Peptidomimetics in organic and medicinal chemistry: the art of transforming peptides in drugs
Saved in:
| Main Author: | |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Chichester, West Sussex
Wiley
2014
|
| Subjects: | |
| Online Access: | TUM01 Volltext |
| Item Description: | "A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"-- "Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature"-- Includes bibliographical references and index |
| Physical Description: | 1 Online-Ressource (xix, 288 p.) |
| ISBN: | 1118683846 1306546982 9781118683842 9781306546980 |
Staff View
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| 500 | |a "Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature"-- | ||
| 500 | |a Includes bibliographical references and index | ||
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| 650 | 4 | |a Proteins / Therapeutic use | |
| 650 | 4 | |a Drugs / Design | |
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| author | Trabocchi, Andrea |
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| dewey-full | 615.1/9 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.1/9 |
| dewey-search | 615.1/9 |
| dewey-sort | 3615.1 19 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Biologie Medizin |
| format | Electronic eBook |
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| illustrated | Not Illustrated |
| indexdate | 2024-07-10T01:10:01Z |
| institution | BVB |
| isbn | 1118683846 1306546982 9781118683842 9781306546980 |
| language | English |
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| spelling | Trabocchi, Andrea Verfasser (DE-588)1053814542 aut Peptidomimetics in organic and medicinal chemistry the art of transforming peptides in drugs Andrea Trabocchi ; Antonio Guarna Chichester, West Sussex Wiley 2014 1 Online-Ressource (xix, 288 p.) txt rdacontent c rdamedia cr rdacarrier "A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"-- "Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature"-- Includes bibliographical references and index SCIENCE / Chemistry / Physical & Theoretical bisacsh MEDICAL / Pharmacology bisacsh Chemie Medizin Peptide drugs Proteins / Therapeutic use Drugs / Design Guarna, Antonio Sonstige (DE-588)1053813309 oth Erscheint auch als Druck-Ausgabe, Hardcover 1-119-95060-0 Erscheint auch als Druck-Ausgabe, Hardcover 978-1-119-95060-8 http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=721589 Aggregator Volltext |
| spellingShingle | Trabocchi, Andrea Peptidomimetics in organic and medicinal chemistry the art of transforming peptides in drugs SCIENCE / Chemistry / Physical & Theoretical bisacsh MEDICAL / Pharmacology bisacsh Chemie Medizin Peptide drugs Proteins / Therapeutic use Drugs / Design |
| title | Peptidomimetics in organic and medicinal chemistry the art of transforming peptides in drugs |
| title_auth | Peptidomimetics in organic and medicinal chemistry the art of transforming peptides in drugs |
| title_exact_search | Peptidomimetics in organic and medicinal chemistry the art of transforming peptides in drugs |
| title_full | Peptidomimetics in organic and medicinal chemistry the art of transforming peptides in drugs Andrea Trabocchi ; Antonio Guarna |
| title_fullStr | Peptidomimetics in organic and medicinal chemistry the art of transforming peptides in drugs Andrea Trabocchi ; Antonio Guarna |
| title_full_unstemmed | Peptidomimetics in organic and medicinal chemistry the art of transforming peptides in drugs Andrea Trabocchi ; Antonio Guarna |
| title_short | Peptidomimetics in organic and medicinal chemistry |
| title_sort | peptidomimetics in organic and medicinal chemistry the art of transforming peptides in drugs |
| title_sub | the art of transforming peptides in drugs |
| topic | SCIENCE / Chemistry / Physical & Theoretical bisacsh MEDICAL / Pharmacology bisacsh Chemie Medizin Peptide drugs Proteins / Therapeutic use Drugs / Design |
| topic_facet | SCIENCE / Chemistry / Physical & Theoretical MEDICAL / Pharmacology Chemie Medizin Peptide drugs Proteins / Therapeutic use Drugs / Design |
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