Nanoparticle- and microparticle-based delivery systems: encapsulation, protection and release of active compounds
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| Language: | English |
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Boca Rato, Fla. [u.a.]
CRC Press
2015
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| Online Access: | Cover image Inhaltsverzeichnis |
| Physical Description: | XXIV, 572 S. Ill., graph. Darst. |
| ISBN: | 9781482233155 |
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| 245 | 1 | 0 | |a Nanoparticle- and microparticle-based delivery systems |b encapsulation, protection and release of active compounds |c David Julian McClements |
| 264 | 1 | |a Boca Rato, Fla. [u.a.] |b CRC Press |c 2015 | |
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| 650 | 7 | |a TECHNOLOGY & ENGINEERING / Food Science |2 bisacsh | |
| 650 | 4 | |a Chemie | |
| 650 | 4 | |a Food |x Biotechnology | |
| 650 | 4 | |a Transport theory | |
| 650 | 4 | |a Colloids | |
| 650 | 4 | |a Microencapsulation | |
| 650 | 4 | |a SCIENCE / Chemistry / Physical & Theoretical | |
| 650 | 4 | |a TECHNOLOGY & ENGINEERING / Food Science | |
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Titel: Nanoparticle- and microparticle-based delivery systems
Autor: McClements, David Julian
Jahr: 2015
Contents
Foreword.xxi
Preface.xxiii
Author.xxv
1 Background and Context.1
1.1 Introduction.1
1.2 Terminology.6
1.3 Active Ingredients and the Need for Encapsulation.7
1.3.1 Flavors and Colors.7
1.3.2 Antioxidants.8
1.3.3 Antimicrobials.8
1.3.4 Bioactive Lipids.8
1.3.3 Bioactive Carbohydrates.9
1.3.6 Bioactive Proteins.9
1.3.7 Bioactive Minerals.10
1.4 Challenges to Incorporating Active Ingredients in Foods.11
1.4.1 Low Solubility.11
1.4.2 Inappropriate Physical State.11
1.4.3 Poor Physicochemical Stability.12
1.4.4 Poor Biochemical Stability.12
1.4.5 Poor Flavor Profile.12
1.4.6 Poor Handling Characteristics.13
1.5 Fabrication of Delivery Systems.13
1.5.1 Surfactant-Based Systems.15
1.5.2 Emulsion-Based Systems.18
1.5.3 Biopolymer-Based Systems.21
1.5.4 Hybrid Systems.22
1.5.5 Nature-Inspired Systems.22
1.6 Desirable Characteristics of Delivery Systems.23
1.6.1 Food-Grade.23
1.6.2 Economic Production.24
viii ¦ Contents
1.6.3 Food Matrix Compatibility.24
1.6.4 Protection against Chemical Degradation.24
1.6.5 Loading Capacity, Encapsulation Efficiency, and
Retention.24
1.6.6 Delivery Mechanism.24
1.6.7 Bioavailability/Bioactivity.25
1.7 Release Mechanisms.25
1.7.1 Diffusion.25
1.7.2 Dissolution.26
1.7.3 Erosion.26
1.7.4 Fragmentation.26
1.7.5 Swelling.27
1.7.6 Designing Release Profiles.27
1.8 Summary.29
References.29
2 Active Ingredients.37
2.1 Introduction.37
2.2 Lipid-Based Ingredients.37
2.2.1 Neutral Oils.41
2.2.2 Flavor and Essential Oils.41
2.2.3 Oil-Soluble Colorants.42
2.2.4 Lipophilic Nutraceuticals.43
2.2.4.1 Polyunsaturated Lipids.44
2.2.4.2 Fat-Soluble Antioxidants.45
2.2.4.3 Fat-Soluble Vitamins.46
2.2.4.4 Fat-Soluble Nutraceuticals.49
2.2.5 Challenges to Delivery of Lipid-Based Ingredients.51
2.3 Protein-Based Ingredients.52
2.3.1 Proteins.53
2.3.2 Peptides and Amino Acids.54
2.3.3 Challenges to Delivery of Proteins, Peptides, and
Amino acids.55
2.4 Carbohydrate-Based Ingredients.56
2.4.1 Polysaccharides.57
2.4.1.1 Digestible Polysaccharides.57
