Follow up of high risk HPV induced changes in patients with CIN lesions before and after therapy:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | III, 76 Bl. Ill., graph. Darst. 30 cm |
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Record in the Search Index
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|---|---|
| adam_text | CONTENTS
CONTENTS I_N
ABBREVIATION LIST III
PAGE
1 INTRODUCTION 1
1.1 CERVICAL CANCER 1
1.1.1 EPIDEMIOLOGY 1
1.1.2 AETIOLOGY 1
1.1.3 PAP SMEAR 1
1.2 CERVICAL INTRAEPITHELIAL NEOPLASIAS 3
1.2.1 GRADING AND NOMENCLATURE OF CIN 3
1.2.1.1 CIN1 3
1.2.1.2 CIN2 3
1.2.1.3 CIN3 4
1.2.2 BEHAVIOUR OF CIN 4
1.3 HUMAN PAPILLOMAVIRUS (HPV) 4
1.3.1 DEFINITION AND STRUCTURE 4
1.3.2 SUBTYPES 5
1.3.3 PATHOGENESIS 6
1.3.4 DIAGNOSIS 7
1.4 PROTEINS LINKED TO CELL CYCLE AND PROLIFERATION 9
1.4.1 P16INK4A 9
1.4.2 KI-67 10
1.4.3 DUAL P16/KI-67 (THE CINTEC PLUS) 10
1.5 AIM OF THE STUDY 11
2 MATERIALS AND METHODS 12
2.1 MATERIALS 12
2.2. METHODS 12
2.2.1 IMMUNOCYTOCHEMICAL STUDIES 12
2.2.2 PL6/KI-67 CYTOLOGIC SLIDE INTERPRETATION 14
I
HTTP://D-NB.INFO/1048132773
3 RESULTS 15
3.1 LASER THERAPY 15
3.1.1 FOLLOW UP OF 10 PATIENTS WITH CIN 2 TREATED BY LASER 15
3.1.2 FOLLOW UP OF 2 PATIENTS WITH THE FIRST DIAGNOSIS CIN 1 TREATED
WITH LASER 26
3.1.3 FOLLOW UP OF 1 PATIENT WITH THE FIRST DIAGNOSIS CIN 3 TREATED WITH
LASER 29
3.2 CONISATION THERAPY 31
3.2.1 FOLLOW UP OF 6 PATIENTS WITH DIAGNOSIS OF CIN2, TREATED WITH
CONISATION 31
3.2.2 FOLLOW UP OF 2 PATIENTS WITH DIAGNOSIS CIN 3, TREATED WITH
CONISATION 38
3.3 ALDARA THERAPY 41
3.3.1 FOLLOW UP OF ONE PATIENT DIAGNOSIS OF CIN 1, TREATED WITH ALDARA
41
3.4 EFFECT OF THERAPY IN PATIENTS WITH CIN2 43
3.4.1 OVERVIEW OF CHANGES OF CIN2 43
3.4. 1.1 OVERVIEW OF CHANGES OF CIN2 AFTER LASER THERAPY 44
3.4.1.2 OVERVIEW OF CHANGES OF CIN2 AFTER CONIZATION THERAPY 45
3.4.2 OVERVIEW OF FOLLOW UP OF THE RESULTS OF HPV TESTING OF 16 PATIENTS
WITH CIN2 46
3.4.2.1 FOLLOW UP OF RESULTS OF HPV TESTING OF 10 PATIENTS WITH CIN2 DUE
TO LASER 47
3.4.2.2 FOLLOW UP OF RESULTS OF HPV TESTING OF 6 PATIENTS WITH CIN2 DUE
TO CONIZATION 48
3.4.3 OVERVIEW OF E6/E7 FINDING OF 12 PATIENTS HAD CIN2 DUE TO THERAPY
49
3.4.3.1 OVERVIEW OF E6/E7 FINDING OF 7 PATIENTS HAD CIN2 DUE TO LASER 50
3.4.3.2 OVERVIEW OF E6/E7 FINDING OF 5 PATIENTS HAD CIN2 DUE TO
CONIZATION 51
3.4.4 OVERVIEW OF FOLLOW UP OF ICCH VALUES OF 16 PATIENTS WITH CIN2DUE
TO THERAPY 52
3.4.4.1 FOLLOW UP OF ICCH VALUES OF 10 PATIENTS WITH CIN2DUE TO LASER 53
3.4.4.2 FOLLOW UP OF ICCH VALUES OF 6 PATIENTS WITH CIN2DUE TO
CONIZATION 54
3.5 SUMMARY OF RESULTS 57
4 DISCUSSION 58
5 SUMMARY 61
6 REFERENCES 62
7 CURRICULUM VITAE 75
8 ACKNOWLEDGEMENTS 76
II
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| indexdate | 2024-07-10T01:11:21Z |
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| spelling | El Wihiashi, Hanan 1972- Verfasser (DE-588)1047246236 aut Follow up of high risk HPV induced changes in patients with CIN lesions before and after therapy presented by Hanan el Wihiashi 2013 III, 76 Bl. Ill., graph. Darst. 30 cm txt rdacontent n rdamedia nc rdacarrier Freiburg (Breisgau), Univ., Diss., 2014 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027488822&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | El Wihiashi, Hanan 1972- Follow up of high risk HPV induced changes in patients with CIN lesions before and after therapy |
| subject_GND | (DE-588)4113937-9 |
| title | Follow up of high risk HPV induced changes in patients with CIN lesions before and after therapy |
| title_auth | Follow up of high risk HPV induced changes in patients with CIN lesions before and after therapy |
| title_exact_search | Follow up of high risk HPV induced changes in patients with CIN lesions before and after therapy |
| title_full | Follow up of high risk HPV induced changes in patients with CIN lesions before and after therapy presented by Hanan el Wihiashi |
| title_fullStr | Follow up of high risk HPV induced changes in patients with CIN lesions before and after therapy presented by Hanan el Wihiashi |
| title_full_unstemmed | Follow up of high risk HPV induced changes in patients with CIN lesions before and after therapy presented by Hanan el Wihiashi |
| title_short | Follow up of high risk HPV induced changes in patients with CIN lesions before and after therapy |
| title_sort | follow up of high risk hpv induced changes in patients with cin lesions before and after therapy |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027488822&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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