
3.4
3.4.1
3.5
4
4.1
4.2
4.3
4.3.1
4.3.2
4.3.3
4.3.3.1
4.3.3.2
4.3.3.3
4.3.3.4
4.3.4
4.3.5
4.3.6
4.4
MIRNA AND SIRNA, GENE EXPRESSION REGULATORS 39
MRNA SPLICING 41
RNA-SEQ 41
PROTEOMICS 42
MOLECULAR GENOMICS 43
PHENOTYPIC ANCHORING, DOSE RESPONSE, TIME COURSE 45
BIOINFORMATICS AND DATA ANALYSIS 46
EFFECT MARKERS AND MACHINE LEARNING 47
MULTIPLE OMIC APPROACHES IN THE EVALUATION OF IMMUNOSUPPRESSIVE
COMPOUNDS 48
MULTIPLE OMIC APPROACHES IN THE STUDY OF HYPERSENSITIVITY 52
SUMMARY AND CONCLUSIONS 54
REFERENCES 56
BREAKDOWN OF THE MOLECULAR PROCESSES DRIVING THE ADVERSE OUTCOME
PATHWAYS (AOPS) OF SKIN
AND RESPIRATORY SENSITIZATION INDUCTION IN
HUMANS EXPOSED TO XENOBIOTICS AND PROTEINS 67
ERWIN L ROGGEN
INTRODUCTION 67
THE AOP FOR SKIN SENSITIZATION
68
THE MOLECULAR PROCESSES IN THE MOA FOR SENSITIZATION
INDUCTION
68
BIOAVAILABILITY: THE COMPOUND ACQUIRES ACCESS TO
THE SYSTEM
68
HAPTENATION: THE CHEMICAL REACTS COVALENTLY WITH A
"CARRIER PROTEIN" 69
INFLAMMATION: INNATE RECOGNITION OF HAPTENS FOLLOWED BY ACTIVATION
OF INNATE IMMUNITY 70
HAPTENS ENGAGE TOLL-LIKE RECEPTORS (TLR) 2 AND 4 71
REACTIVE OXYGEN SPECIES (ROS) AND OXIDATIVE STRESS PLAY A ROLE IN
CHEMICAL ALLERGEN-INDUCED SKIN CELL ACTIVATION 73
EPITHELIAL ROS PRODUCTION RESULTS IN DEGRADATION OF ENDOGENOUS
HA, AND TLR2
AND TLR4 ACTIVATION 75
ROS SIGNAL THE NLRP3 INFLAMMOSOME RESULTING IN IL-IP, IL-18, AND
IL-33 ACTIVATION 75
DENDRITIC CELL ACTIVATION: FROM INNATE RESPONSES TO DC
MATURATION 77
DENDRITIC CELL MIGRATION: TRANSLATING THE MESSAGE INTO SPECIFIC
ACTIONS 80
T-CELL PRIMING AND PROLIFERATION: THE TURNING-POINT BETWEEN
SENSITIZATION AND EFFECT 82
SUMMARY 83
REFERENCES 84
CONTENTS
VII
5 CHEMICAL ALLERGEN-INDUCED SKIN CELL ACTIVATION 91
STEFAN F. MARTIN AND
PHILIPP R. ESSER
5.1 INTRODUCTION 91
5.2 BREACHING THE BARRIERS 92
5.3 ROLE OF THE EXTRACELLULAR MATRIX IN SKIN INFLAMMATION 94
5.4 CYTOPROTECTIVE RESPONSES AND SKIN INFLAMMATION 95
5.5 SKIN DENDRITIC CELLS - TOLERANCE VERSUS IMMUNITY 97
5.6 DC ACTIVATION AND MIGRATION 98
5.7 THE ROLE OF DANGER SIGNALS 100
5.8 INAPPROPRIATE/COMPROMISED DC ACTIVATION 102
5.9 T-CELL ACTIVATION AND IMMUNE REGULATION 102