2.4.1.2 Indigestible Polysaccharides.58
2.4.2 Monosaccharides and Oligosaccharides.59
2.4.3 Challenges to Delivery of Carbohydrates.59
2.5 Mineral-Based Ingredients.60
2.5.1 Iron.60
2.5.2 Zinc.61
Contents ¦ ix
2.5.3 Calcium.61
2.5.4 Challenges to Delivery of Minerals.61
2.6 Microorganisms.62
2.6.1 Probiotics.63
2.6.2 Challenges to Delivery of Probiotics.64
2.7 Summary.65
References.65
3 Particle Characteristics and Their Impact on Physicochemical
Properties of Delivery Systems.79
3.1 Introduction.79
3.2 Particle Building Blocks.80
3.2.1 Molecules, Particles, and Phases.80
3.2.2 Molecular and Colloidal Interactions.81
3.3 Particle Characteristics.81
3.3.1 Composition.81
3.3.2 Morphology.84
3.3.3 Concentration.86
3.3.4 Particle Physicochemical Properties.87
3-3.4.1 Density.87
3.3.4.2 Rheology.87
3.3.4.3 Refractive Index.89
3.3.5 Particle Dimensions.89
3.3.5.1 Particle Size Distributions.90
3.3.5.2 Mean and Standard Deviation.91
3.3.5.3 Internal Dimensions.92
3.3.6 Particle Charge.94
3.3.7 Particle Interactions.94
3.3.8 Loading Characteristics.96
3.3.9 Release Characteristics.98
3.4 Impact of Particle Properties on Physicochemical Properties.99
3.4.1 Rheology and Texture.99
3.4.2 Optical Properties and Appearance.103
3.4.3 Stability and Shelf Life.105
3.4.3.1 Gravitational Separation.106
3.4.3.2 Particle Aggregation.107
3.4.3.3 Ostwald Ripening.Ill
3.4.4 Molecular Partitioning and Transport.113
3.4.4.1 Molecular Partitioning.113
3.4.4.2 Mass Transport Processes.116
3.5 Summary.117
References.118
x ¦ Contents
4 Mechanical Particle Fabrication Methods.123
4.1 Introduction.123
4.2 Homogenization Methods.124
4.2.1 Higher-Shear Mixers.124
4.2.2 Colloid Mills.125
4.2.3 High-Pressure Valve Homogenizers.126
4.2.4 Ultrasonic Homogenizers.128
4.2.5 Microfluidization.130
4.2.6 Membrane and MicroChannel Homogenizers.131
4.3 Atomization Methods.133
4.3.1 Spray Drying.133
4.3.2 Spray Chilling.136
4.3.3 Rotary Disk Atomization.137
4.3.4 Electrospraying.137
4.4 Milling Methods.137
4.5 Extrusion Methods.138
4.6 Coating Methods.140
4.7 Supercritical Fluid Methods.142
4.8 Summary.143
References.143
5 Surfactant-Based Delivery Systems.149
5.1 Introduction.149
5.2 Building Blocks: Surfactants.149
5.2.1 Molecular Characteristics.150
5.2.2 Physicochemical Properties.153
5.2.2.1 Molecular Organization in Solution.153
5.2.2.2 Critical Micelle Concentration.155
5.2.2.3 Krafft Point.156
5.2.2.4 Cloud Point.156
5.2.2.5 Solubilization Capacity.157
5-2.3 Surfactant Classification Schemes.158
5.2.3.1 Bancrofts Rule.159
5.2.3.2 Hydrophile—Lipophile Balance (HLB).160
5.2.3.3 Molecular Geometry.161
5.2.3.4 Hydrophilic—Lipophilic Deviation.162
5.2.3.5 Additional Factors.165
5.2.4 Food-Grade Surfactants.165
5.2.4.1 Mono- and Diglycerides.166
5.2.4.2 Organic Acid Esters of Mono- and Diglycerides. 166
5.2.4.3 Polyol Esters of Fatty Acids.167
5.2.4.4 Stearoyl Lactylate Salts.168
5.2.4.5 Lecithins.168
Contents ¦ xi
5.3 Micelle and Microemulsion Delivery Systems.168
5.3.1 Composition and Structure.169
5.3.2 Formation.170
5.3.3 Properties.171
5.3.3.1 Optical Properties.171
5.3.3.2 Rheological Properties.171
5.3.3.3 Stability.172
5.3.3.4 Flavor.173
5.3.4 Applications.173
5.4 Liposome Delivery Systems.174
5.4.1 Composition and Structure.174
5.4.2 Formation.176
