Imaging of the human brain in health and disease:
Saved in:
| Other Authors: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Amsterdam [u.a.]
Elsevier AP
2014
|
| Edition: | 1. ed. |
| Series: | Neuroscience-net reference book series
1 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIV, 517 S. Ill., graph. Darst. |
| ISBN: | 9780124186774 0124186777 |
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| 245 | 1 | 0 | |a Imaging of the human brain in health and disease |c ed. by Philip Seeman ... |
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| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier AP |c 2014 | |
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Record in the Search Index
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| adam_text | Titel: Imaging the human brain in health and disease
Autor: Seeman, Philip
Jahr: 2014
CONTENTS
List of Contributors xi
1. Neuroimaging of Addiction 1
Nora D.Volkow, Gene-Jack Wang, Joanna S. Fowler, DardoTomasi and Ruben Baler
1. Introduction 1
2.1. Magnetic resonance-based imaging techniques 1
2.2. Nuclear medicine imaging techniques 10
2.3. Clinical applications of imaging 16
3. Conclusions 20
Acknowledgments 20
References 20
2. Brain PET Imaging in the Cannabinoid System 27
Dean F. Wong, Ayon Nandi, Eram Zaidi, Emily Gean, Andrew Horti, Boris Frolov,
Noble George and James R. Brasic
1. Introduction 27
2.1. First attempts at imaging CB1R with pet: a historical perspective 28
2.2. The currently available pet radioligands 29
2.3. Applications of cannabinoid imaging 32
3. Conclusions 33
References 34
3. Brain Imaging of Cannabinoid Receptors 37
Cindy Casteels, Guy Bormans and Ko en Van Laere
1. Introduction 37
1.2. ECS in brain pathology 41
2.1. Molecular imaging of the ECS 45
2.2. Imaging of cannabinoid receptors 49
3. Conclusions 68
References 68
4. Human Brain Imaging of Opioid Receptors: Application to CNS Biomarker
and Drug Development 81
Udi E. Ghitza
1. Introduction
2.1. CNS opioid receptors
81
83
vi
Contents
2.2. OR-radiolabeled tracers 84
2.3. PET imaging of | OR 85
2.4. PET imaging of 6-OR and k-OR 86
2.5. PET imaging studies of the p-OR and drug use 87
2.6. Characterizing actions of putative OR-acting analgesics: combined molecular
imaging of occupancy of (j-OR in tandem with reward-related or pain-related
functional brain activation in humans 92
3. Conclusions 93
Acknowledgments 96
References 96
5. Brain Imaging of Sigma Receptors 99
Muneyuki Sakata, Jun Toyohara and Kiichi Ishiwata
1. Introduction 99
2.1. Postmortem studies 100
2.2. Radioligands for imaging sigma receptors 102
2.3. Human PET imaging of the sigma, receptor 104
3. Conclusions 108
Abbreviations 109
References 109
6. Human Brain Imaging of Acetylcholine Receptors 113
Jun Toyohara, Muneyuki Sakata and Kiichi Ishiwata
1. Introduction 113
2.1. Postmortem studies 117
2.2. Radioligands for imaging AChRs 118
2.3. Human SPECT/PET imaging of mAChR 125
2.4. Human SPECT/PET imaging of mAChR in the diseased brain 131
2.5. Human SPECT/PET imaging of a4ß2 nAChR 136
2.6. Human SPECT/PET imaging of a7 nAChR 143
3. Conclusions 145
Abbreviations 145
References 147
7. Human Brain Imaging of Adenosine Receptors 161
Masahiro Mishina, Yuichi Kimura and Kiich Ishiwata
1. Introduction 161
2.1. Postmortem studies 163
2.2. Imaging of A, and A2A receptors 164
2.3. Quantification of adenosine receptors 170
Contents
vii
3. Conclusions 180
Abbreviations 180
References 181
8. Human Brain Imaging of Dopamine Ü! Receptors 187
Hironobu Fujiwara, HidehikoTakahashi, Hitoshi Shimada, Yoshiro Okubo
and Tetsuya Suhara
1. Introduction 187
2.1. Affective and cognitive functions and D, receptors in humans 188
2.2. Dj receptor and psychiatric disorders 197
3. Conclusions 199
References 200
9. Human Brain Imaging of Dopamine Transporters 203
Andrea Varrone and Christer Halldin
1. Introduction 203
2.1. In vivo imaging of the DAT-Part I 210
2.2. In vivo imaging of the DAT-Part II 216
2.3. In vivo imaging of the DAT - Part III 220
3. Conclusions 227
References 238
10. Imaging of Dopamine and Serotonin Receptors and Transporters 241
Andre C. Felicio and A. Jon Stoessl
1. Introduction 241
2.1. Parkinson s disease as a model for understanding
molecular imaging 242
2.2. Tracers for the assessment of presynaptic dopamine function 244
2.3. Transporters 245
2.4. Tracers for the assessment of postsynaptic dopamine function 248
2.5. Other tracers: serotonergic binding ligands 249
2.6. Clinical relevance 250
3. Conclusions 257
Acknowledgments 257
References 258
11. Imaging the Dopamine D3 Receptor In Vivo 265
Mark Slifstein, Eugenii A. Rabiner and Roger N. Gunn
1. Introduction 265
2.1. PET imaging with [1lC]-(+)-phno 267
viii
Contents
2.2. D3 receptor imaging in neuropsychiatrie illness 275
3. Conclusions 281
References 282
12. Dopamine Receptors and Dopamine Release 289
Robert M. Kessler
1. Introduction 289
2.1. Dopamine D, family receptors 289
2.2. Clinical studies of the dopamine D, receptor 293
2.3. Dopamine D2 family receptors 295
2.4. Effects of extracellular DA levels on dopamine D2ß receptor binding 307
2.5. Clinical studies using dopamine D2 type receptor ligands 315