5.10 ALLERGIC CONTACT DERMATITIS AS A (STERILE)
"INFECTION" - IMPLICATIONS 103
ABBREVIATIONS 104
REFERENCES 105
6 THE ARYL HYDROCARBON RECEPTOR (AHR) AS A MEDIATOR OF ADVERSE
IMMUNE REACTIONS 117
CHARLOTTE ESSER
6.1 INTRODUCTION 117
6.1.1 RECOGNITION AND RESPONSE - THE BASIC FEATURES OF THE IMMUNE
SYSTEM 117
6.1.2 THE CONCEPT OF "ADVERSE REACTION" IN IMMUNOTOXICOLOGY 118
6.1.2.1 CHEMICALS CAUSING HAPTENATION, NEO-ANTIGENS, AND CRYPTIC
ANTIGENS 118
6.1.2.2 CHEMICAL-INDUCED IMMUNOSUPPRESSION 120
6.1.2.3 IMMUNOSUPPRESSIVE CHEMICALS AND METALS 120
6.2 THE ARYLHYDROCARBON RECEPTOR - A SENSOR OF CHEMICALS AND A LINK
TO OUR CHEMICAL ENVIRONMENT 122
6.2.1 BIOCHEMISTRY OF AHR SIGNALING 122
6.2.2 THE REALM OF AHR LIGANDS 124
6.2.3 AHR-MEDIATED GENE EXPRESSION IS CELL SPECIFIC 124
6.3 IMMUNOTOXICITY OF TCDD, THE PARADIGM LIGAND OF AHR 126
6.3.1 GENERATION OF DIOXINS IN THE ENVIRONMENT 126
6.3.2 IMMUNOTOXICITY OF TCDD 127
6.3.2.1 ANIMAL STUDIES 127
6.3.2.2 HUMAN EXPOSURE DATA 127
6.3.2.3 HUMAN IMMUNOTOXIC EFFECTS - EPIDEMIOLOGY AND IN VITRO
STUDIES 129
6.4 AHR-DEFICIENT ANIMAL MODELS TO STUDY AHR FUNCTION IN THE
IMMUNE SYSTEM 129
6.4.1 INFECTION MODELS 130
6.4.2 ADAPTIVE IMMUNITY: REGULATORY T CELLS (TREG) AND THL7 131
6.4.3 DENDRITIC CELLS (DCS) 131
6.4.4 BARRIER IMMUNITY - Y5 T CELLS AND ILC3 132
VIII
CONTENTS
6.4.5 OTHER IMMUNE CELLS - MACROPHAGES, NEUTROPHILS, AND MORE 133
6.5 CONCLUDING REMARKS 134
ACKNOWLEDGMENTS 134
ABBREVIATIONS 134
REFERENCES 135
7 IMMUNOTOXICOLOGICAL EFFECTS OF PHARMACEUTICALS ON SIGNAL
TRANSDUCTION IN INNATE AND ADAPTIVE IMMUNITY 145
TSUGUTO TODA
AND KAZUICHI NAKAMURA
7.1 INTRODUCTION 145
7.2 DRUG AFFECTING SIGNAL TRANSDUCTION IN
INNATE IMMUNITY 146
7.2.1 TLR SIGNALING PATHWAYS 146
7.2.2 RLR SIGNALING PATHWAYS 149
7.3 DRUG AFFECTING SIGNAL TRANSDUCTION IN ADAPTIVE IMMUNITY 150
7.3.1 TCR AND COSTIMULATORY SIGNALING PATHWAYS 150
7.3.1.1 MECHANISM OF ACTION OF CYCLOSPORIN A AND TACROLIMUS 151
7.3.1.2 MECHANISM OF CYTOKINE RELEASE SYNDROME 152
7.3.1.3 EFFECTS OF TOFACITINIB ON JAK/STAT SIGNALING PATHWAY 153
7.3.2 BCR SIGNALING PATHWAYS 155
REFERENCES 156
8 PROMISES AND CHALLENGES WITH IMMUNOMODULATORY BIOLOGIES 159
RAFAEL A. PONCE
8.1 INTRODUCTION 159