5.4.2.1 Vesicle Fabrication.176
5.4.2.2 Loading.177
5.4.3 Properties.178
5.4.3.1 Optical Properties.178
5.4.3.2 Rheological Properties.178
5.4.3.3 Stability.178
5.4.3.4 Flavor.180
5.4.3.5 Release Characteristics.180
5.4.4 Applications.181
5.4.4.1 Enzymes.181
5.4.4.2 Nutraceuticals and Minerals.182
5.4.4.3 Controlling Biological Fate.182
5.4.4.4 Taste Masking.182
5.4.4.5 Inhibiting Physicochemical Reactions.183
5.5 Summary.183
References.184
6 Emulsion-Based Delivery Systems.191
6.1 Introduction.191
6.2 Building Blocks: Fat Droplets.192
6.2.1 Droplet Concentration.193
6.2.2 Particle Size.194
6.2.3 Particle Charge.194
6.2.4 Interfacial Characteristics.195
6.2.5 Physical State.196
6.2.6 Colloidal Interactions.196
6.2.7 Controlling Droplet Characteristics for Improved
Performance.198
6.3 Physicochemical Properties of Emulsions.198
6.3.1 Appearance.198
6.3.2 Rheology.200
¦ Contents
6.3.3 Stability.201
6.3.4 Molecular Distribution and Release Characteristics.204
6.3-5 Implications for Design of Delivery Systems.204
6.4 Emulsion-Based Delivery Systems.205
6.4.1 Emulsions and Nanoemulsions.205
6.4.1.1 Composition and Structure.205
6.4.1.2 Formation.208
6.4.1.3 Properties.210
6.4.1.4 Applications.212
6.4.2 Multiple Emulsions.214
6.4.2.1 Composition and Structure.214
6.4.2.2 Formation.215
6.4.2.3 Properties.216
6.4.2.4 Applications.219
6.4.3 Multilayer Emulsions.220
6.4.3.1 Composition and Structure.220
6.4.3.2 Formation.220
6.4.3.3 Properties.224
6.4.3.4 Applications.226
6.4.4 Solid Lipid Particles.229
6.4.4.1 Composition and Structure.229
6.4.4.2 Formation.229
6.4.4.3 Properties.231
6.4.4.4 Applications.234
6.4.5 Filled Hydrogel Particles.234
6.4.5.1 Composition and Structure.234
6.4.5.2 Formation.235
6.4.5.3 Properties.238
6.4.5.4 Applications.240
6.4.6 Microclusters.241
6.4.6.1 Composition and Structure.241
6.4.6.2 Formation.242
6.4.6.3 Properties.243
6.4.6.4 Applications.244
6.4.7 Miscellaneous Systems.246
6.4.7.1 Particle-Stabilized Emulsions.246
6.4.7.2 Emulsified Microemulsions and Cubosomes . 246
6.4.7.3 Nanocrystal Suspensions.247
6.5 Summary.247
References.247
Biopolymer-Based Delivery Systems.265
7.1 Introduction.265
Contents ¦ xiii
7.2 Building Blocks: Biopolymers.265
7.2.1 Proteins.267
7.2.1.1 Molecular Conformation.267
7.2.1.2 Electrical Characteristics.270
7.2.1.3 Hydrophobic Characteristics.271
7.2.1.4 Physical Interactions.272
7.2.1.5 Chemical Reactivity.272
7.2.1.6 Commonly Used Proteins.273
7.2.1.7 Protein Selection.275
7.2.2 Polysaccharides.276
7.2.2.1 Molecular Conformation.276
7.2.2.2 Electrical Characteristics.278
7.2.2.3 Hydrophobic Characteristics.279
7.2.2.4 Physical Interactions.279
7.2.2.5 Chemical Reactivity.279
7.2.2.6 Commonly Used Polysaccharides.280
7.2.2.7 Polysaccharide Selection.286
7.3 Molecular Interactions.287
7.3.1 Electrostatic Interactions.288
7.3.2 Hydrogen Bonding.290
7.3.3 Hydrophobic Interactions.290
7.3.4 Excluded Volume Effects.291
7.3.5 Covalent Interactions.292
7.3.6 Assembling Biopolymer Structures.293
7.3.6.1 Single Biopolymer Systems.294
7.3.6.2 Mixed Biopolymer Systems.295
7.4 Physiochemical Methods for Biopolymer Particle Formation.299
7.4.1 Formation of Molecular Complexes.300
7.4.1.1 Individual Biopolymer Molecules.300
7.4.1.2 Biopolymer Molecular Clusters: Single
Biopolymer Type.301