3. Conclusions 322
References 323
13. Dopamine Receptor Imaging in Schizophrenia: Focus on Genetic Vulnerability 341
Jussi Hirvonen and Jarmo Hietala
1. Introduction 341
2.1. Overview of molecular imaging techniques 342
2.2. Dopamine D2 receptor imaging in schizophrenia 344
2.3. Dopamine D, receptor imaging in schizophrenia 349
2.4. Summary: the dopamine hypothesis of schizophrenia vulnerability 351
3. Conclusions 353
References 354
14. Human Brain Imaging in Tardive Dyskinesia 361
Sofia N. Chatziioannou and Emmanouil N. Rizos
1. Introduction 361
2.1. Nuclear medicine modalities 362
2.2. Magnetic resonance imaging 366
2.3. Computed tomography 368
3. Conclusions 368
References 368
15. Human Brain Imaging of Autism Spectrum Disorders 373
James Robert Brasic and Mona Mohamed
1. Introduction 373
2.1. Structural human brain imaging of autism spectrum disorders 376
2.2. Functional human brain imaging of autism spectrum disorders 377
3. Conclusions 388
Contents
ix
Acknowledgments 396
References 396
16. Radiotracers Used to Image the Brains of Patients with Alzheimer s Disease 407
Noble George, Emily Gean, Ayon Nandi, James Robert Brasic and Dean F. Wong
1. Introduction 407
2.1. Overview 408
2.2. Amyloid plaques 409
2.3. Tau imaging agents 414
3. Conclusions 415
References 415
17. Human Brain Imaging of Anger 417
Sharmin Ghaznavi,Thilo Deckersbach and Darin D. Dougherty
1. Introduction 417
2.1. Angered: neuroimaging of the subjective experience of anger 417
2.2. Angry faces, bodies, and voices: neuroimaging of the perception of anger 419
2.3. From anger to aggression to violence 422
3. Conclusions 423
References 424
18. Imaging Pain in the Human Brain 427
Marco L. Loggia and Karin B. Jensen
1. Introduction 427
2.1. Pain processing in the brain 429
2.2. The descending pain modulatory pathway 432
2.3. Psychological modulation of pain 433
2.4. Chronic pain 436
3. Conclusions 443
Acknowledgments 443
References 443
19. Imaging of Neurochemical Transmission in the Central Nervous System 453
Lora Deuitch and Rajesh Narendran
1. Introduction 453
2.1. Imaging of da transmission 454
2.2. Imaging of serotonin transmission 472
2.3. Imaging of gamma-aminobutyric acid transmission 474
2.4. Imaging of glutamate transmission 474
2.5. Imaging of opioid transmission 475
X
Contents
3. Conclusions 476
References 476
20. Characterizing Recovery of the Human Brain following Stroke:
Evidence from fMRI Studies 485
Christian La, Brittany M.Young, Camille Garcia-Ramos,Veena A. Nair
and Vivek Prabhakaran
1. Introduction 485
2.1. fMRI and stroke 486
3. Conclusions 501
Acknowledgments 501
References 501
Index 507
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| isbn | 9780124186774 0124186777 |
| language | English |
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| spelling | Imaging of the human brain in health and disease ed. by Philip Seeman ... 1. ed. Amsterdam [u.a.] Elsevier AP 2014 XIV, 517 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Neuroscience-net reference book series 1 Neuroimaging methods Substance-Related Disorders radionuclide imaging Brain Chemistry physiology Brain Diseases radionuclide imaging Mental Disorders radionuclide imaging Bildgebendes Verfahren (DE-588)4006617-4 gnd rswk-swf Hirnfunktion (DE-588)4159930-5 gnd rswk-swf Hirnfunktion (DE-588)4159930-5 s Bildgebendes Verfahren (DE-588)4006617-4 s DE-604 Seeman, Philip edt Neuroscience-net reference book series 1 (DE-604)BV042046753 1 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027465019&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Imaging of the human brain in health and disease Neuroscience-net reference book series Neuroimaging methods Substance-Related Disorders radionuclide imaging Brain Chemistry physiology Brain Diseases radionuclide imaging Mental Disorders radionuclide imaging Bildgebendes Verfahren (DE-588)4006617-4 gnd Hirnfunktion (DE-588)4159930-5 gnd |
| subject_GND | (DE-588)4006617-4 (DE-588)4159930-5 |
| title | Imaging of the human brain in health and disease |
| title_auth | Imaging of the human brain in health and disease |
| title_exact_search | Imaging of the human brain in health and disease |
| title_full | Imaging of the human brain in health and disease ed. by Philip Seeman ... |
| title_fullStr | Imaging of the human brain in health and disease ed. by Philip Seeman ... |
| title_full_unstemmed | Imaging of the human brain in health and disease ed. by Philip Seeman ... |
| title_short | Imaging of the human brain in health and disease |
| title_sort | imaging of the human brain in health and disease |
| topic | Neuroimaging methods Substance-Related Disorders radionuclide imaging Brain Chemistry physiology Brain Diseases radionuclide imaging Mental Disorders radionuclide imaging Bildgebendes Verfahren (DE-588)4006617-4 gnd Hirnfunktion (DE-588)4159930-5 gnd |
| topic_facet | Neuroimaging methods Substance-Related Disorders radionuclide imaging Brain Chemistry physiology Brain Diseases radionuclide imaging Mental Disorders radionuclide imaging Bildgebendes Verfahren Hirnfunktion |
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