8.1.1 LOCAL DISEASE, SYSTEMIC TREATMENT 160
8.1.2 CONTEXT 161
8.1.3 TIPPING POINTS 161
8.2 ADAPTIVE IMMUNITY IN THE CONTROL OF TUMORS 162
8.2.1 ADAPTIVE ANTITUMOR IMMUNITY 162
8.2.2 CD8+ T-CELL EFFECTOR ACTIVITY IS ESTABLISHED BY PROPERLY ACTIVATED
DC WITH CD4+ T-CELL HELP 165
8.2.3 VARIOUS FACTORS REGULATE DC ACTIVATION 166
8.2.4 REGULATION OF T-CELL ACTIVATION 166
8.3 RECENT DEVELOPMENTS IN ONCOLOGY IMMUNOTHERAPY - CASE
EXAMPLES 167
8.3.1 CASE STUDY 1: IMMUNE CHECKPOINT BLOCKADE 169
8.3.1.1 NONCLINICAL SAFETY ASSESSMENT OF ANTI-CTL A-4 172
8.3.2 BI-SPECIFIC T-CELL ENGAGEMENT (REDIRECTED LYSIS) 173
8.3.3 ONCOLYTIC VIRAL THERAPY 175
8.4 CONCLUSIONS 177
REFERENCES 179
CONTENTS IIX
9 THE NONCLINICAL EVALUATION OF BIOTECHNOLOGY-DERIVED PHARMACEUTICALS,
MOVING ON AFTER THE TEGENERO CASE 189
JAN
WILLEM VAN
DERLAAN,
CARTA HERBERTS, DAVID JONES,
SUSAN J. THORPE,
RICHARD STEBBINGS,
AND ROBIN
THORPE
9.1 THE TEGENERO (TGN1412) CASE 189
9.2 THE EU CHMP RISK MITIGATION DOCUMENT 191
9.3 MABEL VERSUS NOAEL APPROACH 192
9.4 PREDICTIVITY OF ANTIBODY PROPERTIES, PHARMACODYNAMICS,
PHARMACOKINETICS, AND TOXICOLOGY 193
9.4.1 REPRODUCTIVE TOXICITY TESTING 194
9.4.2 DOSE TO BE APPLIED AND DURATION OF CHRONIC TOXICITY STUDIES 194
9.4.3 SELECTION OF SPECIES AND THE USE OF SURROGATES/TRANSGENICS 196
9.5 NEW DEVELOPMENTS IN BIOLOGICAL TESTING: IN VITRO
APPROACHES? 197
9.6 CYTOKINE RELEASE ASSAYS 198
9.7 CONCLUSIONS 204
REFERENCES 205
10 GLUCOCORTICOID-LNDUCED IMMUNOMODULATION 209
SIMONA RONCHETTI,
GRAZIELLA MIGIIORATI,
AND CARLO
RICCARDI
10.1 INTRODUCTION 209
10.2 MECHANISM OF ACTION 210
10.3 GC RESISTANCE 211
10.4 GC EFFECTS ON THE IMMUNE SYSTEM 212
10.4.1 T CELLS AND APOPTOSIS 212
10.4.2 B CELLS 215
10.4.3 CELLS OF INNATE IMMUNITY 215
10.5 GC, INFLAMMATION, AND IMMUNOSUPPRESSION 216
10.6 GC AND AUTOIMMUNITY 217
10.7 CONCLUSIONS AND PERSPECTIVES 218
REFERENCES 219
11 PARTICULATE MATTER-INDUCED IMMUNE ACTIVATION 227
MARTINUS LOVIK
11.1 BACKGROUND AND INTRODUCTION 227
11.2 THE HUMAN EVIDENCE 228
11.3 DO PHYSICAL OR CHEMICAL PARTICLE COMPONENTS MEDIATE IMMUNE
STIMULATION? 230
11.4 PARTICLE ADJUVANT EFFECT - THE PRIMARY AND SECONDARY
RESPONSE 231