7.4.1.3 Biopolymer Molecular Clusters: Mixed
Biopolymer Type.302
7.4.2 Formation of Hydrogel Particles.302
7.4.2.1 Hydrogel Particles: Single Biopolymer Type.302
7.4.2.2 Hydrogel Particles: Mixed Biopolymer Type . 304
7.5 Mechanical Methods for Biopolymer Particle Formation.305
7.5.1 Extrusion Methods.306
7.5.2 Microfluidic Methods.307
7.5.3 Spray Drying and Other Drying Methods.308
7.5.4 Antisolvent Precipitation.309
7.5.5 Emulsion Templating.309
7.5.6 Shearing Methods.310
xiv ¦ Contents
7.5.7 Molding Techniques.312
7.6 Biopolymer Particle Properties.312
7.6.1 Particle Structure.313
7.6.1.1 External Structure: Particle Dimension and
Morphology.313
7.6.1.2 Internal Structure.313
7.6.2 Particle Electrical Characteristics.314
7.6.3 Particle Physicochemical Properties.316
7.6.3.1 Particle Integrity and Environmental
Responsiveness.316
7.6.3.2 Optical Properties.316
7.6.3.3 Rheological Properties.318
7.6.3.4 Stability.319
7.6.3.5 Release Characteristics.322
7.7 Potential Applications.324
7.7.1 Encapsulation and Protection.324
7.7.2 Controlled Release.325
7.7.3 Lightening Agents.325
7.7.4 Texture Modification.326
7.7.5 Fat Replacement.326
7.8 Summary.327
References.327
8 Delivery System Characterization Methods.341
8.1 Introduction.341
8.2 Particle Characteristics.342
8.2.1 Particle Concentration.342
8.2.2 Particle Morphology and Organization.342
8.2.2.1 Optical Microscopy.343
8.2.2.2 Electron Microscopy.346
8.2.2.3 Atomic Force Microscopy.349
8.2.2.4 Practical Considerations.349
8.2.3 Particle Size.351
8.2.3.1 Static Light Scattering.352
8.2.3.2 Dynamic Light Scattering.353
8.2.3.3 Optical Pulse Counting.354
8.2.3.4 Electrical Pulse Counting.355
8.2.3.5 Gravitational Settling and Centrifugation.356
8.2.3.6 Miscellaneous Techniques.357
8.2.3.7 Practical Considerations.357
8.2.4 Particle Charge.358
8.2.4.1 Microelectrophoresis.359
8.2.4.2 Electroacoustics.360
8.2.4.3 Practical Considerations.361
Contents ¦ xv
8.2.5 Particle Physical State.361
8.2.5.1 Dilatometry.362
8.2.5.2 Differential Scanning Calorimetry.362
8.2.5.3 Nuclear Magnetic Resonance.362
8.2.5.4 Ultrasonics.362
8.2.5.5 X-Ray Analysis.362
8.2.5.6 Microscopy.363
8.2.5.7 Practical Considerations.363
8.3 Bulk Physicochemical Properties.363
8.3.1 Optical Properties.363
8.3.2 Rheology.365
8.3.2.1 Shear Testing.365
8.3.2.2 Compression Testing.366
8.3.2.3 Compression—Shear Testing.366
8.3.3 Flavor.367
8.3.3.1 Analysis of Volatile Flavors.367
8.3.3.2 Analysis of Nonvolatile Flavors.369
8.3.3.3 Sensory Analysis.370
8.3.4 Stability.371
8.3.4.1 Particle Location Changes: Gravitational
Separation.371
8.3.4.2 Particle Size Changes: Aggregation, Ostwald
Ripening, and Dissociation.377
8.3.4.3 Environmental Stress Tests.377
8.4 Protection, Retention, and Release Characteristics.379
8.4.1 Protection.379
8.4.2 Retention and Release.381
8.4.2.1 Nondestructive Methods.381
8.4.2.2 Destructive Methods.382
8.5 Biological Fate.383
8.5.1 In Vitro Approaches.384
8.5.1.1 Passage through GIT.384
8.5.1.2 Absorption.386
8.5.2 In Vivo Approaches.388
8.5-3 In Vitro versus In Vivo Correlations.388
8.5-4 Measurement of Changes in Delivery System Properties .389
8.6 Summary.391
References.391
9 Selection of Delivery Systems: Case Studies.401
9.1 Introduction.401
9.1.1 Design Criteria for Colloidal Delivery Systems.401
9.1.1.1 Economics.401
xvi ¦ Contents
9.1.1.2 Ease and Reliability of Fabrication.402
9.1.1.3 Transportation and Storage.402
9.1.1.4 Labeling and Marketing.402
9.1.1.5 Legislation.402
9.1.1.6 Patent Status.403
9.1.1.7 Shelf Life.403
9.1.1.8 Matrix Compatibility.403
9.1.1.9 Loading, Retention, and
Release Characteristics.404
9.1.2 Identification of Appropriate Colloidal Delivery Systems. 404
9.2 Nutraceutical-Fortified Soft Drinks.404
9.2.1 Design Criteria.405
9.2.1.1 Loading and Retention Characteristics.405
9.2.1.2 Influence on Physicochemical and Sensory
Properties of Product.405
9.2.1.3 Product Stability.406
9.2.1.4 Storage Form.408
9.2.2 Potential Delivery Systems.409
9.2.2.1 Surfactant-Based Delivery Systems.409
9.2.2.2 Emulsion-Based Delivery Systems.410
9.2.2.3 Biopolymer-Based Delivery Systems.411
9.3 Dairy-Based Functional Beverages Designed to Enhance
Nutraceutical Bioavailability.411
9.3.1 Design Criteria.412
9.3.1.1 Loading and Retention Characteristics.412
9.3.1.2 Influence on Physicochemical and Sensory
Properties of Product.412
9.3.1.3 Product Stability.413
9.3.1.4 Bioavailability Enhancement.414
9.3.2 Potential Delivery Systems.417
9.3.2.1 Surfactant-Based Delivery Systems.417
9-3.2.2 Emulsion-Based Delivery Systems.418
9.3.2.3 Biopolymer-Based Delivery Systems.420
9.4 Delivery of Probiotics to the Colon.421
9.4.1 Design Criteria.422
9.4.1.1 Loading and Retention Characteristics.422
9.4.1.2 Influence on Physicochemical and Sensory
Properties of Product.422
9.4.1.3 Product Stability.422
9.4.1.4 Maintain Viability within Foods.423
9.4.1.5 Maintain Viability within the GIT.423
9.4.1.6 Release Probiotics within the Large Intestine.424
9.4.2 Potential Delivery Systems.425
Contents ¦ xvii
9.4.2.1 Surfactant-Based Delivery Systems.425
9.4.2.2 Emulsion-Based Delivery Systems.425
9.4.2.3 Biopolymer-Based Delivery Systems.426
9.5 Controlled Flavor Release.428
9.5.1 Design Criteria.429
9.5.1.1 Loading and Retention Characteristics.429
9.5.1.2 Influence on Physicochemical and Sensory
Properties of Product.429
9.5.1.3 Product Stability.429
9.5.1.4 Flavor Release Profile.430
9.5.2 Potential Delivery Systems.430
9.5.2.1 Surfactant-Based Delivery Systems.431
9.5.2.2 Emulsion-Based Delivery Systems.431
9.5.2.3 Biopolymer-Based Delivery Systems.433
9.6 Protection of Lipophilic Active Agents against Oxidation.434
9.6.1 Design Criteria.435
9.6.1.1 Loading and Retention Characteristics.435
9.6.1.2 Influence on Physicochemical and Sensory
Properties of Product.435
9.6.1.3 Product Stability.435
9.6.2 Potential Delivery Systems.437
9.6.2.1 Surfactant-Based Delivery Systems.437
9.6.2.2 Emulsion-Based Delivery Systems.438
9.6.2.3 Biopolymer-Based Delivery Systems.441
9.7 Summary.442
References.442
Key Physicochemical Concepts.453
10.1 Introduction.453
10.2 Physical States and Phase Transitions.453
10.2.1 Physical States.454
10.2.1.1 Thermodynamics.454
10.2.1.2 Practical Implications.454
10.2.2 Crystallization and Melting.456
10.2.2.1 Supercooling.456
10.2.2.2 Nucleation.456
10.2.2.3 Crystal Growth.460
10.2.2.4 Crystal Morphology and Structure.461
10.2.2.5 Melting.463
10.2.3 Crystallization and Dissolution.464
10.2.3.1 Saturation.464
10.2.3.2 Supersaturation.465
10.2.3.3 Dissolution Rate.467
xviii ¦ Contents
10.2.3.4 Temperature Dependence of Dissolution.468