11.5 PARTICLE PROPERTIES AND ADJUVANT EFFECT - SIZE IS A CRITICAL
FACTOR 232
11.6 INTERACTIONS OF PARTICLES WITH THE IMMUNE SYSTEM 234
11.7 GENETIC FACTORS 235
11.8 MECHANISMS OF PARTICLE ADJUVANTICITY 235
X |
CONTENTS
11.9 OXIDATIVE STRESS 237
11.10 SUMMARY AND CONCLUSIONS 238
REFERENCES 238
'I2 GENOTOXIC MECHANISMS OF PAH-LNDUCED IMMUNOTOXICITY 245
JUN GAO
AND SCOTT
W. BURCHIEL
12.1 INTRODUCTION 245
12.2 GENERAL CHEMICAL STRUCTURE OF PAHS 247
12.3 ARYL HYDROCARBON RECEPTOR (AHR)-MEDIATED IMMUNOTOXICITY
PATHWAYS 247
12.4 PAH-LNDUCED IMMUNOTOXICITY VIA AHR-INDEPENDENT PATHWAY 249
12.5 MICROSOMAL EPOXIDE HYDROLASE (MEH) 251
12.6 GENOTOXIC PATHWAYS 252
12.6.1 PAH-ACTIVATED DOWNSTREAM SENSORS AND EFFECTORS: P53 252
12.6.2 ATAXIA TELANGIECTASIA MUTATED PROTEIN (ATM) AND ATAXIA
TELANGIECTASIA AND RAD3-RELATED PROTEIN (ATR) 253
12.7 PAH-LNDUCED APOPTOSIS PATHWAYS IN T CELLS, B CELLS, AND
MACROPHAGES 254
REFERENCES 256
13 IMMUNOTOXIC EFFECTS OF PERFLUOROALKYLATED COMPOUNDS: MECHANISMS
OF ACTION 263
JAMIE
C. DEWITT,
MARGIE M. PEDEN-ADAMS,
AND DEBORAH E. KEIL
13.1 INTRODUCTION 263
13.2 IMMUNE EFFECTS OF PFOA AND PFOS IN ANIMAL MODELS 265
13.2.1 ANTIBODY PRODUCTION AND HOST RESISTANCE 266
13.2.2 INFLAMMATION: TNF-A AND IL-6 267
13.3 IMMUNE EFFECTS OF PFOA AND PFOS IN HUMANS 268
13.4 MECHANISMS OF ACTION 272
13.4.1 PPAR-DEPENDENT MODES OF ACTION IN PHYSIOLOGICAL PATHWAYS OTHER
THAN IMMUNE FUNCTION 272
13.4.2 BINDING TO SERUM ALBUMIN 274
13.4.3 NEUROTOXICITY 275
13.4.4 OXIDATIVE STRESS AND APOPTOTIC PROTEIN EXPRESSION 275
13.4.5 DNA ADDUCT FORMATION 276
13.4.6 BINDING HORMONE RECEPTORS 276
13.4.7 THYROID 277
13.5 CONCLUSIONS 277
REFERENCES 279
14 PESTICIDE-INDUCED IMMUNOTOXICITY: MOLECULAR TARGETS 285
JOHN B. BARNETT
14.1 INTRODUCTION 285
14.1.1 MEMBRANE-BASED EFFECTS 287
14.1.1.1 CYTOPLASMIC MEMBRANE EFFECTS 287
CONTENTS
I XI
14.1.1.2 ENDOPLASMIC RETICULUM (ER) 293
14.1.2 POST-RECEPTOR SIGNALING (SIGNAL TRANSDUCTION) 293
14.1.2.1 MITOGEN-ACTIVATED PROTEIN KINASE (MAPK) PATHWAY 293
14.1.3 APOPTOSIS 298
14.1.4 OXIDATIVE AND NITROSATIVE STRESS 300
14.2 SUMMARY 301
REFERENCES 301
15 MODE OF ACTION OF ORGANOTINS IN IMMUNE CELLS 307
PETER J.M.
HENDRIKSEN, PETER
CJ.