10.2.3.5 Dissolution in Multiphase Systems.469
10.2.3.6 Nucleation and Crystal Growth.471
10.3 Partitioning Phenomenon.472
10.3.1 Equilibrium Partitioning Coefficients.472
10.3.2 Solute Partitioning in Delivery Systems.474
10.3.2.1 Solute Partitioning below the Saturation
Limit.474
10.3.2.2 Solute Partitioning above the Saturation
Level.476
10.3.2.3 Partitioning of Volatile Solutes.477
10.3.2.4 Influence of Particle Size on Solubility.479
10.4 Mass Transport Processes.480
10.4.1 Diffusion.480
10.4.2 Convection.482
10.5 Modeling Release Profiles from Colloidal Delivery Systems.483
10.5.1 Diffusion.483
10.5.1.1 Release from Homogeneous Spheres.483
10.5.1.2 Release from Homogeneous Spheres
Containing Insoluble Active Ingredients.487
10.5.1.3 Release from Porous Polymeric Spheres.487
10.5.1.4 Release from Coated Spheres.489
10.5.1.5 Release from Heterogeneous Spheres.490
10.5.2 Particle Dissolution.491
10.5.3 Particle Swelling.492
10.5.4 Particle Matrix Degradation.493
10.5.5 Particle Matrix Fragmentation.494
10.5.6 Establishing Release Mechanisms.495
10.6 Modeling Particle Aggregation.495
10.6.1 Colloidal Interactions.495
10.6.1.1 van der Waals Interactions.496
10.6.1.2 Steric Interactions.496
10.6.1.3 Electrostatic Interactions.497
10.6.1.4 Hydrophobic Interactions.498
10.6.1.5 Depletion Interactions.499
10.6.1.6 Overall Interactions.499
10.6.2 Calculation of Aggregation Kinetics.501
10.7 Modeling Bioavailability of Bioactives in the GIT.502
10.7.1 Release of Bioactive Components.502
10.7.1.1 Mouth.504
10.7.1.2 Stomach.504
10.7.1.3 Small Intestine.505
10.7.1.4 Colon.507
Contents ¦ xix
10.7.2 Absorption of Bioactive Components.507
10.7.2.1 Absorption of Particles.508
10.7.2.2 Bioactive Absorption.511
10.8 Summary.514
References.514
Index.523 |
| any_adam_object | 1 |
| author | McClements, David Julian |
| author_GND | (DE-588)135790026 |
| author_facet | McClements, David Julian |
| author_role | aut |
| author_sort | McClements, David Julian |
| author_variant | d j m dj djm |
| building | Verbundindex |
| bvnumber | BV042030839 |
| callnumber-first | T - Technology |
| callnumber-label | TP248 |
| callnumber-raw | TP248.65.F66 |
| callnumber-search | TP248.65.F66 |
| callnumber-sort | TP 3248.65 F66 |
| callnumber-subject | TP - Chemical Technology |
| ctrlnum | (OCoLC)1012746383 (DE-599)BVBBV042030839 |
| dewey-full | 664 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 664 - Food technology |
| dewey-raw | 664 |
| dewey-search | 664 |
| dewey-sort | 3664 |
| dewey-tens | 660 - Chemical engineering |
| discipline | Chemie / Pharmazie |
| format | Book |
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| id | DE-604.BV042030839 |
| illustrated | Illustrated |
| indexdate | 2024-12-11T13:03:17Z |
| institution | BVB |
| isbn | 9781482233155 |
| language | English |
| lccn | 014022773 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027472284 |
| oclc_num | 1012746383 |
| open_access_boolean | |
| owner | DE-188 |
| owner_facet | DE-188 |
| physical | XXIV, 572 S. Ill., graph. Darst. |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | CRC Press |
| record_format | marc |
| spelling | McClements, David Julian Verfasser (DE-588)135790026 aut Nanoparticle- and microparticle-based delivery systems encapsulation, protection and release of active compounds David Julian McClements Boca Rato, Fla. [u.a.] CRC Press 2015 XXIV, 572 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier SCIENCE / Chemistry / Physical & Theoretical bisacsh TECHNOLOGY & ENGINEERING / Food Science bisacsh Chemie Food Biotechnology Transport theory Colloids Microencapsulation SCIENCE / Chemistry / Physical & Theoretical TECHNOLOGY & ENGINEERING / Food Science Mikroverkapselung (DE-588)4169865-4 gnd rswk-swf Kolloid (DE-588)4164695-2 gnd rswk-swf Kolloid (DE-588)4164695-2 s Mikroverkapselung (DE-588)4169865-4 s DE-188 http://images.tandf.co.uk/common/jackets/websmall/978148223/9781482233155.jpg Cover image HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027472284&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | McClements, David Julian Nanoparticle- and microparticle-based delivery systems encapsulation, protection and release of active compounds SCIENCE / Chemistry / Physical & Theoretical bisacsh TECHNOLOGY & ENGINEERING / Food Science bisacsh Chemie Food Biotechnology Transport theory Colloids Microencapsulation SCIENCE / Chemistry / Physical & Theoretical TECHNOLOGY & ENGINEERING / Food Science Mikroverkapselung (DE-588)4169865-4 gnd Kolloid (DE-588)4164695-2 gnd |
| subject_GND | (DE-588)4169865-4 (DE-588)4164695-2 |
| title | Nanoparticle- and microparticle-based delivery systems encapsulation, protection and release of active compounds |
| title_auth | Nanoparticle- and microparticle-based delivery systems encapsulation, protection and release of active compounds |
| title_exact_search | Nanoparticle- and microparticle-based delivery systems encapsulation, protection and release of active compounds |
| title_full | Nanoparticle- and microparticle-based delivery systems encapsulation, protection and release of active compounds David Julian McClements |
| title_fullStr | Nanoparticle- and microparticle-based delivery systems encapsulation, protection and release of active compounds David Julian McClements |
| title_full_unstemmed | Nanoparticle- and microparticle-based delivery systems encapsulation, protection and release of active compounds David Julian McClements |
| title_short | Nanoparticle- and microparticle-based delivery systems |
| title_sort | nanoparticle and microparticle based delivery systems encapsulation protection and release of active compounds |
| title_sub | encapsulation, protection and release of active compounds |
| topic | SCIENCE / Chemistry / Physical & Theoretical bisacsh TECHNOLOGY & ENGINEERING / Food Science bisacsh Chemie Food Biotechnology Transport theory Colloids Microencapsulation SCIENCE / Chemistry / Physical & Theoretical TECHNOLOGY & ENGINEERING / Food Science Mikroverkapselung (DE-588)4169865-4 gnd Kolloid (DE-588)4164695-2 gnd |
| topic_facet | SCIENCE / Chemistry / Physical & Theoretical TECHNOLOGY & ENGINEERING / Food Science Chemie Food Biotechnology Transport theory Colloids Microencapsulation Mikroverkapselung Kolloid |
| url | http://images.tandf.co.uk/common/jackets/websmall/978148223/9781482233155.jpg http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027472284&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT mcclementsdavidjulian nanoparticleandmicroparticlebaseddeliverysystemsencapsulationprotectionandreleaseofactivecompounds |