SCHMEITS, HENK VAN LOVEREN,
JIA SHAO,
AND
AD A. PEIJNENBURG
15.1 INTRODUCTION TO TRIBUTYLTIN COMPOUNDS 307
15.2 FINDINGS ON IMMUNOTOXICITY OF TBTS BASED ON ANIMAL STUDIES 308
15.3 DIFFERENTIAL EFFECTS OF TBTS ON PRENATAL, POSTNATAL, OR ADULT
RATS 310
15.4 LACTATIONAL TRANSFER OF TBT 311
15.5 EFFECTS OF ORGANOTIN COMPOUNDS ON THE IMMUNE FUNCTION OF
AQUATIC ORGANISMS 312
15.6 MODES OF ACTION OF TBTO AS ASSESSED BY CYTOLOGICAL AND
BIOCHEMICAL ASSAYS 312
15.7 TOXICOGENOMICS STUDIES ON THE MODES OF ACTION OF TBTS 314
15.8 SUMMARY 320
REFERENCES 320
INDEX 327 |
| any_adam_object | 1 |
| author2 | Corsini, Emanuela |
| author2_role | edt |
| author2_variant | e c ec |
| author_GND | (DE-588)1059725436 |
| author_facet | Corsini, Emanuela |
| building | Verbundindex |
| bvnumber | BV042167068 |
| classification_rvk | VT 5300 XI 6600 |
| ctrlnum | (OCoLC)878979292 (DE-599)DNB1050181166 |
| dewey-full | 616.97071 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.97071 |
| dewey-search | 616.97071 |
| dewey-sort | 3616.97071 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>00000nam a2200000 c 4500</leader><controlfield tag="001">BV042167068</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20160425</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">141104s2015 gw ad|| |||| 00||| eng d</controlfield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">14,N18</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">14,A44</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">1050181166</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783527335190</subfield><subfield code="c">Pp. : EUR 139.00 (DE, freier Pr.), EUR 142.90 (AT, freier Pr.), sfr 187.00 (freier Pr.)</subfield><subfield code="9">978-3-527-33519-0</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3527335196</subfield><subfield code="9">3-527-33519-6</subfield></datafield><datafield tag="024" ind1="3" ind2=" "><subfield code="a">9783527335190</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)878979292</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DNB1050181166</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE-BW</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-20</subfield><subfield code="a">DE-188</subfield><subfield code="a">DE-19</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616.97071</subfield><subfield code="2">22/ger</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">VT 5300</subfield><subfield code="0">(DE-625)147745:253</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">XI 6600</subfield><subfield code="0">(DE-625)153022:12905</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">610</subfield><subfield code="2">sdnb</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Molecular immunotoxicology</subfield><subfield code="c">ed. by Emanuela Corsini ...</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Weinheim</subfield><subfield code="b">Wiley-VCH-Verl.</subfield><subfield code="c">2015</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XVIII, 333 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Literaturangaben</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Immuntoxikologie</subfield><subfield code="0">(DE-588)1059845393</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Immuntoxikologie</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Toxikologie</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Umwelttoxikologie</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">TN000</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Immuntoxikologie</subfield><subfield code="0">(DE-588)1059845393</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Corsini, Emanuela</subfield><subfield code="0">(DE-588)1059725436</subfield><subfield code="4">edt</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">X:MVB</subfield><subfield code="q">text/html</subfield><subfield code="u">http://deposit.dnb.de/cgi-bin/dokserv?id=4642575&prov=M&dok_var=1&dok_ext=htm</subfield><subfield code="3">Inhaltstext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027606585&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="943" ind1="1" ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-027606585</subfield></datafield></record></collection> |
| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV042167068 |
| illustrated | Illustrated |
| indexdate | 2024-09-10T01:29:21Z |
| institution | BVB |
| isbn | 9783527335190 3527335196 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027606585 |
| oclc_num | 878979292 |
| open_access_boolean | |
| owner | DE-20 DE-188 DE-19 DE-BY-UBM |
| owner_facet | DE-20 DE-188 DE-19 DE-BY-UBM |
| physical | XVIII, 333 S. Ill., graph. Darst. |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Wiley-VCH-Verl. |
| record_format | marc |
| spelling | Molecular immunotoxicology ed. by Emanuela Corsini ... Weinheim Wiley-VCH-Verl. 2015 XVIII, 333 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Immuntoxikologie (DE-588)1059845393 gnd rswk-swf Immuntoxikologie Toxikologie Umwelttoxikologie TN000 (DE-588)4143413-4 Aufsatzsammlung gnd-content Immuntoxikologie (DE-588)1059845393 s DE-604 Corsini, Emanuela (DE-588)1059725436 edt X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=4642575&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027606585&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Molecular immunotoxicology Immuntoxikologie (DE-588)1059845393 gnd |
| subject_GND | (DE-588)1059845393 (DE-588)4143413-4 |
| title | Molecular immunotoxicology |
| title_auth | Molecular immunotoxicology |
| title_exact_search | Molecular immunotoxicology |
| title_full | Molecular immunotoxicology ed. by Emanuela Corsini ... |
| title_fullStr | Molecular immunotoxicology ed. by Emanuela Corsini ... |
| title_full_unstemmed | Molecular immunotoxicology ed. by Emanuela Corsini ... |
| title_short | Molecular immunotoxicology |
| title_sort | molecular immunotoxicology |
| topic | Immuntoxikologie (DE-588)1059845393 gnd |
| topic_facet | Immuntoxikologie Aufsatzsammlung |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=4642575&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027606585&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT corsiniemanuela molecularimmunotoxicology |